| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Drzazga, Daria Kamińska, Anna Gliszczyńska, Edyta Gendaszewska-Darmac. Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs. International journal of molecular sciences. vol 22. issue 11. 2021-06-21. PMID:34072220. |
isoprenoid derivatives of lysophosphatidylcholines enhance insulin and glp-1 secretion through lipid-binding gpcrs. |
2021-06-21 |
2023-08-13 |
Not clear |
| Anna Drzazga, Daria Kamińska, Anna Gliszczyńska, Edyta Gendaszewska-Darmac. Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs. International journal of molecular sciences. vol 22. issue 11. 2021-06-21. PMID:34072220. |
glucose-induced insulin secretion (gsis) is augmented by glucagon-like peptide (glp-1), a gastrointestinal peptide released in response to ingesting nutriments. |
2021-06-21 |
2023-08-13 |
Not clear |
| Anna Drzazga, Daria Kamińska, Anna Gliszczyńska, Edyta Gendaszewska-Darmac. Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs. International journal of molecular sciences. vol 22. issue 11. 2021-06-21. PMID:34072220. |
the secretion of insulin and glp-1 is mediated by the binding of nutrients to g protein-coupled receptors (gpcrs) expressed by pancreatic β-cells and enteroendocrine cells, respectively. |
2021-06-21 |
2023-08-13 |
Not clear |
| Anna Drzazga, Daria Kamińska, Anna Gliszczyńska, Edyta Gendaszewska-Darmac. Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs. International journal of molecular sciences. vol 22. issue 11. 2021-06-21. PMID:34072220. |
insulin and glp-1 release appeared to be gpr40-, gpr55-, gpr119- and gpr120-dependent. |
2021-06-21 |
2023-08-13 |
Not clear |
| Mehdi Farokhnia, Gray R McDiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo Leggi. Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32075958. |
repeated blood samples were obtained, and the following endocrine markers were measured: total ghrelin, acyl-ghrelin, leptin, glucagon-like peptide-1 (glp-1), and insulin. |
2021-06-18 |
2023-08-13 |
human |
| Wenjiao Jiao, Zijian Zhang, Yue Xu, Lian Gong, Weixun Zhang, Hao Tang, Song Zeng, Qiang Zhang, Zhaoli Sun, Ling Liu, Xiaopeng H. Butyric acid normalizes hyperglycemia caused by the tacrolimus-induced gut microbiota. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 20. issue 9. 2021-06-18. PMID:32243709. |
furthermore, oral supplementation with butyrate, whether for remedy or prevention, significantly increased the butyric acid content in the cecum and arrested hyperglycemia through the regulation of glucose-regulating hormones, including glucagon-like peptide-1 (glp-1), peptide yy (pyy), and insulin, in serum. |
2021-06-18 |
2023-08-13 |
mouse |
| Elena Presas, Sulay Tovar, Juan Cuñarro, Joseph P O'Shea, Caitriona M O'Driscol. Pre-Clinical Evaluation of a Modified Cyclodextrin-Based Nanoparticle for Intestinal Delivery of Liraglutide. Journal of pharmaceutical sciences. vol 110. issue 1. 2021-06-17. PMID:33152374. |
however, as with human insulin analogues, translation of glp-1 analogues into oral pharmaceutical products has been limited due to reduced oral bioavailability. |
2021-06-17 |
2023-08-13 |
human |
| Heyu Wang, Rensong Huang, Hui Li, Lili Jiao, Shuying Liu, Wei W. Serum metabolomic analysis of the anti-diabetic effect of Ginseng berry in type II diabetic rats based on ultra high-performance liquid chromatography-high resolution mass spectrometry. Journal of pharmaceutical and biomedical analysis. vol 196. 2021-06-17. PMID:33508764. |
this study verified the anti-diabetic and anti-oxidation effects of ginseng berry, elaborated that gb regulated the secretion of bile acids, activated glp-1 pathway, increased the secretion of insulin, promoted the hydrolysis of fat and triglyceride, inhibited the activity of 5α - reductase, reduced weight and insulin resistance, so as to improved and treated t2dm, and laid the foundation for the further development and utilization. |
2021-06-17 |
2023-08-13 |
rat |
| Francis S Willard, Jonathan D Douros, Maria Bn Gabe, Aaron D Showalter, David B Wainscott, Todd M Suter, Megan E Capozzi, Wijnand Jc van der Velden, Cynthia Stutsman, Guemalli R Cardona, Shweta Urva, Paul J Emmerson, Jens J Holst, David A D'Alessio, Matthew P Coghlan, Mette M Rosenkilde, Jonathan E Campbell, Kyle W Sloo. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI insight. vol 5. issue 17. 2021-06-16. PMID:32730231. |
experiments in primary islets reveal β-arrestin1 limits the insulin response to glp-1, but not gip or tirzepatide, suggesting that the biased agonism of tirzepatide enhances insulin secretion. |
2021-06-16 |
2023-08-13 |
Not clear |
| Yao Wang, Aiping Wang, Hana Alkhalidy, Jing Luo, Elizabeth Moomaw, Andrew P Neilson, Dongmin Li. Flavone Hispidulin Stimulates Glucagon-Like Peptide-1 Secretion and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice. Molecular nutrition & food research. vol 64. issue 6. 2021-06-04. PMID:31967385. |
