Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Guo-Quan Wang, Peng Zhou, Dao-Jun Xie, Shu Ye, Hua-Wu Gao, Yan Wang, Zheng-Qing Fang, Biao Ca. [Effects of Huangpu Tongqiao Capsules on EGFR-PLCγ signal pathway of hippocampus in rats with Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 9. 2020-09-17. PMID:32495567. |
rt-pcr results showed that the mrna levels of egfr, plcγ, ip3 r and tau in hippocampus of ad rats were significantly increased(p<0.01), and hptqc could reduce the mrna levels of egfr, plcγ, ip3 r and tau in ad rats(p<0.05). |
2020-09-17 |
2023-08-13 |
rat |
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces aβ and tau pathology in the hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
using a novel transgenic mouse line to model the impact of human app (happ)/aβ accumulation on tauopathy in the entorhinal cortex-hippocampal (ec-hipp) network, we demonstrate that happ overexpression aggravates ec-tau aggregation and accelerates pathological tau spread into the hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
chronic chemogenetic attenuation of ec neuronal hyperactivity led to reduced happ/aβ accumulation and reduced pathological tau spread into downstream hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
Emily L Munger, Melissa K Edler, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. The Journal of comparative neurology. vol 527. issue 7. 2020-09-16. PMID:30578640. |
both prefrontal cortex layer i and hippocampal astrocytes exhibit a high degree of astrogliosis that is positively correlated with accumulation of amyloid beta and tau proteins. |
2020-09-16 |
2023-08-13 |
chimpanzee |
Hyemin Jang, Jongyun Park, Sookyoung Woo, Seonwoo Kim, Hee Jin Kim, Duk L Na, Samuel N Lockhart, Yeshin Kim, Ko Woon Kim, Soo Hyun Cho, Seung Joo Kim, Joon-Kyung Seong, Sang Won Se. Prediction of fast decline in amyloid positive mild cognitive impairment patients using multimodal biomarkers. NeuroImage. Clinical. vol 24. 2020-09-16. PMID:31376643. |
the associations of potential covariates (mci stage, apoe4 genotype, corrected hippocampal volume (hv), fdg pet suvr, av45 pet suvr, csf aβ, total tau (t-tau), and phosphorylated tau (p-tau)) with the outcome were tested and nomograms were constructed using logistic regression models in the training dataset (n=124, n of fast decliners=52). |
2020-09-16 |
2023-08-13 |
Not clear |
Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. |
[effect of electroacupuncture on cyclin-dependent kinase 5 and tau protein in hippocampus of samp8 mice]. |
2020-09-16 |
2023-08-13 |
mouse |
Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. |
to observe the effect of electroacupuncture (ea) and manual acupuncture (ma) on learning-memory ability, changes of ultrastructure of neurons and expression of cdk5 and tau proteins in hippocampus of samp8 mice,so as to explore its mechanisms underlying improvement of alzheimer's disease (ad).. |
2020-09-16 |
2023-08-13 |
mouse |
Dylan J Finneran, Dave Morgan, Marcia N Gordon, Kevin R Nas. CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30499006. |
these benefits were achieved without detectable reductions in tau hyperphosphorylation, hippocampal atrophy, or microglial cd45 expression. |
2020-09-11 |
2023-08-13 |
mouse |
Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging. vol 11. issue 18. 2020-09-08. PMID:31548435. |
we here show that employing single prolonged stress (sps), as a consensus ptsd model, induced a typical anxiety and abnormal hyperphosphorylation of tau at ser202/thr205 (at8) and ser404 but not at ser199 and ser396 in the hippocampus compared to the control rats. |
2020-09-08 |
2023-08-13 |
rat |
S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. |
the content of asp, glu, gaba, gly, and tau of the medulla oblongata, hippocampus and cerebral cortex were determined using high-performance liquid chromatography (hplc) in intact km rats, km rats exposed to a series of epileptiform seizures, and wistar rats (control group). |
2020-09-08 |
2023-08-13 |
rat |
S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. |
the changes observed in male rats after the set of seizures included the increase in gaba concentration and a decrease in the gly level in all investigated brain parts, as well as the decrease of the tau content in the cortex and hippocampus. |
2020-09-08 |
2023-08-13 |
rat |
Tauqeerunnisa Syeda, Rachel M Foguth, Emily Llewellyn, Jason R Canno. PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease. Toxicology. vol 437. 2020-08-31. PMID:32169473. |
phip exposure for 16 weeks resulted in increased hippocampal oxidative damage, app, bace1, aβ aggregation, and tau phosphorylation. |
2020-08-31 |
2023-08-13 |
mouse |
Yang Zhao, Haiyan Deng, Kun Li, Lijun Wang, Yongkang Wu, Xianwen Dong, Xingyu Wang, Yongjun Chen, Ying X. Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31376499. |
we observed that tca treatment reversed abnormal expression of synaptic proteins and tau hyperphosphorylation in the hippocampus and prefrontal cortex of ps cdko mice. |
2020-08-25 |
2023-08-13 |
mouse |
Heidi I L Jacobs, Jean C Augustinack, Aaron P Schultz, Bernard J Hanseeuw, Joseph Locascio, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. vol 94. issue 18. 2020-08-21. PMID:32273431. |
to identify the hippocampal subregions linking initial amyloid and tau pathology to memory performance in clinically normal older individuals, reflecting preclinical alzheimer disease (ad). |
2020-08-21 |
2023-08-13 |
Not clear |
Anna Mietelska-Porowska, Anna Gasiorowska, Ewelina Palasz, Dave J Koss, Gernot Riedel, Grazyna Niewiadomsk. Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride. Journal of neuroscience methods. vol 319. 2020-08-19. PMID:30448465. |
wistar rats 3, 9 and 15 month-old were surgically prepared for hippocampal loading with pore-former polymeric 1,3-alkylpyridinium salts (poly-aps) and recombinant human tau including pharmacological inhibition of phosphatase activity by okadaic acid co-administration. |
2020-08-19 |
2023-08-13 |
mouse |
Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31782760. |
amyloid-β peptide attenuation reduced hippocampal tau pathology and rescued adult hippocampal neurogenesis and neuronal function, via improvements in cross-frequency coupling between theta and gamma bands. |
2020-08-18 |
2023-08-13 |
rat |
Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31782760. |
reduction of amyloid-β peptide in the entorhinal cortex had no effect on entorhinal tau pathology or entorhinal-hippocampal neuronal network dysfunction, as measured by an impairment in hippocampal response to entorhinal stimulation. |
2020-08-18 |
2023-08-13 |
rat |
Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
we examined these pathways, as well as amyloid-β and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). |
2020-08-18 |
2023-08-13 |
Not clear |
Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
pathological phosphorylation of two distinct tau species was also increased in both regions, but increases in amyloid-β1-42 peptide, the main component of amyloid plaques, were restricted to the hippocampus. |
2020-08-18 |
2023-08-13 |
Not clear |