| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa Neri-Gómez, Judith Espinosa-Raya, Sofía Díaz-Cintra, Julia Segura-Uribe, Sandra Orozco-Suárez, Juan Manuel Gallardo, Christian Guerra-Araiz. Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. Neural regeneration research. vol 12. issue 4. 2020-09-29. PMID:28553339. |
tibolone modulates neuronal plasticity through regulating tau, gsk3β/akt/pi3k pathway and cdk5 p35/p25 complexes in the hippocampus of aged male mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Teresa Neri-Gómez, Judith Espinosa-Raya, Sofía Díaz-Cintra, Julia Segura-Uribe, Sandra Orozco-Suárez, Juan Manuel Gallardo, Christian Guerra-Araiz. Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. Neural regeneration research. vol 12. issue 4. 2020-09-29. PMID:28553339. |
the aim of this work was to evaluate the long-term effects of tib (0.01 mg/kg and 1 mg/kg, intragastrically for 12 weeks) on the content of total and hyperphosphorylated tau (phf-1) proteins and the regulation of gsk3β/akt/pi3k pathway and cdk5/p35/p25 complexes in the hippocampus of aged male mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Cai Shi, Jia Zeng, Zixi Li, Qingjie Chen, Weijian Hang, Liangtao Xia, Yue Wu, Juan Chen, Anbing Sh. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Frontiers in molecular neuroscience. vol 11. 2020-09-29. PMID:29416502. |
by using primary hippocampal neurons and mouse brain, we showed that ka treatment specifically induced er stress and activated gsk-3β and cdk5, two major kinases responsible for tau phosphorylation. |
2020-09-29 |
2023-08-13 |
mouse |
| Rodolfo Pinto-Almazan, Julia J Segura-Uribe, Marvin A Soriano-Ursúa, Eunice D Farfán-García, Juan M Gallardo, Christian Guerra-Araiz. Effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of Tau in the hippocampus of rats exposed to ozone. Neural regeneration research. vol 13. issue 3. 2020-09-29. PMID:29623928. |
effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of tau in the hippocampus of rats exposed to ozone. |
2020-09-29 |
2023-08-13 |
rat |
| Christian Griñán-Ferré, Vanesa Izquierdo, Eduard Otero, Dolors Puigoriol-Illamola, Rubén Corpas, Coral Sanfeliu, Daniel Ortuño-Sahagún, Mercè Pallà. Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30158856. |
neurodegenerative markers as β-ctf and tau hyperphosphorylation, reduced protein levels whiles appα, postsynaptic density 95 (psd95) and synaptophysin (syn) protein levels increased protein levels in the hippocampus of 5xfad-ee mice group. |
2020-09-29 |
2023-08-13 |
mouse |
| Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Su. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542451. |
hippocampal regions were examined for the presence of amyloid plaques, neuronal apoptosis and tau phosphorylation. |
2020-09-29 |
2023-08-13 |
mouse |
| Emrah Düzel, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Matthew Betts, Gabriel Ziegler, Yi Chen, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Martin Reuter, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Peter Nestor, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Alfredo Ramirez, Anja Schneider, Barbara Kofler, Oliver Speck, Stefan Teipel, Ingo Kilimann, Martin Dyrba, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jesse. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimer's & dementia (Amsterdam, Netherlands). vol 10. 2020-09-29. PMID:30555890. |
csf total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. |
2020-09-29 |
2023-08-13 |
Not clear |
| Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadha. Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:31920624. |
in this study we investigated whether genetic background has an influence in the spread of tau pathology, using hippocampal inoculations of insoluble tau from ad brains in rodent models of tauopathy with either a spontaneously hypertensive (shr72) or wistar-kyoto (wky72) genetic background. |
2020-09-28 |
2023-08-13 |
human |
| Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadha. Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:31920624. |
we observed that insoluble tau from human ad induced at8-positive neurofibrillary structures in the hippocampus of both lines. |
2020-09-28 |
2023-08-13 |
human |
| Marta Fernández-Nogales, José J Luca. Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington's Disease. Frontiers in cellular neuroscience. vol 13. 2020-09-28. PMID:32009905. |
