| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Gavin, J Roth, D M Neville, P de Meyts, D N Buel. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 1. 1974-03-22. PMID:4359334. |
chronic (5-16 hr) exposure of cultured human lymphocytes to 10(-8) m insulin at 37 degrees in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. |
1974-03-22 |
2023-08-11 |
mouse |
| J R Gavin, J Roth, D M Neville, P de Meyts, D N Buel. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 1. 1974-03-22. PMID:4359334. |
these results reproduced observations in vivo where chronic hyperinsulinemia (e.g., 10(-8) m insulin in the circulation of obese insulinresistant hyperglycemic mice) is associated with a substantial reduction in the concentration of insulin receptors per cell, while acute hyperinsulinemia in vivo has no effect on receptor concentration. |
1974-03-22 |
2023-08-11 |
mouse |
| J R Gavin, J Roth, D M Neville, P de Meyts, D N Buel. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 1. 1974-03-22. PMID:4359334. |
these data suggest a reciprocal relationship between insulin in the extracellular fluid and the concentration of insulin receptors per cell, which is mediated at the target cell itself by intracellular insulin-sensitive regulatory processes and directly affects target-cell sensitivity to hormone. |
1974-03-22 |
2023-08-11 |
mouse |
| H J Eisen, I D Goldfine, W H Glinsman. Regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 70. issue 12. 1974-02-13. PMID:4357871. |
regulation of hepatic glycogen synthesis during fetal development: roles of hydrocortisone, insulin, and insulin receptors. |
1974-02-13 |
2023-08-11 |
rat |
| D D Soderman, J Germershauden, H M Katze. Affinity binding of intact fat cells and their ghosts to immobilized insulin. Proceedings of the National Academy of Sciences of the United States of America. vol 70. issue 3. 1973-09-04. PMID:4351804. |
various lines of evidence indicate that the insulin receptor on the plasma membrane, in addition to the insulin coupled to the agarose, was responsible for the observed binding. |
1973-09-04 |
2023-08-11 |
Not clear |
| J A Archer, P Gorden, J R Gavin, M A Lesniak, J Rot. Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man. The Journal of clinical endocrinology and metabolism. vol 36. issue 4. 1973-04-04. PMID:4686369. |
insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man. |
1973-04-04 |
2023-08-11 |
human |
| C R Kahn, D M Neville, P Gorden, P Freychet, J Rot. Insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse. Biochemical and biophysical research communications. vol 48. issue 1. 1972-09-12. PMID:5041873. |
insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse. |
1972-09-12 |
2023-08-11 |
mouse |
| G Vann Bennett, P Cuatrecasa. Insulin receptor of fat cells in insulin-resistant metabolic states. Science (New York, N.Y.). vol 176. issue 4036. 1972-08-07. PMID:4260623. |
this decrease in response is not accompanied by changes in the quantity of insulin receptor of these cells or in the affinity of these receptors for insulin. |
1972-08-07 |
2023-08-11 |
mouse |
| G Vann Bennett, P Cuatrecasa. Insulin receptor of fat cells in insulin-resistant metabolic states. Science (New York, N.Y.). vol 176. issue 4036. 1972-08-07. PMID:4260623. |
similarly, the decreased responsiveness to insulin of fat cells obtained from certain species (hamster, rabbit, mouse, guinea pig) is not explainable in terms of alterations of the insulin receptor. |
1972-08-07 |
2023-08-11 |
mouse |
| P Freychet, J Roth, D M Nevill. Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. Proceedings of the National Academy of Sciences of the United States of America. vol 68. issue 8. 1972-02-23. PMID:4331561. |
insulin receptors in the liver: specific binding of ( 125 i)insulin to the plasma membrane and its relation to insulin bioactivity. |
1972-02-23 |
2023-08-11 |
human |