| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P DeMeyts, A R Bainco, J Rot. Site-site interactions among insulin receptors. Characterization of the negative cooperativity. The Journal of biological chemistry. vol 251. issue 7. 1976-08-02. PMID:5434. |
insulin receptor sites appear to switch from a "slow dissociating" state to a "fast dissociating" state when their occupancy increases; the proportion of sites in each state is a function of occupancy of the receptor sites by the insulin monomer as well as of the physiochemical environment. |
1976-08-02 |
2023-08-11 |
human |
| M M Rechler, J M Podskaln. Insulin receptors in cultured human fibroblasts. Diabetes. vol 25. issue 4. 1976-08-02. PMID:178554. |
in order to study human insulin resistance, we have first characterized the interaction of insulin with specific insulin receptors in cultures of normal human fibroblasts. |
1976-08-02 |
2023-08-11 |
human |
| R D Fussganger, C R Kahn, J Roth, P De Meyt. Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. The Journal of biological chemistry. vol 251. issue 9. 1976-07-06. PMID:4460. |
in the presence of inhibitors of degradation, binding sites for insulin with high affinity were detected, which by multiple criteria were true insulin receptors. |
1976-07-06 |
2023-08-11 |
human |
| R D Fussganger, C R Kahn, J Roth, P De Meyt. Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. The Journal of biological chemistry. vol 251. issue 9. 1976-07-06. PMID:4460. |
as shown previously for all other insulin receptors, binding was highly ph-dependent, and insulin analogues had affinities for these sites that closely correlated with their biological potencies. |
1976-07-06 |
2023-08-11 |
human |
| Insulin receptors, insulin resistance, diabetes and obesity. Nutrition reviews. vol 34. issue 5. 1976-07-06. PMID:177909. |
insulin receptors, insulin resistance, diabetes and obesity. |
1976-07-06 |
2023-08-11 |
Not clear |
| C Karakash, F Assimacopoulos-Jeannet, B Jeanrenau. An anomaly of insulin removal in perfused livers of obese-hyperglycemic (ob/ob) mice. The Journal of clinical investigation. vol 57. issue 5. 1976-07-06. PMID:1262459. |
the characteristics of hepatic insulin removal reported in this study, as well as the differences observed between livers of lean and ob/ob mice, may reflect changes in membrane insulin receptors and/or in processes responsible for the degradation of the horomone. |
1976-07-06 |
2023-08-11 |
mouse |
| C R Kahn, J S Flier, R S Bar, J A Archer, P Gorden, M M Martin, J Rot. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. The New England journal of medicine. vol 294. issue 14. 1976-05-25. PMID:176581. |
studies of insulin receptors on circulating monocytes suggest that the insulin resistance in these patients was due to a marked decrease in insulin binding to its membrane receptors. |
1976-05-25 |
2023-08-11 |
Not clear |
| J M Olefsky, G M Reave. Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. The American journal of medicine. vol 60. issue 1. 1976-04-23. PMID:175653. |
the binding affinity for insulin was the same for both groups of cells, and the decreased binding could be accounted for by a 45 per cent decrease in the number of available insulin receptor sites per cell. |
1976-04-23 |
2023-08-11 |
human |
| J M Olefsky, G M Reave. Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. The American journal of medicine. vol 60. issue 1. 1976-04-23. PMID:175653. |
in conclusion, (1) mononuclear cells from nonobese, nonketotic, untreated adult diabetic patients with fasting hyperglycemia demonstrate a decreased ability to bind insulin due to decreased numbers of insulin receptors per cell; (2) treatment with an oral hypoglycemic agent is associated with a diminution in hyperglycemia and a return toward normal of insulin binding. |
1976-04-23 |
2023-08-11 |
human |
| J Olefsky, V C Bacon, S Bau. Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. Metabolism: clinical and experimental. vol 25. issue 2. 1976-04-10. PMID:2834. |
insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. |
1976-04-10 |
2023-08-11 |
rat |
| R Geiger, K Geisen, H D Summ, D Lange. [(A1-D-alanine) insulin (author's transl)]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie. vol 356. issue 10. 1976-04-10. PMID:1213677. |
