| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Har. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PloS one. vol 13. issue 1. 2018-01-29. PMID:29293525. |
integrative network analysis highlights biological processes underlying glp-1 stimulated insulin secretion: a direct study. |
2018-01-29 |
2023-08-13 |
mouse |
| Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Har. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PloS one. vol 13. issue 1. 2018-01-29. PMID:29293525. |
glucagon-like peptide 1 (glp-1) stimulated insulin secretion has a considerable heritable component as estimated from twin studies, yet few genetic variants influencing this phenotype have been identified. |
2018-01-29 |
2023-08-13 |
mouse |
| Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Har. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PloS one. vol 13. issue 1. 2018-01-29. PMID:29293525. |
we performed the first genome-wide association study (gwas) of glp-1 stimulated insulin secretion in non-diabetic individuals from the netherlands twin register (n = 126). |
2018-01-29 |
2023-08-13 |
mouse |
| Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Har. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PloS one. vol 13. issue 1. 2018-01-29. PMID:29293525. |
some of the upstream regulators of differentially expressed genes in the white adipose tissue of ob/ob mice were also detected in the human beta-cell network of genes associated with glp-1 stimulated insulin secretion. |
2018-01-29 |
2023-08-13 |
mouse |
| Valborg Gudmundsdottir, Helle Krogh Pedersen, Karla Viviani Allebrandt, Caroline Brorsson, Nienke van Leeuwen, Karina Banasik, Anubha Mahajan, Christopher J Groves, Martijn van de Bunt, Adem Y Dawed, Andreas Fritsche, Harald Staiger, Annemarie M C Simonis-Bik, Joris Deelen, Mark H H Kramer, Axel Dietrich, Thomas Hübschle, Gonneke Willemsen, Hans-Ulrich Häring, Eco J C de Geus, Dorret I Boomsma, Elisabeth M W Eekhoff, Jorge Ferrer, Mark I McCarthy, Ewan R Pearson, Ramneek Gupta, Søren Brunak, Leen M 't Har. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PloS one. vol 13. issue 1. 2018-01-29. PMID:29293525. |
the findings provide biological insight into the mechanisms through which the effects of glp-1 may be modulated and highlight a potential role of the beta-cell expressed genes ryr2, gdi2, kiaa0232, col4a1 and col4a2 in glp-1 stimulated insulin secretion. |
2018-01-29 |
2023-08-13 |
mouse |
| Masaki Kato, Takenori Nakanishi, Tsubasa Tani, Takanori Tsud. Low-molecular fraction of wheat protein hydrolysate stimulates glucagon-like peptide-1 secretion in an enteroendocrine L cell line and improves glucose tolerance in rats. Nutrition research (New York, N.Y.). vol 37. 2018-01-26. PMID:28215313. |
in this study, we investigated whether wheat protein hydrolysate stimulates glp-1 secretion and its molecular mechanism in an enteroendocrine l cell line (glutag cells), and we examined the effect on glucose tolerance via stimulation of glp-1 secretion followed by induction of insulin secretion in rats. |
2018-01-26 |
2023-08-13 |
rat |
| Yoo Hoi Park, Hyun Ho Choi, Dong Hoon Lee, Soo Yong Chung, Na Yeon Yang, Do Hoon Kim, Mi Kyeong Ju, Tae Dong Han, Su Youn Nam, Kyu-Won Ki. YH18421, a novel GPR119 agonist exerts sustained glucose lowering and weight loss in diabetic mouse model. Archives of pharmacal research. vol 40. issue 6. 2018-01-26. PMID:28593550. |
g-protein-coupled receptor 119 (gpr119) represents a promising target for the treatment of type 2 diabetes as it can increase both glp-1 secretion from intestinal l cells and glucose-stimulated insulin secretion (gsis) from pancreatic β cells. |
2018-01-26 |
2023-08-13 |
mouse |
| Vanita R Aroda, Stephen C Bain, Bertrand Cariou, Milivoj Piletič, Ludger Rose, Mads Axelsen, Everton Rowe, J Hans DeVrie. Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial. The lancet. Diabetes & endocrinology. vol 5. issue 5. 2018-01-24. PMID:28344112. |
we assessed the efficacy and safety of semaglutide, a glucagon-like peptide-1 (glp-1) analogue in clinical development, compared with insulin glargine in patients with type 2 diabetes who were inadequately controlled with metformin (with or without sulfonylureas). |
2018-01-24 |
2023-08-13 |
Not clear |
| Francisco Javier Escalad. [The physiology of glucagon-like peptide-1 and its role in the pathophysiology of type 2 diabetes mellitus]. Medicina clinica. vol 143 Suppl 2. 2018-01-17. PMID:25326836. |
biological activities of glp-1 include stimulation of insulin biosynthesis and glucose-dependent insulin secretion by pancreatic beta cell, inhibition of glucagon secretion, delay of gastric emptying and inhibition of food intake. |
2018-01-17 |
2023-08-13 |
Not clear |
| Esteban Jóda. [Characteristics and types of GLP-1 receptor agonists. An opportunity for individualized therapy]. Medicina clinica. vol 143 Suppl 2. 2018-01-17. PMID:25326838. |
glucagon-like peptide 1 (glp-1) is secreted from enteroendocrine l-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. |
2018-01-17 |
2023-08-13 |
Not clear |
