| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V R Soman, V A Koivisto, D Deibert, P Felig, R A DeFronz. Increased insulin sensitivity and insulin binding to monocytes after physical training. The New England journal of medicine. vol 301. issue 22. 1980-01-24. PMID:503113. |
binding of [125i]insulin to monocytes also rose by 35 per cent after physical training (p less than 0.02), primarily because of an increase in the concentration of insulin receptors. |
1980-01-24 |
2023-08-11 |
Not clear |
| D J Flint, P A Sinnett-Smith, R A Clegg, R G Verno. Role of insulin receptors in the changing metabolism of adipose tissue during pregnancy and lactation in the rat. The Biochemical journal. vol 182. issue 2. 1980-01-24. PMID:508293. |
changes in the volume, the rates of fatty acid synthesis and synthesis of the glycerol moiety of acylglycerols, the activity of lipoprotein lipase, and the number and affinity of insulin receptors of adipocytes, and concentrations of serum insulin, prolactin and progesterone were determined in virgin rats and in rats at various stages of pregnancy and lactation. |
1980-01-24 |
2023-08-11 |
rat |
| C R Kah. The role of insulin receptors and receptor antibodies in states of altered insulin action. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 162. issue 1. 1980-01-19. PMID:504220. |
the role of insulin receptors and receptor antibodies in states of altered insulin action. |
1980-01-19 |
2023-08-11 |
Not clear |
| Iu S Apostolova, L M Sirako. [Insulin receptors in isolated cells of murine lactating mammary gland]. Problemy endokrinologii. vol 25. issue 5. 1979-12-27. PMID:493256. |
insulin receptors in isolated cells from lactating mouse mammary gland were investigated by 125i-labeled insulin. |
1979-12-27 |
2023-08-11 |
mouse |
| W Bachmann, M Haslbeck, I Böttger, K D Hepp, H Mehner. Reduced insulin binding to hepatic plasma membranes in D-galactosamine-treated rats. Diabetologia. vol 17. issue 2. 1979-12-18. PMID:488565. |
these data suggest that a reduction in the number of hepatic insulin receptors in galactosamine hepatitis can lead to insulin resistance and hyperinsulinaemia. |
1979-12-18 |
2023-08-11 |
rat |
| R B Steel, J D Mosley, C H Smit. Insulin and placenta: degradation and stabilization, binding to microvillous membrane receptors, and amino acid uptake. American journal of obstetrics and gynecology. vol 135. issue 4. 1979-11-28. PMID:484652. |
human placenta possesses insulin receptors, yet whether insulin affects uptake of substrate or other placental functions is still controversial. |
1979-11-28 |
2023-08-11 |
human |
| G Blohmé, U Smit. Metabolic studies in a case of Werner's syndrome. Diabete & metabolisme. vol 5. issue 2. 1979-11-21. PMID:478081. |
this reduced insulin sensitivity seems to be due to a reduction in the number of cellular insulin receptors. |
1979-11-21 |
2023-08-11 |
human |
| D M Mott, B V Howard, P H Bennet. Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels. The Journal of biological chemistry. vol 254. issue 18. 1979-11-21. PMID:479155. |
stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels. |
1979-11-21 |
2023-08-11 |
human |
| H Tager, B Given, D Baldwin, M Mako, J Markese, A Rubenstein, J Olefsky, M Kobayashi, O Kolterman, R Pouche. A structurally abnormal insulin causing human diabetes. Nature. vol 281. issue 5727. 1979-10-26. PMID:381941. |
insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. |
1979-10-26 |
2023-08-11 |
human |
| J Simo. Effect of insulin on glucose oxidation and amino isobutyric acid transport and binding of insulin in chicken thymocytes. Biochimica et biophysica acta. vol 585. issue 4. 1979-10-26. PMID:465540. |
maximal binding capacity was estimated at 1250 pg insulin/10(8) cells, i.e., 1250 binding sites/cell with an apparent dissociation constant of 200 ng insulin/ml at 15 degrees c. degradation of 125i-labelled chicken insulin in the incubation medium was negligible at 15 degrees c but very noticeable at 37 degrees c. therefore, the low level of insulin binding at 15 degrees c reflects a true scarcity of insulin receptors in chicken thymocytes as compared to rat thymocytes. |
1979-10-26 |
2023-08-11 |
rat |
| S G Nerurkar, K K Gambhi. Insulin receptor assay in human erythrocytes as an index to insulin sensitivity of body tissues. Clinical chemistry. vol 25. issue 9. 1979-10-26. PMID:466803. |
insulin receptor assay in human erythrocytes as an index to insulin sensitivity of body tissues. |
1979-10-26 |
2023-08-11 |
human |
| M M Rechler, H J Eisen, O Z Higa, P Nissley, A C Moses, E E Schilling, I Fennoy, C B Bruni, L S Phillips, K L Bair. Characterization of a somatomedin (insulin-like growth factor) synthesized by fetal rat liver organ cultures. The Journal of biological chemistry. vol 254. issue 16. 1979-10-26. PMID:468799. |
