All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Jing Guo, Cheng Xu, Shaozhou Ni, Shujuan Zhang, Qihang Li, Peng Zeng, Guilin Pi, Enjie Liu, Dong-Sheng Sun, Yanchao Liu, Zhouyi Wang, Haote Chen, Ying Yang, Jian-Zhi Wan. Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775994. in retina and/or the hippocampus, significant loss of retinal ganglion cells and stenosis of retinal arteries with the ad-like tau and amyloid-β (aβ) pathologies and memory deficit were shown only in the 14-day hcy group. 2020-06-22 2023-08-13 rat
Jing Guo, Cheng Xu, Shaozhou Ni, Shujuan Zhang, Qihang Li, Peng Zeng, Guilin Pi, Enjie Liu, Dong-Sheng Sun, Yanchao Liu, Zhouyi Wang, Haote Chen, Ying Yang, Jian-Zhi Wan. Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775994. interestingly, accumulation of ser262 hyperphosphorylated tau (ps262-tau) but not aβ with decreased methylation of protein phosphatase-2a catalytic subunit (m-pp2ac) and increased de-methylated pp2ac (dm-pp2ac) was detected in retina of the 3-day hcy group, in which the retinal pathologies were preceded by those of the hippocampus. 2020-06-22 2023-08-13 rat
Linlin Fan, Lingling Chen, Zhi Liang, Hongkun Bao, Dan Wang, Yilong Dong, Shangyong Zheng, Chunjie Xiao, Jing Du, Hongliang L. A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice. International journal of medicinal mushrooms. vol 21. issue 11. 2020-06-10. PMID:32450016. furthermore, pgm treatment significantly enhanced the level of ampar and bdnf in the hippocampus, while suppressing the tau protein hyperphosphorylation at the ser396 site. 2020-06-10 2023-08-13 mouse
Sen Li, Furong Xian, Xiao Guan, Kai Huang, Wenwen Yu, Dandan Li. Neural Protective Effects of Millet and Millet Polyphenols on High-Fat Diet-Induced Oxidative Stress in the Brain. Plant foods for human nutrition (Dordrecht, Netherlands). vol 75. issue 2. 2020-06-04. PMID:32078112. our results suggested that the intake of millet could alleviate oxidative stress in the hippocampus and downregulate the expression of the alzheimer's disease (ad)-related genes amyloid precursor protein (app), tau, and γ-secretase. 2020-06-04 2023-08-13 rat
Katarina Ilic, Kristina Mlinac-Jerkovic, Natasa Jovanov-Milosevic, Goran Simic, Nikola Habek, Nenad Bogdanovic, Svjetlana Kalanj-Bogna. Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-05-21. PMID:30488668. here, we investigated the hippocampal expression of brain-specific neuroplastin isoform (np65), its relationship with amyloid and tau pathology in alzheimer's disease (ad), and potential involvement of neuroplastin in tissue response during the disease progression. 2020-05-21 2023-08-13 human
C Dirk Keene, Angela M Wilson, Mitchell D Kilgore, Lauren T Bruner, Nadia O Postupna, Martin Darva. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-05-18. PMID:30573871. consistent with the neuropathologic assessment, luminex assay detected high amounts of amyloid beta in the frontal cortex and striatum, and high amounts of hyperphosphorylated tau in the frontal cortex and hippocampus, of cases with high ad neuropathologic change. 2020-05-18 2023-08-13 human
Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. we show for the first time that treatment of adult (7-8 month-old) male c57bl/6 mice with cisplatin results in reduced cognitive function and a marked increase in the number of large endogenous tau clusters in the hippocampus when assessed 4 months later. 2020-05-13 2023-08-13 mouse
Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. in contrast, we detected only few small tau clusters in the hippocampus of age-matched 11-12 month-old control mice. 2020-05-13 2023-08-13 mouse
Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. 2020-05-12 2023-08-13 rat
Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. the focus of this study was to determine whether aβ plaques and phosphorylated tau aggregates occur in the hippocampus as a consequence of lipopolysaccharide administration, and whether behavioral abnormalities related to the hippocampus, particularly the dentate gyrus, can be demonstrated. 2020-05-12 2023-08-13 rat
Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. seven days post injection, aβ plaques and phosphorylated tau in the hippocampus were quantified following immunostaining. 2020-05-12 2023-08-13 rat
Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. lipopolysaccharide treatment results in the deposition of beta amyloid plaques and intracellular phosphorylated tau in the hippocampus, including the dorsal dentate gyrus. 2020-05-12 2023-08-13 rat
Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. lipopolysaccharide administration results in hippocampal deposition of amyloid-beta plaques and intracellular phosphorylated tau and results in specific behavioral deficits attributable to the dorsal dentate gyrus. 2020-05-12 2023-08-13 rat
Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. the activity of both tau and gsk3β in the hippocampus was increased in aged grk5-knockout mice, which is consistent with what occurs in app/ps1 transgenic mice. 2020-05-04 2023-08-13 mouse
Minori Iwata, Shoji Watanabe, Ayaka Yamane, Tomohiro Miyasaka, Hiroaki Misono. Regulatory mechanisms for the axonal localization of tau protein in neurons. Molecular biology of the cell. vol 30. issue 19. 2020-05-01. PMID:31364926. in this study, we found that the axonal localization of tau in cultured rat hippocampal neurons mainly occur during early neuronal development. 2020-05-01 2023-08-13 human
Susanne Wegmann, Rachel E Bennett, Louis Delorme, Ashley B Robbins, Miwei Hu, Danny McKenzie, Molly J Kirk, Julia Schiantarelli, Nahel Tunio, Ana C Amaral, Zhanyun Fan, Samantha Nicholls, Eloise Hudry, Bradley T Hyma. Experimental evidence for the age dependence of tau protein spread in the brain. Science advances. vol 5. issue 6. 2020-04-30. PMID:31249873. old animals showed more tau spreading in the hippocampus and adjacent cortical areas and accumulated more misfolded tau in ec neurons. 2020-04-30 2023-08-13 mouse
Alan King Lun Liu, Tsz Wing Chau, Ernest Junwei Lim, Idil Ahmed, Raymond Chuen-Chung Chang, Michail E Kalaitzakis, Manuel B Graeber, Steve M Gentleman, Ronald K B Pearc. Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31023342. hippocampal sections from 67 pd, 34 pd with mild cognitive impairment and 96 pdd cases were immunostained for tau and alpha-synuclein, and the respective pathology burden was assessed semi-quantitatively. 2020-04-21 2023-08-13 Not clear
Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U Monsch, Michel Goedert, Markus Tolnay, David T Winkle. Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31064413. csf obtained from ad or mci patients increased hippocampal tau hyperphosphorylation and tau tangle formation in these mice at 4 months post-seeding. 2020-04-21 2023-08-13 mouse
Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U Monsch, Michel Goedert, Markus Tolnay, David T Winkle. Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31064413. tau pathology was also accentuated in the contralateral hippocampus, and in anterior and posterior directions, indicative of spreading.we provide first evidence for in vivo prion-like properties of ad patients' csf, accelerating tau pathology in susceptible tau transgenic mice. 2020-04-21 2023-08-13 mouse
Yun Zhang, Jing Yang, Wei Jiang, Rong Li, Min Zhu, Feng Xiong, Cui Son. Brain Development Measured With MRI in Children With Down Syndrome Correlates With Blood Biochemical Biomarkers. Pediatric neurology. vol 92. 2020-04-20. PMID:30612744. in a case-control study, we quantitatively evaluated whole brain and hippocampal volumes of ds children and analyzed the correlation of hippocampal volumes with blood levels of aβ, tau and va. 2020-04-20 2023-08-13 Not clear