| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Olefsk. Insensitivity of large rat adipocytes to the antilipolytic effects of insulin. Journal of lipid research. vol 18. issue 4. 1977-10-20. PMID:894138. |
in other words, the dose response curve for insulin's antilipolytic action was shifted to the right, and this is consistent with the previously reported decrease of insulin receptors in these cells. |
1977-10-20 |
2023-08-11 |
rat |
| P Freyche. [New data in the domain of insulin resistance]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. vol 53. issue 24. 1977-10-14. PMID:197631. |
the measurement of insulin receptors brings a new dimension to the investigation of insulin resistance. |
1977-10-14 |
2023-08-11 |
Not clear |
| S Gammeltoft, J Vinten, J Gliemann, S Lind. Degradation, receptor binding affinity and biological potency of monoiodoinsulin in isolated rat fat cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 9. issue 3. 1977-09-22. PMID:885469. |
assuming that the insulin receptor binding is a simple, reversible, bimolecular reaction, the following are the consequences for the interpretation of experiments at equilibrium in which an unlabelled species of insulin competes with (125i) monoiodoinsulin present in a concentration much below the dissociation constant for the insulin: 1. |
1977-09-22 |
2023-08-11 |
rat |
| R T Moxle. Metabolic studies in muscular dystrophy: a role for insulin. Advances in neurology. vol 17. 1977-09-22. PMID:888734. |
study of the peripheral action of insulin by forearm investigations of myotonic dystrophy patients and disease controls has suggested that the peripheral skeletal muscle insulin receptor may be relatively insensitive im myotonic dystrophy. |
1977-09-22 |
2023-08-11 |
Not clear |
| R T Moxle. Metabolic studies in muscular dystrophy: a role for insulin. Advances in neurology. vol 17. 1977-09-22. PMID:888734. |
if neuromuscular disorders other than myotonic dystrophy have evidence of peripheral insulin ineffectiveness, reasonable causes could be an excessive level of an antagonistic hormone, a faulty insulin receptor, or inadequate pancreatic insulin release. |
1977-09-22 |
2023-08-11 |
Not clear |
| J Simon, P Freychet, G Rosseli. A study of insulin binding sites in the chicken tissues. Diabetologia. vol 13. issue 3. 1977-08-25. PMID:873089. |
that chicken cells are equipped with insulin receptors which are less numerous than in mammalian cells may explain, partly at least, the physiological state of insulin resistance observed in the chicken. |
1977-08-25 |
2023-08-11 |
rat |
| R S Bar, P Gorden, J Roth, C W Sieber. Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration. The Journal of clinical endocrinology and metabolism. vol 44. issue 6. 1977-08-12. PMID:194912. |
in all patients the concentration of insulin receptors was inversely related to the basal, circulating level of insulin (corrected for proinsulin content). |
1977-08-12 |
2023-08-11 |
Not clear |
| V Soman, P Feli. Glucagon and insulin binding to liver membranes in a partially nephrectomized uremic rat model. The Journal of clinical investigation. vol 60. issue 1. 1977-08-12. PMID:326810. |
to investigate the role of glucagon and insulin receptor binding in the glucagon hypersensitivity and insulin resistance which characterize the glucose intolerance of uremia, liver plasma membranes were prepared from control rats (blood urea nitrogen [bun] 15+/-1 mg/100 ml, creatinine 0.7+/-0.2 mg/100 ml), and from 70% nephrectomized rats (bun 30+/-2 mg/100 ml, creatinine 2.2+/-0.2 mg/100 ml), and from 90% nephrectomized rats (bun 46+/-3 mg/100 ml, creatinine 4.20+/-0.7 mg/100 ml), 4 wk after surgery. |
1977-08-12 |
2023-08-11 |
rat |
| P Gorde. The role of the insulin receptor in states of insulin resistance in experimental animals and man. Panminerva medica. vol 19. issue 2. 1977-07-29. PMID:865860. |
the role of the insulin receptor in states of insulin resistance in experimental animals and man. |
1977-07-29 |
2023-08-11 |
Not clear |
