| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Johnsen, H Beck-Nielse. Insulin receptors, insulin secretion, and glucose disappearance rate in patients with periodic hypokalaemic paralysis. Acta endocrinologica. vol 90. issue 2. 1979-04-25. PMID:419916. |
insulin receptors, insulin secretion, and glucose disappearance rate in patients with periodic hypokalaemic paralysis. |
1979-04-25 |
2023-08-11 |
human |
| S Durán-García, J G Nieto, A M Cabell. Effect of gestational diabetes on insulin receptors in human placenta. Diabetologia. vol 16. issue 2. 1979-03-28. PMID:759257. |
the existence of a negative feed-back regulation of the insulin receptors in placental membranes was suggested by the fact that plasma insulin levels were significantly higher in the gestational diabetic mothers. |
1979-03-28 |
2023-08-11 |
human |
| J P Wigand, J H Anderson, S S Jennings, W G Blackar. Effect of dietary composition on insulin receptors in normal subjects. The American journal of clinical nutrition. vol 32. issue 1. 1979-03-24. PMID:760504. |
glucose tolerance testing with plasma immunoreactive insulin levels was performed along with insulin receptor quantitation after a control period and after each of the dietary manipulations. |
1979-03-24 |
2023-08-11 |
human |
| J P Wigand, J H Anderson, S S Jennings, W G Blackar. Effect of dietary composition on insulin receptors in normal subjects. The American journal of clinical nutrition. vol 32. issue 1. 1979-03-24. PMID:760504. |
despite improved carbohydrate tolerance and decreased plasma immuno-reactive insulin after the high carbohydrate diet (evidence for increased insulin sensitivity) insulin receptor number and affinity were unchanged. |
1979-03-24 |
2023-08-11 |
human |
| H Beck-Nielsen, O Pedersen, H O Lindsko. Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year. Acta endocrinologica. vol 90. issue 1. 1979-03-13. PMID:760352. |
the insulin receptor defect seems to be one of the major factors responsible for the insulin resistance. |
1979-03-13 |
2023-08-11 |
human |
| J Havrankova, D Schmechel, J Roth, M Brownstei. Identification of insulin in rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 11. 1979-02-23. PMID:364489. |
the role of insulin in the central nervous system is not clear at present but, because both insulin and insulin receptors are abundant in the central nervous system, an extensive physiological regulation of the central nervous system by insulin is proposed. |
1979-02-23 |
2023-08-11 |
rat |
| M P Czech, D K Richardson, S G Becker, C G Walters, W Gitomer, J Heinric. Insulin response in skeletal muscle and fat cells of the genetically obese Zucker rat. Metabolism: clinical and experimental. vol 27. issue 12 Suppl 2. 1979-02-12. PMID:723645. |
this apparent rightward shift in the dose response-relationship could not be adequately explained on the basis of decreased insulin receptors since (125i-) insulin binding per fat cell was increased 2.5--3-fold in obesity, while receptor density on the cell surface in obesity was decreased only slightly. |
1979-02-12 |
2023-08-11 |
rat |
| Y Le Marchand-Brustel, P Freyche. Studies of insulin insensitivity in soleus muscles of obese mice. Metabolism: clinical and experimental. vol 27. issue 12 Suppl 2. 1979-02-12. PMID:723646. |
studies in obese mice have pointed to discrete sites of insulin resistance of skeletal muscle in obesity: (1) a decrease in the number of insulin receptors, which may result in diminished insulin sensitivity (i.e., impaired responses to submaximally stimulating doses of insulin); and (2) alterations that lay apart from, or beyond, the insulin receptor: thus, glucose transport (and/or phosphorylation) appears to be intrinsically altered and the stimulation by insulin of glycogen synthesis is markedly depressed. |
1979-02-12 |
2023-08-11 |
mouse |
| C S Rubin, A Hirsch, C Fung, O M Rose. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. The Journal of biological chemistry. vol 253. issue 20. 1978-12-27. PMID:81205. |
insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3t3-l1 cells. |
1978-12-27 |
2023-08-11 |
Not clear |
| C R Kahn, K L Baird, D B Jarrett, J S Flie. Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 9. 1978-12-27. PMID:279910. |
exposure of adipocytes to antibodies to the insulin receptor results in a blockade of (125)i-labeled insulin binding, stimulation of glucose oxidation, and many more insulin-like effects. |
1978-12-27 |
2023-08-11 |
Not clear |
