| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawood Khan, Srividya Vasu, R Charlotte Moffett, Nigel Irwin, Peter R Flat. Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival. Molecular and cellular endocrinology. vol 436. 2017-11-17. PMID:27465830. |
however, in vitro, pyy(1-36) and pyy(3-36) inhibited (p < 0.05 to p < 0.001) glucose, alanine and glp-1 stimulated insulin secretion from immortalised rodent and human beta-cells, as well as isolated mouse islets, by impeding alterations in membrane potential, [ca(2+)]i and elevations of camp. |
2017-11-17 |
2023-08-13 |
mouse |
| Naoki Oshima, Hiroshi Onimaru, Hidehito Matsubara, Takahiro Uchida, Atsushi Watanabe, Toshihiko Imakiire, Yasuhiro Nishida, Hiroo Kumaga. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. vol 344. 2017-11-09. PMID:28062192. |
direct effects of glucose, insulin, glp-1, and gip on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. |
2017-11-09 |
2023-08-13 |
rat |
| Naoki Oshima, Hiroshi Onimaru, Hidehito Matsubara, Takahiro Uchida, Atsushi Watanabe, Toshihiko Imakiire, Yasuhiro Nishida, Hiroo Kumaga. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. vol 344. 2017-11-09. PMID:28062192. |
we hypothesized that the bulbospinal neurons in the rostral ventrolateral medulla (rvlm) are affected by the levels of glucose, insulin, or incretins (glucagon like peptide-1 [glp-1] or glucose-dependent insulinotropic peptide [gip]) in patients with dm. |
2017-11-09 |
2023-08-13 |
rat |
| Naoki Oshima, Hiroshi Onimaru, Hidehito Matsubara, Takahiro Uchida, Atsushi Watanabe, Toshihiko Imakiire, Yasuhiro Nishida, Hiroo Kumaga. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. vol 344. 2017-11-09. PMID:28062192. |
to investigate whether rvlm neurons are activated by glucose, insulin, glp-1, or gip, we examined changes in the membrane potentials of bulbospinal rvlm neurons using whole-cell patch-clamp technique during superfusion with various levels of glucose or these hormones in neonatal wistar rats. |
2017-11-09 |
2023-08-13 |
rat |
| Naoki Oshima, Hiroshi Onimaru, Hidehito Matsubara, Takahiro Uchida, Atsushi Watanabe, Toshihiko Imakiire, Yasuhiro Nishida, Hiroo Kumaga. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. vol 344. 2017-11-09. PMID:28062192. |
during insulin superfusion, almost all the rvlm neurons were depolarized, while during glp-1 or gip superfusion, almost all the rvlm neurons were hyperpolarized. |
2017-11-09 |
2023-08-13 |
rat |
| Naoki Oshima, Hiroshi Onimaru, Hidehito Matsubara, Takahiro Uchida, Atsushi Watanabe, Toshihiko Imakiire, Yasuhiro Nishida, Hiroo Kumaga. Direct effects of glucose, insulin, GLP-1, and GIP on bulbospinal neurons in the rostral ventrolateral medulla in neonatal wistar rats. Neuroscience. vol 344. 2017-11-09. PMID:28062192. |
next, histological examinations were performed to examine transporters for glucose and receptors for insulin, glp-1, and gip on rvlm neurons. |
2017-11-09 |
2023-08-13 |
rat |
| E Patorno, B M Everett, A B Goldfine, R J Glynn, J Liu, C Gopalakrishnan, S C Ki. Comparative cardiovascular safety of glucagon-like peptide-1 receptor agonists versus other antidiabetic drugs in routine care: a cohort study. Diabetes, obesity & metabolism. vol 18. issue 8. 2017-11-07. PMID:27003762. |
to evaluate the comparative cardiovascular disease (cvd) safety of glucagon-like peptide-1 receptor agonists (glp-1 ras) in head-to-head comparisons with dipeptidyl peptidase-4 (dpp-4) inhibitors, sulphonylureas or insulin, when added to metformin, as used in 'real-world' patients with type 2 diabetes mellitus (t2dm). |
2017-11-07 |
2023-08-13 |
Not clear |
| David Preiss, Adem Dawed, Paul Welsh, Alison Heggie, Angus G Jones, Jacqueline Dekker, Robert Koivula, Tue H Hansen, Caitlin Stewart, Rury R Holman, Paul W Franks, Mark Walker, Ewan R Pearson, Naveed Satta. Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes. Diabetes, obesity & metabolism. vol 19. issue 3. 2017-11-07. PMID:27862873. |
to investigate, in the carotid atherosclerosis: metformin for insulin resistance (camera) trial (nct00723307), whether the influence of metformin on the glucagon-like peptide (glp)-1 axis in individuals with and without type 2 diabetes (t2dm) is sustained and related to changes in glycaemia or weight, and to investigate basal and post-meal glp-1 levels in patients with t2dm in the cross-sectional diabetes research on patient stratification (direct) study. |
2017-11-07 |
2023-08-13 |
Not clear |
| Hong-Yan Cai, Zhao-Jun Wang, Christian Hölscher, Li Yuan, Jun Zhang, Peng Sun, Jing Li, Wei Yang, Mei-Na Wu, Jin-Shun Q. Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats. Behavioural brain research. vol 318. 2017-11-06. PMID:27776993. |
lixisenatide, a novel long-lasting glucagon-like peptide 1 (glp-1) analogue, facilitates insulin signaling and has neuroprotective properties. |
2017-11-06 |
2023-08-13 |
rat |
| Lisa Griffith, Ella H Haddad, Serena Tonsta. Postprandial effects of consuming a staggered meal on gut peptide and glycemic responses in obese women and men. Obesity research & clinical practice. vol 10. issue 3. 2017-11-02. PMID:26311660. |