partially purified fetal msa: 1) inhibited the binding of brl-msa to the msa receptor of rat liver plasma membranes, to somatomedin-binding proteins from rat serum, and to rabbit anti-brl-msa serum; 2) had a molecular weight of 4,500 to 12,500 determined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate; 3) stimulated the incorporation of [3h]thymidine into the dna of chick embryo fibroblasts and induced cell multiplication; 4) stimulated glucose oxidation in rat adipocytes and weakly inhibited the binding of insulin to the insulin receptors of im-9 lymphocytes; and 5) stimulated sulfate uptake in costal cartilage from hypophysectomized rats. |
1979-10-26 |
2023-08-11 |
rat |
| B H Ginsberg, T Brown, M Raizad. Decrease in insulin receptors during Friend erythroleukemia cell differentiation. Diabetes. vol 28. issue 9. 1979-10-17. PMID:288716. |
the friend erythroleukemia cell has an insulin receptor with all the properties of mammalian insulin receptors: rapid, reversible, and saturable binding of insulin; specific for insulin and insulin analogs; inversely proportional to temperatures; sharply ph dependent (optimum = 8.0); and demonstrated ligand-induced accelerated dissociation consistent with negative cooperativity. |
1979-10-17 |
2023-08-11 |
Not clear |
| P Grimaldi, R Negrel, J P Vincent, G Ailhau. Differentiation of ob 17 preadipocytes to adipocytes. Effect of insulin on the levels of insulin receptors and on the transport of alpha-aminoisobutyrate. The Journal of biological chemistry. vol 254. issue 15. 1979-09-27. PMID:457655. |
effect of insulin on the levels of insulin receptors and on the transport of alpha-aminoisobutyrate. |
1979-09-27 |
2023-08-11 |
mouse |
| P Grimaldi, R Negrel, J P Vincent, G Ailhau. Differentiation of ob 17 preadipocytes to adipocytes. Effect of insulin on the levels of insulin receptors and on the transport of alpha-aminoisobutyrate. The Journal of biological chemistry. vol 254. issue 15. 1979-09-27. PMID:457655. |
with chronic insulin exposure for 3 to 11 days after confluence, ob 17 cells showed a decrease in insulin receptor concentrations from 8,000 to 1,600 high affinity sites/cell (kd from 0.45 to 1.10(-9) m) while similar levels of "low affinity" sites were found (80,000 to 100,000 sites/cell; kd from 10(-8) to 3 x 10(-8) m). |
1979-09-27 |
2023-08-11 |
mouse |
| P Grimaldi, R Negrel, J P Vincent, G Ailhau. Differentiation of ob 17 preadipocytes to adipocytes. Effect of insulin on the levels of insulin receptors and on the transport of alpha-aminoisobutyrate. The Journal of biological chemistry. vol 254. issue 15. 1979-09-27. PMID:457655. |
therefore, in contrast to 3t3-l1 fibroblasts, the ob 17 cells present, in culture, a self-modulation of insulin receptors and a loss of insulin sensitivity after chronic exposure to insulin. |
1979-09-27 |
2023-08-11 |
mouse |
| G J Tevaarwerk, K P Strickland, C H Lin, A J Hudso. Studies on insulin resistance and insulin receptor binding in myotonia dystrophica. The Journal of clinical endocrinology and metabolism. vol 49. issue 2. 1979-09-27. PMID:457841. |
studies on insulin resistance and insulin receptor binding in myotonia dystrophica. |
1979-09-27 |
2023-08-11 |
Not clear |
| J Havrankova, J Roth, M J Brownstei. Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. The Journal of clinical investigation. vol 64. issue 2. 1979-09-25. PMID:156737. |
concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. |
1979-09-25 |
2023-08-11 |
mouse |
| J Havrankova, J Roth, M J Brownstei. Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. The Journal of clinical investigation. vol 64. issue 2. 1979-09-25. PMID:156737. |
in view of the potent influences of the central nervous system on glucose metabolism and on its hormonal regulators, and our recent finding of insulin and insulin receptors throughout the central nervous systsem, we have examined extreme conditions of hyperinsulinemia (obese mice) and hypoinsulinemia (streptozotocin-treated rats) with respect to changes in brain insulin and receptor content. |
1979-09-25 |
2023-08-11 |
mouse |
| J Havrankova, J Roth, M J Brownstei. Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. The Journal of clinical investigation. vol 64. issue 2. 1979-09-25. PMID:156737. |
both at 7 d and at 30 d after streptozotocin treatment there was no significant change in brain insulin or in brain content of insulin receptors, despite the fact that peripheral hepatic receptors were elevated and pancreatic insulin was markedly depleted. |
1979-09-25 |
2023-08-11 |
mouse |