| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katsunori Nonogaki, Takao Kaj. The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice. Diabetes research and clinical practice. vol 120. 2016-12-13. PMID:27585115. |
the acute anorexic effect of liraglutide, a glp-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide. |
2016-12-13 |
2023-08-13 |
mouse |
| K Nonogaki, T Kaj. Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice. Diabetes & metabolism. vol 41. issue 5. 2016-08-25. PMID:26234524. |
the present study aimed to investigate the role of serotonin (5-ht)1b receptors in the regulation of plasma active glp-1 levels and glucose tolerance under dpp-4 inhibition. |
2016-08-25 |
2023-08-13 |
mouse |
| Z Y Hu, Z Y Yin, X Y Lin, Z G Yan, Z H Wan. Effects of feeding fatty acid calcium and the interaction of forage quality on production performance and biochemical indexes in early lactation cow. Journal of animal physiology and animal nutrition. vol 99. issue 5. 2016-07-20. PMID:25816839. |
supplemented fatty acid decreased concentration of blood bhba (p < 0.05), but increased tg, nefa, glucagon, glp-1, cck, leptin, apoa-iv, serotonin and msh concentration in blood, the cck concentration and feed intake showed a significant negative correlation (p < 0.05). |
2016-07-20 |
2023-08-13 |
Not clear |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
gcs also blocked the induction of serotonin synthesis by prolactin or by a previously unknown serotonin activator, the glp-1 analog exendin-4. |
2016-07-18 |
2023-08-13 |
mouse |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
in conclusion, our results demonstrate an original inhibition of serotonin synthesis by gcs, both in basal condition and after stimulation by prolactin or activators of the glp-1 receptor. |
2016-07-18 |
2023-08-13 |
mouse |
| Lara Pizzorn. Bariatric Surgery: Bad to the Bone, Part 2. Integrative medicine (Encinitas, Calif.). vol 15. issue 2. 2016-06-22. PMID:27330488. |
these mechanisms include mechanical unloading, calcium malabsorption despite maintenance of vitamin d levels of ≥30 ng/ml, and changes in a number of hormones, including leptin, adiponectin, testosterone, estradiol, serotonin, ghrelin, glucagon-like peptide 1 (glp-1), and gastric inhibitory peptide (gip). |
2016-06-22 |
2023-08-13 |
Not clear |
| Katsunori Nonogaki, Takao Kaj. Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice. Diabetes research and clinical practice. vol 110. issue 3. 2016-06-09. PMID:26497774. |
mosapride, a selective serotonin 5-ht4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active glp-1 levels and glucose tolerance in mice. |
2016-06-09 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice. Diabetes research and clinical practice. vol 110. issue 3. 2016-06-09. PMID:26497774. |
pharmacologic stimulation of serotonin 5-ht4 receptors increased plasma active glucagon-like-peptide-1 (glp-1) levels independent of feeding, and that pharmacologic stimulation of 5-ht4 receptors and pharmacologic inhibition of dipeptidyl peptidase-4 exerted synergic effects on plasma active glp-1 levels and glucose tolerance in mice. |
2016-06-09 |
2023-08-13 |
mouse |
| Fumio Kondo, Masahiko Tachi, Masahiko Gosho, Minoru Fukayama, Kazuhiro Yoshikawa, Shoshiro Okad. Changes in hypothalamic neurotransmitter and prostanoid levels in response to NMDA, CRF, and GLP-1 stimulation. Analytical and bioanalytical chemistry. vol 407. issue 18. 2016-03-18. PMID:25633219. |
in the present study, we investigated whether centrally administered nmda, crf, and glp-1 can release five neurotransmitters, acetylcholine (ach), histamine, glutamate (glu), γ-aminobutyric acid (gaba), and serotonin (5-ht), along with six prostanoids, txb2, prostaglandin (pg) e2, pgd2, 15-deoxy-∆(12,14) (15d)-pgj2, 6-keto-pgf1α, and pgf2α in rat pvn microdialysates after optimization of lc-itms(n) conditions . |
2016-03-18 |
2023-08-13 |
rat |
| Fumio Kondo, Masahiko Tachi, Masahiko Gosho, Minoru Fukayama, Kazuhiro Yoshikawa, Shoshiro Okad. Changes in hypothalamic neurotransmitter and prostanoid levels in response to NMDA, CRF, and GLP-1 stimulation. Analytical and bioanalytical chemistry. vol 407. issue 18. 2016-03-18. PMID:25633219. |
all stimulations increased the levels of 5-ht, txb2, pge2, and pgf2α (except for 5-ht stimulated with glp-1). |
2016-03-18 |
2023-08-13 |
rat |
| Y Yang, X Cui, Y Chen, Y Wang, X Li, L Lin, H Zhan. Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 65. issue 3. 2015-04-22. PMID:24930506. |
the levels of serotonin (5-ht) and glp-1 were measured by elisa assay. |
2015-04-22 |
2023-08-13 |
rat |
| Y Yang, X Cui, Y Chen, Y Wang, X Li, L Lin, H Zhan. Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 65. issue 3. 2015-04-22. PMID:24930506. |
