| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
our data demonstrated that sal could reverse insulin resistance and stimulates the glp-1 secretion by alleviating ros-mediated activation of mapks signaling pathway and mitigating apoptosis. |
2021-05-26 |
2023-08-13 |
Not clear |
| Emma Rose McGlone, Khalefah Malallah, Joyceline Cuenco, Nicolai J Wewer Albrechtsen, Jens J Holst, Royce P Vincent, Charlotte Ling, Omar A Khan, Surabhi Verma, Ahmed R Ahmed, Julian R F Walters, Bernard Khoo, Stephen R Bloom, Tricia M M Ta. Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study. American journal of physiology. Endocrinology and metabolism. vol 320. issue 4. 2021-05-24. PMID:33459181. |
glucose, insulin, glp-1, oxm, pyy, gip, glucagon, ghrelin, and fibroblast growth factor 19 were measured prior to ba administration at -60 and 0 min (just prior to mixed meal) and 15, 30, 60, 120, 180, and 240 min after the meal. |
2021-05-24 |
2023-08-13 |
human |
| Emma Rose McGlone, Khalefah Malallah, Joyceline Cuenco, Nicolai J Wewer Albrechtsen, Jens J Holst, Royce P Vincent, Charlotte Ling, Omar A Khan, Surabhi Verma, Ahmed R Ahmed, Julian R F Walters, Bernard Khoo, Stephen R Bloom, Tricia M M Ta. Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study. American journal of physiology. Endocrinology and metabolism. vol 320. issue 4. 2021-05-24. PMID:33459181. |
cdca increased fasting glp-1 and oxm secretion in parallel with an increase in insulin. |
2021-05-24 |
2023-08-13 |
human |
| Emmanouil Korakas, Aikaterini Kountouri, Athanasios Raptis, Alexander Kokkinos, Vaia Lambadiar. Bariatric Surgery and Type 1 Diabetes: Unanswered Questions. Frontiers in endocrinology. vol 11. 2021-05-21. PMID:33071965. |
the reasons for these results are yet to be elucidated; possible explanations include preservation of beta cell mass and increased residual function post-surgery, improvement in insulin action, altered glp-1 function, timing of surgery, and association with residual islet cell mass. |
2021-05-21 |
2023-08-13 |
Not clear |
| Barrie Chubb, Palvi Gupta, Jatin Gupta, Solomon Nuhoho, Klaus Kallenbach, Michelle Orm. Once-Daily Oral Semaglutide Versus Injectable GLP-1 RAs in People with Type 2 Diabetes Inadequately Controlled on Basal Insulin: Systematic Review and Network Meta-analysis. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 12. issue 5. 2021-05-21. PMID:33723769. |
once-daily oral semaglutide versus injectable glp-1 ras in people with type 2 diabetes inadequately controlled on basal insulin: systematic review and network meta-analysis. |
2021-05-21 |
2023-08-13 |
human |
| Barrie Chubb, Palvi Gupta, Jatin Gupta, Solomon Nuhoho, Klaus Kallenbach, Michelle Orm. Once-Daily Oral Semaglutide Versus Injectable GLP-1 RAs in People with Type 2 Diabetes Inadequately Controlled on Basal Insulin: Systematic Review and Network Meta-analysis. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 12. issue 5. 2021-05-21. PMID:33723769. |
the relative efficacy and safety of once-daily oral semaglutide vs. injectable glucagon-like peptide-1 receptor agonists (glp-1 ras) in subjects with type 2 diabetes (t2d) inadequately controlled on basal insulin were assessed using network meta-analysis (nma). |
2021-05-21 |
2023-08-13 |
human |
| Ben Jone. The therapeutic potential of GLP-1 receptor biased agonism. British journal of pharmacology. 2021-05-21. PMID:33880754. |
glucagon-like peptide-1 (glp-1) receptor agonists are effective treatments for type 2 diabetes as they stimulate insulin release and promote weight loss through appetite suppression. |
2021-05-21 |
2023-08-13 |
human |
| Jana Pavlisova, Olga Horakova, Veronika Kalendova, Jana Buresova, Kristina Bardova, Blanka Holendova, Lydie Plecita-Hlavata, Sarka Vackova, Jindra Windrichova, Ondrej Topolcan, Jan Kopecky, Martin Rossmeis. Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice. Food & function. vol 11. issue 11. 2021-05-18. PMID:33078809. |
chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates glp-1 in high-fat diet-fed obese mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Jana Pavlisova, Olga Horakova, Veronika Kalendova, Jana Buresova, Kristina Bardova, Blanka Holendova, Lydie Plecita-Hlavata, Sarka Vackova, Jindra Windrichova, Ondrej Topolcan, Jan Kopecky, Martin Rossmeis. Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice. Food & function. vol 11. issue 11. 2021-05-18. PMID:33078809. |
in addition, these mice had improved glucose tolerance, which was consistent with an increased insulin response to oral glucose and plasma glucagon-like peptide-1 (glp-1) levels. |
2021-05-18 |
2023-08-13 |
mouse |
| Atefeh Pegah, Ebrahim Abbasi-Oshaghi, Iraj Khodadadi, Fatemeh Mirzaei, Heidar Tayebina. Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats. Metabolism open. vol 10. 2021-05-18. PMID:33997755. |
