| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro, Nils Wieru. Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels. Peptides. vol 90. 2017-11-29. PMID:28242256. |
in conclusion, rygb in lean pigs increases the response of gip, total glp-1, and insulin, but reduces levels of active glp-1 in response to an oral glucose load. |
2017-11-29 |
2023-08-13 |
human |
| Jingjing Chen, Dandan Wang, Fangai Wang, Shaobo Shi, Yuting Chen, Bo Yang, Yanhong Tang, Congxin Huan. Exendin-4 inhibits structural remodeling and improves Ca Peptides. vol 90. 2017-11-29. PMID:28242257. |
exendin-4 inhibits structural remodeling and improves ca the glucagon-like peptide-1 receptor (glp-1r) agonist exendin-4 is a long-acting analog of glp-1, which stimulates insulin secretion and is clinically used in the treatment of type 2 diabetes. |
2017-11-29 |
2023-08-13 |
rat |
| Thomas A Lutz, Elena Ost. Glucagon-like peptide-1, glucagon-like peptide-2, and lipid metabolism. Current opinion in lipidology. vol 27. issue 3. 2017-11-27. PMID:27031273. |
glucagon-like peptide-1 (glp-1) is the best known incretin hormone able to potentiate glucose-induced insulin secretion. |
2017-11-27 |
2023-08-13 |
Not clear |
| Harpreet S Bajaj, Karri Venn, Chenglin Ye, Avril Patrick, Shivani Kalra, Hasnain Khandwala, Nadeem Aslam, David Twum-Barima, Ronnie Aronso. Lowest Glucose Variability and Hypoglycemia Are Observed With the Combination of a GLP-1 Receptor Agonist and Basal Insulin (VARIATION Study). Diabetes care. vol 40. issue 2. 2017-11-27. PMID:27913575. |
lowest glucose variability and hypoglycemia are observed with the combination of a glp-1 receptor agonist and basal insulin (variation study). |
2017-11-27 |
2023-08-13 |
Not clear |
| Harpreet S Bajaj, Karri Venn, Chenglin Ye, Avril Patrick, Shivani Kalra, Hasnain Khandwala, Nadeem Aslam, David Twum-Barima, Ronnie Aronso. Lowest Glucose Variability and Hypoglycemia Are Observed With the Combination of a GLP-1 Receptor Agonist and Basal Insulin (VARIATION Study). Diabetes care. vol 40. issue 2. 2017-11-27. PMID:27913575. |
this cohort study compares gv using continuous glucose monitoring (cgm) in patients with well-controlled type 2 diabetes using four common insulin regimens: basal insulin + oral drugs (bo), basal insulin + glucagon-like peptide 1 receptor agonist (glp-1 ra) (bglp), premixed insulin (pm), and basal-bolus insulin (bb). |
2017-11-27 |
2023-08-13 |
Not clear |
| Nizar I Mourad, Andrea Perota, Daela Xhema, Cesare Galli, Pierre Gianell. Transgenic Expression of Glucagon-Like Peptide-1 (GLP-1) and Activated Muscarinic Receptor (M3R) Significantly Improves Pig Islet Secretory Function. Cell transplantation. vol 26. issue 5. 2017-11-27. PMID:27938490. |
herein we show that β-cell-specific expression of a modified glucagon-like peptide-1 (glp-1) and of a constitutively activated type 3 muscarinic receptor (m3r) efficiently amplifies glucose-stimulated insulin secretion (gsis). |
2017-11-27 |
2023-08-13 |
Not clear |
| Nizar I Mourad, Andrea Perota, Daela Xhema, Cesare Galli, Pierre Gianell. Transgenic Expression of Glucagon-Like Peptide-1 (GLP-1) and Activated Muscarinic Receptor (M3R) Significantly Improves Pig Islet Secretory Function. Cell transplantation. vol 26. issue 5. 2017-11-27. PMID:27938490. |
while expression of glp-1 did not affect basal or stimulated insulin secretion, activated m3r produced a twofold increase in both first and second phases of gsis. |
2017-11-27 |
2023-08-13 |
Not clear |
| Masaki Kato, Sho Nishikawa, Akiho Ikehata, Kojiro Dochi, Tsubasa Tani, Tsukasa Takahashi, Atsushi Imaizumi, Takanori Tsud. Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion. Molecular nutrition & food research. vol 61. issue 3. 2017-11-27. PMID:27990751. |
however, it is not clear whether its action in vivo directly enhances glp-1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. |
2017-11-27 |
2023-08-13 |
Not clear |
| Sara F Michaliszyn, SoJung Lee, Fida Bacha, Hala Tfayli, Lama Farchoukh, Andrea Mari, Ele Ferrannini, Silva Arslania. Differences in β-cell function and insulin secretion in Black vs. White obese adolescents: do incretin hormones play a role? Pediatric diabetes. vol 18. issue 2. 2017-11-24. PMID:26799689. |
to investigate if the same holds true during an oral glucose challenge and because of the important role of glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) in augmenting insulin secretion, we examined β-cell function and incretin hormones in 85 black and 78 white obese adolescents, with normal glucose tolerance (ngt), during a 2-h oral glucose tolerance test (ogtt) with mathematical modeling of plasma glucose and c-peptide concentrations to assess β-cell glucose sensitivity (βcgs), rate sensitivity, potentiation factor, and insulin sensitivity. |
2017-11-24 |
2023-08-13 |
Not clear |
