| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lori Asaria. Loss of cholecystokinin and glucagon-like peptide-1-induced satiation in mice lacking serotonin 2C receptors. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 1. 2009-02-06. PMID:19005016. |
these results indicate that serotonin signaling via serotonin 2cr is necessary for the full satiating effects of cck and glp-1. |
2009-02-06 |
2023-08-12 |
mouse |
| Luigi Brunetti, Giustino Orlando, Lucia Recinella, Sheila Leone, Claudio Ferrante, Annalisa Chiavaroli, Francesco Lazzarin, Michele Vacc. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Peptides. vol 29. issue 8. 2008-12-01. PMID:18502539. |
glucagon-like peptide 1 (7-36) amide (glp-1) and exendin-4 stimulate serotonin release in rat hypothalamus. |
2008-12-01 |
2023-08-12 |
rat |
| Luigi Brunetti, Giustino Orlando, Lucia Recinella, Sheila Leone, Claudio Ferrante, Annalisa Chiavaroli, Francesco Lazzarin, Michele Vacc. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Peptides. vol 29. issue 8. 2008-12-01. PMID:18502539. |
in the present paper we have evaluated the effects of glp-1 and exendin-4 on dopamine, norepinephrine, and serotonin release from rat hypothalamic synaptosomes, in vitro. |
2008-12-01 |
2023-08-12 |
rat |
| Luigi Brunetti, Giustino Orlando, Lucia Recinella, Sheila Leone, Claudio Ferrante, Annalisa Chiavaroli, Francesco Lazzarin, Michele Vacc. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Peptides. vol 29. issue 8. 2008-12-01. PMID:18502539. |
we can conclude that the central anorectic effects of glp-1 agonists could be partially mediated by increased serotonin release in the hypothalamus, leaving the catecholamine release unaffected. |
2008-12-01 |
2023-08-12 |
rat |
| Leonard G Forgan, Malcolm E Forste. Effects of potential mediators of an intestinal brake mechanism on gut motility in Chinook salmon (Oncorhynchus tshawytscha). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 146. issue 3. 2007-10-11. PMID:17500043. |
concentration-response curves of gut contractility were produced for cholecystokinin-8 (cck-8), gastrin-1, glucagon-like peptide-1 (glp-1) and 5-hydroxytryptamine (5-ht) using gut rings from cardiac stomach (cs), pyloric stomach (py), pyloric sphincter (psp) and intestine (int). |
2007-10-11 |
2023-08-12 |
Not clear |
| Kate Sutherland, Richard L Young, Nicole J Cooper, Michael Horowitz, L Ashley Blacksha. Phenotypic characterization of taste cells of the mouse small intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 5. 2007-07-06. PMID:17290008. |
immunohistochemistry was performed throughout the mouse small intestine for alpha-gustducin, enteroendocrine cell markers 5-ht and glucagon-like peptide-1 (glp-1), and brush cell markers neuronal nitric oxide synthase and ulex europaeus agglutinin-1 (uea-1) lectin binding, singly, and in combination. |
2007-07-06 |
2023-08-12 |
mouse |
| Kate Sutherland, Richard L Young, Nicole J Cooper, Michael Horowitz, L Ashley Blacksha. Phenotypic characterization of taste cells of the mouse small intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 5. 2007-07-06. PMID:17290008. |
here, 27% of alpha-gustducin cells colabeled for 5-ht and 15% for glp-1; 57% of alpha-gustducin cells colabeled uea-1, with no triple labeling. |
2007-07-06 |
2023-08-12 |
mouse |
| Kate Sutherland, Richard L Young, Nicole J Cooper, Michael Horowitz, L Ashley Blacksha. Phenotypic characterization of taste cells of the mouse small intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 5. 2007-07-06. PMID:17290008. |
alpha-gustducin cells that colabeled for 5-ht or glp-1 were of distinct morphology and exhibited a different alpha-gustducin immunolabeling pattern to those colabeled with uea-1. |
2007-07-06 |
2023-08-12 |
mouse |
| Kate Sutherland, Richard L Young, Nicole J Cooper, Michael Horowitz, L Ashley Blacksha. Phenotypic characterization of taste cells of the mouse small intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 5. 2007-07-06. PMID:17290008. |
intestinal taste modalities may be signaled by these enteroendocrine cells via the release of 5-ht, glp-1, or coexpressed mediators or by brush cells via a nonnitrergic mediator in distinct regions of the intestine. |
2007-07-06 |
2023-08-12 |
mouse |
| M A Gülpinar, B C Yege. The physiology of learning and memory: role of peptides and stress. Current protein & peptide science. vol 5. issue 6. 2005-02-08. PMID:15581416. |
arginine vasopressin (avp), oxytocin, angiotensin ii, insulin, growth factors, serotonin (5-ht), melanin concentrating hormone, histamine, bombesin and gastrin-releasing peptide (grp), glucagon-like peptide-1 (glp-1), cholecystokinin (cck), dopamine, corticotropin releasing factor (crf) have modulatory effects on learning and memory. |
