| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Chen, Lingmin Hu, Yingchun Ling, Yuhua Xu, Xiao Yu, Luping Ma, Mengna Sho. Risk Correlation Analysis between Polycystic Ovary Syndrome (PCOS) and Serum Visfatin Levels in Middle-Aged Women: Systematic Review and Meta-Analysis. Discovery medicine. vol 35. issue 175. 2023-04-27. PMID:37105926. |
serum visfatin can affect insulin resistance by binding to insulin receptors and further affect the occurrence and development of pcos. |
2023-04-27 |
2023-08-14 |
Not clear |
| Matthäus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Schere. Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway. Molecular metabolism. 2023-04-26. PMID:37100238. |
brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the mapk pathway. |
2023-04-26 |
2023-08-14 |
Not clear |
| Mengjuan Wei, Tianyu Zhang, Hao Ouyang, Zhenlin Huang, Bin Lu, Jian Li, Hong Xu, Zhengtao Wang, Lili J. Erianin alleviated liver steatosis by enhancing Nrf2-mediated VE-cadherin expression in vascular endothelium. European journal of pharmacology. 2023-04-24. PMID:37094711. |
insulin reduced nrf2 activation by decreasing sequestosome-1 (p62/sqstm1) expression downstream of insulin receptor. |
2023-04-24 |
2023-08-14 |
mouse |
| Nazia Siddiqui, Javed Ali, Suhel Parvez, Abul Kalam Najmi, Mohd Akhta. Neuroprotective Role of DPP-4 Inhibitor Linagliptin Against Neurodegeneration, Neuronal Insulin Resistance and Neuroinflammation Induced by Intracerebroventricular Streptozotocin in Rat Model of Alzheimer's Disease. Neurochemical research. 2023-04-20. PMID:37079222. |
type 2 diabetes mellitus and neuronal insulin resistance due to serine phosphorylation of insulin receptor substrate-1 at 307 exhibits correlation with ad. |
2023-04-20 |
2023-08-14 |
rat |
| Sarah Wing-Yiu Poon, Brian Hon-Yin Chung, Mabel Siu-Chun Wong, Anita Man-Ching Tsan. Diazoxide-unresponsive Hyperinsulinemic Hypoglycaemia in a Preterm Infant with Heterozygous Insulin Receptor Gene Mutation. Journal of clinical research in pediatric endocrinology. 2023-04-19. PMID:37074094. |
homozygous or compound heterozygous mutations in insulin receptor gene (insr) lead to marked insulin resistance and hyperglycaemia in donohue syndrome and rabson-mendenhall syndrome, conditions which are associated with significant morbidity early in life. |
2023-04-19 |
2023-08-14 |
Not clear |
| Worarat Rojanaverawong, Navinee Wongmanee, Wanthanee Hanchan. Sacha Inchi ( Preventive nutrition and food science. vol 28. issue 1. 2023-04-17. PMID:37066030. |
furthermore, si treatment enhanced the hepatic insulin sensitivity of the diabetic rats, as shown by the increased insulin receptor substrate-1 and p-akt protein expression, decreased phosphoenolpyruvate carboxykinase-1 and glucose-6-phospatase protein expression, and increased hepatic glycogen content. |
2023-04-17 |
2023-08-14 |
rat |
| Xuefei Zhao, Xuedong An, Cunqing Yang, Wenjie Sun, Hangyu Ji, Fengmei Lia. The crucial role and mechanism of insulin resistance in metabolic disease. Frontiers in endocrinology. vol 14. 2023-04-14. PMID:37056675. |
mechanistically, any factor leading to abnormalities in the insulin signaling pathway leads to the development of ir in the host, including insulin receptor abnormalities, disturbances in the internal environment (regarding inflammation, hypoxia, lipotoxicity, and immunity), metabolic function of the liver and organelles, and other abnormalities. |
2023-04-14 |
2023-08-14 |
Not clear |
