| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| . Glucose Variability in a 26-Week Randomized Comparison of Mealtime Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants With Type 2 Diabetes at High Cardiovascular Risk. Diabetes care. vol 39. issue 6. 2017-10-24. PMID:27208320. |
glucose variability in a 26-week randomized comparison of mealtime treatment with rapid-acting insulin versus glp-1 agonist in participants with type 2 diabetes at high cardiovascular risk. |
2017-10-24 |
2023-08-13 |
human |
| Thea A S Halden, Erlend J Egeland, Anders Åsberg, Anders Hartmann, Karsten Midtvedt, Hassan Z Khiabani, Jens J Holst, Filip K Knop, Mads Hornum, Bo Feldt-Rasmussen, Trond Jensse. GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes. Diabetes care. vol 39. issue 4. 2017-10-23. PMID:26908914. |
glp-1 restores altered insulin and glucagon secretion in posttransplantation diabetes. |
2017-10-23 |
2023-08-13 |
Not clear |
| V R Aroda, T S Bailey, B Cariou, S Kumar, L A Leiter, P Raskin, J Zacho, T H Andersen, A Philis-Tsimika. Effect of adding insulin degludec to treatment in patients with type 2 diabetes inadequately controlled with metformin and liraglutide: a double-blind randomized controlled trial (BEGIN: ADD TO GLP-1 Study). Diabetes, obesity & metabolism. vol 18. issue 7. 2017-10-23. PMID:26990378. |
effect of adding insulin degludec to treatment in patients with type 2 diabetes inadequately controlled with metformin and liraglutide: a double-blind randomized controlled trial (begin: add to glp-1 study). |
2017-10-23 |
2023-08-13 |
Not clear |
| Joseph Lim, Christiani Jeyakumar Henry, Sumanto Halda. Vinegar as a functional ingredient to improve postprandial glycemic control-human intervention findings and molecular mechanisms. Molecular nutrition & food research. vol 60. issue 8. 2017-10-23. PMID:27213723. |
these mechanisms include (i) activation of the free fatty acid receptor 2 (ffar2) receptors localized in the enteroendocrine l-cells of the intestinal lumen, leading to increased glucagon like peptide 1 (glp-1) secretion, (ii) increased 5'adenosine monophosphate-activated protein kinase (ampk) activation, leading to increased fatty acid oxidation and decreased hepatic gluconeogenesis, (iii) lowering of free fatty acid in circulation, potentially leading to improved insulin sensitivity, (iv) increased blood flow to the peripheral tissues and (v) increased satiety, leading to lower food intake. |
2017-10-23 |
2023-08-13 |
human |
| George Tharakan, Preeshila Behary, Nicolai J Wewer Albrechtsen, Harvinder Chahal, Julia Kenkre, Alexander D Miras, Ahmed R Ahmed, Jens J Holst, Stephen R Bloom, Tricia Ta. Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass. European journal of endocrinology. vol 177. issue 6. 2017-10-20. PMID:28855269. |
the pathophysiology of pph remains unclear with multiple mechanisms suggested including nesidioblastosis, altered insulin clearance and increased glucagon-like peptide-1 (glp-1) secretion. |
2017-10-20 |
2023-08-13 |
Not clear |
| Ali Jazayeri, Mathieu Rappas, Alastair J H Brown, James Kean, James C Errey, Nathan J Robertson, Cédric Fiez-Vandal, Stephen P Andrews, Miles Congreve, Andrea Bortolato, Jonathan S Mason, Asma H Baig, Iryna Teobald, Andrew S Doré, Malcolm Weir, Robert M Cooke, Fiona H Marshal. Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature. vol 546. issue 7657. 2017-10-19. PMID:28562585. |
glucagon-like peptide 1 (glp-1) regulates glucose homeostasis through the control of insulin release from the pancreas. |
2017-10-19 |
2023-08-13 |
mouse |
| C Guo, T Huang, A Chen, X Chen, L Wang, F Shen, X G. Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 49. issue 12. 2017-10-16. PMID:27878229. |
we hypothesized that glp-1 analogue therapy in patients with t2d could suppress the inflammatory response of macrophages, and therefore inhibit insulin resistance. |
2017-10-16 |
2023-08-13 |
Not clear |
| C Guo, T Huang, A Chen, X Chen, L Wang, F Shen, X G. Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 49. issue 12. 2017-10-16. PMID:27878229. |
in conclusion, our results indicated that glp-1 improved inflammatory macrophage-derived insulin resistance by inhibiting nf-κb pathway and secretion of inflammatory cytokines in macrophages. |
2017-10-16 |
2023-08-13 |
Not clear |
| Jennifer Pichette, Nancy Fynn-Sackey, Jeffrey Gagno. Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice. Endocrinology. vol 158. issue 10. 2017-10-16. PMID:28977605. |
these animals also had enhanced glp-1 and insulin secretion, improved oral glucose tolerance, and reduced food consumption. |
2017-10-16 |
2023-08-13 |
mouse |
| Ohad Cohen, Sebastiano Filetti, Javier Castañeda, Marianna Maranghi, Mariela Gland. When Intensive Insulin Therapy (MDI) Fails in Patients With Type 2 Diabetes: Switching to GLP-1 Receptor Agonist Versus Insulin Pump. Diabetes care. vol 39 Suppl 2. 2017-10-13. PMID:27440831. |
