| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Pillion, J R Grantham, M P Czec. Biological properties of antibodies against rat adipocyte intrinsic membrane proteins. Dependence on multivalency for insulin-like activity. The Journal of biological chemistry. vol 254. issue 9. 1979-06-29. PMID:107169. |
253, 3761-3764) that the anti-membrane immunoglobulins do not interact with the insulin binding site of the insulin receptor. |
1979-06-29 |
2023-08-11 |
rat |
| O G Kolterman, G M Reaven, J M Olefsk. Relationship between in vivo insulin resistance and decreased insulin receptors in obese man. The Journal of clinical endocrinology and metabolism. vol 48. issue 3. 1979-06-29. PMID:429500. |
relationship between in vivo insulin resistance and decreased insulin receptors in obese man. |
1979-06-29 |
2023-08-11 |
Not clear |
| J M Olefsky, M Saeko. The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes. Endocrinology. vol 103. issue 6. 1979-06-11. PMID:748046. |
however, a probable explanation for this apparent paradox is provided by the enhanced activity of the cellular insulin effector systems distal to the insulin receptor. |
1979-06-11 |
2023-08-11 |
rat |
| C R Kahn, I D Goldfine, D M Neville, P De Meyt. Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. Endocrinology. vol 103. issue 4. 1979-05-26. PMID:217665. |
to evaluate the role of the insulin receptor in these states, we have studied [125i]insulin binding to purified liver plasma membranes obtained from rats with a variety of perturbations of both glucocorticoids and gh. |
1979-05-26 |
2023-08-11 |
rat |
| C R Kahn, I D Goldfine, D M Neville, P De Meyt. Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. Endocrinology. vol 103. issue 4. 1979-05-26. PMID:217665. |
these findings suggest that alterations in insulin receptor affinity and number may play a major role in the states of altered insulin sensitivity which accompany glucocorticoid excess and deficiency, and follow hypophysectomy. |
1979-05-26 |
2023-08-11 |
rat |
| R S Bar, L C Harrison, M Muggeo, P Gorden, C R Kahn, J Rot. Regulation of insulin receptors in normal and abnormal physiology in humans. Advances in internal medicine. vol 24. 1979-05-26. PMID:218432. |
insulin receptors in human tissue undergo marked changes in both their concentration and their affinity for insulin. |
1979-05-26 |
2023-08-11 |
human |
| R S Bar, L C Harrison, M Muggeo, P Gorden, C R Kahn, J Rot. Regulation of insulin receptors in normal and abnormal physiology in humans. Advances in internal medicine. vol 24. 1979-05-26. PMID:218432. |
in several clinical states, especially those associated with changes in receptor affinity, receptor alterations are unrelated to either ambient insulin levels or anti-receptor antibodies, suggesting the presence of several as yet unknown mediators of the insulin receptor. |
1979-05-26 |
2023-08-11 |
human |
| J A Whitsett, J L Lessar. Characteristics of the microvillus brush border of human placenta: insulin receptor localization in brush border membranes. Endocrinology. vol 103. issue 4. 1979-05-26. PMID:758022. |
the localization of the insulin receptor in the microvillus brush border of the human placenta suggests that this receptor interacts with maternal, rather than fetal insulin. |
1979-05-26 |
2023-08-11 |
human |
| D Baxter, K Stanton, N R Lazarus, H Kee. The relation between insulin and adipocyte insulin receptors during treatment of human obesity. European journal of clinical investigation. vol 8. issue 6. 1979-05-24. PMID:105908. |
the relation between insulin and adipocyte insulin receptors during treatment of human obesity. |
1979-05-24 |
2023-08-11 |
human |
| H Beck-Nielsen, O Pedersen, H O Lindsko. Increased insulin sensitivity and cellular insulin binding in obese diabetics following treatment with glibenclamide. Acta endocrinologica. vol 90. issue 3. 1979-05-23. PMID:106617. |
the aim of the present study was to examine the effect of glibenclamide on the insulin receptors, the insulin sensitivity and the insulin secretion in obese non-ketotic diabetics. |
1979-05-23 |
2023-08-11 |
Not clear |
| H Beck-Nielsen, O Pedersen, H O Lindsko. Increased insulin sensitivity and cellular insulin binding in obese diabetics following treatment with glibenclamide. Acta endocrinologica. vol 90. issue 3. 1979-05-23. PMID:106617. |
