| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, Jos\\xc3\\xa9 L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
in this study, we aimed to identify the effects of amyloid-\xce\xb2 peptide 42 (amyloid-\xce\xb242) and phosphorylated tau on the patterns of functional connectomics involved in hippocampal downregulation. |
2020-07-06 |
2023-08-13 |
human |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, Jos\\xc3\\xa9 L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
across subjects, our main findings during hippocampal downregulation were: (i) in the absence of abnormal biomarkers, age correlated with eigenvector centrality negatively in the insula and midcingulate cortex, and positively in the inferior temporal gyrus; (ii) abnormal csf amyloid-\xce\xb242 (<1098) correlated negatively with eigenvector centrality in the anterior cingulate cortex and primary motor cortex; and (iii) abnormal csf phosphorylated tau levels (>19.2) correlated with eigenvector centrality positively in the ventral striatum, anterior cingulate and somatosensory cortex, and negatively in the precuneus and orbitofrontal cortex. |
2020-07-06 |
2023-08-13 |
human |
| Grace I Hallinan, Mariana Vargas-Caballero, Jonathan West, Katrin Deinhard. Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 48. 2020-07-02. PMID:31658988. |
tau misfolding efficiently propagates between individual intact hippocampal neurons. |
2020-07-02 |
2023-08-13 |
Not clear |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah D\\xc3\\xbcze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
higher csf tau levels are related to hippocampal hyperactivity and object mnemonic discrimination in older adults. |
2020-06-29 |
2023-08-13 |
human |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah D\\xc3\\xbcze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
importantly, csf tau levels were associated with increased fmri activity in the hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnemonic discrimination of objects, but again not scenes. |
2020-06-29 |
2023-08-13 |
human |
| Elise Gondard, Maria Luisa Soto-Montenegro, Amanda Cassol, Andres M Lozano, Clement Haman. Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease. Journal of psychiatric research. vol 114. 2020-06-25. PMID:31054455. |
in addition, ad transgenics had an increased expression of tau, phosphorylated-tau and amyloid precursor protein in the hippocampus. |
2020-06-25 |
2023-08-13 |
mouse |
| Jing Guo, Cheng Xu, Shaozhou Ni, Shujuan Zhang, Qihang Li, Peng Zeng, Guilin Pi, Enjie Liu, Dong-Sheng Sun, Yanchao Liu, Zhouyi Wang, Haote Chen, Ying Yang, Jian-Zhi Wan. Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775994. |
in retina and/or the hippocampus, significant loss of retinal ganglion cells and stenosis of retinal arteries with the ad-like tau and amyloid-\xce\xb2 (a\xce\xb2) pathologies and memory deficit were shown only in the 14-day hcy group. |
2020-06-22 |
2023-08-13 |
rat |
| Jing Guo, Cheng Xu, Shaozhou Ni, Shujuan Zhang, Qihang Li, Peng Zeng, Guilin Pi, Enjie Liu, Dong-Sheng Sun, Yanchao Liu, Zhouyi Wang, Haote Chen, Ying Yang, Jian-Zhi Wan. Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775994. |
interestingly, accumulation of ser262 hyperphosphorylated tau (ps262-tau) but not a\xce\xb2 with decreased methylation of protein phosphatase-2a catalytic subunit (m-pp2ac) and increased de-methylated pp2ac (dm-pp2ac) was detected in retina of the 3-day hcy group, in which the retinal pathologies were preceded by those of the hippocampus. |
2020-06-22 |
2023-08-13 |
rat |
| Linlin Fan, Lingling Chen, Zhi Liang, Hongkun Bao, Dan Wang, Yilong Dong, Shangyong Zheng, Chunjie Xiao, Jing Du, Hongliang L. A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice. International journal of medicinal mushrooms. vol 21. issue 11. 2020-06-10. PMID:32450016. |
furthermore, pgm treatment significantly enhanced the level of ampar and bdnf in the hippocampus, while suppressing the tau protein hyperphosphorylation at the ser396 site. |
2020-06-10 |
2023-08-13 |
mouse |
| Sen Li, Furong Xian, Xiao Guan, Kai Huang, Wenwen Yu, Dandan Li. Neural Protective Effects of Millet and Millet Polyphenols on High-Fat Diet-Induced Oxidative Stress in the Brain. Plant foods for human nutrition (Dordrecht, Netherlands). vol 75. issue 2. 2020-06-04. PMID:32078112. |
our results suggested that the intake of millet could alleviate oxidative stress in the hippocampus and downregulate the expression of the alzheimer's disease (ad)-related genes amyloid precursor protein (app), tau, and \xce\xb3-secretase. |
2020-06-04 |
2023-08-13 |
rat |
| Katarina Ilic, Kristina Mlinac-Jerkovic, Natasa Jovanov-Milosevic, Goran Simic, Nikola Habek, Nenad Bogdanovic, Svjetlana Kalanj-Bogna. Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-05-21. PMID:30488668. |
here, we investigated the hippocampal expression of brain-specific neuroplastin isoform (np65), its relationship with amyloid and tau pathology in alzheimer's disease (ad), and potential involvement of neuroplastin in tissue response during the disease progression. |
2020-05-21 |
2023-08-13 |
human |
| C Dirk Keene, Angela M Wilson, Mitchell D Kilgore, Lauren T Bruner, Nadia O Postupna, Martin Darva. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-05-18. PMID:30573871. |
consistent with the neuropathologic assessment, luminex assay detected high amounts of amyloid beta in the frontal cortex and striatum, and high amounts of hyperphosphorylated tau in the frontal cortex and hippocampus, of cases with high ad neuropathologic change. |
2020-05-18 |
2023-08-13 |
human |
| Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. |
we show for the first time that treatment of adult (7-8\xe2\x80\xafmonth-old) male c57bl/6 mice with cisplatin results in reduced cognitive function and a marked increase in the number of large endogenous tau clusters in the hippocampus when assessed 4\xe2\x80\xafmonths later. |
2020-05-13 |
2023-08-13 |
mouse |
| Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. |
in contrast, we detected only few small tau clusters in the hippocampus of age-matched 11-12\xe2\x80\xafmonth-old control mice. |
2020-05-13 |
2023-08-13 |
mouse |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\\xce\\xb2 plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\xce\xb2 plaque and phosphorylated tau deposition and corresponding behavioral deficits. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\\xce\\xb2 plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
the focus of this study was to determine whether a\xce\xb2 plaques and phosphorylated tau aggregates occur in the hippocampus as a consequence of lipopolysaccharide administration, and whether behavioral abnormalities related to the hippocampus, particularly the dentate gyrus, can be demonstrated. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\\xce\\xb2 plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
seven days post injection, a\xce\xb2 plaques and phosphorylated tau in the hippocampus were quantified following immunostaining. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\\xce\\xb2 plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
lipopolysaccharide treatment results in the deposition of beta amyloid plaques and intracellular phosphorylated tau in the hippocampus, including the dorsal dentate gyrus. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-\\xce\\xb2 plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
lipopolysaccharide administration results in hippocampal deposition of amyloid-beta plaques and intracellular phosphorylated tau and results in specific behavioral deficits attributable to the dorsal dentate gyrus. |
2020-05-12 |
2023-08-13 |
rat |
| Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3\\xce\\xb2 and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. |
the activity of both tau and gsk3\xce\xb2 in the hippocampus was increased in aged grk5-knockout mice, which is consistent with what occurs in app/ps1 transgenic mice. |
2020-05-04 |
2023-08-13 |
mouse |