All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qi. The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats. Biochemical and biophysical research communications. vol 510. issue 1. 2019-11-29. PMID:30660367. in conclusion, the present study highlighted that gv might induce diabetic central neuropathy through the hyperphosphorylation of tau in the hippocampus by inhibiting the akt/gsk3β pathway and that it may cause dpn through oxidative stress and inflammatory responses by activating the nf-κb pathway. 2019-11-29 2023-08-13 rat
Veronika Hanko, Alexandra C Apple, Kathryn I Alpert, Kristen N Warren, Julie A Schneider, Konstantinos Arfanakis, David A Bennett, Lei Wan. In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies. Neurobiology of aging. vol 74. 2019-11-26. PMID:30453234. in vivo hippocampal subfield shape related to tdp-43, amyloid beta, and tau pathologies. 2019-11-26 2023-08-13 human
Vishruti Makani, Bin Zhang, Heeoon Han, Yuemang Yao, Pierrik Lassalas, Kevin Lou, Ian Paterson, Virginia M Y Lee, John Q Trojanowski, Carlo Ballatore, Amos B Smith, Kurt R Brunde. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications. vol 4. issue 1. 2019-11-20. PMID:27687527. moreover, epothilone d enhanced cognitive performance and decreased hippocampal neuron loss, with evidence of reduced tau pathology. 2019-11-20 2023-08-13 mouse
Vishruti Makani, Bin Zhang, Heeoon Han, Yuemang Yao, Pierrik Lassalas, Kevin Lou, Ian Paterson, Virginia M Y Lee, John Q Trojanowski, Carlo Ballatore, Amos B Smith, Kurt R Brunde. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications. vol 4. issue 1. 2019-11-20. PMID:27687527. importantly, as previously observed with epothilone d, the dictyostatin-treated ps19 mice displayed improved mt density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated ps19 mice. 2019-11-20 2023-08-13 mouse
Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069820. we confirmed that grk5 translocates from the cellular membrane to the cytosol in the hippocampus of alzheimer's disease mice and that grk5 deficiency promotes tau hyperphosphorylation, a hallmark of alzheimer's disease pathology. 2019-11-20 2023-08-13 mouse
S Tomaszewski, S Gauthier, A Wimo, P Rosa-Net. Combination Therapy of Anti-Tau and Anti-Amyloid Drugs for Disease Modification in Early-stage Alzheimer's Disease: Socio-economic Considerations Modeled on Treatments for Tuberculosis, HIV/AIDS and Breast Cancer. The journal of prevention of Alzheimer's disease. vol 3. issue 3. 2019-11-20. PMID:29205255. patients with alzheimer's disease (ad) are known to have characteristic pathology, including senile plaques with amyloid beta-protein aggregates and neurofibrillary tangles with assembled tau proteins, which start in the hippocampus and spread to neighboring areas. 2019-11-20 2023-08-13 Not clear
Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Erratum to: Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2019-11-20. PMID:29429142. erratum to: forskolin induces hyperphosphorylation of tau accompanied by cell cycle reactivation in primary hippocampal neurons. 2019-11-20 2023-08-13 Not clear
Stanislav Sutovsky, Tomas Smolek, Peter Turcani, Robert Petrovic, Petra Brandoburova, Santosh Jadhav, Petr Novak, Johannes Attems, Norbert Zilk. Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 6. 2019-11-12. PMID:29404783. in the neocortex, tau pathology, especially neuropil threads, was more abundant in the frontal and occipital cortex and in the hippocampus. 2019-11-12 2023-08-13 human
Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. glycosaminoglycans from alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. 2019-11-04 2023-08-13 Not clear
Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. here, we show that total sulfated gags from hippocampus of alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including fgf-2, vegf, and bdnf while their capacity to bind to tau is remarkable increased. 2019-11-04 2023-08-13 Not clear
Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30279527. chronic noise exposure led to progressive overproduction of aβ and increased the hyperphosphorylation of tau at ser396, thr205, and thr231 sites in the hippocampus and the prefrontal cortex (pfc) in young samp8 mice, similar to that observed in aging samp8 mice. 2019-10-31 2023-08-13 mouse
Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30279527. these findings demonstrate that chronic noise stress exacerbated ad-like neuropathology, possibly by disrupting wnt signaling and triggering aberrant tau hyperphosphorylation and aβ in the pfc and hippocampus. 2019-10-31 2023-08-13 mouse
Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H Chang, Anil K Malhotra, Peter Davie. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30238463. in another experiment, acutely following reboxetine injections, tau phosphorylation was quantified in the frontal cortex, striatum, and hippocampus of the mice. 2019-10-28 2023-08-13 mouse
H-B Zheng, Y-T Fu, G Wang, L-H Sun, Y-Y Fan, T-W Yan. Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. European review for medical and pharmacological sciences. vol 22. issue 11. 2019-10-22. PMID:29917212. hyperphosphorylation of protein tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. 2019-10-22 2023-08-13 rat
Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. tau accumulation in clinically normal older adults is associated with hippocampal hyperactivity. 2019-10-16 2023-08-13 human
Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. the relationship between hippocampal hyperactivity and early ad molecular pathology (amyloid-β and tau accumulation) before clinical symptoms remains to be elucidated. 2019-10-16 2023-08-13 human
Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. in this subset, we found that inferior temporal tau accumulation was associated with increased fmri activity in the hippocampus, but showed no clear association with amyloid. 2019-10-16 2023-08-13 human
Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. together, the findings support a hypothetical model of the evolution of preclinical ad that place hippocampal hyperactivity concurrent with spread of tau pathology to neocortical regions before clinical impairment. 2019-10-16 2023-08-13 human
Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. 2019-10-14 2023-08-13 mouse
Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. we found that acute knockdown of tau in the adult hippocampus significantly impaired motor coordination and spatial memory. 2019-10-14 2023-08-13 mouse