| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brenda De la Cruz Concepción, Yaccil Adilene Flores Cortez, Martha Isela Barragán Bonilla, Juan Miguel Mendoza Bello, Monica Espinoza Roj. Insulin: A connection between pancreatic β cells and the hypothalamus. World journal of diabetes. vol 14. issue 2. 2023-03-17. PMID:36926659. |
reactive oxygen species activate stress-sensitive kinases, such as c-jun n-terminal kinase and p38 mitogen-activated protein kinase, that induce phos-phorylation in serine residues in the insulin receptor, which blocks the insulin signaling pathway, continuing the mechanism of ir. |
2023-03-17 |
2023-08-14 |
Not clear |
| Vuong M Pham, Prashanth Komirishetty, Aparna Areti, Trevor Poitras, Nitish Thakor, Douglas W Zochodn. Combined PTEN knockdown and local insulin in chronic experimental diabetic neuropathy. Diabetes. 2023-03-17. PMID:36930748. |
ir (insulin receptor) expression was not altered by high glucose conditions in neurons or scs and insulin promoted survival of neurons and proliferation of scs in vitro. |
2023-03-17 |
2023-08-14 |
mouse |
| Yixuan Wang, Hao Hu, Xinyu Liu, Xiangyu Gu. Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism. Frontiers in pharmacology. vol 14. 2023-03-13. PMID:36909158. |
binding to insulin receptor substrates, insulin can transport through the blood-brain barrier (bbb), thus mediating insulin signaling pathways to regulate physiological functions. |
2023-03-13 |
2023-08-14 |
Not clear |
| Xue-Mei Xie, Qiu-Li Cao, Yu-Jie Sun, Jie Zhang, Kai-Li Liu, Ying-Fen Qin, Wen-Jun Long, Zuo-Jie Luo, Xiao-Wei Li, Xing-Huan Liang, Guan-Dou Yuan, Xiao-Ping Luo, Xiu-Ping Xua. LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR. Current medical science. 2023-03-13. PMID:36913109. |
lrp6 bidirectionally regulates insulin sensitivity through insulin receptor and s6k signaling in rats with cg-iugr. |
2023-03-13 |
2023-08-14 |
rat |
| Kazushi Yamamoto, Masashi Yamashita, Masataka Oda, Vindy Tjendana Tjhin, Hiroyuki Inagawa, Gen-Ichiro Som. Oral Administration of Lipopolysaccharide Enhances Insulin Signaling-Related Factors in the KK/Ay Mouse Model of Type 2 Diabetes Mellitus. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902049. |
furthermore, the expressions of factors involved in insulin signaling, such as insulin receptor, insulin receptor substrate 1, thymoma viral proto-oncogene, and glucose transporter type 4, were upregulated in the adipose tissues of kk/ay mice, where this effect was observed. |
2023-03-11 |
2023-08-14 |
mouse |
| Jingjing Lin, Seiya Asai, Irena Selicharová, Katarína Mitrová, Jakub Kaminský, Elinor Young, Jiří Jiráče. Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities. International journal of peptide research and therapeutics. vol 29. issue 2. 2023-03-09. PMID:36891560. |
in this study, we were inspired by the successful development of insulin dimers capable of antagonizing insulin effects on the insulin receptor (ir) by simultaneous binding to two separated binding sites and by blocking structural rearrangement of the ir. |
2023-03-09 |
2023-08-14 |
Not clear |
| Xarubet Ruiz-Herrera, Ivan Luzardo-Ocampo, Gonzalo Martínez de la Escalera, Carmen Clapp, Yazmín Macotel. Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance. Journal of visualized experiments : JoVE. issue 192. 2023-03-06. PMID:36876927. |
insulin resistance is a reduced effect of insulin on its target cells, usually derived from decreased insulin receptor signaling. |
2023-03-06 |
2023-08-14 |
mouse |
| Jun Shirakaw. Signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes. Journal of diabetes investigation. 2023-03-05. PMID:36871280. |
insulin and insulin receptor (ir)-mediated signaling pathways play an important role in the mechanism that increases β-cell mass by compensatory β-cell proliferation in response to chronic insulin resistance. |
2023-03-05 |
2023-08-14 |
human |
| Waldemar B Minich, Brent S Abel, Christian Schwiebert, Tim Welsink, Petra Seemann, Rebecca J Brown, Lutz Schombur. A novel in vitro assay correlates insulin receptor autoantibodies to fasting insulin in type B insulin resistance. The Journal of clinical endocrinology and metabolism. 2023-03-04. PMID:36869714. |
a novel in vitro assay correlates insulin receptor autoantibodies to fasting insulin in type b insulin resistance. |
2023-03-04 |
2023-08-14 |
Not clear |
| Waldemar B Minich, Brent S Abel, Christian Schwiebert, Tim Welsink, Petra Seemann, Rebecca J Brown, Lutz Schombur. A novel in vitro assay correlates insulin receptor autoantibodies to fasting insulin in type B insulin resistance. The Journal of clinical endocrinology and metabolism. 2023-03-04. PMID:36869714. |
severe insulin resistance in the presence of insulin receptor autoantibodies (insr-aab) is known as type b insulin resistance (tbir). |
2023-03-04 |
2023-08-14 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects. Inflammopharmacology. 2023-02-28. PMID:36849855. |