| D S Straus, R A Williamso. Responsiveness to insulin is a dominant characteristic in somatic cell hybrids. Journal of cellular physiology. vol 97. issue 2. 1978-12-20. PMID:701385. |
to examine the possibility that the unresponsiveness to insulin of the melanoma cells is attributable to a lack of insulin receptors, we have measured the binding of 125i-labeled insulin to the fibroblasts, melanoma cells, and fibroblast x melanoma hybrids. |
1978-12-20 |
2023-08-11 |
mouse |
| M Kasuga, Y Akanuma, Y Iwamoto, K Kosak. Insulin binding and glucose metabolism in adipocytes of streptozotocin-diabetic rats. The American journal of physiology. vol 235. issue 2. 1978-10-27. PMID:150797. |
increased insulin binding was found in cells from diabetic rats, and this was due to an increased number of insulin receptors rather than a change in receptor affinity. |
1978-10-27 |
2023-08-11 |
rat |
| M Kasuga, Y Akanuma, Y Iwamoto, K Kosak. Insulin binding and glucose metabolism in adipocytes of streptozotocin-diabetic rats. The American journal of physiology. vol 235. issue 2. 1978-10-27. PMID:150797. |
in conclusion, although the cellular insulin insensitivity exists in adipocytes from diabetic rats, the number of insulin receptors was increased, coupling between insulin receptors and the glucose transport system is intact in adipocytes from diabetic rats, and a defect in intracellular glucose metabolism rather than glucose transport plays a major role in the insulin insensitivity of adipocytes from diabetic rats. |
1978-10-27 |
2023-08-11 |
rat |
| J M Maturo, M D Hollenber. Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277909. |
in crude receptor preparations (either particulate or soluble) of rat liver membranes, the insulin receptor exhibits complicated binding kinetics (two binding plateaus, half-saturated at approximately 60 pm and 700 pm insulin) and an apparent chromatographic heterogeneity, suggested by the presence of two detectable, soluble insulin-binding components with apparent stokes radii of 72 a and 38 a. |
1978-10-25 |
2023-08-11 |
human |
| J M Maturo, M D Hollenber. Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277909. |
in contrast, the insulin receptor isolated by affinity chromatography exhibits a simple binding isotherm (half-maximal saturation of binding at 700 pm insulin) without evidence for negative cooperativity and behaves as a single component (apparent stokes radius of 38 a) upon chromatography on sepharose 6b. |
1978-10-25 |
2023-08-11 |
human |
| J M Maturo, M D Hollenber. Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277909. |
we conclude that the insulin receptor in rat liver membranes can interact with another nonreceptor membrane glycoprotein that may represent either a nonrecognition moiety of the receptor oligomer or an effector molecule to the biological action of insulin. |
1978-10-25 |
2023-08-11 |
human |
| M Kobayashi, J M Olefsky, J Elders, M E Mako, B D Given, H K Schedwie, R H Fiser, R L Hintz, J A Horner, A H Rubenstei. Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277948. |
insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. |
1978-10-25 |
2023-08-11 |
rat |
| M Kobayashi, J M Olefsky, J Elders, M E Mako, B D Given, H K Schedwie, R H Fiser, R L Hintz, J A Horner, A H Rubenstei. Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277948. |
furthermore, the purified insulin competed effectively with (125)i-labeled insulin for binding to insulin receptors on cultured im-9 lymphocytes and rat fat cells and also exhibited normal biological potency when tested on rat fat cells. |
1978-10-25 |
2023-08-11 |
rat |
| M Kobayashi, J M Olefsky, J Elders, M E Mako, B D Given, H K Schedwie, R H Fiser, R L Hintz, J A Horner, A H Rubenstei. Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277948. |
studies on the patient's fibroblasts revealed normal levels of insulin receptors but a total absence of insulin's ability to accelerate glucose transport. |
1978-10-25 |
2023-08-11 |
rat |
| M Kobayashi, J M Olefsky, J Elders, M E Mako, B D Given, H K Schedwie, R H Fiser, R L Hintz, J A Horner, A H Rubenstei. Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 7. 1978-10-25. PMID:277948. |
because rates of glucose transport and metabolism were normal in the basal state in the absence of insulin, we conclude that this patient's insulin resistance is due to an inherited cellular defect in the coupling mechanism between occupied insulin receptors and the plasma membrane glucose transport system. |
1978-10-25 |
2023-08-11 |
rat |