| L Kessler, M Abél. [Pancreatic infringement exocrine and endocrine in cystic fibrosis]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. vol 23. issue 12S. 2018-01-16. PMID:28231890. |
its pathophysiology combines a lack of insulin secretion, an insulin resistance secondary to chronic infection, and a decrease in the production of the gip and glp-1. |
2018-01-16 |
2023-08-13 |
Not clear |
| Stephan Wueest, Céline I Laesser, Marianne Böni-Schnetzler, Flurin Item, Fabrizio C Lucchini, Marcela Borsigova, Werner Müller, Marc Y Donath, Daniel Konra. IL-6-Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion. Diabetes. vol 67. issue 1. 2018-01-11. PMID:29066599. |
compared with control littermates, knockout mice showed impaired glucose tolerance and circulating leptin, glp-1, and insulin levels were reduced. |
2018-01-11 |
2023-08-13 |
mouse |
| R D Car. Drug development from the bench to the pharmacy: with special reference to dipeptidyl peptidase-4 inhibitor development. Diabetic medicine : a journal of the British Diabetic Association. vol 33. issue 6. 2018-01-09. PMID:26773271. |
glucagon-like peptide 1 (glp-1), a hormone with a spectrum of favourable metabolic actions, including glucose-dependent stimulation of insulin and inhibition of glucagon secretion, provided the endocrine basis from which the idea of using dpp-4 inhibitors as anti-diabetic agents was developed. |
2018-01-09 |
2023-08-13 |
Not clear |
| Caslin A Gilroy, Kelli M Luginbuhl, Ashutosh Chilkot. Controlled release of biologics for the treatment of type 2 diabetes. Journal of controlled release : official journal of the Controlled Release Society. vol 240. 2018-01-05. PMID:26655062. |
this review focuses on two peptide drugs - insulin and glucagon-like peptide 1 (glp-1) - for treatment of type 2 diabetes. |
2018-01-05 |
2023-08-13 |
Not clear |
| Caslin A Gilroy, Kelli M Luginbuhl, Ashutosh Chilkot. Controlled release of biologics for the treatment of type 2 diabetes. Journal of controlled release : official journal of the Controlled Release Society. vol 240. 2018-01-05. PMID:26655062. |
the development of insulin and glp-1 analogs highlights the broad spectrum of drug delivery strategies that have been used to solve these problems. |
2018-01-05 |
2023-08-13 |
Not clear |
| Caslin A Gilroy, Kelli M Luginbuhl, Ashutosh Chilkot. Controlled release of biologics for the treatment of type 2 diabetes. Journal of controlled release : official journal of the Controlled Release Society. vol 240. 2018-01-05. PMID:26655062. |
continual improvements in delivery methods for insulin and glp-1 receptor agonists are paving the way towards better patient compliance and improved disease management, and thereby enhanced patient quality of life. |
2018-01-05 |
2023-08-13 |
Not clear |
| Louis Monnier, Claude Colette, David R Owen. Comment on the FLAT-SUGAR Trial Investigators. Glucose Variability in a 26-Week Randomized Comparison of Mealtime Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants With Type 2 Diabetes at High Cardiovascular Risk. Diabetes Care 2016;39:973-981. Diabetes care. vol 39. issue 10. 2018-01-05. PMID:27660130. |
glucose variability in a 26-week randomized comparison of mealtime treatment with rapid-acting insulin versus glp-1 agonist in participants with type 2 diabetes at high cardiovascular risk. |
2018-01-05 |
2023-08-13 |
human |
| Kevin D O'Brien, Irl B Hirsch, Matthew C Riddle, Jeffrey L Probstfiel. Response to Comment on the FLAT-SUGAR Trial Investigators. Glucose Variability in a 26-Week Randomized Comparison of Mealtime Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants With Type 2 Diabetes at High Cardiovascular Risk. Diabetes Care 2016;39:973-981. Diabetes care. vol 39. issue 10. 2018-01-05. PMID:27660131. |
glucose variability in a 26-week randomized comparison of mealtime treatment with rapid-acting insulin versus glp-1 agonist in participants with type 2 diabetes at high cardiovascular risk. |
2018-01-05 |
2023-08-13 |
human |
| Simon Veedfald, Marie Hansen, Louise Wulff Christensen, Sara Agnete Hjort Larsen, Karina Rahr Hjøllund, Astrid Plamboeck, Bolette Hartmann, Carolyn Fiona Deacon, Jens Juul Hols. The insulinotropic effect of exogenous glucagon-like peptide-1 is not affected by acute vagotomy in anaesthetized pigs. Experimental physiology. vol 101. issue 7. 2018-01-02. PMID:27027735. |
glucagon-like peptide 1 (glp-1) is secreted from the gut in response to luminal stimuli and stimulates insulin secretion in a glucose-dependent manner. |
2018-01-02 |
2023-08-13 |
Not clear |
| Simon Veedfald, Marie Hansen, Louise Wulff Christensen, Sara Agnete Hjort Larsen, Karina Rahr Hjøllund, Astrid Plamboeck, Bolette Hartmann, Carolyn Fiona Deacon, Jens Juul Hols. The insulinotropic effect of exogenous glucagon-like peptide-1 is not affected by acute vagotomy in anaesthetized pigs. Experimental physiology. vol 101. issue 7. 2018-01-02. PMID:27027735. |
we found no effect of vagotomy on insulin or glucagon secretion during administration of exogenous glp-1 in any experiment. |
2018-01-02 |
2023-08-13 |
Not clear |