| M M Rechler, S P Nissley, J M Podskalny, A C Moses, L Fryklun. Identification of a receptor for somatomedin-like polypeptides in human fibroblasts. The Journal of clinical endocrinology and metabolism. vol 44. issue 5. 1977-06-30. PMID:192752. |
although insulin and proinsulin also strongly inhibited msa binding, the properties of the growth peptide receptor differed from those of the human fibroblasts insulin receptor. |
1977-06-30 |
2023-08-11 |
human |
| R S Bar, C R Kahn, H S Kore. Insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages. Nature. vol 265. issue 5595. 1977-06-30. PMID:859563. |
insulin inhibition of antibody-dependent cytoxicity and insulin receptors in macrophages. |
1977-06-30 |
2023-08-11 |
Not clear |
| K Kawanish. [Insulin receptor antibody and insulin resistance]. Nihon rinsho. Japanese journal of clinical medicine. vol 35. issue 2. 1977-06-11. PMID:558362. |
[insulin receptor antibody and insulin resistance]. |
1977-06-11 |
2023-08-11 |
Not clear |
| R S Bar, J Rot. Insulin receptor status in disease states of man. Archives of internal medicine. vol 137. issue 4. 1977-05-20. PMID:192162. |
studies of insulin receptors in people indicate that the insulin receptor is altered in many common disorders such as obesity and diabetes, as well as in rare disorders such as extreme insulin resistance due to circulating antibodies directed at the insulin receptor itself. |
1977-05-20 |
2023-08-11 |
Not clear |
| J H Helderman, T B Stro. Emergence of insulin receptors upon alloimmune T cells in the rat. The Journal of clinical investigation. vol 59. issue 2. 1977-03-15. PMID:299859. |
this report concerns a test of the hypothesis that the t cell is directly affected by insulin and that an insulin receptor emerges upon t lymphocytes consequent to immune activation. |
1977-03-15 |
2023-08-11 |
human |
| J H Helderman, T B Stro. Emergence of insulin receptors upon alloimmune T cells in the rat. The Journal of clinical investigation. vol 59. issue 2. 1977-03-15. PMID:299859. |
these data confirm a physiologic role for insulin in t-lymphocyte effector function and describe the emergence of insulin receptors concomitant with cell sensitivity to ligand. |
1977-03-15 |
2023-08-11 |
human |
| S Oseid, H Beck-Nielsen, O Pedersen, O Sovi. Decreased binding of insulin to its receptor in patients with congenital generalized lipodystrophy. The New England journal of medicine. vol 296. issue 5. 1977-02-26. PMID:831106. |
to ascertain whether this resistance is due to an insulin receptor defect, we tested four young patients with congenital generalized lipodystrophy and seven healthy persons of comparable age for the binding of 125i insulin to mononuclear leukocytes isolated from peripheral blood. |
1977-02-26 |
2023-08-11 |
human |
| S Oseid, H Beck-Nielsen, O Pedersen, O Sovi. Decreased binding of insulin to its receptor in patients with congenital generalized lipodystrophy. The New England journal of medicine. vol 296. issue 5. 1977-02-26. PMID:831106. |
altered insulin receptors may be responsible for the pronounced insulin resistance and the decreased synthesis of triglycerides in congenital generalized lipodystrophy. |
1977-02-26 |
2023-08-11 |
human |
| P Freyche. [Insulin receptors-a review (author's transl)]. Diabete & metabolisme. vol 1. 1977-01-29. PMID:791721. |
a variety of data, both in vivo and in vitro, indicate an inverse relationship between the concentration of insulin and the number of insulin receptors, and suggest a negative feedback effect of the hormone on its own receptor... |
1977-01-29 |
2023-08-11 |
mouse |
| J M Olefsk. The insulin receptor: its role in insulin resistance of obesity and diabetes. Diabetes. vol 25. issue 12. 1977-01-29. PMID:791735. |
the insulin receptor: its role in insulin resistance of obesity and diabetes. |
1977-01-29 |
2023-08-11 |
Not clear |
| D B Jarrett, J Roth, C R Kahn, J S Flie. Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 73. issue 11. 1977-01-29. PMID:1069300. |
direct method for detection and characterization of cell surface receptors for insulin by means of 125i-labeled autoantibodies against the insulin receptor. |
1977-01-29 |
2023-08-11 |
Not clear |