| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizaveta D Mamontova, Svetlana S Michurina, Iurii S Stafeev, Ekaterina L Sorkina, Igor A Sklyanik, Ekaterina O Koksharova, Mikhail Y Menshikov, Marina V Shestakova, Yelena V Parfyonov. Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity. Biochemistry. Biokhimiia. vol 86. issue 3. 2021-05-10. PMID:33838634. |
in the present work effects of the glp-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3t3-l1 adipocytes were examined. |
2021-05-10 |
2023-08-13 |
Not clear |
| Elizaveta D Mamontova, Svetlana S Michurina, Iurii S Stafeev, Ekaterina L Sorkina, Igor A Sklyanik, Ekaterina O Koksharova, Mikhail Y Menshikov, Marina V Shestakova, Yelena V Parfyonov. Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity. Biochemistry. Biokhimiia. vol 86. issue 3. 2021-05-10. PMID:33838634. |
enhancement of insulin sensitivity of mature adipocytes by the glp-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. |
2021-05-10 |
2023-08-13 |
Not clear |
| Masoud Nouri-Vaskeh, Neda Khalili, Amirreza Khalaji, Pouya Behnam, Leila Alizadeh, Sara Ebrahimi, Neda Gilani, Mehdi Mohammadi, Seyed Alisalar Madinehzadeh, Mohammad Zare. Circulating glucagon-like peptide-1 level in patients with liver cirrhosis. Archives of physiology and biochemistry. 2021-05-06. PMID:33043692. |
glucagon-like peptide-1 (glp-1), a gut-derived incretin hormone, plays a pivotal role in glucose-induced insulin secretion. |
2021-05-06 |
2023-08-13 |
Not clear |
| Quan Liu, Shuainan Liu, Hui Cao, Wenming Ji, Caina Li, Yi Huan, Lei Lei, Yaxin Fu, Xuefeng Gao, Yuling Liu, Zhufang She. Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Glucose Metabolism Accompanied by the Modulation of Gut Microbiota and Ileal Inflammatory Damage in Type 2 Diabetic KKAy Mice. Frontiers in pharmacology. vol 12. 2021-05-04. PMID:33935735. |
sz-a improved glucose metabolism with enhanced insulin response and elevated glucagon-like peptide 1 (glp-1) nearly 2.7-fold during the glucose tolerance test in diabetic kkay mice. |
2021-05-04 |
2023-08-13 |
mouse |
| LongQing Zhang, Wen Zhang, XueBi Tia. The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases. The International journal of neuroscience. 2021-05-04. PMID:33941038. |
glucagon-like peptide-1(glp-1) is a multifunctional polypeptide throughout the lifespan via activating glucagon-like peptide-1 receptor (glp-1r).glp-1 can affect food ingestion, enhance the secretion of insulin from pancreatic islets induced by glucose and be utilized to treat type 2 diabetes mellitus(t2dm).but, accumulating evidences from the decades suggest that activation glp-1r can not only regulate the blood glucose, but also sustain the homeostasis of intracellular environment and protect neuron from various damaged responses such as oxidative stress, inflammation, excitotoxicity, ischemia and so on. |
2021-05-04 |
2023-08-13 |
Not clear |
| Mingcui Zheng, Pengwen Wan. Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927970. |
furthermore, anti-diabetic drugs including metformin, thiazolidinediones, and glucagon-like peptide-1 (glp-1) analogue could modulate irs-1 phosphorylation, brain ir, pi3k/akt insulin signaling pathway, and other pathologic processes of ad. |
2021-05-02 |
2023-08-13 |
Not clear |
| Mourad Ferdaoussi, Nancy Smith, Haopeng Lin, Austin Bautista, Aliya F Spigelman, James Lyon, XiaoQing Dai, Jocelyn E Manning Fox, Patrick E MacDonal. Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion. Physiological reports. vol 8. issue 8. 2021-04-30. PMID:32339440. |
we examined the correlation of glp-1 induced insulin secretion from human islets with key donor characteristics, glucose-responsiveness, and the ability of glucose to augment exocytosis in β-cells. |