the specific binding to insulin receptors of rat liver is decreased as, compared to insulin, but increased as compared to the l-alanine analogue. |
1976-04-10 |
2023-08-11 |
rat |
| J M Olefsk. Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. The Journal of clinical investigation. vol 56. issue 6. 1976-03-01. PMID:1202081. |
since dexamethasone treatment leads to decreased insulin binding to adipocytes in vivo, we examined the possibility that the in vitro decreases in insulin-mediated glucose transport could be due to decreased insulin receptors. |
1976-03-01 |
2023-08-11 |
rat |
| K Megyesi, C R Kahn, J Roth, D M Neville, S P Nissley, R E Humbel, E R Froesc. The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. The Journal of biological chemistry. vol 250. issue 23. 1976-02-09. PMID:391. |
we have demonstrated previously that liver plasma membranes possess separate receptors for nsila-s and insulin and have characterized the insulin receptor in detail. |
1976-02-09 |
2023-08-11 |
Not clear |
| K Megyesi, C R Kahn, J Roth, D M Neville, S P Nissley, R E Humbel, E R Froesc. The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. The Journal of biological chemistry. vol 250. issue 23. 1976-02-09. PMID:391. |
with the insulin receptor, nsila-s and insulin analogues compete for binding in proportion to their insulin-like potency: insulin greater than proinsulin greater than nsila-s. with the nsila-s receptor, nsila-s is most potent and the order is reversed: nsila-s greater than proinsulin greater than insulin. |
1976-02-09 |
2023-08-11 |
Not clear |
| I D Goldfin. Binding of insulin to thymocytes from suckling and hypophysectomized rats: evidence for two mechanisms regulating insulin sensitivity. Endocrinology. vol 97. issue 4. 1976-02-09. PMID:172319. |
thymocytes from hypophysectomized adult rats bound more insulin than did cells from sham-operated controls, suggesting that insulin sensitivity in this condition was due to an increase in the number of insulin receptors. |
1976-02-09 |
2023-08-11 |
rat |
| I Dumont, F Kruyen, F Legro. [Specific insulin binding to chloroplasts isolated from Acetabularia mediterranea]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 169. issue 1. 1976-01-29. PMID:171035. |
kinetics of insulin fixation to chloroplasts, exponential dissociation of bound hormone, competition between radioactive and native insulins for binding and for release indicate that chloroplasts possess insulin receptors. |
1976-01-29 |
2023-08-11 |
Not clear |
| H D Sölin. [The mechanism of the acute action of insulin (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 117. issue 41. 1976-01-26. PMID:127120. |
all the known acute actions of insulin are based on the reaction of insulin with specific insulin receptors in the cell membranes of the insulin-sensitive organs. |
1976-01-26 |
2023-08-11 |
Not clear |
| D E Denni. [New developments in insulin therapy of diabetic coma (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 117. issue 41. 1976-01-26. PMID:810692. |
this form of therapy is based on recent knowledge of the physiological degree of the serum insulin level (20-200 muu/ml) and the quantity required to saturate the insulin receptors. |
1976-01-26 |
2023-08-11 |
Not clear |
| P V Clarke, A H Kissebah, H Hope-Gill, N Vydelingum, B Tulloch, T R Frase. The role of calcium in insulin action. IV. Mechanism of insulin resistance in adipose tissue of obese (ob/ob) mice and old Wistar rats. European journal of clinical investigation. vol 5. issue 4. 1975-12-29. PMID:1175674. |
response to these agents, however, was restored by prewashing the tissue, suggesting that the apparent resistance in this tissue reflected saturation of the insulin receptors to endogenous insulin. |
1975-12-29 |
2023-08-11 |
mouse |
| P V Clarke, A H Kissebah, H Hope-Gill, N Vydelingum, B Tulloch, T R Frase. The role of calcium in insulin action. IV. Mechanism of insulin resistance in adipose tissue of obese (ob/ob) mice and old Wistar rats. European journal of clinical investigation. vol 5. issue 4. 1975-12-29. PMID:1175674. |
these results suggest that the insulin response of fat cells from old rats is impaired because of a defect either in their insulin receptors or in their post-receptor responses. |
1975-12-29 |
2023-08-11 |
mouse |