| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O M Rosen, G H Chia, C Fung, C S Rubi. Tunicamycin-mediated depletion of insulin receptors in 3T3-L1 adipocytes. Journal of cellular physiology. vol 99. issue 1. 1979-09-17. PMID:457783. |
disappearance of insulin receptors occurred more rapidly in the presence of tunicamycin than when protein synthesis was inhibited by cycloheximide and was accompanied by a diminution in sensitivity of the adipocytes to the acute effects of insulin and anti-insulin receptor antibody on hexose uptake and metabolism. |
1979-09-17 |
2023-08-11 |
Not clear |
| C K Osborne, M E Monaco, C R Kahn, K Huff, D Bronzert, M E Lippma. Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture. Cancer research. vol 39. issue 7 Pt 1. 1979-09-01. PMID:445441. |
dexamethasone did not inhibit insulin effects by altering insulin receptor affinity or concentration, as determined by scatchard analyses of insulin binding. |
1979-09-01 |
2023-08-11 |
human |
| O G Kolterman, M Greenfield, G M Reaven, M Saekow, J M Olefsk. Effect of a high carbohydrate diet on insulin binding to adipocytes and on insulin action in vivo in man. Diabetes. vol 28. issue 8. 1979-09-01. PMID:446930. |
in conclusion, (1) the short-term adaptive response of the insulin receptor is a decrease in binding affinity whereas the long-term response is a decrease in receptor number, (2) sustained and chronic hyperinsulinemia can lead to a decrease in the number of cellular insulin receptors, (3) high carbohydrate diets lead to a general increase in insulin's ability to promote glucose removal from plasma, and (4) the paradox of enhanced insulin sensitivity in the face of decreased insulin binding can be explained if high carbohydrate diets also lead to an increase in the activity of steps in glucose metabolism distal to the insulin receptor. |
1979-09-01 |
2023-08-11 |
human |
| P S Schein, D Kisner, D Haller, M Blecher, M Hamos. Cachexia of malignancy: potential role of insulin in nutritional management. Cancer. vol 43. issue 5 Suppl. 1979-08-29. PMID:445387. |
in our patients this has been correlated with a marked resistance to administered insulin, while insulin receptors on monocytes are normal. |
1979-08-29 |
2023-08-11 |
Not clear |
| P J Savage, L J Bennion, E V Flock, M Nagulesparan, D Mott, J Roth, R H Unger, P H Bennet. Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 48. issue 6. 1979-08-29. PMID:447806. |
diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. |
1979-08-29 |
2023-08-11 |
Not clear |
| M Muggeo, E Van Obberghen, C R Kahn, J Roth, B H Ginsberg, B H De Meyts, S O Emdin, S Falkme. The insulin receptor and insulin of the Atlantic hagfish. Extraordinary conservation of binding specificity and negative cooperativity in the most primitive vertebrate. Diabetes. vol 28. issue 3. 1979-08-16. PMID:446902. |
the insulin receptor and insulin of the atlantic hagfish. |
1979-08-16 |
2023-08-11 |
Not clear |
| A S Hajek, J H Joist, R K Baker, L Jarett, W H Daughada. Demonstration and partial characterization of insulin receptors in human platelets. The Journal of clinical investigation. vol 63. issue 5. 1979-08-16. PMID:447828. |
to examine whether human platelets contain specific insulin receptors, washed human platelets suspended in hepes buffer were incubated at 24 degrees c with 125i-insulin in the presence and absence of unlabeled insulin and specific insulin binding was determined. |
1979-08-16 |
2023-08-11 |
human |
| M Muggeo, B H Ginsberg, J Roth, D M Neville, P De Meyts, C R Kah. The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. Endocrinology. vol 104. issue 5. 1979-07-28. PMID:35339. |
the insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. |
1979-07-28 |
2023-08-11 |
Not clear |
| T Sasaki, A Makita, S Nakagaw. Insulin receptors in AH-66 ascites hepatoma cells and liver of tumor-bearing rats. Gan. vol 69. issue 6. 1979-07-28. PMID:220127. |
insulin receptors of the hepatoma cells were considered to be highly specific for insulin from the results of competition with other peptide hormones. |
1979-07-28 |
2023-08-11 |
rat |
| T Sasaki, A Makita, S Nakagaw. Insulin receptors in AH-66 ascites hepatoma cells and liver of tumor-bearing rats. Gan. vol 69. issue 6. 1979-07-28. PMID:220127. |
