| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuang Wu, Yan Tang, Shaojun Su, Wenbing Ding, Hualiang He, Jin Xue, Qiao Gao, Lin Qiu, Youzhi L. RNA interference knockdown of insulin receptor inhibits ovarian development in Chilo suppressalis. Molecular biology reports. 2022-10-06. PMID:36201100. |
as an integral component of the iis pathway, insulin receptor (inr), a receptor tyrosine kinase, plays a role in the insulin pathway by controlling reproduction in many insect species. |
2022-10-06 |
2023-08-14 |
Not clear |
| Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M Dreyfuss, A M James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N Kulkarn. E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance. Cell reports. vol 41. issue 1. 2022-10-05. PMID:36198264. |
here, we report the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by s961, a pharmacological insulin receptor antagonist. |
2022-10-05 |
2023-08-14 |
mouse |
| Nicholas A Smith, John G Menting, Michael A Weiss, Michael C Lawrence, Brian J Smit. Single-chain Insulin Analogs Threaded by the Insulin Receptor αCT Domain. Biophysical journal. 2022-10-01. PMID:36181268. |
single-chain insulin analogs threaded by the insulin receptor αct domain. |
2022-10-01 |
2023-08-14 |
Not clear |
| Nicholas S Kirk, Qi Chen, Yingzhe Ginger Wu, Anastasia L Asante, Haitao Hu, Juan F Espinosa, Francisco Martínez-Olid, Mai B Margetts, Faiz A Mohammed, Vladislav V Kiselyov, David G Barrett, Michael C Lawrenc. Activation of the human insulin receptor by non-insulin-related peptides. Nature communications. vol 13. issue 1. 2022-09-28. PMID:36171189. |
of particular therapeutic interest is whether insulin receptor signalling can be replicated by molecules other than insulin. |
2022-09-28 |
2023-08-14 |
human |
| Nicholas S Kirk, Qi Chen, Yingzhe Ginger Wu, Anastasia L Asante, Haitao Hu, Juan F Espinosa, Francisco Martínez-Olid, Mai B Margetts, Faiz A Mohammed, Vladislav V Kiselyov, David G Barrett, Michael C Lawrenc. Activation of the human insulin receptor by non-insulin-related peptides. Nature communications. vol 13. issue 1. 2022-09-28. PMID:36171189. |
our findings thus illuminate unexplored pathways for controlling the signalling of the insulin receptor as well as opportunities for development of insulin mimetics. |
2022-09-28 |
2023-08-14 |
human |
| Junhee Park, Jie Li, John P Mayer, Kerri A Ball, Jiayi Wu, Catherine Hall, Domenico Accili, Michael H B Stowell, Xiao-Chen Bai, Eunhee Cho. Activation of the insulin receptor by an insulin mimetic peptide. Nature communications. vol 13. issue 1. 2022-09-23. PMID:36151101. |
activation of the insulin receptor by an insulin mimetic peptide. |
2022-09-23 |
2023-08-14 |
mouse |
| Xingfeng Liu, Kai Wang, Shaocong Hou, Qian Jiang, Chunxiao Ma, Qijin Zhao, Lijuan Kong, Jingwen Chen, Zhenhe Wang, Huabing Zhang, Tao Yuan, Yuxiu Li, Yi Huan, Zhufang Shen, Zhuowei Hu, Zhifeng Huang, Bing Cui, Pingping L. Insulin induces insulin receptor degradation in the liver through EphB4. Nature metabolism. 2022-09-21. PMID:36131205. |
insulin induces insulin receptor degradation in the liver through ephb4. |
2022-09-21 |
2023-08-14 |
mouse |
| Xingfeng Liu, Kai Wang, Shaocong Hou, Qian Jiang, Chunxiao Ma, Qijin Zhao, Lijuan Kong, Jingwen Chen, Zhenhe Wang, Huabing Zhang, Tao Yuan, Yuxiu Li, Yi Huan, Zhufang Shen, Zhuowei Hu, Zhifeng Huang, Bing Cui, Pingping L. Insulin induces insulin receptor degradation in the liver through EphB4. Nature metabolism. 2022-09-21. PMID:36131205. |
insulin signaling is essential for glucose metabolism, and insulin decreases insulin receptor (insr) levels in a dose-dependent and time-dependent manner. |
2022-09-21 |
2023-08-14 |
mouse |
| Hui Xue, Xingxing Huang, Guofeng Chang, Weihua Ma, J Joe Hull, Lizhen Che. Reproductive capacity in Adelphocoris suturalis (Hemiptera: Miridae) is regulated by the insulin signaling pathway. Pesticide biochemistry and physiology. vol 187. 2022-09-20. PMID:36127067. |
here, we used rna interference (rnai)-mediated knockdown to examine the role of three critical insulin signaling pathway components (insulin receptor, inr; insulin receptor substrate 1, irs1; and forkhead box o, foxo) on reproductive capacity in the mirid adelphocoris suturalis. |
2022-09-20 |
2023-08-14 |
Not clear |
| Kyoichiro Tsuchiy. Role of insulin action in the pathogenesis of diabetic complications. Diabetology international. vol 13. issue 4. 2022-09-19. PMID:36117926. |
the liver, skeletal muscle, and adipose tissue are the major organs of action of insulin in systemic glucose metabolism, but insulin receptors and their downstream insulin signaling molecules are also constitutively expressed in vascular endothelial cells, vascular smooth muscle, and monocytes/macrophages. |
