| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosa M Leon, Tito Borner, David J Reiner, Lauren M Stein, Rinzin Lhamo, Bart C De Jonghe, Matthew R Haye. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 10. 2020-03-16. PMID:30959513. |
here, we investigate whether interactions between central 5-ht and glp-1 signaling are behaviorally and physiologically relevant for the control of food intake and pica (i.e., behavioral measure of malaise). |
2020-03-16 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, David J Reiner, Lauren M Stein, Rinzin Lhamo, Bart C De Jonghe, Matthew R Haye. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 10. 2020-03-16. PMID:30959513. |
results show that the anorexia and body weight changes induced by administration of exogenous hindbrain 5-ht are dependent on central glp-1 receptor signaling. |
2020-03-16 |
2023-08-13 |
rat |
| Rosa M Leon, Tito Borner, David J Reiner, Lauren M Stein, Rinzin Lhamo, Bart C De Jonghe, Matthew R Haye. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 10. 2020-03-16. PMID:30959513. |
our findings highlight 5-ht as a novel endogenous modulator of the central glp-1 system and suggest that the central interaction between 5-ht and glp-1 is involved in the control of food intake in rats. |
2020-03-16 |
2023-08-13 |
rat |
| Donald K Layman, Tracy G Anthony, Blake B Rasmussen, Sean H Adams, Christopher J Lynch, Grant D Brinkworth, Teresa A Davi. Defining meal requirements for protein to optimize metabolic roles of amino acids. The American journal of clinical nutrition. vol 101. issue 6. 2019-11-20. PMID:25926513. |
recent research has focused on amino acids as metabolic signals that influence the rate of protein synthesis, inflammation responses, mitochondrial activity, and satiety, exerting their influence through signaling systems including mammalian/mechanistic target of rapamycin complex 1 (mtorc1), general control nonrepressed 2 (gcn2), glucagon-like peptide 1 (glp-1), peptide yy (pyy), serotonin, and insulin. |
2019-11-20 |
2023-08-13 |
Not clear |
| Erin Howell, Hannah M Baumgartner, Lia J Zallar, Joaquín A Selva, Liv Engel, Paul J Curri. Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT International journal of molecular sciences. vol 20. issue 4. 2019-06-04. PMID:30791361. |
glucagon-like peptide-1 (glp-1) and 5-hydroxytryptamine 2c (5-ht current literature indicates that the orexigenic peptide ghrelin increases appetitive motivation via signaling in the mesolimbic reward system. |
2019-06-04 |
2023-08-13 |
Not clear |
| Erin Howell, Hannah M Baumgartner, Lia J Zallar, Joaquín A Selva, Liv Engel, Paul J Curri. Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT International journal of molecular sciences. vol 20. issue 4. 2019-06-04. PMID:30791361. |
another gastric peptide, glucagon-like peptide-1 (glp-1), and the neurotransmitter 5-hydroxytryptamine (5-ht), are both known to suppress operant responding for food by acting on key mesolimbic nuclei, including the ventral tegmental area (vta). |
2019-06-04 |
2023-08-13 |
Not clear |
| Erin Howell, Hannah M Baumgartner, Lia J Zallar, Joaquín A Selva, Liv Engel, Paul J Curri. Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT International journal of molecular sciences. vol 20. issue 4. 2019-06-04. PMID:30791361. |
in order to investigate the interaction effects of ghrelin, glp-1, and 5-ht within the vta, we measured operant responding for sucrose pellets after the administration of ghrelin, the glp-1 receptor agonist exendin-4 (ex-4), and the 5-ht |
2019-06-04 |
2023-08-13 |
Not clear |
| Mari L Lund, Kristoffer L Egerod, Maja S Engelstoft, Oksana Dmytriyeva, Elvar Theodorsson, Bhavik A Patel, Thue W Schwart. Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites. Molecular metabolism. vol 11. 2019-04-11. PMID:29576437. |
enterochromaffin 5-ht cells - a major target for glp-1 and gut microbial metabolites. |
2019-04-11 |
2023-08-13 |
Not clear |
| Marie K Holt, Ida J Llewellyn-Smith, Frank Reimann, Fiona M Gribble, Stefan Trap. Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse. Molecular metabolism. vol 6. issue 8. 2018-12-12. PMID:28752054. |
glucagon-like peptide-1 (glp-1) and 5-ht are potent regulators of food intake within the brain. |
2018-12-12 |
2023-08-13 |
mouse |
| Chloé Terciolo, Marc Maresca, Philippe Pinton, Isabelle P Oswal. Review article: Role of satiety hormones in anorexia induction by Trichothecene mycotoxins. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 121. 2018-12-11. PMID:30243968. |
the indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (cck) and peptide yy (pyy) but also glucagon-like peptide 1 (glp-1), gastric inhibitory peptide (gip) and 5-hydroxytryptamine (5-ht), which transmitted signals to the brain via the gut-brain axis. |
