| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca L Paszkiewicz, Richard N Bergma. Mechanisms of improved glucose handling after metabolic surgery: the big 6. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 12. issue 6. 2017-09-11. PMID:27568470. |
a plethora of medicines have been introduced to reduce the fasting and postprandial glucose levels (including insulin, glucagon-like peptide receptor 1 [glp-1] agonists, and sodium-glucose co-transporter 2 [sglt2] inhibitors, among others). |
2017-09-11 |
2023-08-13 |
Not clear |
| Marzieh Salehi, David A D'Alessi. Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 12. issue 6. 2017-09-11. PMID:27568473. |
given the tenfold increase in postmeal glucagon-like peptide-1 (glp-1) response compared to unchanged integrated levels of postprandial glucose-dependent insulinotropic peptide after rygb, enhanced meal-induced insulin secretion after this procedure was thought to be the result of elevated glucose and glp-1 levels. |
2017-09-11 |
2023-08-13 |
Not clear |
| Louis S Matza, Sarah E Curtis, Jessica B Jordan, Omolara Adetunji, Sherry A Martin, Kristina S Boy. Physician perceptions of GLP-1 receptor agonists in the UK. Current medical research and opinion. vol 32. issue 5. 2017-09-04. PMID:26807507. |
physicians' most common reasons for prescribing a glp-1 receptor agonist were: associated with weight loss (65.8%), good efficacy (55.7%), less hypoglycemia risk than insulin (55.2%), not associated with weight gain (34.5%), and better efficacy than oral medications (32.7%). |
2017-09-04 |
2023-08-13 |
Not clear |
| Mehdi Bin Samad, Md Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir, J M A Hanna. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr BMC complementary and alternative medicine. vol 17. issue 1. 2017-09-01. PMID:28793909. |
[6]-gingerol, from zingiber officinale, potentiates glp-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases rab8/rab10-regulated membrane presentation of glut4 transporters in skeletal muscle to improve hyperglycemia in lepr [6]-gingerol, a major component of zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. |
2017-09-01 |
2023-08-13 |
mouse |
| Éva A Csajbók, Gábor Tamá. Cerebral cortex: a target and source of insulin? Diabetologia. vol 59. issue 8. 2017-08-28. PMID:27207082. |
modulation of insulin production by brain neurons via glucagon-like peptide 1 (glp-1) agonists might be useful in counteracting diabetes, obesity and neurodegenerative diseases. |
2017-08-28 |
2023-08-13 |
Not clear |
| Karly C Sourris, Henry Yao, George Jerums, Mark E Cooper, Elif I Ekinci, Melinda T Coughla. Can Targeting the Incretin Pathway Dampen RAGE-Mediated Events in Diabetic Nephropathy? Current drug targets. vol 17. issue 11. 2017-08-22. PMID:26201485. |
glucagon like peptide-1 (glp-1) is an incretin hormone released by the l-cells of the small intestine to mediate glucose-dependent insulin release from pancreatic islets. |
2017-08-22 |
2023-08-13 |
Not clear |
| Judith N Gorski, Michele J Pachanski, Joel Mane, Christopher W Plummer, Sarah Souza, Brande S Thomas-Fowlkes, Aimie M Ogawa, Adam B Weinglass, Jerry Di Salvo, Boonlert Cheewatrakoolpong, Andrew D Howard, Steven L Colletti, Maria E Trujill. GPR40 reduces food intake and body weight through GLP-1. American journal of physiology. Endocrinology and metabolism. vol 313. issue 1. 2017-08-21. PMID:28292762. |
the class of small-molecule gpr40 modulators, known as agopams (agonist also capable of acting as positive allosteric modulators), differentiate from partial agonists, binding to a distinct site and functioning as full agonists to stimulate the secretion of both insulin and glucagon-like peptide-1 (glp-1). |
2017-08-21 |
2023-08-13 |
mouse |
| Cordelia Manickam, Lynn Wachtman, Amanda J Martinot, Luis D Giavedoni, R Keith Reeve. Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus). PloS one. vol 12. issue 1. 2017-08-18. PMID:28085952. |
although most animals showed a transient decline in blood glucose, infection resulted in several fold increases in plasma insulin, glucagon and glucagon-like peptide 1 (glp-1). |
2017-08-18 |
2023-08-13 |
human |
| David W Boulto. Clinical Pharmacokinetics and Pharmacodynamics of Saxagliptin, a Dipeptidyl Peptidase-4 Inhibitor. Clinical pharmacokinetics. vol 56. issue 1. 2017-08-16. PMID:27282159. |
inhibition of dpp-4 increases intact plasma glp-1 and gip concentrations, augmenting glucose-dependent insulin secretion. |
2017-08-16 |
2023-08-13 |
Not clear |
| Radwan H Ahmed, Hasniza Zaman Huri, Sekaran Muniandy, Zaid Al-Hamodi, Boshra Al-Absi, Abdulsamad Alsalahi, Muhammad Fm Razi. Altered circulating concentrations of active glucagon-like peptide (GLP-1) and dipeptidyl peptidase 4 (DPP4) in obese subjects and their association with insulin resistance. Clinical biochemistry. vol 50. issue 13-14. 2017-08-14. PMID:28288852. |
