| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Zeve, Eric Stas, Joshua de Sousa Casal, Prabhath Mannam, Wanshu Qi, Xiaolei Yin, Sarah Dubois, Manasvi S Shah, Erin P Syverson, Sophie Hafner, Jeffrey M Karp, Diana L Carlone, Jose Ordovas-Montanes, David T Breaul. Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nature communications. vol 13. issue 1. 2022-01-12. PMID:35017529. |
we observed marked induction of ee cell differentiation and gut-derived expression and secretion of sst, 5ht, gip, cck, glp-1 and pyy upon treatment with various combinations of three small molecules: rimonabant, sp600125 and as1842856. |
2022-01-12 |
2023-08-13 |
human |
| Mauro Chivite, Fatemeh Naderi, Marta Conde-Sieira, José Luis Soengas, Marcos A Lopez-Patiño, Jesús M Mígue. Central serotonin participates in the anorexigenic effect of GLP-1 in rainbow trout (Oncorhynchus mykiss). General and comparative endocrinology. vol 304. 2021-11-25. PMID:33484717. |
central serotonin participates in the anorexigenic effect of glp-1 in rainbow trout (oncorhynchus mykiss). |
2021-11-25 |
2023-08-13 |
Not clear |
| b' Volkan Solmaz, Aslan Tekatas, M\\xc3\\xbcmin Alper Erdo\\xc4\\x9fan, Oytun Erba\\xc5\\x9. Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32745285.' |
exenatide, a glp-1 analog, has healing effects on lps-induced autism model: inflammation, oxidative stress, gliosis, cerebral gaba, and serotonin interactions. |
2021-08-26 |
2023-08-13 |
rat |
| Patrícia Rocha Martins, Josiane Fakhry, Adriana Jacaúna de Oliveira, Thayse Batista Moreira, Linda J Fothergill, Enio Chaves de Oliveira, Débora d'Ávila Reis, John B Furnes. The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon. Histochemistry and cell biology. vol 155. issue 4. 2021-08-23. PMID:33404704. |
using immunohistochemistry, eecs were identified by applying antibodies to chromogranin a (cga), glucagon-like peptide 1 (glp-1), 5-hydroxytryptamine (5-ht), peptide yy (pyy) and somatostatin (sst). |
2021-08-23 |
2023-08-13 |
Not clear |
| Patrícia Rocha Martins, Josiane Fakhry, Adriana Jacaúna de Oliveira, Thayse Batista Moreira, Linda J Fothergill, Enio Chaves de Oliveira, Débora d'Ávila Reis, John B Furnes. The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon. Histochemistry and cell biology. vol 155. issue 4. 2021-08-23. PMID:33404704. |
greater numbers of eec expressing glp-1 and sst occurred in the dilated portion compared to the non-dilated portion of the same patients with chagas disease and in control colon, but numbers of 5-ht and pyy eec were not significantly different. |
2021-08-23 |
2023-08-13 |
Not clear |
| Motoshi Okumura, Akihiro Hamada, Fumina Ohsaka, Takeshi Tsuruta, Tohru Hira, Kei Sonoyam. Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine. Pflugers Archiv : European journal of physiology. vol 472. issue 10. 2021-07-05. PMID:32870377. |
in the epithelium, htr2a, htr2b, and htr4 colocalized with 5-ht, and htr4 colocalized with glucagon-like peptide 1 (glp-1) and peptide yy (pyy). |
2021-07-05 |
2023-08-13 |
mouse |
| Motoshi Okumura, Akihiro Hamada, Fumina Ohsaka, Takeshi Tsuruta, Tohru Hira, Kei Sonoyam. Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine. Pflugers Archiv : European journal of physiology. vol 472. issue 10. 2021-07-05. PMID:32870377. |
murine intestinal organoids show a colocalization pattern that is similar to in vivo htr2a and htr4 with 5-ht, glp-1, and pyy. |
2021-07-05 |
2023-08-13 |
mouse |
| Jocelijn Meijerin. The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates. Molecules (Basel, Switzerland). vol 26. issue 5. 2021-06-01. PMID:33807994. |
in the intestinal tract, ors are expressed on serotonin (5-ht) and glucagon-like-peptide-1 (glp-1) producing enterochromaffin and enteroendocrine l cells, respectively. |
2021-06-01 |
2023-08-13 |
Not clear |
| Rosa M Leon, Tito Borner, Lauren M Stein, Norma A Urrutia, Bart C De Jonghe, Heath D Schmidt, Matthew R Haye. Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology. vol 187. 2021-04-14. PMID:33581143. |
within the hindbrain, serotonin (5-ht) functions as a modulator of the central glucagon-like peptide-1 (glp-1) system. |
2021-04-14 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, Lauren M Stein, Norma A Urrutia, Bart C De Jonghe, Heath D Schmidt, Matthew R Haye. Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology. vol 187. 2021-04-14. PMID:33581143. |