2005-02-08 |
2023-08-12 |
Not clear |
| Rong Zhang, Tetsuya Tachibana, Tomo Takagi, Tomoyuki Koutoku, D Michael Denbow, Mitsuhiro Furus. Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks. Behavioural brain research. vol 151. issue 1-2. 2004-07-19. PMID:15084420. |
glucagon-like peptide-1 (glp-1) decreased corticotropin-releasing factor (crf)-induced behaviors in neonatal chicks, and serotonin is one of the possible mechanisms through which glp-1 affects crf-induced behaviors. |
2004-07-19 |
2023-08-12 |
Not clear |
| Lene Hansen, Jens J Hols. The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop? Regulatory peptides. vol 110. issue 1. 2003-07-29. PMID:12468108. |
in search for an endocrine pathway, we studied the effect of a range of concentrations of cholecystokinin octapeptide (26-33) (cck 8), gastric inhibitory peptide 1-42 (gip), secretin, motilin, calcitonin gene-related peptide (cgrp), and the modified amino acid, 5-hydroxytryptamine (serotonin, 5-ht) on glp-1 and somatostatin release from isolated perfused segments of porcine ileum.glp-1 secretion was stimulated by 1 nm cck 8 and 10 nm gip, but suppressed by 1 nm motilin and 1 microm 5-ht. |
2003-07-29 |
2023-08-12 |
Not clear |
| T Tachibana, S Tanaka, M Furuse, S Hasegawa, H Kato, K Sugahar. Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks. British poultry science. vol 43. issue 1. 2002-10-22. PMID:12003328. |
we measured the concentrations of dopamine (da), norepinephrine (ne), epinephrine (e) and 5-hydroxytryptamine (5-ht) in the hypothalamus of 21-d-old male brown-egg layer-type chicks after intracerebroventricular injection of glucagon-like peptide-1 (glp-1). |
2002-10-22 |
2023-08-12 |
chicken |
| T Tachibana, S Tanaka, M Furuse, S Hasegawa, H Kato, K Sugahar. Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks. British poultry science. vol 43. issue 1. 2002-10-22. PMID:12003328. |
however, concentrations of da, ne and e, but not 5-ht, in the ventromedial hypothalamic nucleus (vmh) were significantly decreased by glp-1. |
2002-10-22 |
2023-08-12 |
chicken |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
in this study the actions of glp-1 and its related peptides, exendin-4 (glp-1r agonist), exendin (9-39) (glp-1r antagonist) and glp-1 (9-36) amide (the major glp-1 metabolite) on levels of serotonin (5-ht), 5-hydroxyindolacetic acid (5-hiaa) and amino acids (glu, asp, gln, gly, tyr, trp, gaba) in the hypothalamus were investigated. |
2002-06-12 |
2023-08-12 |
rat |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
intracerebroventricular (icv) injection of glp-1 (4 nmol) produced a significant reduction in levels of 5-ht (54%) and all measured amino acids (34 to 56%) compared with saline injected controls, whereas exendin (9-39) (4 nmol) was ineffective. |
2002-06-12 |
2023-08-12 |
rat |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
icv injection of glp-1(9-36) amide showed a statistically significant increase in the level of 5-ht, 5-hiaa and all the amino acids tested in this study. |
2002-06-12 |
2023-08-12 |
rat |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
prior administration of exendin (9-39) or glp-1 (9-36) amide blocked the effects of glp-1 on the levels of 5-ht and the amino acids. |
2002-06-12 |
2023-08-12 |
rat |
| J C Halfor. Pharmacology of appetite suppression: implication for the treatment of obesity. Current drug targets. vol 2. issue 4. 2002-05-24. PMID:11732637. |
drugs that can be considered suitable candidates for appetite suppressants are agents that enhance peripherally satiety peptide systems (such as cck, bombesin/grp, enterostatin and glp-1), alter the cns levels of various hypothalamic neuropeptides (npy, galanin, orexin, cart and melanocortins) or monoamine neurotransmitters (such as serotonin, nor-adrenaline and possibly dopamine). |
2002-05-24 |
2023-08-12 |
Not clear |
| J C Halford, J E Blundel. Pharmacology of appetite suppression. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 54. 2000-06-29. PMID:10857385. |
of the drugs considered suitable candidates for appetite suppressants are agents which act via peripherally satiety peptide systems (such as cck, bombesin/grp, enterostatin and glp-1), or alter the cns levels of various hypothalamic neuropeptides (npy, galanin, orexin and melanocortins) or levels of the key cns appetite monoamine neurotransmitters such as serotonin (5-ht) and noradrenaline (na). |
2000-06-29 |
2023-08-12 |
Not clear |