t2dm and peripheral insulin resistance (ir) augment the risk of ad with the development of brain ir with inhibition of neuronal insulin receptors. |
2023-02-28 |
2023-08-14 |
Not clear |
| Jinghua Peng, Balamurugan Ramatchandirin, Alexia Pearah, Ling H. Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor. Bio-protocol. vol 13. issue 4. 2023-02-27. PMID:36845537. |
the binding of the insulin receptor substrate (irs) to the insulin receptor is essential for the propagation of downstream signaling after the activation of the insulin receptor by insulin. |
2023-02-27 |
2023-08-14 |
Not clear |
| Jan A Veenstr. Different neuroendocrine cell types in the pars intercerebralis of Periplaneta americana produce their own specific IGF-related peptides. General and comparative endocrinology. 2023-02-15. PMID:36791825. |
the separate cellular localization of these peptides and the existence of multiple insulin receptors in this species implies a more complex regulation by insulin and igf-related peptides in cockroaches than in the fruit fly. |
2023-02-15 |
2023-08-14 |
drosophila_melanogaster |
| Jéssica Paloma Álvarez-Rendón, Juan Rafael Riesgo-Escova. Activation of the Cap'n'collar C pathway (Nrf2 pathway in vertebrates) signaling in insulin pathway compromised Drosophila melanogaster flies ameliorates the diabetic state upon pro-oxidant conditions. General and comparative endocrinology. 2023-02-13. PMID:36781022. |
we then tested two hypomorphic viable conditions of the insulin pathway (heteroallelic combination for the insulin receptor and the s6 kinase), challenged in the same way: whereas they also die in the pro-oxidant conditions, they fare significantly better when heterozygous for keap1, in contrast to controls. |
2023-02-13 |
2023-08-14 |
drosophila_melanogaster |
| Christopher Mendoza, Cameron Hanegan, Alek Sperry, Logan Vargas, Trevor Case, Benjamin Bikman, Dario Mizrach. Insulin receptor-inspired soluble insulin binder. European journal of cell biology. vol 102. issue 2. 2023-02-05. PMID:36739671. |
the insulin receptor (ir) is a 320 kda membrane receptor tyrosine kinase mediating the pleiotropic actions of insulin, leading to phosphorylation of several intracellular substrates including serine/threonine-protein kinase (akt1), and ir autophosphorylation. |
2023-02-05 |
2023-08-14 |
Not clear |
| Nawon Lee, Jieun Jeong, Hyejin Park, Chang-Seok Ki, Jin-Kyung Ki. A case of Type A insulin resistance syndrome in a 14-year-old girl without common clinical features. Annals of pediatric endocrinology & metabolism. 2023-02-02. PMID:36731506. |
type a insulin resistance syndrome is a rare congenital disorder caused by insulin receptor dysfunction arising from heterozygous mutations in the insulin receptor (insr) gene. |
2023-02-02 |
2023-08-14 |
Not clear |
| Aashutosh U Shetti, Abhirami Ramakrishnan, Liudmila Romanova, Wenping Li, Khanh Vo, Ipsita Volety, Ishara Ratnayake, Terilyn Stephen, Richard D Minshall, Stephanie M Cologna, Orly Lazaro. Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes. Brain : a journal of neurology. 2023-02-02. PMID:36731883. |
interactome analysis revealed the insulin receptor interacts with cav-1 and caveolae-associated proteins, insulin degrading enzyme, and the tight junction protein zonula occludence-1 in brain endothelial cells. |
2023-02-02 |
2023-08-14 |
mouse |
| Giancarlo G M Talarico, Mélissa Grégoire, Jean-Michel Weber, Jan A Mennige. The mammalian insulin antagonist S961 does not exhibit insulin receptor antagonism in rainbow trout in vivo. Journal of fish biology. 2023-01-27. PMID:36704867. |
the mammalian insulin antagonist s961 does not exhibit insulin receptor antagonism in rainbow trout in vivo. |
2023-01-27 |
2023-08-14 |
cattle |
| Giancarlo G M Talarico, Mélissa Grégoire, Jean-Michel Weber, Jan A Mennige. The mammalian insulin antagonist S961 does not exhibit insulin receptor antagonism in rainbow trout in vivo. Journal of fish biology. 2023-01-27. PMID:36704867. |
here, we report two separate in vivo experiments to test the ability of the mammalian insulin receptor antagonist, s961, to efficiently block insulin signaling in liver and muscle in response to endogenously released insulin and to exogenously infused bovine insulin. |
2023-01-27 |
2023-08-14 |
cattle |
| Nahla E El-Ashmawy, Eman G Khedr, Nehal H Alfeky, Amera O Ibrahi. Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti-hyperglycemic effects of proanthocyanidins. Medicine international. vol 2. issue 3. 2023-01-26. PMID:36698506. |
the results indicated that opc ameliorated the diabetic state, as evidenced by a significant decrease in serum glucose levels, and a significant increase in the levels of insulin, amylin, insulin receptor phosphorylation, glycogen and glucose transporter-4 translocation; it also improved the lipid profile in stz-diabetic rats. |
2023-01-26 |
2023-08-14 |
rat |