| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rabeet Khan, Alejandra Tomas, Guy A Rutte. Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide. Peptides. vol 125. 2021-02-08. PMID:31751656. |
glucose-dependent insulinotropic polypeptide (gip) is a gut-derived incretin that, in common with glucagon-like peptide-1 (glp-1), has both insulin releasing and extra-pancreatic glucoregulatory actions. |
2021-02-08 |
2023-08-13 |
Not clear |
| Farnaz Keyhani-Nejad, Renate Luisa Barbosa Yanez, Margrit Kemper, Rita Schueler, Olga Pivovarova-Ramich, Natalia Rudovich, Andreas F H Pfeiffe. Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction. Peptides. vol 125. 2021-02-08. PMID:31870938. |
endogenously released gip reduces and glp-1 increases hepatic insulin extraction. |
2021-02-08 |
2023-08-13 |
mouse |
| Farnaz Keyhani-Nejad, Renate Luisa Barbosa Yanez, Margrit Kemper, Rita Schueler, Olga Pivovarova-Ramich, Natalia Rudovich, Andreas F H Pfeiffe. Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction. Peptides. vol 125. 2021-02-08. PMID:31870938. |
we compared effects of sucrose vs. isomaltulose on gip and glucagon-like peptide-1 (glp-1) secretion, hepatic insulin clearance (hic) and insulin sensitivity in normal (ngt), impaired glucose tolerant (igt) and type 2 diabetes mellitus (t2dm) participants. |
2021-02-08 |
2023-08-13 |
mouse |
| R Charlotte Moffett, Violetta Naughto. Emerging role of GIP and related gut hormones in fertility and PCOS. Peptides. vol 125. 2021-02-08. PMID:31935429. |
this is considered to reflect indirect effects mediated by alleviation of insulin resistance together with possible direct effects of surgically induced changes of gip, glp-1 and related peptide hormones on ovaries and the hypothalamic-pituitary-adrenal axis. |
2021-02-08 |
2023-08-13 |
Not clear |
| Jens Juul Holst, Mette Marie Rosenkild. GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists. The Journal of clinical endocrinology and metabolism. vol 105. issue 8. 2021-02-08. PMID:32459834. |
the 2 hormones responsible for the amplification of insulin secretion after oral as opposed to intravenous nutrient administration are the gut peptides, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2021-02-08 |
2023-08-13 |
Not clear |
| Colin G Nichols, Nathaniel W York, Maria S Remed. Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression? The Journal of clinical investigation. vol 130. issue 12. 2021-02-08. PMID:33196460. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are two incretins secreted from gastrointestinal cells that amplify insulin secretion when glucose is high. |
2021-02-08 |
2023-08-13 |
mouse |
| Candan Yasemin Eren-Yazicioglu, Arya Yigit, Ramazan Efe Dogruoz, Hale Yapici-Ese. Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol. Frontiers in behavioral neuroscience. vol 14. 2021-02-06. PMID:33536884. |
the role of glucagon-like peptide 1 (glp-1) in insulin-dependent signaling is well-known; glp-1 enhances glucose-dependent insulin secretion and lowers blood glucose in diabetes. |
2021-02-06 |
2023-08-13 |
Not clear |
| Priska Stahel, Changting Xiao, Avital Nahmias, Gary F Lewi. Role of the Gut in Diabetic Dyslipidemia. Frontiers in endocrinology. vol 11. 2021-02-01. PMID:32231641. |
insulin resistance and t2d represent perturbed metabolic states in which intestinal sensitivity to key regulatory hormones such as insulin, leptin and glucagon-like peptide-1 (glp-1) may be altered, contributing to increased cm secretion. |
2021-02-01 |
2023-08-13 |
human |
| Meng-Ting Kuang, Jin-Yu Li, Xiao-Bei Yang, Liu Yang, Jing-Yue Xu, Sha Yan, Yong-Feng Lv, Fu-Cai Ren, Jiang-Miao Hu, Jun Zho. Structural characterization and hypoglycemic effect via stimulating glucagon-like peptide-1 secretion of two polysaccharides from Dendrobium officinale. Carbohydrate polymers. vol 241. 2021-02-01. PMID:32507202. |
in vivo assays showed that d. officinale polysaccharides (dops) exerted significant hypoglycemic effects accompanying increased serum insulin and glucagon-like peptide-1 (glp-1) levels in streptozotocin-induced diabetic rats. |
2021-02-01 |
2023-08-13 |
rat |
| Ji Hyun Chun, Amy Butt. Long-acting GLP-1RAs: An overview of efficacy, safety, and their role in type 2 diabetes management. JAAPA : official journal of the American Academy of Physician Assistants. vol 33. issue S8 Suppl 1. 2021-02-01. PMID:32756220. |
glp-1ras when used alone (without sulfonylureas or insulin) have a low risk of hypoglycemia because, like endogenous glp-1, their insulinotropic effects are glucose-dependent. |
2021-02-01 |
2023-08-13 |