this interaction between 5-ht and glp-1 is achieved via 5-ht2c and 5-ht3 receptors and is relevant for glp-1-mediated feeding behavior. |
2021-04-14 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, Lauren M Stein, Norma A Urrutia, Bart C De Jonghe, Heath D Schmidt, Matthew R Haye. Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology. vol 187. 2021-04-14. PMID:33581143. |
whether 5-ht modulates glp-1's role in the stress response in unknown. |
2021-04-14 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, Lauren M Stein, Norma A Urrutia, Bart C De Jonghe, Heath D Schmidt, Matthew R Haye. Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology. vol 187. 2021-04-14. PMID:33581143. |
together, these findings identify a direct rmg to nts pathway responsible for the modulatory effect of 5-ht on the central glp-1 system-specifically via activation of 5-ht2c and 5-ht3 receptors-in the facilitation of acute stress responses. |
2021-04-14 |
2023-08-13 |
rat |
| Ji Yeon Chung, Jae-Ho Jeong, Juhyun Son. Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota. Frontiers in aging neuroscience. vol 12. 2020-12-18. PMID:33328965. |
based on previous findings, resveratrol is involved in glucagon-like peptide 1 (glp-1) secreted by intestine l cells, the patterns of microbiome in the intestine, the 5-hydroxytryptamine (5-ht) level, and cns inflammation. |
2020-12-18 |
2023-08-13 |
Not clear |
| Alyce M Martin, Emily W Sun, Geraint B Rogers, Damien J Keatin. The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release. Frontiers in physiology. vol 10. 2020-09-30. PMID:31057420. |
enteroendocrine cells within the mucosal lining of the gut synthesize and secrete a number of hormones including cck, pyy, glp-1, gip, and 5-ht, which have regulatory roles in key metabolic processes such as insulin sensitivity, glucose tolerance, fat storage, and appetite. |
2020-09-30 |
2023-08-13 |
human |
| Shu-Zhi Wang, Yi-Jing Yu, Khosrow Adel. Role of Gut Microbiota in Neuroendocrine Regulation of Carbohydrate and Lipid Metabolism via the Microbiota-Gut-Brain-Liver Axis. Microorganisms. vol 8. issue 4. 2020-09-28. PMID:32272588. |
vagal afferent neurons also express receptors for gut peptides that are secreted from enteroendocrine cells (eecs), such as cholecystokinin (cck), ghrelin, leptin, peptide tyrosine tyrosine (pyy), glucagon-like peptide-1 (glp-1), and 5-hydroxytryptamine (5-ht; serotonin). |
2020-09-28 |
2023-08-13 |
Not clear |
| Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M Gribble, Daniel J Drucker, Eelco J P de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W Schwartz, Natalia Peterse. L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling. Diabetes. vol 69. issue 4. 2020-08-03. PMID:32041793. |
l-cell differentiation is induced by bile acids through gpbar1 and paracrine glp-1 and serotonin signaling. |
2020-08-03 |
2023-08-13 |
mouse |
| Alyce M Martin, Emily W Sun, Damien J Keatin. Mechanisms controlling hormone secretion in human gut and its relevance to metabolism. The Journal of endocrinology. vol 244. issue 1. 2020-06-11. PMID:31751295. |
these hormones include glp-1, pyy, gip, serotonin, and cck, each of whom play pivotal roles in maintaining energy balance and glucose homeostasis. |
2020-06-11 |
2023-08-13 |
human |
| Rosa M Leon, Tito Borner, David J Reiner, Lauren M Stein, Rinzin Lhamo, Bart C De Jonghe, Matthew R Haye. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 10. 2020-03-16. PMID:30959513. |
hypophagia induced by hindbrain serotonin is mediated through central glp-1 signaling and involves 5-ht2c and 5-ht3 receptor activation. |
2020-03-16 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, David J Reiner, Lauren M Stein, Rinzin Lhamo, Bart C De Jonghe, Matthew R Haye. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 10. 2020-03-16. PMID:30959513. |
the interaction between serotonin (5-ht) and glucagon-like peptide-1 (glp-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli. |
2020-03-16 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, David J Reiner, Lauren M Stein, Rinzin Lhamo, Bart C De Jonghe, Matthew R Haye. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 10. 2020-03-16. PMID:30959513. |
we hypothesize that 5-ht acts as an endogenous modulator of the central glp-1 system to mediate satiation and malaise in rats. |
2020-03-16 |
2023-08-13 |
rat |