| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Themistoklis Tzotzas, Spyridon N Karras, Niki Katsik. Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in the Treatment of Obese Women with Polycystic Ovary Syndrome. Current vascular pharmacology. vol 15. issue 3. 2017-12-12. PMID:28003008. |
glucagon-like peptide-1 (glp-1), a gut hormone secreted after a meal, enhances glucosestimulated insulin secretion and additionally suppresses appetite and gastric motility. |
2017-12-12 |
2023-08-13 |
Not clear |
| Themistoklis Tzotzas, Spyridon N Karras, Niki Katsik. Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in the Treatment of Obese Women with Polycystic Ovary Syndrome. Current vascular pharmacology. vol 15. issue 3. 2017-12-12. PMID:28003008. |
recently, some small trials of short duration using glp-1 ras as monotherapy or combined with metformin in obese pcos women showed positive results regarding weight reduction and a decrease in testosterone levels but without significant effects on insulin levels, insulin sensitivity and menstrual patterns. |
2017-12-12 |
2023-08-13 |
Not clear |
| Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barret. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938487. |
regulation of endogenous (male) rodent glp-1 secretion and human islet insulin secretion by antagonism of somatostatin receptor 5. |
2017-12-12 |
2023-08-13 |
mouse |
| Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barret. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938487. |
because somatostatin (sst) has been shown to suppress insulin and glucagonlike peptide-1 (glp-1) secretion through the gi-coupled sst receptor 5 (sstr5) isoform in vitro, antagonism of sstr5 may improve glycemic control via intervention in both pathways. |
2017-12-12 |
2023-08-13 |
mouse |
| Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barret. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938487. |
here, we show that a potent and selective sstr5 antagonist reverses the blunting effects of sst on insulin secretion from isolated human islets, and demonstrate that sstr5 antagonism affords increased levels of systemic glp-1 in vivo. |
2017-12-12 |
2023-08-13 |
mouse |
| Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barret. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938487. |
taken together, these data suggest that sstr5 antagonism should increase circulating glp-1 levels and stimulate insulin secretion (directly and via glp-1) in humans, improving glycemic control in patients with diabetes. |
2017-12-12 |
2023-08-13 |
mouse |
| Rituraj Khound, Jennifer Taher, Christopher Baker, Khosrow Adeli, Qiaozhu S. GLP-1 Elicits an Intrinsic Gut-Liver Metabolic Signal to Ameliorate Diet-Induced VLDL Overproduction and Insulin Resistance. Arteriosclerosis, thrombosis, and vascular biology. vol 37. issue 12. 2017-12-12. PMID:29074588. |
glp-1 elicits an intrinsic gut-liver metabolic signal to ameliorate diet-induced vldl overproduction and insulin resistance. |
2017-12-12 |
2023-08-13 |
Not clear |
| Eleni Rebelos, Brenno Astiarraga, Roberto Bizzotto, Andrea Mari, Maria Laura Manca, Alex Gonzalez, Armando Mendez, Claudia A Martinez, Barry E Hurwitz, Ele Ferrannin. GLP-1 response to sequential mixed meals: influence of insulin resistance. Clinical science (London, England : 1979). vol 131. issue 24. 2017-12-12. PMID:29097626. |
glp-1 response to sequential mixed meals: influence of insulin resistance. |
2017-12-12 |
2023-08-13 |
Not clear |
| Eleni Rebelos, Brenno Astiarraga, Roberto Bizzotto, Andrea Mari, Maria Laura Manca, Alex Gonzalez, Armando Mendez, Claudia A Martinez, Barry E Hurwitz, Ele Ferrannin. GLP-1 response to sequential mixed meals: influence of insulin resistance. Clinical science (London, England : 1979). vol 131. issue 24. 2017-12-12. PMID:29097626. |
previous work has shown that potentiation of insulin release is impaired in non-diabetic insulin resistance; we tested the hypothesis that this defect may be related to altered glucagon-like peptide-1 (glp-1) release. |
2017-12-12 |
2023-08-13 |
Not clear |
| Dao Thi Thuy Nguyen, Danny van Noort, In-Kyung Jeong, Sungsu Par. Endocrine system on chip for a diabetes treatment model. Biofabrication. vol 9. issue 1. 2017-12-07. PMID:28222044. |
thus, we constructed a co-culture of intestinal-pancreatic cells to measure the effect of glucose on the production of glucagon-like peptide-1 (glp-1) from the l-cell line (glutag) and insulin from the pancreatic β-cell line (ins-1). |
