| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sami L Case, Hilaree N Frazier, Katie L Anderson, Ruei-Lung Lin, Olivier Thibaul. Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009470. |
here, we discuss age-dependent alterations in central modalities that may contribute to gait dysregulation, summarize current data supporting the role of insulin signaling in the brain, and highlight key findings that suggest insulin receptor sensitivity may be preserved in the aged brain. |
2022-08-26 |
2023-08-14 |
Not clear |
| Thaysa Ghiarone, Jorge A Castorena-Gonzalez, Christopher A Foote, Francisco I Ramirez-Perez, Larissa Ferreira-Santos, Francisco J Cabral-Amador, Roger de la Torre, Rama R Ganga, Andrew A Wheeler, Camila Manrique-Acevedo, Jaume Padilla, Luis A Martinez-Lemu. ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance. American journal of physiology. Heart and circulatory physiology. 2022-08-26. PMID:36018759. |
adam17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance. |
2022-08-26 |
2023-08-14 |
human |
| Xue Pan, Yanfang Pei, Cuici Zhang, Yaling Huang, Ling Chen, Liqiong Wei, Chuanren Li, Xiaolin Dong, Xiang Che. Effect of Insulin Receptor on Juvenile Hormone Signal and Fecundity in Insects. vol 13. issue 8. 2022-08-25. PMID:36005325. |
effect of insulin receptor on juvenile hormone signal and fecundity in insulin signaling can regulate various physiological functions, such as energy metabolism and reproduction and so on, in many insects, including mosquito and locust. |
2022-08-25 |
2023-08-14 |
Not clear |
| Rezvan Salehidoost, Márta Korbonit. Glucose and lipid metabolism abnormalities in Cushing's syndrome. Journal of neuroendocrinology. 2022-08-18. PMID:35980242. |
these include gcs causing excess gluconeogenesis via upregulation of key enzymes in the liver, a reduction of insulin sensitivity in skeletal muscle, liver and adipose tissue by inhibiting the insulin receptor signalling pathway, and inhibition of insulin secretion in beta cells leading to dysregulated glucose metabolism. |
2022-08-18 |
2023-08-14 |
Not clear |
| Yenniffer Ávalos, María Paz Hernández-Cáceres, Pablo Lagos, Daniela Pinto-Nuñez, Patricia Rivera, Paulina Burgos, Francisco Díaz-Castro, Michelle Joy-Immediato, Leslye Venegas-Zamora, Erik Lopez-Gallardo, Catalina Kretschmar, Ana Batista-Gonzalez, Flavia Cifuentes-Araneda, Lilian Toledo-Valenzuela, Marcelo Rodriguez-Peña, Jasson Espinoza-Caicedo, Claudio Perez-Leighton, Cristina Bertocchi, Mauricio Cerda, Rodrigo Troncoso, Valentina Parra, Mauricio Budini, Patricia V Burgos, Alfredo Criollo, Eugenia Morsell. Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism. Cell death & disease. vol 13. issue 7. 2022-07-28. PMID:35902579. |
we further demonstrate a role for the cilium in insulin sensitivity, as cilium loss in hypothalamic neuronal cells disrupts insulin signaling and insulin-dependent glucose uptake, an effect that correlates with the ciliary localization of the insulin receptor (ir). |
2022-07-28 |
2023-08-14 |
mouse |
| Xiaohong Zhang, Xuezhen Zhu, Xiaoyang Bi, Jiguang Huang, Lijuan Zho. The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887136. |
the insulin receptor (ir) is a transmembrane protein that is activated by ligands in insulin signaling pathways. |
2022-07-27 |
2023-08-14 |
human |
| Izael Costa, Mayara Lima, Amanda Medeiros, Lucas Bezerra, Paula Santos, Alexandre Serquiz, Maíra Lima, Gerciane Oliveira, Elizeu Santos, Bruna Maciel, Norberto Monteiro, Ana Heloneida Morai. An Insulin Receptor-Binding Multifunctional Protein from Foods (Basel, Switzerland). vol 11. issue 15. 2022-07-27. PMID:35892791. |
an insulin receptor-binding multifunctional protein from the objectives of this study were to evaluate the hypoglycemic effect of the trypsin inhibitor isolated from tamarind seeds (tti) in an experimental model of t2dm and the in silico interaction between the conformational models of tti 56/287 and the insulin receptor (ir). |
2022-07-27 |
2023-08-14 |
rat |
| Joel Alves da Silva Junior, Rosane Aparecida Ribeir. Potential Binding Sites for Taurine on the Insulin Receptor: A Molecular Docking Study. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882801. |