2021-04-30 |
2023-08-13 |
mouse |
| Kimberly Sassenrath, Beth Bryles Phillips, Rebecca H Ston. Evaluation of GLP-1 Receptor Agonists in Combination With Multiple Daily Insulin Injections for Type 2 Diabetes. Journal of pharmacy practice. 2021-04-30. PMID:33926305. |
evaluation of glp-1 receptor agonists in combination with multiple daily insulin injections for type 2 diabetes. |
2021-04-30 |
2023-08-13 |
Not clear |
| Kimberly Sassenrath, Beth Bryles Phillips, Rebecca H Ston. Evaluation of GLP-1 Receptor Agonists in Combination With Multiple Daily Insulin Injections for Type 2 Diabetes. Journal of pharmacy practice. 2021-04-30. PMID:33926305. |
to assess the available literature evaluating the efficacy and safety of glucagon-like peptide-1 receptor agonists (glp-1 ras) with multiple daily insulin injections (mdii). |
2021-04-30 |
2023-08-13 |
Not clear |
| Y Inabu, J Haisan, M Oba, T Sugin. Effects of feeding a moderate- or high-energy close-up diet to cows on response of newborn calves to milk replacer feeding and intravenous injection of glucagon-like peptide 1. Domestic animal endocrinology. vol 74. 2021-04-29. PMID:32810655. |
blood samples were obtained through a jugular vein catheter at -10, 0, 10, 20, 30, 40, 50, 60, 90, and 120 min relative to mr feeding at 2, 10, and 20 d after birth, and plasma glucose, insulin, and glp-1 concentrations were measured. |
2021-04-29 |
2023-08-13 |
Not clear |
| Y Inabu, J Haisan, M Oba, T Sugin. Effects of feeding a moderate- or high-energy close-up diet to cows on response of newborn calves to milk replacer feeding and intravenous injection of glucagon-like peptide 1. Domestic animal endocrinology. vol 74. 2021-04-29. PMID:32810655. |
these results indicate that feeding a high-energy close-up diet to cows affects glucose status in their female offspring via suppression of postprandial plasma concentrations of glp-1 and insulin as well as the alteration in the glucose-lowering action of glp-1 after feeding depending on the day after birth. |
2021-04-29 |
2023-08-13 |
Not clear |
| Deborah A Goldspink, Van B Lu, Emily L Miedzybrodzka, Christopher A Smith, Rachel E Foreman, Lawrence J Billing, Richard G Kay, Frank Reimann, Fiona M Gribbl. Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture. Cell reports. vol 31. issue 13. 2021-04-28. PMID:32610134. |
glucagon-like peptide-1 (glp-1) from intestinal l-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. |
2021-04-28 |
2023-08-13 |
human |
| Yoshimasa Aso, Yoshihisa Takada, Ken Tomotsune, Yasuko Chiba, Mihoko Matsumura, Teruo Jojima, Minoru Sato, Nobuya Fujita, Hisamoto Kuroda, Shunichi Murano, Isao Usu. Comparison of insulin degludec (IDeg)/insulin Aspart (IAsp) co-formulation therapy twice-daily with free combination of GLP-1 receptor agonist liraglutide plus insulin degludec in Tochigi: IDEAL Trial. International journal of clinical practice. vol 75. issue 4. 2021-04-27. PMID:33099848. |
comparison of insulin degludec (ideg)/insulin aspart (iasp) co-formulation therapy twice-daily with free combination of glp-1 receptor agonist liraglutide plus insulin degludec in tochigi: ideal trial. |
2021-04-27 |
2023-08-13 |
Not clear |
| Yoshimasa Aso, Yoshihisa Takada, Ken Tomotsune, Yasuko Chiba, Mihoko Matsumura, Teruo Jojima, Minoru Sato, Nobuya Fujita, Hisamoto Kuroda, Shunichi Murano, Isao Usu. Comparison of insulin degludec (IDeg)/insulin Aspart (IAsp) co-formulation therapy twice-daily with free combination of GLP-1 receptor agonist liraglutide plus insulin degludec in Tochigi: IDEAL Trial. International journal of clinical practice. vol 75. issue 4. 2021-04-27. PMID:33099848. |