inhibition of insulin binding with the tumor cell membranes by concanavalin-a, a competitive inhibitor for insulin receptor sites, did not differ very greatly from that of normal liver. |
1979-07-28 |
2023-08-11 |
rat |
| A C Santora, F B Wheeler, R L DeHaan, L J Elsa. Relationship of insulin binding to amino acid transport by cultured 14-day embryonic chick heart cells. Endocrinology. vol 104. issue 4. 1979-07-28. PMID:436747. |
occupancy of the lower affinity class of insulin receptors correlates quantitatively with insulin stimulation of 2-aminoisobutyric acid transport. |
1979-07-28 |
2023-08-11 |
mouse |
| F A Karlsson, C Grunfeld, C R Kahn, J Rot. Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts. Endocrinology. vol 104. issue 5. 1979-07-28. PMID:436783. |
regulation of insulin receptors and insulin responsiveness in 3t3-l1 fatty fibroblasts. |
1979-07-28 |
2023-08-11 |
Not clear |
| T Wasada, T Sakimoto, Y Aso, K Kato, H Ibayashi, Y Omor. A case of insulin resistant diabetes with possible antibodies to insulin receptors. Endocrinologia japonica. vol 26. issue 1. 1979-07-25. PMID:436798. |
a case of insulin resistant diabetes with possible antibodies to insulin receptors. |
1979-07-25 |
2023-08-11 |
human |
| T Wasada, T Sakimoto, Y Aso, K Kato, H Ibayashi, Y Omor. A case of insulin resistant diabetes with possible antibodies to insulin receptors. Endocrinologia japonica. vol 26. issue 1. 1979-07-25. PMID:436798. |
the insulin resistance in this case was assumed to be caused primarily by possible blocking antibodies to insulin receptors and partly by anti-insulin antibodies because of the following observations. |
1979-07-25 |
2023-08-11 |
human |
| L Jarett, R M Smit. Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. The Journal of clinical investigation. vol 63. issue 4. 1979-07-25. PMID:438322. |
effect of cytochalasin b and d on groups of insulin receptors and on insulin action in rat adipocytes. |
1979-07-25 |
2023-08-11 |
rat |
| L Jarett, R M Smit. Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. The Journal of clinical investigation. vol 63. issue 4. 1979-07-25. PMID:438322. |
the possible physiological importance of the groups of insulin receptors on rat adipocytes and the relationship of these groups to insulin action were investigated. |
1979-07-25 |
2023-08-11 |
rat |
| L Jarett, R M Smit. Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. The Journal of clinical investigation. vol 63. issue 4. 1979-07-25. PMID:438322. |
the effect of cytochalasin b and d on biological actions of insulin was measured and compared with the effect of these agents on the ultrastructural distribution of groups of insulin receptors. |
1979-07-25 |
2023-08-11 |
rat |
| L Jarett, R M Smit. Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. The Journal of clinical investigation. vol 63. issue 4. 1979-07-25. PMID:438322. |
insulin was capable of fully stimulating remaining basal transport at submaximal concentrations of cytochalasin b. insulin pretreatment of adipocytes partially protected the glucose transport system from inhibition by cytochalasin b. cytochalasin b markedly altered the distribution pattern of insulin receptors, which caused an increase in the number of single receptor molecules by decreasing the number of larger groups. |
1979-07-25 |
2023-08-11 |
rat |
| L Jarett, R M Smit. Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. The Journal of clinical investigation. vol 63. issue 4. 1979-07-25. PMID:438322. |
ferritin-insulin pretreatment of adipocytes prevented disruption of the groups of insulin receptors by cytochalasin b. cytochalasin d had no effect on the biological actions of insulin or on the groups of insulin receptors. |
1979-07-25 |
2023-08-11 |
rat |
| L Jarett, R M Smit. Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system. The Journal of clinical investigation. vol 63. issue 4. 1979-07-25. PMID:438322. |
the marked contrast in effects of cytochalasin b and d on groups of insulin receptors and glucose transport suggests that the microfilament system is not involved in insulin action or in holding the groups of insulin receptors together, as both agents are known disrupters of microfilaments and inhibitors of actin gelation. |
1979-07-25 |
2023-08-11 |
rat |