| Takanori Shinjo, Satoru Onizuka, Yumi Zaitsu, Atsushi Ishikado, Kyoungmin Park, Qian Li, Hisashi Yokomizo, Tatsuro Zeze, Kohei Sato, Ronald St-Louis, Jialin Fu, Wu I-Hsien, Koji Mizutani, Hatice Hasturk, Thomas E Van Dyke, Fusanori Nishimura, George L Kin. Dysregulation of CXCL1 expression and neutrophil recruitment in insulin resistance and diabetes-related periodontitis in male mice. Diabetes. 2023-04-14. PMID:37058471. |
this study showed that insulin resistance in the mouse gingiva due to selective deletion of smooth muscle and fibroblast insulin receptor (smirko mice) or systemic metabolic changes induced by high fat diet (hfd) in hfd-fed mice exacerbated periodontitis-induced alveolar bone loss, preceded by delayed neutrophil and monocyte recruitment and impaired bacterial clearance compared to their respective controls. |
2023-04-14 |
2023-08-14 |
mouse |
| Judith Gruber, Ruth Hanssen, Mishal Qubad, Aicha Bouzouina, Vivi Schack, Hannah Sochor, Carmen Schiweck, Mareike Aichholzer, Silke Matura, David A Slattery, Yurdaguel Zopf, Stephanie L Borgland, Andreas Reif, Sharmili Edwin Thanaraja. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing- an underexplored mechanism in the pathophysiology of depression? Neuroscience and biobehavioral reviews. 2023-04-14. PMID:37059404. |
since the discovery of insulin receptors in the brain and the brain's reward system, evidence has accumulated indicating that insulin modulates dopaminergic (da) signalling and reward behaviour. |
2023-04-14 |
2023-08-14 |
human |
| Osamu Horikawa, Satoshi Ugi, Tomofumi Takayoshi, Yasushi Omura, Maya Yonishi, Daisuke Sato, Yukihiro Fujita, Tomoya Fuke, Yushi Hirota, Wataru Ogawa, Hiroshi Maegaw. A family with type A insulin resistance syndrome caused by a novel insulin receptor mutation. Endocrinology, diabetes & metabolism case reports. vol 2023. 2023-04-12. PMID:37042492. |
a family with type a insulin resistance syndrome caused by a novel insulin receptor mutation. |
2023-04-12 |
2023-08-14 |
Not clear |
| Mariia Shypshyna, Oksana Kolesnyk, Svitlana Fedulova, Nickolai Veselovsk. Insulin modulates the paired-pulse plasticity at glutamatergic synapses of hippocampal neurons under hypoinsulinemia. Frontiers in cellular neuroscience. vol 17. 2023-04-07. PMID:37025701. |
dysfunction of signaling cascades of insulin receptors under insulin deficiency can contribute to the development of cognitive disorders associated with impaired synaptic plasticity properties. |
2023-04-07 |
2023-08-14 |
Not clear |
| Angela Costagliola di Polidoro, Zahra Baghbantarghdari, Vincenza De Gregorio, Simona Silvestri, Paolo Antonio Netti, Enza Torin. Insulin Activation Mediated by Uptake Mechanisms: A Comparison of the Behavior between Polymer Nanoparticles and Extracellular Vesicles in 3D Liver Tissues. Biomacromolecules. 2023-04-06. PMID:37023462. |
insulin is activated by interacting with insulin receptors exposed on the liver cell membrane that triggers the uptake and storage of glucose. |
2023-04-06 |
2023-08-14 |
Not clear |
| Dakshita Hardatt, Manju Dahiya, Sonal Vyas, Gurvinder Singh, Jyoti Jain, Sumeet Gupta, Meenakshi Dhanawa. Effect of Vitamin D on Retinoblastoma Protein in Prediabetic Individuals. Current diabetes reviews. 2023-04-03. PMID:37005543. |
vitamin d affects insulin sensitivity by increasing insulin receptors or the sensitivity of insulin receptors to insulin. |
2023-04-03 |
2023-08-14 |
Not clear |
