| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haitham Abdulla, Bethan E Phillips, Daniel J Wilkinson, Marie Limb, Tereza Jandova, Joseph J Bass, Debbie Rankin, Jessica Cegielski, Mariwan Sayda, Hannah Crossland, John P Williams, Kenneth Smith, Iskandar Idris, Philip J Atherto. Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging cell. vol 19. issue 9. 2021-09-07. PMID:32744385. |
despite its known insulin-independent effects, glucagon-like peptide-1 (glp-1) role in muscle protein turnover has not been explored under fed-state conditions or in the context of older age, when declines in insulin sensitivity and protein anabolism, as well as losses of muscle mass and function, occur. |
2021-09-07 |
2023-08-13 |
human |
| Pimnapanut Sridonpai, Aree Prachansuwan, Kemika Praengam, Siriporn Tuntipopipat, Wantanee Kriengsinyo. Postprandial effects of a whey protein-based multi-ingredient nutritional drink compared with a normal breakfast on glucose, insulin, and active GLP-1 response among type 2 diabetic subjects: a crossover randomised controlled trial. Journal of nutritional science. vol 10. 2021-09-07. PMID:34290863. |
postprandial effects of a whey protein-based multi-ingredient nutritional drink compared with a normal breakfast on glucose, insulin, and active glp-1 response among type 2 diabetic subjects: a crossover randomised controlled trial. |
2021-09-07 |
2023-08-13 |
human |
| Pimnapanut Sridonpai, Aree Prachansuwan, Kemika Praengam, Siriporn Tuntipopipat, Wantanee Kriengsinyo. Postprandial effects of a whey protein-based multi-ingredient nutritional drink compared with a normal breakfast on glucose, insulin, and active GLP-1 response among type 2 diabetic subjects: a crossover randomised controlled trial. Journal of nutritional science. vol 10. 2021-09-07. PMID:34290863. |
glucose, insulin, and active glp-1 were measured by standard methods with blood samples collected with a venous catheter for 240 min during a kinetic test. |
2021-09-07 |
2023-08-13 |
human |
| Xiao-Xiao Li, Xiu-Xiu Zhang, Rui Zhang, Zhi-Jing Ni, Elnur Elam, Kiran Thakur, Carlos L Cespedes-Acuña, Jian-Guo Zhang, Zhao-Jun We. Gut modulation based anti-diabetic effects of carboxymethylated wheat bran dietary fiber in high-fat diet/streptozotocin-induced diabetic mice and their potential mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 152. 2021-09-06. PMID:33894295. |
after feeding the diabetic mice with modified dfs for four weeks, the dfs had lipid lowering and anti-hyperglycemic effect, via increasing the levels of insulin, glp-1, pyy, and scfas in diabetic mice, and improving the histopathology of liver and pancreas. |
2021-09-06 |
2023-08-13 |
mouse |
| Tiago Rodrigues, Patrícia Borges, Laura Mar, Daniela Marques, Miguel Albano, Hans Eickhoff, Catarina Carrêlo, Bruno Almeida, Salomé Pires, Margarida Abrantes, Beatriz Martins, Cristina Uriarte, Filomena Botelho, Pedro Gomes, Sónia Silva, Raquel Seiça, Paulo Matafom. GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes. Pharmacological research. vol 161. 2021-09-01. PMID:32942016. |
glp-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes. |
2021-09-01 |
2023-08-13 |
rat |
| Tiago Rodrigues, Patrícia Borges, Laura Mar, Daniela Marques, Miguel Albano, Hans Eickhoff, Catarina Carrêlo, Bruno Almeida, Salomé Pires, Margarida Abrantes, Beatriz Martins, Cristina Uriarte, Filomena Botelho, Pedro Gomes, Sónia Silva, Raquel Seiça, Paulo Matafom. GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes. Pharmacological research. vol 161. 2021-09-01. PMID:32942016. |
lower adipose tissue glo-1 activity was observed in dysmetabolic patients, being a target for glp-1 in improving adipose tissue capillarization and insulin sensitivity. |
2021-09-01 |
2023-08-13 |
rat |
| Ilora Bandyopadhyay, Sunny Dave, Amita Rai, Madhavan Nampoothiri, Mallikarjuna Rao Chamallamudi, Nitesh Kuma. Oral semaglutide in the management of type 2 DM: Clinical status and comparative analysis. Current drug targets. 2021-09-01. PMID:34468297. |
in the incretin system, glucagon-like peptide-1 (glp-1) is a hormone that inhibits the release of glucagon and regulates glucose-dependent insulin secretion. |
2021-09-01 |
2023-08-13 |
Not clear |
| Mandana Hasanzad, Negar Sarhangi, Shekoufeh Nikfar, Seyed Naser Ostad, Hamid Reza Aghaei Meybod. A narrative review of current trends in liraglutide: insights into the unmet needs in management of type 2 diabetes and obesity. Journal of diabetes and metabolic disorders. vol 19. issue 2. 2021-08-29. PMID:33520865. |
glp-1 ras such as liraglutide enhance insulin secretion and inhibit glucagon release via the stimulation of glucagon-like peptide-1 receptors (glp-1rs). |
2021-08-29 |
2023-08-13 |
human |
| Thibault Gautier, Rupesh Silwal, Aramesh Saremi, Anders Boss, Marc D Breto. Modeling the Effect of Subcutaneous Lixisenatide on Glucoregulatory Endocrine Secretions and Gastric Emptying in Type 2 Diabetes to Simulate the Effect of iGlarLixi Administration Timing on Blood Sugar Profiles. Journal of diabetes science and technology. 2021-08-27. PMID:34013770. |
as type 2 diabetes (t2d) progresses, intensification to combination therapies, such as iglarlixi (a fixed-ratio glp-1 ra and basal insulin combination), may be required. |