the colonic sensitized rats showed low levels of glp-1 in plasma and high levels of 5-ht in plasma and colonic tissue (p<0.05). |
2015-04-22 |
2023-08-13 |
rat |
| Natalie A Terry, Erik R Walp, Randall A Lee, Klaus H Kaestner, Catherine Lee Ma. Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 10. 2015-01-15. PMID:25214396. |
gene ablation of isl1 in the intestine results in loss of glp-1, gip, cholecystokinin (cck), and somatostatin-expressing cells and an increase in 5-ht (serotonin)-producing cells, while the chromogranin a population was unchanged. |
2015-01-15 |
2023-08-13 |
mouse |
| Sandy Stayte, Bryce Visse. Advances in non-dopaminergic treatments for Parkinson's disease. Frontiers in neuroscience. vol 8. 2014-06-24. PMID:24904259. |
here we describe newly emerging non-dopaminergic therapeutic strategies for pd, including drugs targeting adenosine, glutamate, adrenergic, and serotonin receptors, as well as glp-1 agonists, calcium channel blockers, iron chelators, anti-inflammatories, neurotrophic factors, and gene therapies. |
2014-06-24 |
2023-08-13 |
human |
| Graham J Dockra. Enteroendocrine cell signalling via the vagus nerve. Current opinion in pharmacology. vol 13. issue 6. 2014-06-19. PMID:24064396. |
these include the release from enteroendocrine cells of mediators including 5ht, cck, glp-1, pyy and ghrelin that act on vagal afferent neurons regulating food intake and autonomic reflexes controlling motility, secretion, inflammatory responses and mucosal defence. |
2014-06-19 |
2023-08-12 |
human |
| I J Llewellyn-Smith, G J E Gnanamanickam, F Reimann, F M Gribble, S Trap. Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem. Neuroscience. vol 229. 2013-06-06. PMID:23069752. |
our data also indicate a synaptic connection between glp-1 neurons and 5-ht neurons, some of which might contribute to the regulation of appetite. |
2013-06-06 |
2023-08-12 |
mouse |
| André M Faria, Marcio C Mancini, Maria Edna de Melo, Cintia Cercato, Alfredo Halper. [Recent progress and novel perspectives on obesity pharmacotherapy]. Arquivos brasileiros de endocrinologia e metabologia. vol 54. issue 6. 2011-10-03. PMID:20857056. |
this review will discuss the efficacy and safety of these compounds, which include lorcaserin (selective serotonin 5-ht2c agonist), tesofensine (triple monoamine reuptake inhibitor), liraglutide (glp-1 analogue) and cetilistat (gastrointestinal lipase inhibitor), as well as the combination therapies of bupropion/naltrexone, bupropion/zonisamide, phentermine/topiramate and pramlintide/metreleptin. |
2011-10-03 |
2023-08-12 |
Not clear |
| Taiki Takahash. Toward molecular neuroeconomics of obesity. Medical hypotheses. vol 75. issue 4. 2010-12-22. PMID:20462703. |
it is suggested that neurobiological substrates such as adiponectin, dopamine (d2 receptors), endocannabinoids, ghrelin, leptin, nesfatin-1, norepinephrine, orexin, oxytocin, serotonin, vasopressin, cck, glp-1, mch, pyy, and stress hormones (e.g., crf) in the brain (e.g., ofc, vta, nacc, and the hypothalamus) may determine parameters in the economic theory of obesity. |
2010-12-22 |
2023-08-12 |
Not clear |
| Yu-Cheng Wang, Emerick Gallego-Arteche, Gioia Iezza, Xiaochen Yuan, Mary R Matli, Su-Pin Choo, Marlene B Zuraek, Ravi Gogia, Francis C Lynn, Michael S German, Emily K Bergsland, David B Donner, Robert S Warren, Eric K Nakakur. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocrine-related cancer. vol 16. issue 1. 2009-05-11. PMID:18987169. |
in the intestine of nkx2.2 (-/-) mice, we found a dramatic reduction in the number of cells producing numerous hormones, such as serotonin, gastrin, cholecystokinin, somatostatin, glucagon-like peptide 1 (glp-1), and secretin, but an increase in cells producing ghrelin. |
2009-05-11 |
2023-08-12 |
mouse |
| Lori Asaria. Loss of cholecystokinin and glucagon-like peptide-1-induced satiation in mice lacking serotonin 2C receptors. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 1. 2009-02-06. PMID:19005016. |
to investigate the role of serotonin 2c receptors (2cr), which are expressed only in the central nervous system, in the satiating actions of the gut peptides cck and glucagon-like peptide 1 (glp-1), we examined 1) the effect of null mutations of serotonin 2cr (2cr ko) on the eating-inhibitory potencies of dark-onset intraperitoneal injections of 0.9, 1.7, or 3.5 nmol/kg (1, 2, or 4 microg/kg) cck and 100, 200, and 400 nmol/kg (33, 66, or 132 microg/kg) glp-1, and 2) the effects of intraperitoneal injections of 1.7 nmol//kg cck and 100 nmol/kg glp-1 on neuronal activation in the brain, as measured by c-fos expression. |
2009-02-06 |
2023-08-12 |
mouse |