| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siân Baker, Jürgen Göt. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:27037086. |
oa injection induced tau phosphorylation that was observed not only at the injection site but also in anatomically distinct areas across both hemispheres, including the cortex and hippocampus 24 h post-injection. |
2016-10-14 |
2023-08-13 |
mouse |
| Yan Yang, Delin Ma, Weijie Xu, Fuqiong Chen, Tingting Du, Wenzhu Yue, Shiying Shao, Gang Yua. Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level. Molecular and cellular neurosciences. vol 70. 2016-10-13. PMID:26640240. |
we found that peripheral ex-4 injection in t2d rats reduced hyperphosphorylation of tau protein in rat hippocampus, probably via increasing hippocampal insulin which activated insulin signaling. |
2016-10-13 |
2023-08-13 |
rat |
| Ke Li, Fang-Fang Liu, Chun-Xue He, He-Zhou Huang, Ao-Ji Xie, Fan Hu, Dan Liu, Jian-Zhi Wang, Ling-Qiang Zh. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Molecular neurobiology. vol 53. issue 1. 2016-10-10. PMID:25465240. |
we found that tau phosphorylation in hippocampus was increased at thr-205, ser-214, thr-231, and ser-396 after obx. |
2016-10-10 |
2023-08-13 |
mouse |
| Venkata Siva Sai Sujith Sajja, W Brad Hubbard, Christina S Hall, Farhad Ghoddoussi, Matthew P Galloway, Pamela J VandeVor. Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury. Scientific reports. vol 5. 2016-09-26. PMID:26537106. |
at three months, tau was selectively elevated in the pfc and hipp whereas α-synuclein transiently increased in the hipp at one month after blast exposure. |
2016-09-26 |
2023-08-13 |
Not clear |
| Mohcene Sadallah, Vivien Labat-Gest, Filippo Tempi. Propagation of Neuronal Damage to Embryonic Grafts Transplanted in the Hippocampus of Murine Models of Alzheimer's Disease. Rejuvenation research. vol 18. issue 6. 2016-09-26. PMID:26540615. |
to throw light on the mechanisms of propagation of neuronal damage to healthy tissue, wild-type (wt) hippocampal solid tissue chunks derived from green fluorescent protein (gfp)-positive embryos were grafted into the hippocampus of 6-month-old wt and 3xtg-ad mice, a triple-transgenic mouse model that exhibits both amyloid-beta (aβ) and tau protein pathology. |
2016-09-26 |
2023-08-13 |
mouse |
| Liam Scott, Tamás Kiss, Thomas T Kawabe, Mihály Hajó. Neuronal network activity in the hippocampus of tau transgenic (Tg4510) mice. Neurobiology of aging. vol 37. 2016-09-26. PMID:26610388. |
neuronal network activity in the hippocampus of tau transgenic (tg4510) mice. |
2016-09-26 |
2023-08-13 |
mouse |
| C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
in the present study, we removed the gene encoding a2ar from thy-tau22 mice and analysed the subsequent effects on both pathological (tau phosphorylation and aggregation, neuro-inflammation) and functional impairments (spatial learning and memory, hippocampal plasticity, neurotransmitter profile). |
2016-09-16 |
2023-08-13 |
mouse |
| C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
we found that deleting a2ars protect from tau pathology-induced deficits in terms of spatial memory and hippocampal long-term depression. |
2016-09-16 |
2023-08-13 |
mouse |
| C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée, D Blu. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular psychiatry. vol 21. issue 1. 2016-09-16. PMID:25450226. |
these effects were concomitant with a normalization of the hippocampal glutamate/gamma-amino butyric acid ratio, together with a global reduction in neuro-inflammatory markers and a decrease in tau hyperphosphorylation. |
2016-09-16 |
2023-08-13 |
mouse |
| Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
brain-wide insulin resistance, tau phosphorylation changes, and hippocampal neprilysin and amyloid-β alterations in a monkey model of type 1 diabetes. |
2016-09-08 |
2023-08-13 |
human |
| Jose Morales-Corraliza, Harrison Wong, Matthew J Mazzella, Shaoli Che, Sang Han Lee, Eva Petkova, Janice D Wagner, Scott E Hemby, Stephen D Ginsberg, Paul M Mathew. Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 15. 2016-09-08. PMID:27076423. |