insulin acts on target tissues by interacting with the extracellular portion of a tyrosine kinase receptor, whose structure is known as the ectodomain (ecd) of the insulin receptor (ir). |
2022-07-26 |
2023-08-14 |
Not clear |
| Abdulbaset Zidane Shirif, Sanja Kovačević, Biljana Bursać, Iva Lakić, Nataša Veličković, Tanja Jevdjovic, Ana Djordjevi. Combination of chronic stress with fructose diet increases AMP-activated protein kinase phosphorylation and affects agouti-related protein and proopiomelanocortin expression in the hypothalamus of male Wistar rats. Acta biochimica Polonica. 2022-07-25. PMID:35877942. |
hypothalamic insulin signalling was analysed at the level of glucose transporters, as well as at the protein level and phosphorylation of insulin receptor, insulin receptor supstrate-1, akt and erk. |
2022-07-25 |
2023-08-14 |
rat |
| Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zha. Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ. Nature communications. vol 13. issue 1. 2022-07-25. PMID:35879296. |
here, we report that phenylalanine modifies insulin receptor beta (irβ) and inactivates insulin signaling and glucose uptake. |
2022-07-25 |
2023-08-14 |
mouse |
| Jed Wingrove, Owen O'Daly, Alfonso De Lara Rubio, Simon Hill, Magda Swedroska, Ben Forbes, Stephanie Amiel, Fernando Zelay. The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery. Human brain mapping. 2022-07-21. PMID:35860945. |
regions within these systems display insulin receptors and pharmacologically increasing central insulin concentrations using intranasal administration (in-ins) has been shown to significantly reduce appealing food cue responsiveness and also food intake. |
2022-07-21 |
2023-08-14 |
human |
| Ana M Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschöp, Teresa Iglesias, Maria L de Ceballos, Antonia Gutierrez, Ignacio Torres Alema. Insulin regulates neurovascular coupling through astrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 29. 2022-07-20. PMID:35858325. |
mice with insulin receptor (ir)-deficient astrocytes (gfap-ir knockout [ko] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas ir-deficient astrocytes show disturbed mitochondrial responses to glucose. |
2022-07-20 |
2023-08-14 |
mouse |
| Ya-Fen Pang, Ming Huang, Lin Li, Xin Zhao, Hong-Xia Zhang, Yu-Hong L. [Effect of Danlou Tablets on alleviating hepatic adipogenesis, inflammatory response, and insulin resistance in db/db mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 12. 2022-07-19. PMID:35851126. |
western blot was performed to determine the protein levels of insulin receptor-β(irβ), phospho-irβ(p-irβ), phosphatidylinositol 3-kinase(pi3 k), and insulin receptor substrate-1(irs-1) involved in irs-1/pi3 k/akt signaling pathway in the livers of mice to reveal the mechanism of dlt in alleviating insulin resistance in diabetic mice. |
2022-07-19 |
2023-08-14 |
mouse |
| Natalia Grigorova, Zhenya Ivanova, Bodil Bjørndal, Rolf Kristian Berge, Ekaterina Vachkova, Aneliya Milanova, Georgi Penchev, Ivan Penchev Georgie. Diet restriction alone improves glucose tolerance and insulin sensitivity than its coadministration with krill or fish oil in a rabbit model of castration-induced obesity. Journal of animal physiology and animal nutrition. 2022-07-19. PMID:35851693. |
however, this feed regime significantly accelerated insulin secretion and reduced gene expression of insulin receptor substrate-1, pyruvate kinase and 3-hydroxy-3-methylglutaryl-coa synthase 2. |
2022-07-19 |
2023-08-14 |
rabbit |
| Zhiyuan Fang, Wenwen Gao, Qianming Jiang, Juan J Loor, Chenchen Zhao, Xiliang Du, Min Zhang, Yuxiang Song, Zhe Wang, Guowen Liu, Xinwei Li, Lin Le. Targeting IRE1α and PERK in the endoplasmic reticulum stress pathway attenuates fatty acid-induced insulin resistance in bovine hepatocytes. Journal of dairy science. 2022-07-15. PMID:35840398. |
here, nefa induced insulin resistance by increasing the abundance of insulin receptor substrate-1 (irs1) phosphorylation at the inhibitory residue ser 307 (s307) and decreasing the abundance of phosphorylated protein kinase b (akt) and glycogen synthase kinase-3β (gsk3β) in a dose-dependent manner. |
2022-07-15 |