2021-08-27 |
2023-08-13 |
Not clear |
| Hideaki Kaneto, Tomohiko Kimura, Masashi Shimoda, Atsushi Obata, Junpei Sanada, Yoshiro Fushimi, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kak. Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: "The Earlier, the Better" in Therapy with Incretin-Based Medicine. International journal of molecular sciences. vol 22. issue 15. 2021-08-23. PMID:34360682. |
glucagon-like peptide-1 (glp-1) plays a crucial role in pancreatic β-cells; glp-1 binds to the glp-1 receptor (glp-1r) in the β-cell membrane and thereby enhances insulin secretion, suppresses apoptotic cell death and increase proliferation of β-cells. |
2021-08-23 |
2023-08-13 |
Not clear |
| Josh Reed, Stephen Bain, Venkateswarlu Kanamarlapud. A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 14. 2021-08-21. PMID:34413662. |
given that native glp-1 has a very short half-life, glp-1 mimetics with a much longer half-life have been developed, which are currently an effective treatment option for t2d by enhancing insulin secretion in patients. |
2021-08-21 |
2023-08-13 |
Not clear |
| Alvin W K Tan, Sharmila C Subaran, Matthew A Sauder, Weidong Chai, Linda A Jahn, Dale E Fowler, James T Patrie, Kevin W Aylor, Ananda Basu, Zhenqi Li. GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans. Journal of the Endocrine Society. vol 2. issue 2. 2021-08-20. PMID:29568814. |
glp-1 and insulin recruit muscle microvasculature and dilate conduit artery individually but not additively in healthy humans. |
2021-08-20 |
2023-08-13 |
Not clear |
| Alvin W K Tan, Sharmila C Subaran, Matthew A Sauder, Weidong Chai, Linda A Jahn, Dale E Fowler, James T Patrie, Kevin W Aylor, Ananda Basu, Zhenqi Li. GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans. Journal of the Endocrine Society. vol 2. issue 2. 2021-08-20. PMID:29568814. |
glucagon-like peptide-1 (glp-1) and insulin increase muscle microvascular perfusion, thereby increasing tissue endothelial surface area and nutrient delivery. |
2021-08-20 |
2023-08-13 |
Not clear |
| Zhuo Fu, Liying Gong, Jia Liu, Jing Wu, Eugene J Barrett, Kevin W Aylor, Zhenqi Li. Brain Endothelial Cells Regulate Glucagon-Like Peptide 1 Entry Into the Brain via a Receptor-Mediated Process. Frontiers in physiology. vol 11. 2021-08-20. PMID:32547420. |
glucagon-like peptide 1 (glp-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. |
2021-08-20 |
2023-08-13 |
rat |
| Ben Jones, Emma Rose McGlone, Zijian Fang, Phil Pickford, Ivan R Corrêa, Atsuro Oishi, Ralf Jockers, Asuka Inoue, Sunil Kumar, Frederik Görlitz, Chris Dunsby, Paul M W French, Guy A Rutter, Tricia Tan, Alejandra Tomas, Stephen R Bloo. Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors. The Journal of biological chemistry. vol 296. 2021-08-20. PMID:33268378. |
moreover, in wildtype cells, "biased" glp-1, gcg, and gip analogs with selective reductions in β-arrestin-2 recruitment led to reduced receptor endocytosis and increased insulin secretion over a prolonged stimulation period, although the latter effect was only seen at high agonist concentrations. |
2021-08-20 |
2023-08-13 |
Not clear |
| Swapna Poudwal, Ambikanandan Misra, Pravin Shend. Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists. Journal of drug targeting. vol 29. issue 8. 2021-08-19. PMID:33620269. |
role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and glp-1 receptor agonists. |
2021-08-19 |
2023-08-13 |
human |
| Swapna Poudwal, Ambikanandan Misra, Pravin Shend. Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists. Journal of drug targeting. vol 29. issue 8. 2021-08-19. PMID:33620269. |
growing demand for insulin and glucagon-like peptide-1 receptor agonists (glp-1 ra) is observed, considering the progressive nature of diabetes and the potential therapeutic role of peptides in its treatment. |
2021-08-19 |
2023-08-13 |
human |
| Swapna Poudwal, Ambikanandan Misra, Pravin Shend. Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists. Journal of drug targeting. vol 29. issue 8. 2021-08-19. PMID:33620269. |
oral delivery of insulin and glp-1 ra promises better patient compliance owing to their ease of administration and reduction in chances of peripheral hypoglycaemia and weight gain. |
2021-08-19 |
2023-08-13 |
human |
| Swapna Poudwal, Ambikanandan Misra, Pravin Shend. Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists. Journal of drug targeting. vol 29. issue 8. 2021-08-19. PMID:33620269. |
with the rising global burden of diabetes, the lipid nanocarriers show the potential to revolutionise treatment with oral delivery of insulin and glp-1 ra. |
2021-08-19 |
2023-08-13 |
human |
| Keita Watanabe, Mayu Yamano, Yuki Masujima, Ryuji Ohue-Kitano, Ikuo Kimur. Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice. Biochemistry and biophysics reports. vol 27. 2021-08-18. PMID:34401531. |
although body weight and fat mass were not affected by curdlan supplementation in hfd-induced obese mice, hfd-induced hyperglycemia was significantly suppressed with an increase in plasma insulin and incretin glp-1 levels. |
2021-08-18 |
2023-08-13 |
mouse |