one of the important incretins in the improvement of diabetes is glucagon-like peptide (glp-1), which is secreted by the gut and reduces the apoptosis of pancreatic β-cells and improves insulin sensitivity. |
2021-05-18 |
2023-08-13 |
rat |
| Atefeh Pegah, Ebrahim Abbasi-Oshaghi, Iraj Khodadadi, Fatemeh Mirzaei, Heidar Tayebina. Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats. Metabolism open. vol 10. 2021-05-18. PMID:33997755. |
in this experiment we determined the effects of resveratrol and probiotics on insulin resistance, oxidative stress, and glp-1 in type 2 diabetes (t2d) rats. |
2021-05-18 |
2023-08-13 |
rat |
| C J Tack, F A van de Laa. [Starting insulin or not? And if so, which basal insulin?] Nederlands tijdschrift voor geneeskunde. vol 164. 2021-05-17. PMID:33201616. |
our patient achieved reasonable glucose control without weight gain using a combination of basal insulin and a glp-1 receptor agonist. |
2021-05-17 |
2023-08-13 |
Not clear |
| Florian Kahles, Marcia V Rückbeil, Robert W Mertens, Ann C Foldenauer, Maria C Arrivas, Julia Moellmann, Corinna Lebherz, Moritz Biener, Evangelos Giannitsis, Hugo A Katus, Nikolaus Marx, Michael Lehrk. Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction. European heart journal. vol 41. issue 7. 2021-05-14. PMID:31620788. |
glucagon-like peptide 1 (glp-1) is a gut incretin hormone inducing post-prandial insulin secretion. |
2021-05-14 |
2023-08-13 |
Not clear |
| Kaitlin M Love, Jia Liu, Judith G Regensteiner, Jane E B Reusch, Zhenqi Li. GLP-1 and insulin regulation of skeletal and cardiac muscle microvascular perfusion in type 2 diabetes. Journal of diabetes. vol 12. issue 7. 2021-05-14. PMID:32274893. |
glp-1 and insulin regulation of skeletal and cardiac muscle microvascular perfusion in type 2 diabetes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Kaitlin M Love, Jia Liu, Judith G Regensteiner, Jane E B Reusch, Zhenqi Li. GLP-1 and insulin regulation of skeletal and cardiac muscle microvascular perfusion in type 2 diabetes. Journal of diabetes. vol 12. issue 7. 2021-05-14. PMID:32274893. |
thus, treatment of insulin resistant patients with glp-1 receptor agonists may improve skeletal and cardiac muscle microvascular perfusion and increase muscle capillarization, leading to improved delivery of oxygen, nutrients, and hormones such as insulin to the myocytes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jing Huang, Yunhan Liu, Liusiyuan Cheng, Jihong Li, Tangrui Zhang, Gang Zhao, Huinan Zhan. Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes. European journal of pharmacology. vol 887. 2021-05-14. PMID:32949596. |
glucagon-like peptide-1 (glp-1) is an endogenous gut hormone and a key regulator in maintaining glucose homeostasis by stimulating insulin secretion. |
2021-05-14 |
2023-08-13 |
mouse |
| Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zha. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. vol 882. 2021-05-13. PMID:32535096. |
dipeptidyl peptidase-4 (dpp-4) is a specific enzyme hydrolyzing the incretin hormone glucagon like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) to reduce insulin secretion, meanwhile dpp-4 inhibitors play an important role in diabetic therapy. |
2021-05-13 |
2023-08-13 |
Not clear |
| Katarzyna Szkudelska, Marzanna Deniziak, Maciej Sassek, Ignacy Szkudelski, Wojciech Noskowiak, Tomasz Szkudelsk. Resveratrol Affects Insulin Signaling in Type 2 Diabetic Goto-Kakizaki Rats. International journal of molecular sciences. vol 22. issue 5. 2021-05-12. PMID:33671110. |
blood levels of insulin and gip were elevated, whereas proinsulin and glp-1 diminished in gk rats. |
2021-05-12 |
2023-08-13 |
rat |
| Jinyu Wang, Xiaoying Zhang, Luxin Zhang, Tingxu Yan, Bo Wu, Fanxing Xu, Ying Ji. Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells. European journal of pharmacology. vol 881. 2021-05-10. PMID:32497626. |
glucagon-like peptide-1 (glp-1), a glucagon-like peptide secreted mainly from intestinal l cells, possesses the functions of promoting synthesis and secretion of insulin in pancreatic β-cells, and maintaining glucose homeostasis in an insulin-independent manner. |
2021-05-10 |
2023-08-13 |
rat |
| Yuta Fujiwara, Shunsuke Yamane, Norio Harada, Eri Ikeguchi-Ogura, Ryota Usui, Toshihiro Nakamura, Kanako Iwasaki, Kazuyo Suzuki, Daisuke Yabe, Yoshitaka Hayashi, Nobuya Inagak. Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids. American journal of physiology. Gastrointestinal and liver physiology. vol 320. issue 4. 2021-05-10. PMID:33533304. |
glucagon-like peptide-1 (glp-1) is an incretin secreted from enteroendocrine preproglucagon (ppg)-expressing cells (traditionally known as l cells) in response to luminal nutrients that potentiates insulin secretion. |
2021-05-10 |
2023-08-13 |
Not clear |