| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Surya Panicker Rajeev, John Wildin. GLP-1 as a target for therapeutic intervention. Current opinion in pharmacology. vol 31. 2017-07-24. PMID:27591964. |
glucagon-like peptide receptor agonists (glp-1 ra) have multiple effects, including control of glycaemia via stimulation of insulin and suppression of glucagon secretion and reduction of adiposity by enhancing satiety, so are an attractive therapeutic option in type 2 diabetes management. |
2017-07-24 |
2023-08-13 |
Not clear |
| Surya Panicker Rajeev, John Wildin. GLP-1 as a target for therapeutic intervention. Current opinion in pharmacology. vol 31. 2017-07-24. PMID:27591964. |
glp-1 ra are usually used in combination with other glucose-lowering drugs, but dual combinations with basal insulin in a single injection have recently become available. |
2017-07-24 |
2023-08-13 |
Not clear |
| Antonella Tramutola, Andrea Arena, Chiara Cini, D Allan Butterfield, Eugenio Baron. Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology. Expert review of neurotherapeutics. vol 17. issue 1. 2017-07-24. PMID:27715341. |
in this review, we focus on the glucagon-like peptide-1 (glp-1) signaling pathway, whose role in the brain is collecting increasing attention because of its association with insulin signaling activation. |
2017-07-24 |
2023-08-13 |
human |
| Eun-Young Park, Eung-Hwi Kim, Chul-Young Kim, Mi-Hwi Kim, Jin-Seung Choung, Yoon-Sin Oh, Hong-Sub Moon, Hee-Sook Ju. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PloS one. vol 11. issue 7. 2017-07-20. PMID:27391814. |
g protein-coupled receptor (gpr) 119 is expressed in pancreatic β-cells and intestinal l cells, and is involved in glucose-stimulated insulin secretion and glucagon-like peptide-1 (glp-1) release, respectively. |
2017-07-20 |
2023-08-13 |
mouse |
| Eun-Young Park, Eung-Hwi Kim, Chul-Young Kim, Mi-Hwi Kim, Jin-Seung Choung, Yoon-Sin Oh, Hong-Sub Moon, Hee-Sook Ju. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PloS one. vol 11. issue 7. 2017-07-20. PMID:27391814. |
human gpr119 activation was measured in geneblazer t-rex gpr119-cre-bla cho-k1 cells; intracellular camp levels and insulin secretion were measured in ins-1 cells; and glp-1 release was measured in glutag cells. |
2017-07-20 |
2023-08-13 |
mouse |
| Eun-Young Park, Eung-Hwi Kim, Chul-Young Kim, Mi-Hwi Kim, Jin-Seung Choung, Yoon-Sin Oh, Hong-Sub Moon, Hee-Sook Ju. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PloS one. vol 11. issue 7. 2017-07-20. PMID:27391814. |
ad extract-treated cells showed significant increases in gpr119 activation, intracellular camp levels, glp-1 levels and glucose-stimulated insulin secretion as compared with controls. |
2017-07-20 |
2023-08-13 |
mouse |
| Eun-Young Park, Eung-Hwi Kim, Chul-Young Kim, Mi-Hwi Kim, Jin-Seung Choung, Yoon-Sin Oh, Hong-Sub Moon, Hee-Sook Ju. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PloS one. vol 11. issue 7. 2017-07-20. PMID:27391814. |
among these, phellopterin activated gpr119 and increased active glp-1 and insulin secretion in vitro and enhanced glucose tolerance in normal and db/db mice. |
2017-07-20 |
2023-08-13 |
mouse |
| Antonello Emilio Rigamonti, Silvia Bini, Maria Cristina Rocco, Vittorio Giardini, Diego Massimini, Maria Grazia Crippa, Antonella Saluzzi, Marco Casati, Nicoletta Marazzi, Mario Perotti, Vincenzo Cimino, Guido Grassi, Alessandro Sartorio, Angela Ida Pincell. Post-prandial anorexigenic gut peptide, appetite and glucometabolic responses at different eating rates in obese patients undergoing laparoscopic sleeve gastrectomy. Endocrine. vol 55. issue 1. 2017-07-11. PMID:27022941. |
circulating levels of glp-1, pyy, glucose, insulin and triglycerides were measured before and 3 months after lsg. |
2017-07-11 |
2023-08-13 |
Not clear |
| Kazuki Harada, Tetsuya Kitaguchi, Taichi Kamiya, Kyaw Htet Aung, Kazuaki Nakamura, Kunihiro Ohta, Takashi Tsubo. Lysophosphatidylinositol-induced activation of the cation channel TRPV2 triggers glucagon-like peptide-1 secretion in enteroendocrine L cells. The Journal of biological chemistry. vol 292. issue 26. 2017-07-06. PMID:28533434. |
however, the role of lpi in secretion of glucagon-like peptide-1 (glp-1), a hormone that enhances glucose-induced insulin secretion, is unclear. |
2017-07-06 |
2023-08-13 |
Not clear |
| Mark Hopkins, John E Blundel. Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity. Clinical science (London, England : 1979). vol 130. issue 18. 2017-07-05. PMID:27503946. |
these effects are associated with changes in leptin and insulin sensitivity, and in the plasma levels of gastrointestinal (gi) peptides such as glucagon-like peptide-1 (glp-1), ghrelin and cholecystokinin (cck). |
2017-07-05 |
2023-08-13 |
Not clear |
| Ji Liu, Zhiping P Pan. Glucagon-like peptide-1 drives energy metabolism on the synaptic highway. The FEBS journal. vol 283. issue 24. 2017-06-30. PMID:27315220. |
in the pancreas, glp-1 facilitates insulin exocytosis or suppresses glucagon exocytosis via multiple pathways such as regulating k |
2017-06-30 |
2023-08-13 |
Not clear |
| Alessia Tagliavini, Morten Gram Pederse. Spatiotemporal Modeling of Triggering and Amplifying Pathways in GLP-1 Secreting Intestinal L Cells. Biophysical journal. vol 112. issue 1. 2017-06-28. PMID:28076808. |
