| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshim. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. Journal of neuroscience research. vol 94. issue 1. 2016-08-05. PMID:26400044. |
biochemical analysis revealed the inclusion of p-wave1, p-crmp2, and tau in the sarkosyl-insoluble fractions of hippocampal homogenates. |
2016-08-05 |
2023-08-13 |
mouse |
| Zhen Wu, Bin Yang, Chunxia Liu, Ge Liang, Maryellen F Eckenhoff, Weixia Liu, Stephen Pickup, Qingcheng Meng, Yuke Tian, Shitong Li, Huafeng We. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer disease and associated disorders. vol 29. issue 3. 2016-08-02. PMID:25650693. |
the amyloid burden and tau neurofibrillary tangles in the hippocampus were determined using immunohistochemistry. |
2016-08-02 |
2023-08-13 |
mouse |
| Zhen Wu, Bin Yang, Chunxia Liu, Ge Liang, Maryellen F Eckenhoff, Weixia Liu, Stephen Pickup, Qingcheng Meng, Yuke Tian, Shitong Li, Huafeng We. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer disease and associated disorders. vol 29. issue 3. 2016-08-02. PMID:25650693. |
we found that dantrolene significantly decreased the intraneuronal amyloid accumulation by as much as 76% compared with its corresponding vehicle control, together with a trend to reduce phosphorylated tau in the hippocampus. |
2016-08-02 |
2023-08-13 |
mouse |
| Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bus. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26260389. |
enduring elevations of hippocampal amyloid precursor protein and iron are features of β-amyloid toxicity and are mediated by tau. |
2016-07-22 |
2023-08-13 |
mouse |
| Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bus. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26260389. |
here, we utilized an alternative model of aβ toxicity by directly injecting aβ oligomers into the hippocampus of young and old wild-type and tau knockout mice. |
2016-07-22 |
2023-08-13 |
mouse |
| Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bus. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26260389. |
we found that ablation of tau protected against aβ-induced cognitive impairment, hippocampal neuron loss, and iron accumulation. |
2016-07-22 |
2023-08-13 |
mouse |
| Xiao-Fang Zhang, Yan-Feng Zhao, Shun-Wei Zhu, Wei-Jie Huang, Yan Luo, Qing-Ying Chen, Li-Jun Ge, Run-Sheng Li, Jian-Fei Wang, Mu Sun, Zhi-Cheng Xiao, Guo-Huang Fa. CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 48. issue 1. 2016-07-06. PMID:26401931. |
cxcl1 triggers caspase-3 dependent tau cleavage in long-term neuronal cultures and in the hippocampus of aged mice: implications in alzheimer's disease. |
2016-07-06 |
2023-08-13 |
mouse |
| Xiao-Fang Zhang, Yan-Feng Zhao, Shun-Wei Zhu, Wei-Jie Huang, Yan Luo, Qing-Ying Chen, Li-Jun Ge, Run-Sheng Li, Jian-Fei Wang, Mu Sun, Zhi-Cheng Xiao, Guo-Huang Fa. CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 48. issue 1. 2016-07-06. PMID:26401931. |
moreover, intrahippocampal microinjection of lentiviral cxcl1 induced tau cleavage in hippocampal neurons in aged (15-18 months of age) but not adult mice (5-10 months of age). |
2016-07-06 |
2023-08-13 |
mouse |
| Jesper Riise, Niels Plath, Bente Pakkenberg, Anna Parachikov. Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 9. 2016-06-21. PMID:25680440. |
alterations in gsk3β co-appeared with hippocampal kinase-targeted hyperphosphorylation at specific tau epitope in soluble pretangles and prominent tau aggregation exclusively in insoluble neurofibrillary tangles of ad subjects. |
2016-06-21 |
2023-08-13 |
human |
| Jun Jiang, Zhi-Hao Wang, Min Qu, Di Gao, Xiu-Ping Liu, Ling-Qiang Zhu, Jian-Zhi Wan. Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β. Scientific reports. vol 5. 2016-06-21. PMID:26119563. |
in cultured hippocampal neurons and the hippocampus of human tau transgenic mice, dephosphorylation of tau proteins was also detected by stimulation of ephb2 receptor. |
2016-06-21 |
2023-08-13 |
mouse |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
5-ht(2c) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. |
2016-06-13 |
2023-08-13 |
mouse |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
a 14-h exposure to environmental stressors caused an impairment of hippocampal long-term potentiation (ltp) and spatial memory, and an enhanced phosphorylation of tau protein in the ca1 and ca3 regions. |
2016-06-13 |