2022-09-19 |
2023-08-14 |
Not clear |
| Kyoichiro Tsuchiy. Role of insulin action in the pathogenesis of diabetic complications. Diabetology international. vol 13. issue 4. 2022-09-19. PMID:36117926. |
in liver sinusoidal endothelial cells, foxos induces hepatic insulin resistance by inducing nitration of insulin receptor in hepatocytes. |
2022-09-19 |
2023-08-14 |
Not clear |
| Susmita Sinha, Mainul Haqu. Insulin Resistance and Type 2 Diabetes Mellitus: An Ultimatum to Renal Physiology. Cureus. vol 14. issue 9. 2022-09-16. PMID:36111327. |
renal tubular cells and podocytes have insulin receptors, and their purposeful importance has been studied, which discloses critical acts of insulin signaling in podocyte survivability and tubular action. |
2022-09-16 |
2023-08-14 |
Not clear |
| Sommayya Aftab, Tahir Shaheen, Rameen Asif, Muhammad Nadeem Anjum, Anjum Saeed, Jaida Manzoor, Huma Arshad Cheem. Management challenges of Rabson Mendenhall syndrome in a resource limited country: a case report. Journal of pediatric endocrinology & metabolism : JPEM. 2022-09-15. PMID:36106528. |
rabson mendenhall syndrome (rms) is a rare form of insulin resistance syndrome caused by insulin receptor mutation. |
2022-09-15 |
2023-08-14 |
Not clear |
| Shu-Ting Zhuang, Rui Li, Shan-Shan Song, Hao-Ru Duan, Qiu-Yan L. [Effect of electroacupuncture on protein expressions of SOCS3 and IRS-1 in hypothalamus and pancreas islet morphology in diabetic fatty rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 9. 2022-09-08. PMID:36075599. |
to observe the effect of electroacupuncture (ea) on protein expressions of suppressor of cytokine signaling 3 (socs3) and insulin receptor substrate-1 (irs-1) in hypothalamus and morphology of pancreas islet in zucker diabetic fatty (zdf) rats, and to explore its possible mechanism on improving plasma glucose and insulin resistance of type 2 diabetes mellitus (t2dm). |
2022-09-08 |
2023-08-14 |
rat |
| Miao Liu, Man-Yun Chen, Liang An, Si-Qing Ma, Jie Mei, Wei-Hua Huang, Wei Zhan. Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae. Life sciences. 2022-09-05. PMID:36063979. |
effects of apolipoprotein e on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae. |
2022-09-05 |
2023-08-14 |
Not clear |
| Miao Liu, Man-Yun Chen, Liang An, Si-Qing Ma, Jie Mei, Wei-Hua Huang, Wei Zhan. Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae. Life sciences. 2022-09-05. PMID:36063979. |
although impaired insulin signaling at a post-receptor level was a well-established key driver of insulin resistance, the role of surface abnormal insulin receptor (insr) location in insulin resistance pathogenesis tended to be ignored and its molecular mechanisms remained obscure. |
2022-09-05 |
2023-08-14 |
Not clear |
| Tasmia Ahmed, Paola Cruz Flores, Christopher C Pan, Hannah R Ortiz, Yeon S Lee, Paul R Langlais, Karthikeyan Mythreye, Nam Y Le. EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex. The Journal of biological chemistry. vol 298. issue 9. 2022-08-28. PMID:35872017. |
while the endoglin-alk1 complex normally binds to tgf-β or bone morphogenetic protein 9 (bmp9) to promote gene regulation via transcription factors smad1/5, we show that insulin drives insulin receptor oligomerization with endoglin-alk1 at the cell surface to trigger rapid smad1/5 activation. |
2022-08-28 |
2023-08-16 |
Not clear |
| Huanliang Liu, Yunli Zhao, Xin Hua, Dayong Wan. Induction of transgenerational toxicity is associated with the activated germline insulin signals in nematodes exposed to nanoplastic at predicted environmental concentrations. Ecotoxicology and environmental safety. vol 243. 2022-08-28. PMID:36030687. |
these three insulin ligands transgenerationally activated function of insulin receptor daf-2 to control transgenerational toxicity of ps-np. |
2022-08-28 |
2023-08-14 |
caenorhabditis_elegans |
| Sonia M Najjar, Raziyeh Abdolahipour, Hilda E Ghadieh, Marziyeh Salehi Jahromi, John A Najjar, Basil A M Abuamreh, Sobia Zaidi, Sivarajan Kumarasamy, Harrison T Mutur. Regulation of Insulin Clearance by Non-Esterified Fatty Acids. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009446. |
on the other hand, reduced insulin clearance in the liver can cause chronic hyperinsulinemia, followed by downregulation of insulin receptor and insulin resistance. |
2022-08-26 |
2023-08-14 |
Not clear |
| Sami L Case, Hilaree N Frazier, Katie L Anderson, Ruei-Lung Lin, Olivier Thibaul. Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009470. |
insulin resistance, which manifests as a reduction of insulin receptor signaling, is known to correlate with pathological changes in peripheral tissues as well as in the brain. |
2022-08-26 |
2023-08-14 |
Not clear |