| H Shoji, A Watanabe, N Ikeda, M Mori, T Kitamura, K Hisata, T Shimiz. Influence of gestational age on serum incretin levels in preterm infants. Journal of developmental origins of health and disease. vol 7. issue 6. 2017-11-21. PMID:27451916. |
glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are the incretin hormones secreted from the intestine in response to enteral feeding to stimulate insulin secretion. |
2017-11-21 |
2023-08-13 |
Not clear |
| H Shoji, A Watanabe, N Ikeda, M Mori, T Kitamura, K Hisata, T Shimiz. Influence of gestational age on serum incretin levels in preterm infants. Journal of developmental origins of health and disease. vol 7. issue 6. 2017-11-21. PMID:27451916. |
we investigated the relationship serum gip and glp-1 levels with gestational age, and insulin secretion in preterm infants. |
2017-11-21 |
2023-08-13 |
Not clear |
| H Shoji, A Watanabe, N Ikeda, M Mori, T Kitamura, K Hisata, T Shimiz. Influence of gestational age on serum incretin levels in preterm infants. Journal of developmental origins of health and disease. vol 7. issue 6. 2017-11-21. PMID:27451916. |
furthermore, glp-1 levels were significantly correlated with quicki and the serum insulin levels in all infants at 4 weeks. |
2017-11-21 |
2023-08-13 |
Not clear |
| H Shoji, A Watanabe, N Ikeda, M Mori, T Kitamura, K Hisata, T Shimiz. Influence of gestational age on serum incretin levels in preterm infants. Journal of developmental origins of health and disease. vol 7. issue 6. 2017-11-21. PMID:27451916. |
glp-1 is also related to stimulated insulin secretion in early postnatal period. |
2017-11-21 |
2023-08-13 |
Not clear |
| Monica L Castro-Acosta, Leanne Smith, Rosalind J Miller, Danielle I McCarthy, Jonathan A Farrimond, Wendy L Hal. Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. The Journal of nutritional biochemistry. vol 38. 2017-11-21. PMID:27764725. |
plasma glucose, insulin and incretins (gip and glp-1) were measured 0-120min, and plasma 8-isoprostane f |
2017-11-21 |
2023-08-13 |
Not clear |
| Takeshi Yamasaki, Hideki Hirose, Tohru Yamashita, Nobuyuki Takakura, Sachie Morimoto, Takashi Nakahata, Asato Kina, Yoshihide Nakano, Yumiko Okano Tamura, Jun Sugama, Tomoyuki Odani, Yuji Shimizu, Shinji Iwasaki, Masanori Watanabe, Tsuyoshi Maekawa, Shizuo Kasa. Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition. Bioorganic & medicinal chemistry. vol 25. issue 15. 2017-11-21. PMID:28622905. |
sstr5 has an important role in inhibiting the secretion of pancreatic and gastrointestinal hormones (e.g., insulin, glp-1, pyy) through the binding of ssts; hence, sstr5 antagonists are expected to be novel anti-diabetic drugs. |
2017-11-21 |
2023-08-13 |
human |
| Tuğba Bal, Caner Nazli, Alparslan Okcu, Gökhan Duruksu, Erdal Karaöz, Seda Kizile. Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets. Journal of tissue engineering and regenerative medicine. vol 11. issue 3. 2017-11-20. PMID:25393526. |
glp-1 alone was the leading stimulator for insulin secretion. |
2017-11-20 |
2023-08-13 |
rat |
| Tuğba Bal, Caner Nazli, Alparslan Okcu, Gökhan Duruksu, Erdal Karaöz, Seda Kizile. Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets. Journal of tissue engineering and regenerative medicine. vol 11. issue 3. 2017-11-20. PMID:25393526. |
cell adhesion peptides rgds and ikvav improved insulin secretion only when they were used in combination, but could not surpass the effect of glp-1. |
2017-11-20 |
2023-08-13 |
rat |
| Antoni Sicras-Mainar, Ruth Navarro-Artieda, Raúl Morano, Lucía Ruí. Use of healthcare resources and costs associated to the start of treatment with injectable drugs in patients with type 2 diabetes mellitus. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. vol 63. issue 10. 2017-11-20. PMID:27744013. |
the main objective was to assess resource use and costs of starting treatment with insulin or injectable glp-1 receptor analogues (glp-1 ras) in a spanish population of patients with type 2 diabetes mellitus. |
2017-11-20 |
2023-08-13 |
Not clear |
| Shuyang Traub, Daniel T Meier, Friederike Schulze, Erez Dror, Thierry M Nordmann, Nicole Goetz, Norina Koch, Elise Dalmas, Marc Stawiski, Valmir Makshana, Fabrizio Thorel, Pedro L Herrera, Marianne Böni-Schnetzler, Marc Y Donat. Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis. Cell reports. vol 18. issue 13. 2017-11-20. PMID:28355570. |
we studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific glp-1 deficiency. |
2017-11-20 |
2023-08-13 |
mouse |
| Shuyang Traub, Daniel T Meier, Friederike Schulze, Erez Dror, Thierry M Nordmann, Nicole Goetz, Norina Koch, Elise Dalmas, Marc Stawiski, Valmir Makshana, Fabrizio Thorel, Pedro L Herrera, Marianne Böni-Schnetzler, Marc Y Donat. Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis. Cell reports. vol 18. issue 13. 2017-11-20. PMID:28355570. |
in isolated islets from these mice, glucose-stimulated insulin secretion was heavily impaired and exogenous glp-1 or glucagon rescued insulin secretion. |
2017-11-20 |
2023-08-13 |
mouse |