Not clear |
| Yunjung Choi, Do-Yeon Kim, Sang Youl Rhee, Hyunjung Li. Postprandial Glucose, Insulin, and Glucagon-Like Peptide-1 Responses in Healthy Adults after Consumption of Chocolate-Products. Preventive nutrition and food science. vol 25. issue 4. 2021-01-30. PMID:33505927. |
we evaluated the glucose, insulin, and glucagon-like peptide-1 (glp-1) responses in male adults after consumption of three commonly consumed chocolates. |
2021-01-30 |
2023-08-13 |
Not clear |
| Yunjung Choi, Do-Yeon Kim, Sang Youl Rhee, Hyunjung Li. Postprandial Glucose, Insulin, and Glucagon-Like Peptide-1 Responses in Healthy Adults after Consumption of Chocolate-Products. Preventive nutrition and food science. vol 25. issue 4. 2021-01-30. PMID:33505927. |
glucose, insulin, and glp-1 concentrations were assessed at 0, 15, 30, 45, 60, 90, and 120 min after consumption of the test foods. |
2021-01-30 |
2023-08-13 |
Not clear |
| Sarah E Martchenko, Alexandre Martchenko, Brian J Cox, Kendra Naismith, Alison Waller, Patrick Gurges, Maegan E Sweeney, Dana J Philpott, Patricia L Brubake. Circadian GLP-1 Secretion in Mice Is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis. Diabetes. vol 69. issue 12. 2021-01-26. PMID:32928871. |
the circadian pattern of glp-1 release was found to be dependent on the oral route of glucose administration and was necessary for the rhythmic release of insulin and diurnal glycemic control in normal male and female mice. |
2021-01-26 |
2023-08-13 |
mouse |
| Weijuan Shao, Wenjuan Liu, Ping Liang, Zhuolun Song, Odisho Israel, Gerald J Prud'homme, Qinghua Wang, Tianru Ji. GABA requires GLP-1R to exert its pancreatic function during STZ challenge. The Journal of endocrinology. vol 246. issue 3. 2021-01-25. PMID:32544878. |
knockdown txnip in ins-1 cells increased glp-1r, pdx1, nkx6.1 and mafa levels, associated with increased responses to gaba or glp-1 on stimulating insulin secretion. |
2021-01-25 |
2023-08-13 |
mouse |
| Darleen Sandova. Updating the Role of α-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. vol 69. issue 11. 2021-01-25. PMID:33082272. |
updating the role of α-cell preproglucagon products on glp-1 receptor-mediated insulin secretion. |
2021-01-25 |
2023-08-13 |
Not clear |
| Darleen Sandova. Updating the Role of α-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. vol 69. issue 11. 2021-01-25. PMID:33082272. |
the role of intestinally secreted glucagon-like peptide 1 (glp-1) in regulation of insulin secretion has been questioned, and a physiological role of pancreatic glp-1 in regulation of insulin secretion has been proposed. |
2021-01-25 |
2023-08-13 |
Not clear |
| Darleen Sandova. Updating the Role of α-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. vol 69. issue 11. 2021-01-25. PMID:33082272. |
in addition, in the last 2 years, a series of studies demonstrated a physiological role for glucagon, acting via the glp-1 receptor, in paracrine regulation of insulin secretion. |
2021-01-25 |
2023-08-13 |
Not clear |
| Darleen Sandova. Updating the Role of α-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. vol 69. issue 11. 2021-01-25. PMID:33082272. |
this article addresses these new findings surrounding α-cell preproglucagon products, with a particular focus on glp-1, in the context of their roles in insulin secretion and consequently glucose metabolism. |
2021-01-25 |
2023-08-13 |
Not clear |
| Dipak Sarnobat, Charlotte R Moffett, Neil Tanday, Frank Reimann, Fiona M Gribble, Peter R Flatt, Andrei I Taraso. Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation. Biochemical pharmacology. vol 182. 2021-01-21. PMID:32926875. |
gut incretins, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), enhance secretion of insulin in a glucose-dependent manner, predominantly by elevating cytosolic levels of camp in pancreatic β-cells. |
2021-01-21 |
2023-08-13 |
mouse |
| Sarah Tosato, Chiara Bonetto, Simona Tomassi, Roberta Zanardini, Carlo Faravelli, Caterina Bruschi, Armando D'Agostino, Alessandra Minelli, Paolo Scocco, Antonio Lasalvia, Karin Furlato, Massimiliano Imbesi, Antonio Preti, Mirella Ruggeri, Massimo Gennarelli, Luisella Bocchio-Chiavett. Childhood trauma and glucose metabolism in patients with first-episode psychosis. Psychoneuroendocrinology. vol 113. 2021-01-19. PMID:31864124. |
in particular, in 148 fep patients we evaluated serum concentrations of c-peptide, insulin, plasminogen-activator-inhibitor-1 (pai-1), resistin, visfatin, glucagon, glucagon-like peptide-1 (glp-1), gastric-inhibitor-peptide (gip), leptin, and ghrelin. |
2021-01-19 |
2023-08-13 |
Not clear |