thus, we document multiple biochemical changes in the insulin-controlled dm monkey brain that can link dm with the risk of developing ad, including dysregulation of the insulin-signaling pathway, changes in tau phosphorylation, and a decrease in nep expression in the hippocampus that is coupled with a localized increase in aβ. |
2016-09-08 |
2023-08-13 |
human |
| Gaëlle Naert, Valentine Ferré, Johann Meunier, Emeline Keller, Susanna Malmström, Laurent Givalois, François Carreaux, Jean-Pierre Bazureau, Tangui Mauric. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26381812. |
the oxidative stress, apoptotic markers, kinases involved in tau phosphorylation, and synaptic integrity were analyzed by western blot and elisa in the hippocampus. |
2016-08-26 |
2023-08-13 |
mouse |
| Juan Jose Ramos-Rodriguez, Margarita Jimenez-Palomares, Maria Isabel Murillo-Carretero, Carmen Infante-Garcia, Esther Berrocoso, Fernando Hernandez-Pacho, Alfonso Maria Lechuga-Sancho, Irene Cozar-Castellano, Monica Garcia-Alloz. Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease. Psychoneuroendocrinology. vol 62. 2016-08-24. PMID:26254770. |
significant brain atrophy and tau pathology were detected in the cortex by 14 weeks, that spread to the hippocampus by 26 weeks of age. |
2016-08-24 |
2023-08-13 |
mouse |
| Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of disease. vol 82. 2016-08-24. PMID:26385829. |
prefibrillar tau oligomers alter the nucleic acid protective function of tau in hippocampal neurons in vivo. |
2016-08-24 |
2023-08-13 |
mouse |
| Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Gala. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of disease. vol 82. 2016-08-24. PMID:26385829. |
in a mouse model of tauopathy (thy-tau22), we demonstrate that hyperthermia selectively induces nucleic acid oxidative damage and nucleic acid strand breaks in the nucleus and cytoplasm of hippocampal neurons that display early tau phosphorylation but no tau fibrils. |
2016-08-24 |
2023-08-13 |
mouse |
| Danielle Steinmetz, Eugenia Ramos, Shannon N Campbell, Teresa Morales, Robert A Rissma. Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. Journal of neuroendocrinology. vol 27. issue 11. 2016-08-18. PMID:26510116. |
although the specific mechanisms linking stress exposure and ad vulnerability have yet to be fully determined, our laboratory and others have shown that acute and repeated restraint stress in rodents leads to an increase in hippocampal tau phosphorylation (tau-p) and tau insolubility, a critical component of tau pathology in ad. |
2016-08-18 |
2023-08-13 |
rat |
| Danielle Steinmetz, Eugenia Ramos, Shannon N Campbell, Teresa Morales, Robert A Rissma. Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. Journal of neuroendocrinology. vol 27. issue 11. 2016-08-18. PMID:26510116. |
this suggests a steep, yet transient stress-induced dephosphorylation of tau, influenced by gsk3, in the hippocampus of lactating rats. |
2016-08-18 |
2023-08-13 |
rat |
| Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Maciej Tarnowski, Anna Pilutin, Izabela Gutowska, Lidia Strużyńska, Dariusz Chlubek, Agata Adamczy. Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders. Toxicology. vol 347-349. 2016-08-18. PMID:27012722. |
28-day old pups were sacrificed and tau mrna and protein level as well as tau phosphorylation were analyzed in forebrain cortex (fc), cerebellum (c) and hippocampus (h). |
2016-08-18 |
2023-08-13 |
rat |
| Michelle H Le, April M Weissmiller, Louise Monte, Po Han Lin, Tia C Hexom, Orlangie Natera, Chengbiao Wu, Robert A Rissma. Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PloS one. vol 11. issue 1. 2016-08-11. PMID:26790099. |
stress exposure or increased levels of corticotropin-releasing factor (crf) induce hippocampal tau phosphorylation (tau-p) in rodent models, a process that is dependent on the type-1 crf receptor (crfr1). |
2016-08-11 |
2023-08-13 |
mouse |
| Suzanne Attiori Essis, Marie-Elaine Laurier-Laurin, Élise Pépin, Michel Cyr, Guy Massicott. GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. Brain research. vol 1624. 2016-08-10. PMID:26260438. |
these results suggest that activation of s1pr1 by fty720p enhances glun2b receptor phosphorylation in rat hippocampal slices, resulting in increased levels of glun1 and glun2b receptor subunits in neuronal membranes through a mechanism probably involving fyn and tau. |
2016-08-10 |
2023-08-13 |
rat |