| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsu Kawabata, Haruhiko Tokuda, Gen Kuroyanagi, Kazuhiko Fujita, Go Sakai, Woo Kim, Rie Matsushima-Nishiwaki, Hiroki Iida, Ken-Ichiro Yata, Shujie Wang, Akira Mizoguchi, Takanobu Otsuka, Osamu Kozaw. Incretin accelerates platelet-derived growth factor-BB-induced osteoblast migration via protein kinase A: The upregulation of p38 MAP kinase. Scientific reports. vol 10. issue 1. 2021-03-12. PMID:32047216. |
incretins, including glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), secreted from enteroendocrine cells after food ingestion, are currently recognized to regulate glucose metabolism through insulin secretion. |
2021-03-12 |
2023-08-13 |
mouse |
| Tommy H T Wong, Jennifer M F Wan, Iris M Y Tse, W H Sit, Jimmy C Y Loui. Consuming decaffeinated coffee with milk and sugar added before a high-glycaemic index meal improves postprandial glycaemic and insulinaemic responses in healthy adults. The British journal of nutrition. vol 124. issue 8. 2021-03-12. PMID:32418547. |
postprandial levels of glucose, insulin, active glucagon-like peptide 1 (glp-1) and nitrotyrosine between different test drinks were compared using linear mixed models. |
2021-03-12 |
2023-08-13 |
human |
| Md Shahidul Isla. Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells. Cells. vol 9. issue 3. 2021-03-11. PMID:32168890. |
insulin secretion from the β-cells of the islets of langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (glp-1). |
2021-03-11 |
2023-08-13 |
Not clear |
| Chunxia Liu, Yuxing Zou, Hai Qia. GLP-1R agonists for the treatment of obesity: a patent review (2015-present). Expert opinion on therapeutic patents. vol 30. issue 10. 2021-03-10. PMID:32799587. |
glucagon-like peptide-1 (glp-1) is an endogenous peptide which is secreted by enteroendocrine l cells, glp-1 receptor agonists (glp-1 ras) can exhibit glucoregulation by stimulating insulin release, promote satiety, delay gastric emptying, and reduce energy intake. |
2021-03-10 |
2023-08-13 |
Not clear |
| Huan-Ran Zhou, Xue-Fei Ma, Wen-Jian Lin, Ming Hao, Xin-Yang Yu, Hong-Xue Li, Cheng-Ye Xu, Hong-Yu Kuan. Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy. Frontiers in pharmacology. vol 11. 2021-03-10. PMID:33679385. |
the incretin glucagon-like peptide-1 (glp-1), which is secreted by l-cells after food ingestion, could lower blood glucose level through stimulating the release of insulin. |
2021-03-10 |
2023-08-13 |
Not clear |
| Francois Brial, Fawaz Alzaid, Kazuhiro Sonomura, Yoichiro Kamatani, Kelly Meneyrol, Aurélie Le Lay, Noémie Péan, Lyamine Hedjazi, Taka-Aki Sato, Nicolas Venteclef, Christophe Magnan, Mark Lathrop, Marc-Emmanuel Dumas, Fumihiko Matsuda, Pierre Zalloua, Dominique Gauguie. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell reports. vol 30. issue 7. 2021-03-09. PMID:32075738. |
the incubation of mouse isolated islets with 4-cresol results in enhanced insulin secretion, insulin content, and β-cell proliferation of a magnitude similar to that induced by glp-1. |
2021-03-09 |
2023-08-13 |
mouse |
| Domenico Tricò, Lorenzo Nesti, Silvia Frascerra, Simona Baldi, Alessandro Mengozzi, Andrea Natal. A Protein/Lipid Preload Attenuates Glucose-Induced Endothelial Dysfunction in Individuals with Abnormal Glucose Tolerance. Nutrients. vol 12. issue 7. 2021-03-08. PMID:32664350. |
plasma glucose, insulin, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), glucagon, free fatty acids, and amino acids were measured through each test. |
2021-03-08 |
2023-08-13 |
human |
| Jiayue Guo, Libo Tan, Lingyan Kon. Impact of dietary intake of resistant starch on obesity and associated metabolic profiles in human: a systematic review of the literature. Critical reviews in food science and nutrition. vol 61. issue 6. 2021-03-02. PMID:32321291. |
specifically, five out of the eight articles measuring blood glucose reported a decrease in either fasting or postprandial glucose levels; two out of the three articles measuring insulin sensitivity indicated a significant improvement after rs supplementation; studies measuring gut hormone concentrations including glucagon-like peptide 1 (glp-1), and peptide yy (pyy) also showed significant improvements after rs interventions. |
2021-03-02 |
2023-08-13 |
human |
| Chih-Cheng Wu, Chih-Jen Hung, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Ching-Ping Yang, Chun-Jung Che. Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats. Molecules (Basel, Switzerland). vol 25. issue 14. 2021-03-01. PMID:32679813. |
these improved effects regarding propofol on glucose metabolism were accompanied by an increase in insulin, fibroblast growth factor-21 (fgf-21), and glucagon-like peptide-1 (glp-1) secretion. |
2021-03-01 |
2023-08-13 |
rat |
| Chih-Cheng Wu, Chih-Jen Hung, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Ching-Ping Yang, Chun-Jung Che. Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats. Molecules (Basel, Switzerland). vol 25. issue 14. 2021-03-01. PMID:32679813. |
current findings imply that propofol may turn into insulin-sensitizing molecules during situations of existing insulin resistance, which involve fgf-21, glp-1, and er stress. |
2021-03-01 |