2023-08-13 |
mouse |
| Carla Letizia Busceti, Paola Di Pietro, Barbara Riozzi, Anna Traficante, Francesca Biagioni, Robert Nisticò, Francesco Fornai, Giuseppe Battaglia, Ferdinando Nicoletti, Valeria Brun. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological research. vol 99. 2016-06-13. PMID:26145279. |
acute systemic injection of the selective 5-ht2c antagonist, rs-102,221 (2 mg/kg, i.p., 2 min prior the onset of stress), prevented tau hyperphosphorylation and also corrected the defects in hippocampal ltp and spatial memory. |
2016-06-13 |
2023-08-13 |
mouse |
| Shiran Salomon-Zimri, Ori Liraz, Daniel M Michaelso. Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. Alzheimer's & dementia (Amsterdam, Netherlands). vol 1. issue 2. 2016-05-30. PMID:27239500. |
this was performed using young, naïve apoe ε4 and apoe ε3 mice in which the levels of distinct brain parameters are affected by the apoe genotype (e.g., elevated levels of amyloid beta [aβ] and hyperphosphorylated tau and reduced levels of vesicular glutamate transporter (vglut) in hippocampal neurons of apoe ε4 mice). |
2016-05-30 |
2023-08-13 |
mouse |
| Daniel Carneiro Carrettiero, Fernando Enrique Santiago, Anna Carolina Parracho Motzko-Soares, Maria Camila Almeid. Temperature and toxic Tau in Alzheimer's disease: new insights. Temperature (Austin, Tex.). vol 2. issue 4. 2016-05-26. PMID:27227069. |
specifically, we argue that cold might preferentially affects central nervous system structures that are highly reliant upon plasticity, such as the hippocampus, and that the effect of cold on tau phosphorylation may constitute a pathology-initiating trigger leading to neurodegeneration. |
2016-05-26 |
2023-08-13 |
human |
| Yao-Feng Zhu, Xian-Hui Li, Zhi-Peng Yuan, Chun-Yan Li, Rong-Bo Tian, Wei Jia, Zhu-Ping Xia. Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway. European journal of pharmacology. vol 762. 2016-05-24. PMID:26049013. |
tm increased tau phosphorylation, aβ42 deposit, and oxidative stress, and reduced antioxidative enzymes activity in the hippocampus. |
2016-05-24 |
2023-08-13 |
rat |
| Annapaola Prestia, Anna Caroli, Sara K Wade, Wiesjie M van der Flier, Rik Ossenkoppele, Bart Van Berckel, Frederik Barkhof, Charlotte E Teunissen, Anders Wall, Stephen F Carter, Michael Schöll, Il Han Choo, Agneta Nordberg, Philip Scheltens, Giovanni B Frison. Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 10. 2016-05-23. PMID:25646957. |
proposed diagnostic criteria (international working group and national institute on aging and alzheimer's association) for alzheimer's disease (ad) include markers of amyloidosis (abnormal cerebrospinal fluid [csf] amyloid beta [aβ]42) and neurodegeneration (hippocampal atrophy, temporo-parietal hypometabolism on [18f]-fluorodeoxyglucose-positron emission tomography (fdg-pet), and abnormal csf tau). |
2016-05-23 |
2023-08-13 |
Not clear |
| Michiyo Iba, Jennifer D McBride, Jing L Guo, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26150341. |
we recently showed (iba et al., j neurosci 33:1024-1037, 2013) that inoculation of preformed synthetic tau fibrils (tau pffs) into the hippocampus of young transgenic (tg) mice (ps19) overexpressing human p301s mutant tau induced robust tau pathology in anatomically connected brain regions including the locus coeruleus (lc). |
2016-05-17 |
2023-08-13 |
mouse |
| Michiyo Iba, Jennifer D McBride, Jing L Guo, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta neuropathologica. vol 130. issue 3. 2016-05-17. PMID:26150341. |
however, the spreading pattern of tau pathology observed in our lc-injected mice is different from that in ad brains since hippocampus and entorhinal cortex, which are affected in early stages of ad, were largely spared of tau inclusions in our model. |
2016-05-17 |
2023-08-13 |
mouse |
| Jiachen Zhuo, Kaspar Keledjian, Su Xu, Adam Pampori, Volodymyr Gerzanich, J Marc Simard, Rao P Gullapall. Changes in Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy in a Direct Cranial Blast Traumatic Brain Injury (dc-bTBI) Model. PloS one. vol 10. issue 8. 2016-05-17. PMID:26301778. |
concomitant increases in myo-inositol (ins) and taurine (tau) were also observed in the hippocampus, while early changes at 1 day in the glutamine (gln) were observed in the internal capsule, all indicating glial abnormality in these regions. |
2016-05-17 |
2023-08-13 |
rat |