moreover, the insulin binding was raised (p less than 0.01) as a result of a 80% rise of the number of insulin receptors. |
1979-05-23 |
2023-08-11 |
Not clear |
| H Beck-Nielsen, O Pedersen, H O Lindsko. Increased insulin sensitivity and cellular insulin binding in obese diabetics following treatment with glibenclamide. Acta endocrinologica. vol 90. issue 3. 1979-05-23. PMID:106617. |
we conclude that 1) the augmentation of the insulin sensitivity is of great importance for the normalization of the diabetic state in obese, 2) the increase in insulin binding may be of importance for the increase in insulin sensitivity, 3) glibenclamide appears to enhance the insulin sensitivity through an increase in the number of insulin receptors. |
1979-05-23 |
2023-08-11 |
Not clear |
| F A Karlsson, E Van Obberghen, C Grunfeld, C R Kah. Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody. Proceedings of the National Academy of Sciences of the United States of America. vol 76. issue 2. 1979-05-23. PMID:284401. |
the mechanism of desensitization seemed to involve events early after insulin binding to receptor because cells exposed to antibody for prolonged periods of time, although unresponsive to insulin and antireceptor antibodies, responded normally to both spermine and vitamin k(5), agents that stimulate glucose metabolism independently of the insulin receptor. |
1979-05-23 |
2023-08-11 |
Not clear |
| Y Le Marchand, P Freychet, B Jeanrenau. Longitudinal study on the establishment of insulin resistance in hypothalamic obese mice. Endocrinology. vol 102. issue 1. 1979-05-23. PMID:369821. |
it appears that insulin resistance is a multifactorial and progressive abnormality that might involve both insulin receptor and intracellular metabolic alterations. |
1979-05-23 |
2023-08-11 |
mouse |
| M Muggeo, R S Bar, J Roth, C R Kahn, P Gorde. The insulin resistance of acromegaly: evidence for two alterations in the insulin receptor on circulating monocytes. The Journal of clinical endocrinology and metabolism. vol 48. issue 1. 1979-05-23. PMID:422699. |
the insulin resistance of acromegaly: evidence for two alterations in the insulin receptor on circulating monocytes. |
1979-05-23 |
2023-08-11 |
Not clear |
| W G Blackard, P S Guzelian, M E Smal. Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer. Endocrinology. vol 103. issue 2. 1979-05-23. PMID:744100. |
down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) m) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. |
1979-05-23 |
2023-08-11 |
rat |
| J C Lawrence, J Larner, C R Kahn, J Rot. Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes. Molecular and cellular biochemistry. vol 22. issue 2-3. 1979-05-16. PMID:106236. |
autoantibodies to the insulin receptor mimic the effects of insulin on glycogen synthase and phosphorylase. |
1979-05-16 |
2023-08-11 |
rat |
| J C Lawrence, J Larner, C R Kahn, J Rot. Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes. Molecular and cellular biochemistry. vol 22. issue 2-3. 1979-05-16. PMID:106236. |
the interaction of antibodies with adipocyte cell surface insulin receptors seems sufficient to promote stable changes in the activities of these intracellular enzymes, suggesting that internalization or processing of insulin is not important in the generation of these biological responses. |
1979-05-16 |
2023-08-11 |
rat |
| E van Obberghen, P de Meyts, J Rot. Inhibition of insulin receptor binding by dimethyl sulfoxide. Biochimica et biophysica acta. vol 582. issue 3. 1979-05-16. PMID:420863. |
analysis of the data of binding at steady state indicated that the decrease in binding of 125i-labeled insulin was due to a reduced affinity of the insulin receptor without noticeable change in the concentration of receptor sites. |
1979-05-16 |
2023-08-11 |
human |
| H Kather, B Simo. [Obesity and adipose tissue. 2. Hormonal regulation of adipose tissue metabolism]. Fortschritte der Medizin. vol 96. issue 35. 1979-04-25. PMID:216612. |
the insulin-resistance in the obese is associated with a decrease of the number of insulin receptor sites, which is likely to be secondary to increased insulin levels. |
1979-04-25 |
2023-08-11 |
human |