glucagon-like peptide 1 (glp-1) is secreted by intestinal l-cells, and augments glucose-induced insulin secretion, thus playing an important role in glucose control. |
2017-06-28 |
2023-08-13 |
Not clear |
| Siôn A Parry, Jennifer R Smith, Talitha R B Corbett, Rachel M Woods, Carl J Hulsto. Short-term, high-fat overfeeding impairs glycaemic control but does not alter gut hormone responses to a mixed meal tolerance test in healthy, normal-weight individuals. The British journal of nutrition. vol 117. issue 1. 2017-06-26. PMID:28115026. |
nine healthy individuals (five males, four females) performed a mixed meal tolerance test (mtt) before and after consuming a high-fat (65 %), high-energy (+50 %) diet for 7 d. measurements of plasma glucose, nefa, acylated ghrelin, glucagon-like peptide-1 (glp-1), gastric inhibitory polypeptide (gip) and serum insulin were taken before (fasting) and at 30-min intervals throughout the 180-min mtt (postprandial). |
2017-06-26 |
2023-08-13 |
Not clear |
| Chafiq Hamdouchi, Steven D Kahl, Anjana Patel Lewis, Guemalli R Cardona, Richard W Zink, Keyue Chen, Thomas E Eessalu, James V Ficorilli, Marialuisa C Marcelo, Keith A Otto, Kelly L Wilbur, Jayana P Lineswala, Jared L Piper, D Scott Coffey, Stephanie A Sweetana, Joseph V Haas, Dawn A Brooks, Edward J Pratt, Ruth M Belin, Mark A Deeg, Xiaosu Ma, Ellen A Cannady, Jason T Johnson, Nathan P Yumibe, Qi Chen, Pranab Maiti, Chahrzad Montrose-Rafizadeh, Yanyun Chen, Anne Reifel Mille. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). Journal of medicinal chemistry. vol 59. issue 24. 2017-06-19. PMID:27749056. |
compounds 1 (ly2881835), 2 (ly2922083), and 3 (ly2922470) demonstrated potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and glp-1 secretion during preclinical testing. |
2017-06-19 |
2023-08-13 |
human |
| Carol H Wysham, Jay Lin, Louis Kuritzk. Safety and efficacy of a glucagon-like peptide-1 receptor agonist added to basal insulin therapy versus basal insulin with or without a rapid-acting insulin in patients with type 2 diabetes: results of a meta-analysis. Postgraduate medicine. vol 129. issue 4. 2017-06-19. PMID:28294702. |
to consolidate the evidence from randomized controlled trials evaluating the use of glucagon-like peptide-1 receptor agonists (glp-1 ras) as add-on to basal insulin therapy in type 2 diabetes (t2d) patients. |
2017-06-19 |
2023-08-13 |
Not clear |
| Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Loïc Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charto. Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance. Journal of medicinal chemistry. vol 60. issue 10. 2017-06-19. PMID:28414465. |
among them, compound 24 is a potent glp-1 secretagogue, has low effect on gallbladder volume, and improves glucose homeostasis in a preclinical murine model of diet-induced obesity and insulin resistance, making the proof of concept of the potential of topical intestinal tgr5 agonists as therapeutic agents in type-2 diabetes. |
2017-06-19 |
2023-08-13 |
Not clear |
| Weidong Chai, Zhuo Fu, Kevin W Aylor, Eugene J Barrett, Zhenqi Li. Liraglutide prevents microvascular insulin resistance and preserves muscle capillary density in high-fat diet-fed rats. American journal of physiology. Endocrinology and metabolism. vol 311. issue 3. 2017-06-16. PMID:27436611. |
in this study, we aim to determine the effects of sustained stimulation of the glp-1 receptors on insulin-mediated capillary recruitment and metabolic insulin responses, small arterial endothelial function, and muscle capillary density. |
2017-06-16 |
2023-08-13 |
rat |
| Weidong Chai, Zhuo Fu, Kevin W Aylor, Eugene J Barrett, Zhenqi Li. Liraglutide prevents microvascular insulin resistance and preserves muscle capillary density in high-fat diet-fed rats. American journal of physiology. Endocrinology and metabolism. vol 311. issue 3. 2017-06-16. PMID:27436611. |
we conclude that glp-1 receptor agonists may exert their salutary glycemic effect via improving microvascular insulin sensitivity and muscle capillary density during the development of insulin resistance, and early use of glp-1 receptor agonists may attenuate metabolic insulin resistance as well as prevent cardiovascular complications of diabetes. |
2017-06-16 |
2023-08-13 |
rat |
| Tianru Jin, Jianping Wen. Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives. American journal of physiology. Endocrinology and metabolism. vol 311. issue 3. 2017-06-16. PMID:27507553. |
postprandial glp-1 release contributes to insulin secretion, which represses hepatic glucose production. |
2017-06-16 |
2023-08-13 |
human |
| Tianru Jin, Jianping Wen. Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives. American journal of physiology. Endocrinology and metabolism. vol 311. issue 3. 2017-06-16. PMID:27507553. |
great efforts have been made to determine whether glp-1 and its analogs possess direct metabolic effects on the liver, as the determination of the existence of direct hepatic effects may advance the therapeutic theory and clinical practice on subjects with insulin resistance. |
2017-06-16 |
2023-08-13 |
human |