blood obtained prior to and at 30, 60, and 120min following the meals was analysed for acylated ghrelin, unacylated ghrelin, glucagon-like peptide-1 (glp-1), peptide yy, oxyntomodulin, glucose and insulin. |
2017-11-02 |
2023-08-13 |
human |
| Lisa Griffith, Ella H Haddad, Serena Tonsta. Postprandial effects of consuming a staggered meal on gut peptide and glycemic responses in obese women and men. Obesity research & clinical practice. vol 10. issue 3. 2017-11-02. PMID:26311660. |
mixed model statistical analysis of data showed time effects for unacylated ghrelin, glp-1, glucose, insulin, hunger and fullness, however, meal effects were not shown for any of the parameters. |
2017-11-02 |
2023-08-13 |
human |
| Mirna S Abd El Aziz, Melanie Kahle, Juris J Meier, Michael A Nauc. A meta-analysis comparing clinical effects of short- or long-acting GLP-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients. Diabetes, obesity & metabolism. vol 19. issue 2. 2017-11-01. PMID:27717195. |
a meta-analysis comparing clinical effects of short- or long-acting glp-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients. |
2017-11-01 |
2023-08-13 |
Not clear |
| Mirna S Abd El Aziz, Melanie Kahle, Juris J Meier, Michael A Nauc. A meta-analysis comparing clinical effects of short- or long-acting GLP-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients. Diabetes, obesity & metabolism. vol 19. issue 2. 2017-11-01. PMID:27717195. |
to study differences in clinical outcomes between initiating glucagon-like peptide-1 receptor agonist (glp-1 ras) vs insulin treatment in patients with type 2 diabetes treated with oral glucose-lowering medications (oglm). |
2017-11-01 |
2023-08-13 |
Not clear |
| M Hansen, M J Scheltema, D P Sonne, J S Hansen, M Sperling, J F Rehfeld, J J Holst, T Vilsbøll, F K Kno. Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion. Diabetes, obesity & metabolism. vol 18. issue 6. 2017-10-31. PMID:26888164. |
to evaluate the effects of the primary human bile acid, chenodeoxycholic acid (cdca), and the bile acid sequestrant (bas) colesevelam, instilled into the stomach, on plasma levels of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide, glucose, insulin, c-peptide, glucagon, cholecystokinin and gastrin, as well as on gastric emptying, gallbladder volume, appetite and food intake. |
2017-10-31 |
2023-08-13 |
human |
| M A Skow, N C Bergmann, F K Kno. Diabetes and obesity treatment based on dual incretin receptor activation: 'twincretins'. Diabetes, obesity & metabolism. vol 18. issue 9. 2017-10-31. PMID:27160961. |
the gut incretin hormones glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion and regulate glucagon secretion. |
2017-10-31 |
2023-08-13 |
human |
| F Kahles, C Meyer, S Diebold, A C Foldenauer, R Stöhr, J Möllmann, C Lebherz, H M Findeisen, N Marx, M Lehrk. Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice. Diabetes, obesity & metabolism. vol 18. issue 11. 2017-10-31. PMID:27350651. |
recently, glucagon-like peptide-1 (glp-1) levels have been found to be increased in response to inflammatory stimuli, leading to insulin secretion and prevention of hyperglycaemia during endotoxemia in mice. |
2017-10-31 |
2023-08-13 |
mouse |
| Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li, Gangyi Yan. Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry. Cell death & disease. vol 8. issue 2. 2017-10-31. PMID:28182013. |
intestinal glucagon-like peptide-1 (glp-1) is a hormone that stimulates insulin secretion and acts as a neuropeptide to control glucose homeostasis, but little is known whether intestinal glp-1 has any effect in the control of hepatic glucose production (hgp). |
2017-10-31 |
2023-08-13 |
rat |
| Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li, Gangyi Yan. Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry. Cell death & disease. vol 8. issue 2. 2017-10-31. PMID:28182013. |
here we found that intraduodenal infusion of glp-1 activated duodenal pkc-δ, lowered hgp and was accompanied by a decrease in hepatic expression of gluconeogenic enzymes and an increase in hepatic insulin signaling in rats. |
2017-10-31 |
2023-08-13 |
rat |
| Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li, Gangyi Yan. Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry. Cell death & disease. vol 8. issue 2. 2017-10-31. PMID:28182013. |
however, gut co-infusion of either the glp-1 receptor antagonist ex-9, or the pkc-δ inhibitor rottlerin with glp-1, negated the ability of gut glp-1 to lower hgp and to increase hepatic insulin signaling during clamps. |
2017-10-31 |
2023-08-13 |
rat |
| Delsi Altenhofen, Gabrielle da Luz, Marisa Jádna Silva Frederico, Dalila Venzke, Mayara Brich, Silvana Vigil, Tania Silvia Fröde, Carlos Eduardo Blanco Linares, Moacir Geraldo Pizzolatti, Fátima Regina Mena Barreto Silv. Bis-Pyrano Prenyl Isoflavone Improves Glucose Homeostasis by Inhibiting Dipeptidyl Peptidase-4 in Hyperglycemic Rats. Journal of cellular biochemistry. vol 118. issue 1. 2017-10-30. PMID:27238050. |
the in vivo action of the isoflavone exhibits an anti-hyperglycemic effect by improving glucose tolerance, augmenting the liver glycogen, inhibiting maltase activity, and stimulating glucagon-like peptide-1 (glp-1) and insulin secretion. |
2017-10-30 |
2023-08-13 |
rat |