| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyeryeong Cho, Jaechul Li. The emerging role of gut hormones. Molecules and cells. 2024-10-19. PMID:39426686. |
the gut is traditionally recognized as the central organ for the digestion and absorption of nutrients, however it also functions as a significant endocrine organ, secreting a variety of hormones such as glucagon-like peptide 1 (glp-1), serotonin, somatostatin, and glucocorticoids. |
2024-10-19 |
2024-10-22 |
Not clear |
| Katsunori Nonogaki, Takao Kaj. The GLP-1 Receptor Agonist Liraglutide Decreases Primary Bile Acids and Serotonin in the Colon Independently of Feeding in Mice. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063026. |
the glp-1 receptor agonist liraglutide decreases primary bile acids and serotonin in the colon independently of feeding in mice. |
2024-07-27 |
2024-07-29 |
mouse |
| Tingyu Huang, Aoyun Li, Shanshan Zhang, Jiayan Fan, Zeao Hua, Xuebing Wang, Cong Zhang, Xu Yan. The role of gut microbiota in anorexia induced by T-2 toxin. Ecotoxicology and environmental safety. vol 281. 2024-06-19. PMID:38896898. |
this data proved that t-2 toxin was able to induce an anorexia in mice by increased the contents of gastrointestinal hormones (cck, gip, glp-1 and pyy), neurotransmitters (5-ht and sp), as well as pro-inflammatory cytokines (il-1β, il-6 and tnf-α) in serum of mice. |
2024-06-19 |
2024-06-22 |
mouse |
| Tingyu Huang, Aoyun Li, Shanshan Zhang, Jiayan Fan, Zeao Hua, Xuebing Wang, Cong Zhang, Xu Yan. The role of gut microbiota in anorexia induced by T-2 toxin. Ecotoxicology and environmental safety. vol 281. 2024-06-19. PMID:38896898. |
t-2 toxin disturbed the composition of gut microbiota, especially, faecalibaculum and allobaculum, which was positively correlated with cck, glp-1, 5-ht, il-1β, il-6 and tnf-α, which played a certain role in regulating host appetite. |
2024-06-19 |
2024-06-22 |
mouse |
| Louis J Kolling, Kanza Khan, Ruixiang Wang, Samantha R Pierson, Benjamin D Hartman, Nagalakshmi Balasubramanian, Deng-Fu Guo, Kamal Rahmouni, Catherine A Marcinkiewc. Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction. Psychiatry research. vol 337. 2024-05-12. PMID:38735240. |
here, we investigate changes in central serotonin (5-ht) and glucagon-like peptide 1 (glp-1) neurobiology that dually accompany behavioral and metabolic outcomes following social isolation stress throughout adolescence. |
2024-05-12 |
2024-05-27 |
mouse |
| Louis J Kolling, Kanza Khan, Ruixiang Wang, Samantha R Pierson, Benjamin D Hartman, Nagalakshmi Balasubramanian, Deng-Fu Guo, Kamal Rahmouni, Catherine A Marcinkiewc. Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction. Psychiatry research. vol 337. 2024-05-12. PMID:38735240. |
using bulk and spatial transcriptomic techniques, we observe broad changes in neural 5-ht, glp-1, and appetitive circuits. |
2024-05-12 |
2024-05-27 |
mouse |
| Louis J Kolling, Kanza Khan, Ruixiang Wang, Samantha R Pierson, Benjamin D Hartman, Nagalakshmi Balasubramanian, Deng-Fu Guo, Kamal Rahmouni, Catherine A Marcinkiewc. Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction. Psychiatry research. vol 337. 2024-05-12. PMID:38735240. |
we find 5-ht neurons of adolescent-isolation mice to be more excitable, transcribe fewer copies of glp1r (mrna; glp-1 receptor), and demonstrate resistance to the inhibitory effects of the glp-1r agonist semaglutide on action potential thresholds. |
2024-05-12 |
2024-05-27 |
mouse |
| Louis J Kolling, Kanza Khan, Ruixiang Wang, Samantha R Pierson, Benjamin D Hartman, Nagalakshmi Balasubramanian, Deng-Fu Guo, Kamal Rahmouni, Catherine A Marcinkiewc. Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction. Psychiatry research. vol 337. 2024-05-12. PMID:38735240. |
overall, we find that central 5-ht circuitry may simultaneously influence mental well-being and metabolic health in this model, via interactions with glp-1 and proopiomelanocortin circuitry. |
2024-05-12 |
2024-05-27 |
mouse |
| Amanda Marie Vanslette, Pernille Baumann Toft, Mari Lilith Lund, Thomas Moritz, Tulika Aror. Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice. European journal of pharmacology. 2023-11-05. PMID:37926275. |
two important eec subtypes, glucagon like peptide-1 (glp-1) producing l-cells and serotonin (5-ht) producing enterochromaffin (ec) cells interact via paracrine signaling and exhibit bidirectional regulation of expression and secretion of produced hormones. |
2023-11-05 |
2023-11-08 |
mouse |
| Amanda Marie Vanslette, Pernille Baumann Toft, Mari Lilith Lund, Thomas Moritz, Tulika Aror. Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice. European journal of pharmacology. 2023-11-05. PMID:37926275. |
accordingly, in vitro studies suggest potential to modulate 5-ht secretion by glp-1 receptor agonism, and l-cell differentiation via serotonin receptor 4 agonism. |
2023-11-05 |
2023-11-08 |
mouse |
| Amanda Marie Vanslette, Pernille Baumann Toft, Mari Lilith Lund, Thomas Moritz, Tulika Aror. Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice. European journal of pharmacology. 2023-11-05. PMID:37926275. |