when intensive insulin therapy (mdi) fails in patients with type 2 diabetes: switching to glp-1 receptor agonist versus insulin pump. |
2017-10-13 |
2023-08-13 |
human |
| Ohad Cohen, Sebastiano Filetti, Javier Castañeda, Marianna Maranghi, Mariela Gland. When Intensive Insulin Therapy (MDI) Fails in Patients With Type 2 Diabetes: Switching to GLP-1 Receptor Agonist Versus Insulin Pump. Diabetes care. vol 39 Suppl 2. 2017-10-13. PMID:27440831. |
importantly, insulin and glp-1 receptor agonists have complementary effects on glycemia and, hence, can be used either sequentially or in combination in the initial management of diabetes. |
2017-10-13 |
2023-08-13 |
human |
| Ohad Cohen, Sebastiano Filetti, Javier Castañeda, Marianna Maranghi, Mariela Gland. When Intensive Insulin Therapy (MDI) Fails in Patients With Type 2 Diabetes: Switching to GLP-1 Receptor Agonist Versus Insulin Pump. Diabetes care. vol 39 Suppl 2. 2017-10-13. PMID:27440831. |
patients who have not previously failed glp-1 receptor agonist therapy may show reduction in weight and insulin dose, in addition to moderate improvement in hba1c, when glp-1 receptor agonist therapy is added to mdi regimens. |
2017-10-13 |
2023-08-13 |
human |
| Ohad Cohen, Sebastiano Filetti, Javier Castañeda, Marianna Maranghi, Mariela Gland. When Intensive Insulin Therapy (MDI) Fails in Patients With Type 2 Diabetes: Switching to GLP-1 Receptor Agonist Versus Insulin Pump. Diabetes care. vol 39 Suppl 2. 2017-10-13. PMID:27440831. |
in subjects with long-standing type 2 diabetes who do not respond to intensive insulin therapies, switching from mdi to csii and/or the addition of glp-1 receptor agonists to mdi have the potential to improve glycemic control without increasing the risk of adverse events. |
2017-10-13 |
2023-08-13 |
human |
| Amelia K Linnemann, Joseph Blumer, Michelle R Marasco, Therese J Battiola, Heidi M Umhoefer, Jee Young Han, Dudley W Lamming, Dawn Belt Davi. Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 9. 2017-10-13. PMID:28592636. |
within the pancreatic islet, il-6 stimulates secretion of the prosurvival incretin hormone glucagon-like peptide 1 (glp-1) by α cells and acts directly on β cells to stimulate insulin secretion |
2017-10-13 |
2023-08-13 |
Not clear |
| Nunzia Caporarello, Cristina Parrino, Vincenzo Trischitta, Lucia Frittitt. Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. PloS one. vol 12. issue 8. 2017-10-13. PMID:28767692. |
glucagon-like peptide-1 (glp-1) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes mellitus. |
2017-10-13 |
2023-08-13 |
mouse |
| Nunzia Caporarello, Cristina Parrino, Vincenzo Trischitta, Lucia Frittitt. Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. PloS one. vol 12. issue 8. 2017-10-13. PMID:28767692. |
our data indicate that in insulin secreting beta cells in which either enpp1 was up-regulated or insulin receptor was down-regulated, glp-1 positive effects on several pancreatic beta cell activities, including glucose-induced insulin secretion, cell proliferation and cell survival, were strongly reduced. |
2017-10-13 |
2023-08-13 |
mouse |
| Rikke K Kirk, Charles Pyke, Matthias G von Herrath, Jane P Hasselby, Lars Pedersen, Pia G Mortensen, Lotte B Knudsen, Ken Coppieter. Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes. Diabetes, obesity & metabolism. vol 19. issue 5. 2017-10-10. PMID:28094469. |
glucagon-like peptide-1 (glp-1) is an incretin hormone which stimulates insulin release and inhibits glucagon secretion from the pancreas in a glucose-dependent manner. |
2017-10-10 |
2023-08-13 |
Not clear |
| Yan Zhang, Bingfa Sun, Dan Feng, Hongli Hu, Matthew Chu, Qianhui Qu, Jeffrey T Tarrasch, Shane Li, Tong Sun Kobilka, Brian K Kobilka, Georgios Skinioti. Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature. vol 546. issue 7657. 2017-10-10. PMID:28538729. |
glucagon-like peptide 1 (glp-1) is a hormone with essential roles in regulating insulin secretion, carbohydrate metabolism and appetite. |
2017-10-10 |
2023-08-13 |
Not clear |
| Anja Böhm, Robert Wagner, Fausto Machicao, Jens Juul Holst, Baptist Gallwitz, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring, Harald Staige. DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity. PloS one. vol 12. issue 7. 2017-10-09. PMID:28750074. |
dpp4 gene variation affects glp-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity. |
2017-10-09 |
2023-08-13 |
human |
| b' Micaela Morettini, Maria Concetta Palumbo, Massimo Sacchetti, Filippo Castiglione, Claudia Mazz\\xc3\\xa. A system model of the effects of exercise on plasma Interleukin-6 dynamics in healthy individuals: Role of skeletal muscle and adipose tissue. PloS one. vol 12. issue 7. 2017-10-03. PMID:28704555.' |
interleukin-6 (il-6) has been recently shown to play a central role in glucose homeostasis, since it stimulates the production and secretion of glucagon-like peptide-1 (glp-1) from intestinal l-cells and pancreas, leading to an enhanced insulin response. |
2017-10-03 |
2023-08-13 |
Not clear |