| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xi. Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes. Experimental biology and medicine (Maywood, N.J.). 2022-11-21. PMID:36408724. |
disturbed insulin receptor (insr) trafficking is associated with impaired insulin signaling and the development of diabetes. |
2022-11-21 |
2023-08-14 |
Not clear |
| Zhili Tang, Chao Sun, Ying Yan, Zhoumin Niu, Yuying Li, Xi Xu, Jing Zhang, Yuting Wu, Yan Li, Li Wang, Cheng Hu, Zhuoyang Li, Jingjing Jiang, Hao Yin. Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs. Journal of molecular cell biology. 2022-11-10. PMID:36352530. |
insulin could stimulate fto transcription through a mechanism involving the action of intranuclear insulin receptor beta, while knockdown of fto abrogated the lipogenic effect of insulin. |
2022-11-10 |
2023-08-14 |
mouse |
| Bruno Hernandez-Cravero, Sofia Gallino, Jeremy Florman, Cecilia Vranych, Philippe Diaz, Ana Belén Elgoyhen, Mark J Alkema, Diego de Mendoz. Cannabinoids activate the insulin pathway to modulate mobilization of cholesterol in C. elegans. PLoS genetics. vol 18. issue 11. 2022-11-08. PMID:36346800. |
these findings indicate that 2-ag-dependent cholesterol trafficking requires the release of insulin peptides and signaling through the daf-2 insulin receptor. |
2022-11-08 |
2023-08-14 |
caenorhabditis_elegans |
| Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xia. Blocking MG53 Circulation research. 2022-11-07. PMID:36337049. |
however, it also impairs insulin signaling via its e3 ligase activity-mediated ubiquitination-dependent degradation of ir (insulin receptor) and irs1 (insulin receptor substrate 1) and its myokine function-induced allosteric blockage of ir. |
2022-11-07 |
2023-08-14 |
Not clear |
| Yubo Wang, Xiaohan Song, Yan Wang, Nan Wan. Specific interaction of insulin receptor and GLP-1 receptor mediates crosstalk between their signaling. Biochemical and biophysical research communications. vol 636. issue Pt 2. 2022-11-07. PMID:36343488. |
both glp-1 receptor (glp-1r) and insulin receptor (ir) transmit signals for insulin release and/or cellular metabolism although using distinct sets of transducing molecules and separate pathways. |
2022-11-07 |
2023-08-14 |
Not clear |
| Francois Moreau, Nicholas S Kirk, Fa Zhang, Vasily Gelfanov, Edward O List, Martina Chrudinová, Hari Venugopal, Michael C Lawrence, Veronica Jimenez, Fatima Bosch, John J Kopchick, Richard D DiMarchi, Emrah Altindis, C Ronald Kah. Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nature communications. vol 13. issue 1. 2022-11-06. PMID:36335114. |
here we show that while single-chain (sc) and double-chain (dc) lcdv1-vilps have very low affinity for the insulin receptor, sclcdv1-vilp has high affinity for igf1r where it can antagonize human igf-1 signaling, without altering insulin signaling. |
2022-11-06 |
2023-08-14 |
mouse |
| Jingjing Lin, Irena Selicharová, Katarína Mitrová, Benjamin Fabre, Vijay Madhav Miriyala, Martin Lepšík, Jiří Jiráček, María Soledad Garre Hernánde. Targeting the insulin receptor with hormone and peptide dimers. Journal of peptide science : an official publication of the European Peptide Society. 2022-11-06. PMID:36336650. |
the dimeric character of the receptor for insulin evokes ideas about its activation or inhibition with peptide dimers that could either trigger or block the structural transition of the insulin receptor, leading to its activation. |
2022-11-06 |
2023-08-14 |
human |
| Jingjing Lin, Irena Selicharová, Katarína Mitrová, Benjamin Fabre, Vijay Madhav Miriyala, Martin Lepšík, Jiří Jiráček, María Soledad Garre Hernánde. Targeting the insulin receptor with hormone and peptide dimers. Journal of peptide science : an official publication of the European Peptide Society. 2022-11-06. PMID:36336650. |
the prepared dimers were weaker in binding to insulin receptors than human insulin. |
2022-11-06 |
2023-08-14 |
human |
| Jingjing Lin, Irena Selicharová, Katarína Mitrová, Benjamin Fabre, Vijay Madhav Miriyala, Martin Lepšík, Jiří Jiráček, María Soledad Garre Hernánde. Targeting the insulin receptor with hormone and peptide dimers. Journal of peptide science : an official publication of the European Peptide Society. 2022-11-06. PMID:36336650. |
however, some of the insulin dimers showed preferential binding specificity towards the isoform a of the insulin receptor, and the insulin dimers also stimulated the insulin receptor more strongly than would be consistent with their binding affinities. |
2022-11-06 |
2023-08-14 |
human |
| Jingjing Lin, Irena Selicharová, Katarína Mitrová, Benjamin Fabre, Vijay Madhav Miriyala, Martin Lepšík, Jiří Jiráček, María Soledad Garre Hernánde. Targeting the insulin receptor with hormone and peptide dimers. Journal of peptide science : an official publication of the European Peptide Society. 2022-11-06. PMID:36336650. |
