| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Thuy Dung Nguyen, Thi Thuy Le, Van Giau V. Role of Insulin Resistance in the Alzheimer's Disease Progression. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32314178. |
insulin resistance or dysfunction of insulin signaling is a universal feature of t2d, the main culprit for altered glucose metabolism and its interdependence on cell death pathways, forming the basis of linking t2d with ad as it may exacerbate aβ accumulation, tau hyperphosphorylation and devastates glucose transportation, energy metabolism, hippocampal framework and promulgate inflammatory pathways. |
2021-03-29 |
2023-08-13 |
Not clear |
| Amira M Abo-Youssef, Waleed A Khallaf, Mahmoud M Khattab, Basim A S Messih. The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32450287. |
furthermore, it improved cognitive impairment and suppressed hippocampal amyloidogenic markers including amyloid-beta level, phosphorylated tau protein and beta site amyloid precursor protein cleaving enzyme 1 expression, while elevated levels of insulin degrading enzyme and recovered permeability of blood brain barrier (bbb). |
2021-03-29 |
2023-08-13 |
rat |
| Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C Lee, Dave Morgan, Marcia N Gordon, Maj-Linda B Selenic. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in immunology. vol 11. 2021-03-29. PMID:32508844. |
to address this question, ccl2 was delivered via recombinant adeno-associated virus serotype 9 into both cortex and hippocampus of a mouse model with tau pathology (rtg4510). |
2021-03-29 |
2023-08-13 |
mouse |
| Matthew R Barron, Jane Gartlon, Lee A Dawson, Peter J Atkinson, Marie-Christine Pardo. Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. Frontiers in immunology. vol 11. 2021-03-25. PMID:32194553. |
increasing tau 4r tau levels exacerbates hippocampal tau hyperphosphorylation in the htau model of tauopathy but also tau dephosphorylation following acute systemic inflammation. |
2021-03-25 |
2023-08-13 |
mouse |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
by intraperitoneal injection of lipopolysaccharide (lps) with brain medial entorhinal cortex (mec)-specific overexpressing p301l human tau (p301l-htau), we found that both acute and chronic administration of lps remarkably promoted p301l-htau transmission from mec to the hippocampal subsets. |
2021-03-16 |
2023-08-13 |
human |
| Shouchao Wei, Wanjuan Peng, Yingren Mai, Kanglan Li, Wei Wei, Li Hu, Shaoping Zhu, Haihong Zhou, Wanxin Jie, Zhuangsheng Wei, Chenyao Kang, Ruikai Li, Zhou Liu, Bin Zhao, Zhiyou Ca. Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31663118. |
more important, further study showed that omvs induced tau phosphorylation by activating glycogen synthase kinase 3β (gsk-3β) in the hippocampus. |
2021-03-08 |
2023-08-13 |
Not clear |
| César Espino de la Fuente-Muñoz, Mónica Rosas-Lemus, Perla Moreno-Castilla, Federico Bermúdez-Rattoni, Salvador Uribe-Carvajal, Clorinda Aria. Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33227902. |
accumulation of toxic compounds, such as tau and aβ, that occurred in the 3xtg-ad mouse model seemed to participate in the worsening of this decline in the hippocampus. |
2021-03-04 |
2023-08-13 |
mouse |
| Sarah Houben, Mégane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie And. Tau Pathology and Adult Hippocampal Neurogenesis: What Tau Mouse Models Tell us? Frontiers in neurology. vol 12. 2021-03-03. PMID:33643196. |
tau pathology and adult hippocampal neurogenesis: what tau mouse models tell us? |
2021-03-03 |
2023-08-13 |
mouse |
| Daria Pawlik, Antoine Leuzy, Olof Strandberg, Ruben Smit. Compensating for choroid plexus based off-target signal in the hippocampus using NeuroImage. vol 221. 2021-03-02. PMID:32711062. |
compensating for choroid plexus based off-target signal in the hippocampus using the hippocampus is affected by tau pathology early in alzheimer's disease (ad) development. |
2021-03-02 |
2023-08-13 |
Not clear |
| Daria Pawlik, Antoine Leuzy, Olof Strandberg, Ruben Smit. Compensating for choroid plexus based off-target signal in the hippocampus using NeuroImage. vol 221. 2021-03-02. PMID:32711062. |
accurate quantification of hippocampal tau signal using the tau-pet tracer |
2021-03-02 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
alzheimer's disease is characterized by the presence of amyloid-β and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal atrophy over time. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
tdp-43, tau and amyloid-β have all been linked to hippocampal atrophy. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
tdp-43 and tau have also been linked to hippocampal atrophy in cases of primary age-related tauopathy, a pathological entity with features that strongly overlap with those of alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
at present, it is unclear whether and how tdp-43 and tau are associated with early or late hippocampal atrophy in alzheimer's disease and primary age-related tauopathy, whether either protein is also associated with faster rates of atrophy of other brain regions and whether there is evidence for protein-associated acceleration/deceleration of atrophy rates. |
2021-03-01 |
2023-08-13 |
Not clear |
| Laetitia Degiorgis, Meltem Karatas, Marion Sourty, Emilie Faivre, Julien Lamy, Vincent Noblet, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Luc Buée, David Blum, Anne-Laurence Boutillier, Jean-Paul Armspach, Frédéric Blanc, Laura-Adela Harsa. Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33184651. |
disrupted ventral hip-amg functional pathway and altered dynamic functional connectivity were consistent with high pathological tau deposition and astrogliosis in both hippocampus and amygdala, and significant microglial reactivity in amygdalar nuclei. |
2021-03-01 |
2023-08-13 |
mouse |
| Chongyang Chen, Pan Liu, Jing Wang, Haitao Yu, Zaijun Zhang, Jianjun Liu, Xiao Chen, Feiqi Zhu, Xifei Yan. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Frontiers in cell and developmental biology. vol 8. 2021-02-27. PMID:33634105. |
in this study, we investigated the potential therapeutic effects of dauricine (dau), a benzyl tetrahydroisoquinoline alkaloid, on ad, and found that dau administration significantly improved cognitive impairments in 3xtg-ad mice by decreasing aβ plaques and hyperphosphorylated tau and increasing the hippocampal atp level. |
2021-02-27 |
2023-08-13 |
mouse |
| Sara Becker, Oliver Granert, Maarten Timmers, Andrea Pilotto, Luc Van Nueten, Benjamin Roeben, Giacomo Salvadore, Wendy R Galpern, Johannes Streffer, Klaus Scheffler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfon. Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia. Neurology. vol 96. issue 6. 2021-02-23. PMID:33219138. |
to examine whether hippocampal volume loss is primarily associated with cognitive status or pathologic β-amyloid 1-42 (aβ42) levels, this study compared hippocampal subfield volumes between patients with parkinson disease (pd) with mild cognitive impairment (pd-mci) and without cognitive impairment (pd-cn) and between patients with low and high aβ42 levels, in addition exploring the relationship among hippocampal subfield volumes, csf biomarkers (aβ42, phosphorylated and total tau), neuropsychological tests, and activities of daily living. |
2021-02-23 |
2023-08-13 |
Not clear |
| Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377738. |
coenzyme q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein e and phosphorylated tau protein in mouse hippocampal neurons. |
2021-02-16 |
2023-08-13 |
mouse |
| Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377738. |
the present study aimed to reveal the role of apoe in the pathogenesis of tau protein hyperphosphorylation and neuroinflammation enhancement caused by sevoflurane anesthesia, as well as the protective mechanism of coq10 in an anesthetic sevoflurane treatment model of primary mouse hippocampal neurons. |
2021-02-16 |
2023-08-13 |
mouse |