2023-08-14 |
cattle |
| Shee Chee Ong, Alessia Belgi, Allanah L Merriman, Carlie A Delaine, Bianca van Lierop, Sofianos Andrikopoulos, Andrea J Robinson, Briony E Forbe. Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond. Frontiers in endocrinology. vol 13. 2022-07-14. PMID:35832429. |
the mechanisms by which insulin activates the insulin receptor to promote metabolic processes and cellular growth are still not clear. |
2022-07-14 |
2023-08-14 |
Not clear |
| Melany Rios-Morales, Marcel A Vieira-Lara, Esther Homan, Miriam Langelaar-Makkinje, Albert Gerding, Zhuang Li, Nicolette Huijkman, Patrick C N Rensen, Justina C Wolters, Dirk-Jan Reijngoud, Barbara M Bakke. Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. Biochimica et biophysica acta. Molecular basis of disease. 2022-07-10. PMID:35811030. |
butyrate enhanced insulin sensitivity in palmitate-treated, insulin-resistant c2c12 cells, as shown by elevated insulin receptor 1 (irs1) and pakt protein levels and slc2a4 (glut4) mrna, which led to a higher glycolytic capacity. |
2022-07-10 |
2023-08-14 |
Not clear |
| Fei Yan, Ju Liu, Mei-Xiang Chen, Ying Zhang, Sheng-Jiao Wei, Hai Jin, Jing Nie, Xiao-Long Fu, Jing-Shan Shi, Shao-Yu Zhou, Feng Ji. Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799540. |
furthermore, deficits of proteins in the insulin signaling pathway and their phosphorylation levels were significantly reversed, including the insulin receptor, insulin receptor substrate 1, phosphatidylinositol-3-kinase, protein kinase b, and glycogen synthase kinase 3β, and the levels of glucose transporter 1 and 3 were markedly increased. |
2022-07-08 |
2023-08-14 |
mouse |
| Kun Zhou, Qiaoli Chen, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu, Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan, Shuai Che. Spatiotemporal regulation of insulin signaling by liquid-liquid phase separation. Cell discovery. vol 8. issue 1. 2022-07-05. PMID:35790738. |
insulin signals through its receptor to recruit insulin receptor substrates (irs) and phosphatidylinositol 3-kinase (pi3k) to the plasma membrane for production of phosphatidylinositol-3,4,5-trisphosphate (pip3) from phosphatidylinositol-4,5-bisphosphate [pi(4,5)p2], which consequently activates protein kinase b (pkb). |
2022-07-05 |
2023-08-14 |
Not clear |
| Angela Clerk, Peter H Sugde. The insulin receptor family in the heart: new light on old insights. Bioscience reports. 2022-06-29. PMID:35766350. |
insulin was discovered over 100 years ago. whilst the first half century defined many of the physiological effects of insulin, the second emphasised the mechanisms by which it elicits these effects, implicating a vast array of g proteins and their regulators, lipid and protein kinases and counteracting phosphatases, and more. potential growth-promoting and protective effects of insulin on the heart emerged from studies of carbohydrate metabolism in the 1960s, but the insulin receptor (and the related receptor for insulin-like growth factors 1 and 2) were not defined until the 1980s. a related third receptor, the insulin receptor-related receptor (insrr) remained an orphan receptor for many years until it was identified as an alkali-sensor. the mechanisms by which these receptors and the plethora of downstream signalling molecules confer cardioprotection remain elusive. here, we review important aspects of the effects of the three insulin receptor family members in the heart. metabolic studies are set in the context of what is now known of insulin receptor family signalling and the role of protein kinase b (pkb, or akt), and the relationship between this and cardiomyocyte survival versus death is discussed. pkb/akt phosphorylates numerous substrates with potential for cardioprotection in the contractile cardiomyocytes and cardiac non-myocytes. our overall conclusion is that the effects of insulin on glucose metabolism that were initially identified remain highly pertinent in managing cardiomyocyte energetics and preservation of function. this alone provides a high level of cardioprotection in the face of pathophysiological stressors such as ischaemia and myocardial infarction. |
2022-06-29 |
2023-08-14 |
Not clear |