our results suggest that designing insulin dimers may be a promising strategy for modulating the ability of the hormone to activate the receptor or to alter its specificity toward insulin receptor isoforms. |
2022-11-06 |
2023-08-14 |
human |
| Giulia Lunghi, Maria Fazzari, Maria Grazia Ciampa, Laura Mauri, Erika Di Biase, Elena Chiricozzi, Sandro Sonnin. Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3-IR and GM1-TrkA interactions. FEBS letters. 2022-11-04. PMID:36331354. |
we first discuss the interaction between gm3 and insulin receptor in relation to insulin responses, with an increase in gm3 correlating with the onset of metabolic dysfunction. |
2022-11-04 |
2023-08-14 |
Not clear |
| Lingli Wang, Tianxiao Yu, Ruifen Jiao, Xizhenzi Fan, Yafang Wang, Wei Liu, Shaoxiong Wang, Jialiang Xie, Chuan Zha. The association between vitamin D levels in the second trimester of pregnancy and gestational diabetes mellitus. The journal of obstetrics and gynaecology research. vol 48. issue 11. 2022-11-01. PMID:36319200. |
25-hydroxyvitamin d (25(oh)d) affects glucose metabolism by increasing insulin secretion and insulin receptor expression. |
2022-11-01 |
2023-08-14 |
Not clear |
| Ning Deng, Xiupeng Zhang, Yong Zhan. BAIAP2L1 Accelerates Breast Cancer Progression and Chemo-resistance Via activating AKT signaling By Binding with RPL3. Cancer science. 2022-10-29. PMID:36308067. |
bai1-associated protein 2-like 1 (baiap2l1), also known as insulin receptor tyrosine kinase substrate, modulates the insulin network; however, its function in breast cancer has not been explored. |
2022-10-29 |
2023-08-14 |
Not clear |
| Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calo. Cerebrovascular insulin receptors are defective in Alzheimer's disease. Brain : a journal of neurology. 2022-10-24. PMID:36280236. |
using brain cerebral intracarotid perfusion, we found that the transport rate of insulin across the blood-brain barrier remained very low (<0.03 µl/g·s) and was not inhibited by an insulin receptor antagonist. |
2022-10-24 |
2023-08-14 |
mouse |
| Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calo. Cerebrovascular insulin receptors are defective in Alzheimer's disease. Brain : a journal of neurology. 2022-10-24. PMID:36280236. |
such an activation of vascular insulin receptor was blunted in 3xtg-ad mice, suggesting that alzheimer's disease neuropathology induces insulin resistance at the level of the blood-brain barrier. |
2022-10-24 |
2023-08-14 |
mouse |
| Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugère, Vincent Emond, David A Bennett, Frédéric Calo. Cerebrovascular insulin receptors are defective in Alzheimer's disease. Brain : a journal of neurology. 2022-10-24. PMID:36280236. |
overall, the present data in post-mortem alzheimer's disease brains and an animal model of alzheimer's disease indicate that defects in the insulin receptor localized at the blood-brain barrier strongly contribute to brain insulin resistance in alzheimer's disease, in association with β-amyloid pathology. |
2022-10-24 |
2023-08-14 |
mouse |
| Muneeb A Faiq, Trina Sengupta, Madhu Nath, Thirumurthy Velpandian, Daman Saluja, Rima Dada, Tanuj Dada, Kevin C Cha. Ocular manifestations of central insulin resistance. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36255004. |
here, we performed intracerebroventricular injection of s961, a potent and specific blocker of insulin receptor in adult wistar rats to test if central insulin resistance leads to pathological changes in ocular structures. |
2022-10-18 |
2023-08-14 |
rat |
| Masaji Sakaguchi, Shota Okagawa, Yuma Okubo, Yuri Otsuka, Kazuki Fukuda, Motoyuki Igata, Tatsuya Kondo, Yoshifumi Sato, Tatsuya Yoshizawa, Takaichi Fukuda, Kazuya Yamagata, Weikang Cai, Yu-Hua Tseng, Nobuo Sakaguchi, C Ronald Kahn, Eiichi Arak. Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nature communications. vol 13. issue 1. 2022-10-14. PMID:36241662. |
thus, the α4 /y-box protein 1(ybx1)-mediated pathway of insulin receptor signaling is involved in maintaining insulin sensitivity, normal adipose tissue homeostasis and systemic metabolism. |
2022-10-14 |
2023-08-14 |
mouse |
| Lida Fan, Wenzhe Yu, Beiang Zhang, Bin Cao, Mingfu Wang, Xiaoqian H. Distinctive effects of different types of advanced glycation end-products (AGEs) on liver glucose metabolism. Food & function. 2022-10-13. PMID:36226621. |
the results indicate that only cml and mgo-bsa could disturb glucose metabolism, and mgo-bsa was the most active in promoting insulin resistance, as manifested by the inactivation of insulin receptor substrate-1 and decreased phosphorylation of akt. |
2022-10-13 |
2023-08-14 |
mouse |
| Veronica Rivi, Cristina Benatti, Pietro Actis, Fabio Tascedda, Johanna Maria Catharina Blo. Behavioral and transcriptional effects of short or prolonged fasting on the memory performances of Lymnaea stagnalis. Neuroendocrinology. 2022-10-12. PMID:36223719. |
d5 snails were injected with bovine insulin and d1 snails with the insulin receptor antibody (ab). |
2022-10-12 |
2023-08-14 |
cattle |