the incretin hormone glucagon-like peptide-1 (glp-1) plays a critical role in maintaining glycemic homeostasis via potentiating glucose-stimulated insulin secretion and promoting β-cell mass. |
2021-06-04 |
2023-08-13 |
mouse |
| Yao Wang, Aiping Wang, Hana Alkhalidy, Jing Luo, Elizabeth Moomaw, Andrew P Neilson, Dongmin Li. Flavone Hispidulin Stimulates Glucagon-Like Peptide-1 Secretion and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice. Molecular nutrition & food research. vol 64. issue 6. 2021-06-04. PMID:31967385. |
agents that can directly promote glp-1 secretion, thereby increasing insulin secretion and preserving β-cell mass, hold great potential for the treatment of t2d. |
2021-06-04 |
2023-08-13 |
mouse |
| Amal Essaouiba, Teru Okitsu, Rachid Jellali, Marie Shinohara, Mathieu Danoy, Yannick Tauran, Cécile Legallais, Yasuyuki Sakai, Eric Lecler. Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans. Molecular and cellular endocrinology. vol 514. 2021-06-02. PMID:32531418. |
the high responsiveness of the pancreatic islets to glucagon-like peptide 1 (glp-1) stimulation in the biochips was reflected by the upregulation of mrna levels of gcgr, reg3a, neurog3, ins1, ins2, stt and glp-1r and by increased insulin secretion. |
2021-06-02 |
2023-08-13 |
rat |
| Carme Grau-Bové, Iris Ginés, Raúl Beltrán-Debón, Ximena Terra, MTeresa Blay, Montserrat Pinent, Anna Ardévo. Glucagon Shows Higher Sensitivity than Insulin to Grapeseed Proanthocyanidin Extract (GSPE) Treatment in Cafeteria-Fed Rats. Nutrients. vol 13. issue 4. 2021-06-02. PMID:33810265. |
we show here that glucagon is a more sensitive parameter than insulin to gspe treatments, with a secretion that is highly linked to glp-1 ileal functionality and dependent on the type of treatment. |
2021-06-02 |
2023-08-13 |
rat |
| Shun Guo, Tao Yan, Lei Shi, An Liu, Tian Zhang, Yuan Xu, Wei Jiang, Qi Yang, Le Yang, Linna Liu, Rong Zhao, Song Zhan. Matrine, as a CaSR agonist promotes intestinal GLP-1 secretion and improves insulin resistance in diabetes mellitus. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 84. 2021-06-01. PMID:33636577. |
matrine, as a casr agonist promotes intestinal glp-1 secretion and improves insulin resistance in diabetes mellitus. |
2021-06-01 |
2023-08-13 |
Not clear |
| Chandrakant Sojitra, Chintan Dholakia, Padmaja Sudhakar, Kumar K Singh, Sameer Agarwa. Identification of degradation impurity of TGR5 receptor agonist-ZY12201 by LC-MS technique during force degradation study. SN applied sciences. vol 3. issue 6. 2021-06-01. PMID:34056545. |
tgr5 is a g protein-coupled receptor, activation of which promotes secretion of glucagon-like peptide-1 (glp-1) and modulates insulin secretion. |
2021-06-01 |
2023-08-13 |
Not clear |
| Venkateshwaran Thamaraiselvan, Ravichandiran Velayutha. The putative binding site and SAR rationalization of small molecules against glucagon-like peptide-1 receptor using homology model and crystal structures: a comparative study. Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33118484. |
glucagon-like peptide-1 (glp-1) is involved in glucose-stimulated insulin secretion and weight regulating actions through the activation of the glp-1 receptor (glp-1r). |
2021-05-28 |
2023-08-13 |
Not clear |
| Mridusmita Saikia, Marlena M Holter, Leanne R Donahue, Isaac S Lee, Qiaonan C Zheng, Journey L Wise, Jenna E Todero, Daryl J Phuong, Darline Garibay, Reilly Coch, Kyle W Sloop, Adolfo Garcia-Ocana, Charles G Danko, Bethany P Cumming. GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells. JCI insight. vol 6. issue 3. 2021-05-28. PMID:33554958. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that potentiates glucose-stimulated insulin secretion. |
2021-05-28 |
2023-08-13 |
mouse |
| Athanasia K Papazafiropoulou, Andreas Melidonis, Stavros Antonopoulo. Effects of Glucagon-like Peptide-1 Receptor Agonists and Sodium-glucose Cotransporter 2 Inhibitors on Cardiorenal and Metabolic Outcomes in People Without Diabetes. Current pharmaceutical design. vol 27. issue 8. 2021-05-27. PMID:32912116. |
besides improving glycemic control, glp-1 receptor agonists have been shown to modify cardiovascular risk factors, such as insulin resistance, body weight, blood pressure (bp), and lipid profile. |
2021-05-27 |
2023-08-13 |
Not clear |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
cholaensis reverses insulin resistance and stimulates the glp-1 secretion by alleviating ros-mediated activation of mapks signaling pathway and mitigating apoptosis. |
2021-05-26 |
2023-08-13 |
Not clear |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
sal led to the up-regulation of the serum glucagon-like peptide 1 (glp-1) level by facilitating the scfas production, the promotion of glp-1 synthesis by improving p38 mapk phosphorylation and regulating insulin resistance. |
2021-05-26 |
2023-08-13 |
Not clear |