| H Wang, Y W Zhu, J Yang, X Y Wang, Y C Zhan, W C Wang, L Yan. Research Note: Developmental changes of glucose metabolism are associated with insulin signaling in goose embryo. Poultry science. vol 102. issue 5. 2023-04-01. PMID:37003171. |
the hepatic mrna expression related to glucose catabolism (hexokinase, phosphofructokinase, and pyruvate kinase) and insulin signaling (insulin receptor, insulin receptor substrate protein, src homology collagen protein, extracellular signal-regulated kinase, and ribosomal protein s6 kinase, 70 ku) increased quadratically from embryonic day 19 to day of hatchment. |
2023-04-01 |
2023-08-14 |
Not clear |
| H Wang, Y W Zhu, J Yang, X Y Wang, Y C Zhan, W C Wang, L Yan. Research Note: Developmental changes of glucose metabolism are associated with insulin signaling in goose embryo. Poultry science. vol 102. issue 5. 2023-04-01. PMID:37003171. |
serum glucose levels were positively related to serum insulin (r = 1.00) and free triiodothyronine (r = 0.90) levels, as well as the hepatic mrna expression of insulin receptor (r = 1.00), insulin receptor substrate protein (r = 0.64), extracellular signal-regulated kinase (r = 0.81), and ribosomal protein s6 kinase, 70 ku (r = 0.81) related to insulin signaling. |
2023-04-01 |
2023-08-14 |
Not clear |
| Gitit Kra, Jayasimha Rayalu Daddam, Uzi Moallem, Hadar Kamer, Batel Mualem, Yishai Levin, Radka Kočvarová, Alina Nemirovski, Andres G Contreras, Joseph Tam, Maya Zachu. Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows. Scientific reports. vol 13. issue 1. 2023-03-31. PMID:37002295. |
in at, the top canonical pathways, according to the differential phosphoproteome in ala, were protein-kinase-a signaling and insulin-receptor signaling; network analysis and immunoblots validated the lower phosphorylation of protein kinase b (akt), and lower abundance of insulin receptor, together suggesting reduced insulin sensitivity in ala at. |
2023-03-31 |
2023-08-14 |
Not clear |
| Jyoti C Patel, Kenneth D Carr, Margaret E Ric. Actions and Consequences of Insulin in the Striatum. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979453. |
notably, insulin also acts in the striatum, which shows abundant expression of insulin receptors (insrs) throughout. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| Violina Kakoty, Sarathlal Kc, Shobha Kumari, Chih-Hao Yang, Sunil Kumar Dubey, Amirhossein Sahebkar, Prashant Kesharwani, Rajeev Taliya. Brain insulin resistance linked Alzheimer's and Parkinson's disease pathology: An undying implication of epigenetic and autophagy modulation. Inflammopharmacology. 2023-03-23. PMID:36952096. |
in metabolic syndrome, dysregulated signalling activity of the insulin receptor pathway in the brain due to persistent insulin resistance (ir) condition in the periphery may lead to brain ir (bir) development. |
2023-03-23 |
2023-08-14 |
Not clear |
| Dalia Cuenca, Jose Luis Ventura-Gallegos, Paloma Almeda-Valdes, María Teresa Tusié-Luna, Alfredo Reza-Albarran, Laura Ventura-Ayala, Ma Luisa Ordoñez-Sánchez, Yayoi Segura-Kato, Francisco Javier Gomez-Perez, Michelle De Puy Conte, Lizbet Ruilova Gonzalez, Alejandro Zentella-Dehes. A novel nonsense mutation in the insulin receptor gene in a patient with HAIR-AN syndrome and endometrial cancer. Molecular genetics and metabolism reports. vol 35. 2023-03-21. PMID:36941956. |
severe insulin resistance can be caused by rare genetic defects in the insulin receptor known as insulin receptoropathies. |
2023-03-21 |
2023-08-14 |
Not clear |