2023-08-13 |
rat |
| Chao Dong, Hong Yang, Yongkui Wang, Xu Yan, Dongzhe Li, Zhengming Cao, Yongming Ning, Chunlin Zhan. Anagliptin stimulates osteoblastic cell differentiation and mineralization. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-02-26. PMID:32559615. |
anagliptin promotes insulin production via inhibition of dipeptidyl peptidase iv (dpp-4), an enzyme that targets the incretin hormone glucagon-like peptide 1 (glp-1) for degradation. |
2021-02-26 |
2023-08-13 |
Not clear |
| Chinmai Patibandla, Zahidul Islam Khan, Louise MacGregor, Mark James Campbell, Steven Patterso. Costus pictus D. Don leaf extract stimulates GLP-1 secretion from GLUTag L-cells and has cytoprotective effects in BRIN-BD11 β-cells. Journal of ethnopharmacology. vol 260. 2021-02-25. PMID:32422353. |
however, its effects on glp-1 secretion from intestinal endocrine l-cells and potential metabolic and protective effects in insulin secreting pancreatic β-cells are not yet fully understood. |
2021-02-25 |
2023-08-13 |
Not clear |
| Xiangchen Kong, Linxian Feng, Dan Yan, Bingfeng Li, Yanhui Yang, Xiaosong M. FXR-mediated epigenetic regulation of GLP-1R expression contributes to enhanced incretin effect in diabetes after RYGB. Journal of cellular and molecular medicine. 2021-02-21. PMID:33611845. |
in this study, we investigated how roux-en-y gastric bypass (rygb) enhances glucagon-like peptide 1 (glp-1) response in gk rats and explored the potential link between rygb-stimulated bas/fxr signalling and glp-1r-linked signalling in β-cells, a key pathway that regulates glucose-stimulated insulin secretion (gsis). |
2021-02-21 |
2023-08-13 |
rat |
| Mandy Chen, Etty Vider, Roda Plakogianni. Insulin Dosage Adjustments After Initiation of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes. Journal of pharmacy practice. 2021-02-17. PMID:33593125. |
insulin dosage adjustments after initiation of glp-1 receptor agonists in patients with type 2 diabetes. |
2021-02-17 |
2023-08-13 |
Not clear |
| Okechi S Oduori, Naoya Murao, Kenju Shimomura, Harumi Takahashi, Quan Zhang, Haiqiang Dou, Shihomi Sakai, Kohtaro Minami, Belen Chanclon, Claudia Guida, Lakshmi Kothegala, Johan Tolö, Yuko Maejima, Norihide Yokoi, Yasuhiro Minami, Takashi Miki, Patrik Rorsman, Susumu Sein. Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes. The Journal of clinical investigation. vol 130. issue 12. 2021-02-16. PMID:33196462. |
normally, the incretins glp-1 and glucose-dependent insulinotropic polypeptide (gip) jointly maintain normal blood glucose levels by stimulation of insulin secretion in pancreatic β cells. |
2021-02-16 |
2023-08-13 |
mouse |
| Bao Sun, Shiqiong Huang, Jiecan Zho. Perspectives of Antidiabetic Drugs in Diabetes With Coronavirus Infections. Frontiers in pharmacology. vol 11. 2021-02-16. PMID:33584268. |
here, we review the role of antidiabetic agents, mainly including insulin, metformin, pioglitazone, dipeptidyl peptidase-4 (dpp4) inhibitors, sodium-glucose cotransporter 2 (sglt2) inhibitors, and glucagon-like peptide 1 (glp-1) receptor agonists in dm patients with coronavirus infection, addressing the clinical therapeutic choices for these subjects. |
2021-02-16 |
2023-08-13 |
human |
| Penelope C E Fitzgerald, Benoit Manoliu, Benjamin Herbillon, Robert E Steinert, Michael Horowitz, Christine Feinle-Bisse. Effects of L-Phenylalanine on Energy Intake and Glycaemia-Impacts on Appetite Perceptions, Gastrointestinal Hormones and Gastric Emptying in Healthy Males. Nutrients. vol 12. issue 6. 2021-02-11. PMID:32560181. |
in part b, plasma glucose, glucagon-like peptide-1 (glp-1), insulin and glucagon were measured at baseline, after phenylalanine alone, and for 2 h following the drink. |
2021-02-11 |
2023-08-13 |
human |
| Chengcong Chen, Ying Huang, Guoqing Dong, Yongmei Zeng, Ziqiong Zho. The effect of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist in gestational diabetes mellitus: a systematic review. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 36. issue 5. 2021-02-10. PMID:31858859. |
the results suggested that dpp-4 inhibitor and glp-1 ra can reduce the rate of developing postpartum diabetes, help to normalization of blood glucose and improve insulin resistance and β-cell function. |
2021-02-10 |
2023-08-13 |
human |
| Ji Hyun Chun, Amy Butt. Long-acting GLP-1RAs: An overview of efficacy, safety, and their role in type 2 diabetes management. JAAPA : official journal of the American Academy of Physician Assistants. vol 33. issue 8. 2021-02-10. PMID:32740121. |
glp-1ras when used alone (without sulfonylureas or insulin) have a low risk of hypoglycemia because, like endogenous glp-1, their insulinotropic effects are glucose-dependent. |
2021-02-10 |
2023-08-13 |
Not clear |
| Lærke S Gasbjerg, Natasha C Bergmann, Signe Stensen, Mikkel B Christensen, Mette M Rosenkilde, Jens J Holst, Michael Nauck, Filip K Kno. Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists. Peptides. vol 125. 2021-02-08. PMID:31693916. |
glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) potentiate glucose-induced insulin secretion and are therefore thought to be responsible for the incretin effect. |
2021-02-08 |
2023-08-13 |
Not clear |