altered circulating concentrations of active glucagon-like peptide (glp-1) and dipeptidyl peptidase 4 (dpp4) in obese subjects and their association with insulin resistance. |
2017-08-14 |
2023-08-13 |
human |
| Radwan H Ahmed, Hasniza Zaman Huri, Sekaran Muniandy, Zaid Al-Hamodi, Boshra Al-Absi, Abdulsamad Alsalahi, Muhammad Fm Razi. Altered circulating concentrations of active glucagon-like peptide (GLP-1) and dipeptidyl peptidase 4 (DPP4) in obese subjects and their association with insulin resistance. Clinical biochemistry. vol 50. issue 13-14. 2017-08-14. PMID:28288852. |
we evaluated the fasting serum levels of active glp-1 and sdpp4 in obese, overweight and normal weight subjects to assess the association between sdpp4 levels, active glp-1 levels and insulin resistance in obese subjects. |
2017-08-14 |
2023-08-13 |
human |
| Yin Lin, Kasper Krogh-Andersen, Julien Pelletier, Harold Marcotte, Claes-Göran Östenson, Lennart Hammarströ. Oral Delivery of Pentameric Glucagon-Like Peptide-1 by Recombinant Lactobacillus in Diabetic Rats. PloS one. vol 11. issue 9. 2017-08-11. PMID:27610615. |
glucagon-like peptide-1 (glp-1) is an incretin hormone produced by intestinal cells and stimulates insulin secretion from the pancreas in a glucose-dependent manner. |
2017-08-11 |
2023-08-13 |
rat |
| Anping Wang, Ting Li, Ping An, Wenhua Yan, Hua Zheng, Baoan Wang, Yiming M. Exendin-4 Upregulates Adiponectin Level in Adipocytes via Sirt1/Foxo-1 Signaling Pathway. PloS one. vol 12. issue 1. 2017-08-10. PMID:28122026. |
glp-1 receptor agonists have been widely used for treating diabetes and other insulin resistance-related diseases. |
2017-08-10 |
2023-08-13 |
Not clear |
| Anping Wang, Ting Li, Ping An, Wenhua Yan, Hua Zheng, Baoan Wang, Yiming M. Exendin-4 Upregulates Adiponectin Level in Adipocytes via Sirt1/Foxo-1 Signaling Pathway. PloS one. vol 12. issue 1. 2017-08-10. PMID:28122026. |
in this study, we investigated the effects of glp-1 agonist exendin-4 on the expression of adiponectin, an insulin sensitizing hormone. |
2017-08-10 |
2023-08-13 |
Not clear |
| L Bozzetto, G Annuzzi, M Ragucci, O Di Donato, G Della Pepa, G Della Corte, E Griffo, G Anniballi, A Giacco, M Mancini, A A Rivelles. Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 26. issue 7. 2017-08-08. PMID:27134062. |
insulin resistance, postprandial glp-1 and adaptive immunity are the main predictors of nafld in a homogeneous population at high cardiovascular risk. |
2017-08-08 |
2023-08-13 |
Not clear |
| Joel F Habener, Violeta Stanojevi. Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect. Cell metabolism. vol 25. issue 4. 2017-08-08. PMID:28380367. |
the gut is believed to be the source of glp-1 that augments insulin secretion in response to oral nutrients. |
2017-08-08 |
2023-08-13 |
mouse |
| Corinna Lebherz, Georg Schlieper, Julia Möllmann, Florian Kahles, Marvin Schwarz, Jan Brünsing, Nada Dimkovic, Alexander Koch, Christian Trautwein, Jürgen Flöge, Nikolaus Marx, Frank Tacke, Michael Lehrk. GLP-1 Levels Predict Mortality in Patients with Critical Illness as Well as End-Stage Renal Disease. The American journal of medicine. vol 130. issue 7. 2017-08-03. PMID:28366423. |
glucagon-like peptide 1 (glp-1) is an incretin hormone, which stimulates glucose-dependent insulin secretion from the pancreas and holds immune-regulatory properties. |
2017-08-03 |
2023-08-13 |
Not clear |
| Suleiman Al-Saba. Molecular Pharmacology of the Incretin Receptors. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 25 Suppl 1. 2017-07-31. PMID:26111634. |
the incretin hormones glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are important regulators of insulin and glucagon secretion as well as lipid metabolism and appetite. |
2017-07-31 |
2023-08-13 |
mouse |
| Pierre Larraufie, Joël Doré, Nicolas Lapaque, Hervé M Blottièr. TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways. Cellular microbiology. vol 19. issue 2. 2017-07-31. PMID:27405092. |
pyy and glp-1 are implicated in regulation of gut motility, food intake and insulin secretion, and are of great interest regarding obesity and type 2 diabetes. |
2017-07-31 |
2023-08-13 |
human |
| Adora M W Yau, John McLaughlin, William Gilmore, Ronald J Maughan, Gethin H Evan. The Acute Effects of Simple Sugar Ingestion on Appetite, Gut-Derived Hormone Response, and Metabolic Markers in Men. Nutrients. vol 9. issue 2. 2017-07-31. PMID:28216550. |
serum concentrations of ghrelin, glucose dependent insulinotropic polypeptide (gip), glucagon like peptide-1 (glp-1), insulin, lactate, triglycerides, non-esterified fatty acids (nefa), and d-3 hydroxybutyrate, were measured for 60 min. |
2017-07-31 |
2023-08-13 |
Not clear |