2017-12-07 |
2023-08-13 |
Not clear |
| Dao Thi Thuy Nguyen, Danny van Noort, In-Kyung Jeong, Sungsu Par. Endocrine system on chip for a diabetes treatment model. Biofabrication. vol 9. issue 1. 2017-12-07. PMID:28222044. |
we separately measured the dynamic profile of glp-1 and insulin release at glucose concentrations of 0.5 and 20 mm, as well as the combined effect of glp-1 on insulin production at these glucose concentrations. |
2017-12-07 |
2023-08-13 |
Not clear |
| Dao Thi Thuy Nguyen, Danny van Noort, In-Kyung Jeong, Sungsu Par. Endocrine system on chip for a diabetes treatment model. Biofabrication. vol 9. issue 1. 2017-12-07. PMID:28222044. |
in response to glucose stimuli, glutag and ins-1 cells produced higher amounts of glp-1 and insulin, respectively, compared to a static 2d cell culture. |
2017-12-07 |
2023-08-13 |
Not clear |
| Dao Thi Thuy Nguyen, Danny van Noort, In-Kyung Jeong, Sungsu Par. Endocrine system on chip for a diabetes treatment model. Biofabrication. vol 9. issue 1. 2017-12-07. PMID:28222044. |
our results suggest that the endocrine system developed in this study is a useful tool for observing dynamical changes in endocrine hormones (glp-1 and insulin) in a glucose-dependent environment. |
2017-12-07 |
2023-08-13 |
Not clear |
| Dao Thi Thuy Nguyen, Danny van Noort, In-Kyung Jeong, Sungsu Par. Endocrine system on chip for a diabetes treatment model. Biofabrication. vol 9. issue 1. 2017-12-07. PMID:28222044. |
moreover, it can potentially be used to screen glp-1 analogues and natural insulin and glp-1 stimulants for diabetes treatment. |
2017-12-07 |
2023-08-13 |
Not clear |
| G Muscogiuri, A Gastaldell. Albiglutide for the treatment of type 2 diabetes. Drugs of today (Barcelona, Spain : 1998). vol 50. issue 10. 2017-12-05. PMID:25374965. |
the glucagon-like peptide 1 (glp-1) receptor agonists are a new class of antidiabetic drugs that provide the benefits of decreasing hba1c and plasma glucose concentrations, stimulating insulin secretion with a very low risk of hypoglycemia, and promoting weight loss. |
2017-12-05 |
2023-08-13 |
human |
| Mengyu Zhu, Yuanyuan Wei, Claudia Geißler, Kathrin Abschlag, Judit Corbalán Campos, Michael Hristov, Julia Möllmann, Michael Lehrke, Ela Karshovska, Andreas Schobe. Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by Targeting Diabetes. vol 66. issue 12. 2017-12-05. PMID:28970282. |
hyperlipidemia-induced microrna-155-5p improves β-cell function by targeting a high-fat diet increases bacterial lipopolysaccharide (lps) in the circulation and thereby stimulates glucagon-like peptide 1 (glp-1)-mediated insulin secretion by upregulating interleukin-6 (il-6). |
2017-12-05 |
2023-08-13 |
Not clear |
| Naoya Murao, Norihide Yokoi, Kohei Honda, Guirong Han, Tomohide Hayami, Ghupurjan Gheni, Harumi Takahashi, Kohtaro Minami, Susumu Sein. Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion. PloS one. vol 12. issue 11. 2017-12-05. PMID:29091932. |
incretins (glp-1 and gip) potentiate insulin secretion through camp signaling in pancreatic β-cells in a glucose-dependent manner. |
2017-12-05 |
2023-08-13 |
mouse |
| Karin Sterl, Songyan Wang, Lauren Oestricker, Michael J Wallendorf, Bruce W Patterson, Dominic N Reeds, Burton M Wic. Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery. Peptides. vol 82. 2017-11-29. PMID:27288245. |
in healthy humans with normal glucose tolerance (ngt), xen administration causes diarrhea and inhibits postprandial glucagon-like peptide-1 (glp-1) release but not insulin secretion. |
2017-11-29 |
2023-08-13 |
human |
| Karin Sterl, Songyan Wang, Lauren Oestricker, Michael J Wallendorf, Bruce W Patterson, Dominic N Reeds, Burton M Wic. Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery. Peptides. vol 82. 2017-11-29. PMID:27288245. |
with rygb, xen had no statistically significant effect on glucose, insulin secretory, glp-1, glucose-dependent insulinotropic peptide, and glucagon responses. |
2017-11-29 |
2023-08-13 |
human |
| Karin Sterl, Songyan Wang, Lauren Oestricker, Michael J Wallendorf, Bruce W Patterson, Dominic N Reeds, Burton M Wic. Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery. Peptides. vol 82. 2017-11-29. PMID:27288245. |
however, insulin and glucose-dependent insulinotropic peptide secretion preceded glp-1 release suggesting circulating glp-1 does not mediate exaggerated insulin release after rygb. |
2017-11-29 |
2023-08-13 |
human |