after their discovery in hd brains, tnis have also been reported in hippocampal neurons of early braak stage ad cases and in frontal and temporal cortical neurons of ftd-mapt cases due to the intronic ivs10+16 mutation in the tau gene (mapt) which results in an increased 4r-/3r-tau ratio similar to that observed in hd. |
2020-09-28 |
2023-08-13 |
mouse |
| Nobuko Hongo, Yusaku Takamura, Hiroshi Nishimaru, Jumpei Matsumoto, Kazuyuki Tobe, Takashi Saito, Takaomi C Saido, Hisao Nishij. Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32218736. |
astaxanthin ameliorated parvalbumin-positive neuron deficits and alzheimer's disease-related pathological progression in the hippocampus of growing evidence suggests that oxidative stress due to amyloid β (aβ) accumulation is involved in alzheimer's disease (ad) through the formation of amyloid plaque, which leads to hyperphosphorylation of tau, microglial activation, and cognitive deficits. |
2020-09-28 |
2023-08-13 |
mouse |
| Mercedes A Hernández-Sapiéns, Edwin E Reza-Zaldívar, Ricardo R Cevallos, Ana L Márquez-Aguirre, Karlen Gazarian, Alejandro A Canales-Aguirr. A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32655369. |
alzheimer's disease (ad) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory and learning as prefrontal cortex and hippocampus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
agd has a characteristic pattern progressively involving the entorhinal cortex, amygdala, hippocampus, dentate gyrus, presubiculum, subiculum, hypothalamic nuclei, temporal cortex, and neocortex and brainstem, thus suggesting that argyrophilic grain pathology is a natural model of tau propagation. |
2020-09-28 |
2023-08-13 |
mouse |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
abnormal hyper-phosphorylated tau deposits were found in ipsilateral hippocampal neurons, grains (dots) in the hippocampus, and threads, dots and coiled bodies in the fimbria, as well as the ipsilateral and contralateral corpus callosum. |
2020-09-28 |
2023-08-13 |
mouse |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
abnormal hyper-phosphorylated tau deposits were found in neurons in the ipsilateral hippocampus, coiled bodies and threads in the fimbria, and the ipsilateral and contralateral corpus callosum, which extended with time along the anterior-posterior axis and distant regions such as hypothalamic nuclei and nuclei of the septum when comparing mice surviving 7 months with mice surviving 3 months. |
2020-09-28 |
2023-08-13 |
mouse |
| Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. |
we expressed green fluorescent protein (gfp), gfp-full-length, and gpf-caspase-3-cleaved tau proteins in rat hippocampal neurons and immortalized cortical neurons (cn 1.4) and analyzed the expression and localization of these proteins involved in mitochondrial transport regulation. |
2020-09-28 |
2023-08-13 |
rat |
| Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. |
we observed that hippocampal neurons expressing caspase-cleaved tau showed a significant accumulation of a mitochondrial population in the soma. |
2020-09-28 |
2023-08-13 |
rat |
| Rodrigo A Quintanilla, Carola Tapia-Monsalves, Erick H Vergara, María José Pérez, Alejandra Arangui. Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32848607. |
more critically, caspase-cleaved tau significantly decreased the expression of trak2 in immortalized and primary hippocampal neurons without affecting rhot1/t2 and syntaphilin levels. |
2020-09-28 |
2023-08-13 |
rat |
| Yu-Wei Zhang, Xiao-Qian Li, Wen-Fei Tan, Bo Fang, Hong M. Postoperative 24-h Acute Sleep Deprivation Improves Learning and Memory Through Inhibition of Tau Phosphorylation in the Hippocampal Neurons of Splenectomized Rats. Nature and science of sleep. vol 12. 2020-09-28. PMID:32904483. |
postoperative 24-h acute sleep deprivation improves learning and memory through inhibition of tau phosphorylation in the hippocampal neurons of splenectomized rats. |
2020-09-28 |
2023-08-13 |
rat |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. |
in brain soluble extracts, despite reduced uncleaved tau in ad, levels of n368-cleaved tau are comparable in ad and control hippocampus, suggesting that lgmn-mediated cleavage of tau is not altered in ad. |
2020-09-25 |
2023-08-13 |
mouse |