we compared the efficacy and safety of insulin degludec/insulin aspart co-formulation (idegasp) twice-daily to a free combination of basal insulin degludec and glp-1 receptor agonist liraglutide (ideg + lira) once-daily for patients with inadequately controlled type 2 diabetes on insulin therapy and oral antidiabetic drugs. |
2021-04-27 |
2023-08-13 |
Not clear |
| Longchen Shang, Yi Wang, Yanyan Ren, Tingyang Ai, Peiyuan Zhou, Ling Hu, Ling Wang, Jing Li, Bin L. Food & function. vol 11. issue 9. 2021-04-26. PMID:32869813. |
then, their effects on subjective appetite, glycemia, and appetite-related hormones (insulin, glp-1, pyy3-36, cck-8, ghrelin) response were investigated by conducting a randomized, single-blind, crossover trial in 22 healthy adults (11 female and 11 male, mean age (years): 23.2 ± 2.0, bmi (kg m-2): 20.6 ± 2.1). |
2021-04-26 |
2023-08-13 |
human |
| Jaapna Dhillon, Jose A Viscarra, John W Newman, Oliver Fiehn, Daniel E Crocker, Rudy M Orti. Exogenous GLP-1 stimulates TCA cycle and suppresses gluconeogenesis and ketogenesis in late-fasted northern elephant seals pups. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-04-26. PMID:33407018. |
the postweaning fast of northern elephant seal pups is characterized by a lipid-dependent metabolism and associated with a decrease in plasma glucagon-like peptide-1 (glp-1), insulin, and glucose and increased gluconeogenesis (gng) and ketogenesis. |
2021-04-26 |
2023-08-13 |
Not clear |
| Jaapna Dhillon, Jose A Viscarra, John W Newman, Oliver Fiehn, Daniel E Crocker, Rudy M Orti. Exogenous GLP-1 stimulates TCA cycle and suppresses gluconeogenesis and ketogenesis in late-fasted northern elephant seals pups. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 4. 2021-04-26. PMID:33407018. |
we have also demonstrated that exogenous glp-1 infusion increased plasma insulin despite simultaneous increases in cortisol and glucagon, which collectively present contradictory regulatory stimuli of gng, ketogenesis, and glycolysis. |
2021-04-26 |
2023-08-13 |
Not clear |
| Stefania Camastra, Maria Palumbo, Ferruccio Santin. Nutrients handling after bariatric surgery, the role of gastrointestinal adaptation. Eating and weight disorders : EWD. 2021-04-25. PMID:33895917. |
glucose increase is the principal determinant of glp-1 increase with the consequent stimulation of insulin secretion, the latter balanced by a paradoxical glucagon increase that stimulates egp to prevent hypoglycaemia. |
2021-04-25 |
2023-08-13 |
Not clear |
| Benedetta Maria Bonora, Mauro Rigato, Vera Frison, Michele D'Ambrosio, Federica Tadiotto, Annunziata Lapolla, Natalino Simioni, Agostino Paccagnella, Angelo Avogaro, Gian Paolo Fadin. Deintensification of basal-bolus insulin after initiation of GLP-1RA in patients with type 2 diabetes under routine care. Diabetes research and clinical practice. vol 173. 2021-04-23. PMID:33548335. |
we evaluated de-intensification of basal-bolus insulin (bbi) after initiation of a glp-1 receptor agonist (glp-1ra) under routine care. |
2021-04-23 |
2023-08-13 |
Not clear |
| Victor Okoliko Ukwenya, Sunday Aderemi Adelakun, Olusola Olalekan Elekofehint. Exploring the antidiabetic potential of compounds isolated from In silico pharmacology. vol 9. issue 1. 2021-04-21. PMID:33868895. |
dipeptidyl peptidase-4 (dpp-4), on the other hand, degrades hormone glucagon-like peptide-1 (glp-1), an enzyme that plays a major role in the enhancement of glucose-dependent insulin secretion, making these two proteins candidate targets for diabetes. |
2021-04-21 |
2023-08-13 |
Not clear |