2018-12-11 |
2023-08-13 |
mouse |
| M Mazzoni, T B Karunaratne, F Sirri, M Petracci, R De Giorgio, C Sternini, P Clavenzan. Enteroendocrine profile of α-transducin and α-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract. Poultry science. vol 97. issue 11. 2018-11-06. PMID:29955800. |
in the proventriculus tubular gland, gαtran or gαgust/gastrin (gas) immunoreactive (-ir) cells were more abundant than gαtran/or gαgust containing glucagon-like peptide-1 (glp-1) or peptide yy (pyy), whereas only few gαtran or gαgust cells co-stored ghrelin (ghr) or 5-hydroxytryptamine (5-ht). |
2018-11-06 |
2023-08-13 |
chicken |
| M Mazzoni, T B Karunaratne, F Sirri, M Petracci, R De Giorgio, C Sternini, P Clavenzan. Enteroendocrine profile of α-transducin and α-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract. Poultry science. vol 97. issue 11. 2018-11-06. PMID:29955800. |
in the pyloric mucosa, many gαtran or gαgust-ir cells co-expressed gas or ghr, with less gαtran or gαgust cells containing glp-1, pyy, or 5-ht. |
2018-11-06 |
2023-08-13 |
chicken |
| M Mazzoni, T B Karunaratne, F Sirri, M Petracci, R De Giorgio, C Sternini, P Clavenzan. Enteroendocrine profile of α-transducin and α-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract. Poultry science. vol 97. issue 11. 2018-11-06. PMID:29955800. |
in the small intestine, a considerable subset of gαtran or gαgust-ir cells co-expressed 5-ht in the villi of the duodenum and ileum, pyy in the villi of the jejunum, cck or glp-1 in the villi of the ileum, and ghr in the duodenum crypts. |
2018-11-06 |
2023-08-13 |
chicken |
| M Mazzoni, T B Karunaratne, F Sirri, M Petracci, R De Giorgio, C Sternini, P Clavenzan. Enteroendocrine profile of α-transducin and α-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract. Poultry science. vol 97. issue 11. 2018-11-06. PMID:29955800. |
in the large intestine, many gαtran or gαgust-ir cells contained 5-ht or glp-1 in the villi of the rectum, whereas some gαtran/gαgust-ir cells co-expressed pyy- or cck-, and few gαtran/gαgust-ir cells were positive for ghr-ir. |
2018-11-06 |
2023-08-13 |
chicken |
| Giovanna Muscogiuri, Giancarlo Balercia, Luigi Barrea, Angelo Cignarelli, Francesco Giorgino, Jens J Holst, Daniela Laudisio, Francesco Orio, Giacomo Tirabassi, Annamaria Cola. Gut: A key player in the pathogenesis of type 2 diabetes? Critical reviews in food science and nutrition. vol 58. issue 8. 2018-09-28. PMID:27892685. |
at the same time, intestinal milieu regulates the secretion of hormones such as glp-1, gip, ghrelin, gastrin, somatostatin, cck, serotonin, peptide yy, glp-2, all of which importantly influence metabolism in general and in particular glucose metabolism. |
2018-09-28 |
2023-08-13 |
Not clear |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
liraglutide, a glp-1 receptor agonist, which decreases hypothalamic 5-ht2a receptor expression, reduces appetite and body weight independently of serotonin synthesis in mice. |
2018-09-24 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
a recent report suggested that brain-derived serotonin (5-ht) is critical for maintaining weight loss induced by glucagon-like peptide-1 (glp-1) receptor activation in rats and that 5-ht2a receptors mediate the feeding suppression and weight loss induced by glp-1 receptor activation. |
2018-09-24 |
2023-08-13 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice. Journal of diabetes research. vol 2018. 2018-09-24. PMID:29484303. |
these findings suggest that liraglutide reduces appetite and body weight independently of 5-ht synthesis in mice, whereas glp-1 receptor activation downregulates the gene expression of hypothalamic 5-ht2a receptors. |
2018-09-24 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Xuezhen Hu, Changwei Yang, Hailing Xu, Ye Yao, Jiaming Li. Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis. Journal of agricultural and food chemistry. vol 66. issue 31. 2018-08-20. PMID:30040410. |
the levels of cerebral 5-hydroxytryptamine (5-ht), brain derived neurotrophic factor (bdnf), glucagon-like peptide-1 (glp-1) receptor and intestinal were measured. |
2018-08-20 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Xuezhen Hu, Changwei Yang, Hailing Xu, Ye Yao, Jiaming Li. Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis. Journal of agricultural and food chemistry. vol 66. issue 31. 2018-08-20. PMID:30040410. |
meanwhile, cb treatment exhibited prominent effects, increasing 5-ht and glp-1 and upregulating bdnf expression. |
2018-08-20 |
2023-08-13 |
mouse |