in this study, we found that two weeks of high fat diet (hfd) feeding reduced rna expression of gut hormones, including proglucagon (gcg) gene encoding glp-1 and tryptophan hydroxylase1 (tph1) gene encoding rate limiting enzyme in 5-ht synthesis, specifically in the colon and reduced plasma glp-1 levels. |
2023-11-05 |
2023-11-08 |
mouse |
| Louis J Kolling, Kanza Khan, Nagalakshmi Balasubramanian, Deng-Fu Guo, Kamal Rahmouni, Catherine A Marcinkiewc. Involvement of a serotonin/GLP-1 circuit in adolescent isolation-induced diabetes. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398179. |
this circuit may represent an intersectional target to further investigate the relationship between social isolation and type 2 diabetes, as well as a pharmacologically-relevant circuit to explore the effects of serotonin and glp-1 receptor agonists. |
2023-07-03 |
2023-08-14 |
mouse |
| Yanan Wang, Ruixuan Geng, Yuhan Zhao, Jingjing Fang, Mengjie Li, Seong-Gook Kang, Kunlun Huang, Tao Ton. The gut odorant receptor and taste receptor make sense of dietary components: A focus on gut hormone secretion. Critical reviews in food science and nutrition. 2023-02-14. PMID:36785901. |
recent studies indicate that gut cells sense dietary components including fatty acid, carbohydrate, and phytochemical by activating relevant ors, thereby modulating glp-1, pyy, cck, and 5-ht secretion. |
2023-02-14 |
2023-08-14 |
human |
| Katsunori Nonogaki, Takao Kaj. Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice. Frontiers in endocrinology. vol 14. 2023-02-13. PMID:36777350. |
moreover, ingestion of whey protein isolate significantly decreased the expression of tgr5, glucagon-like peptide 1 (glp-1), and tryptophan hydroxylase1 (tph1) in the small intestine, leading to decreases in plasma 5-ht and insulin levels. |
2023-02-13 |
2023-08-14 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice. Frontiers in endocrinology. vol 14. 2023-02-13. PMID:36777350. |
moreover, ingestion of β-conglycinin significantly increased the expression of intestinal tgr5, glp-1, and tph1, leading to increases in plasma 5-ht and insulin levels. |
2023-02-13 |
2023-08-14 |
mouse |
| Dandan Tian, Wei Shi, Yihan Yu, Weishang Zhou, Yu Tang, Weixia Zhang, Lin Huang, Yu Han, Guangxu Li. Enrofloxacin exposure induces anxiety-like behavioral responses in zebrafish by affecting the microbiota-gut-brain axis. The Science of the total environment. 2022-11-13. PMID:36372168. |
moreover, the intestinal contents of interleukin 6 (il-6), tumor necrosis factor-alpha (tnf-α), glucagon-like peptide 1 (glp-1), and 5-hydroxytryptamine (5-ht) in zebrafish were significantly upregulated, whereas those of plasma adrenocorticotropic hormone (acth) and cortisol (cor) were markedly downregulated upon enrofloxacin exposure. |
2022-11-13 |
2023-08-14 |
zebrafish |
| M Mazzoni, M Zampiga, P Clavenzani, G Lattanzio, C Tagliavia, F Sirr. Effect of chronic heat stress on gastrointestinal histology and expression of feed intake-regulatory hormones in broiler chickens. Animal : an international journal of animal bioscience. vol 16. issue 8. 2022-07-30. PMID:35907384. |
haematoxylin-eosin was used for the morphometric evaluations, while immunohistochemistry was applied for the evaluation of eecs expressing ghrelin (ghr), cholecystokinin (cck), neuropeptide y (npy), glucagon-like peptide-1 (glp-1), and serotonin (5-ht). |
2022-07-30 |
2023-08-14 |
Not clear |
| M Mazzoni, M Zampiga, P Clavenzani, G Lattanzio, C Tagliavia, F Sirr. Effect of chronic heat stress on gastrointestinal histology and expression of feed intake-regulatory hormones in broiler chickens. Animal : an international journal of animal bioscience. vol 16. issue 8. 2022-07-30. PMID:35907384. |
similarly, the small intestine villi of the hs group showed greater glp-1 (p ≤ 0.05), 5-ht (p ≤ 0.001) and cck (p ≤ 0.01) eecs. |
2022-07-30 |
2023-08-14 |
Not clear |
| M Mazzoni, M Zampiga, P Clavenzani, G Lattanzio, C Tagliavia, F Sirr. Effect of chronic heat stress on gastrointestinal histology and expression of feed intake-regulatory hormones in broiler chickens. Animal : an international journal of animal bioscience. vol 16. issue 8. 2022-07-30. PMID:35907384. |
moreover, the expression of 5-ht eecs was higher in the duodenal (p ≤ 0.01) and jejunal (p ≤ 0.01) crypts of hs birds, whereas glp-1 and cck eecs increased only in jejunal crypts (p ≤ 0.05). |
2022-07-30 |
2023-08-14 |
Not clear |
| Anna Grete Wessel. Influence of the Gut Microbiome on Feed Intake of Farm Animals. Microorganisms. vol 10. issue 7. 2022-07-27. PMID:35889024. |
based on current evidence, the major mediators appear to be short-chain fatty acids (scfa), peptide hormones such as peptide yy (pyy) and glucagon-like peptide-1 (glp-1), as well as the amino acid tryptophan with the associated neurotransmitter serotonin, dopamine and γ-aminobutyrate (gaba). |
2022-07-27 |
2023-08-14 |
Not clear |