| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael A Nauck, Daniel R Quast, Jakob Wefers, Andreas F H Pfeiffe. The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: A pathophysiological update. Diabetes, obesity & metabolism. vol 23 Suppl 3. 2021-10-18. PMID:34310013. |
gip, but not glp-1 increases triglyceride storage in white adipose tissue not only through stimulating insulin secretion, but also by interacting with regional blood vessels and gip receptors. |
2021-10-18 |
2023-08-13 |
human |
| Alexander Abitbol, Rick Siemens, Natalie Nightingale, John Stewart, Marie-Josée Toutounji, Ronald Goldenber. Persistence of GLP-1 RA in combination with basal insulin among adults with type 2 diabetes in Canada. Diabetes research and clinical practice. vol 177. 2021-10-15. PMID:34139288. |
persistence of glp-1 ra in combination with basal insulin among adults with type 2 diabetes in canada. |
2021-10-15 |
2023-08-13 |
Not clear |
| Alexander Abitbol, Rick Siemens, Natalie Nightingale, John Stewart, Marie-Josée Toutounji, Ronald Goldenber. Persistence of GLP-1 RA in combination with basal insulin among adults with type 2 diabetes in Canada. Diabetes research and clinical practice. vol 177. 2021-10-15. PMID:34139288. |
the purpose of this study is to assess the persistence of canadians with type 2 diabetes mellitus (t2d) on loose-dose combination treatment (i.e., administered by separate devices) with a glucagon-like peptide 1 receptor agonist (glp-1 ra) and basal insulin over 12 months. |
2021-10-15 |
2023-08-13 |
Not clear |
| Estelle Grasset, Anthony Puel, Julie Charpentier, Pascale Klopp, Jeffrey E Christensen, Benjamin Lelouvier, Florence Servant, Vincent Blasco-Baque, François Tercé, Rémy Burceli. Gut microbiota dysbiosis of type 2 diabetic mice impairs the intestinal daily rhythms of GLP-1 sensitivity. Acta diabetologica. 2021-10-14. PMID:34648088. |
the gut-brain-beta cell glucagon-like peptide-1 (glp-1)-dependent axis and the clock genes both control insulin secretion. |
2021-10-14 |
2023-08-13 |
mouse |
| Estelle Grasset, Anthony Puel, Julie Charpentier, Pascale Klopp, Jeffrey E Christensen, Benjamin Lelouvier, Florence Servant, Vincent Blasco-Baque, François Tercé, Rémy Burceli. Gut microbiota dysbiosis of type 2 diabetic mice impairs the intestinal daily rhythms of GLP-1 sensitivity. Acta diabetologica. 2021-10-14. PMID:34648088. |
we analyzed in mice the circadian profile of glp-1 sensitivity on insulin secretion and the impact of the autonomic neuropathy, antibiotic treated in different diabetic mouse models and in germ-free colonized mice. |
2021-10-14 |
2023-08-13 |
mouse |
| Mahmoud Ibrahim, Jason Baker, Avivit Cahn, Robert H Eckel, Nuha Ali El Sayed, Amy Hess Fischl, Peter Gaede, R David Leslie, Silvia Pieralice, Dario Tuccinardi, Paolo Pozzilli, Bjørn Richelsen, Eytan Roitman, Eberhard Standl, Yoel Toledano, Jaakko Tuomilehto, Sandra L Weber, Guillermo E Umpierre. Hypoglycaemia and its management in primary care setting. Diabetes/metabolism research and reviews. vol 36. issue 8. 2021-10-11. PMID:32343474. |
many of such patients may be better treated by the use of glp-1 receptor agonists or sglt2 inhibitors rather than insulin. |
2021-10-11 |
2023-08-13 |
human |
| Christian Hölsche. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases. International review of neurobiology. vol 155. 2021-10-11. PMID:32854859. |
first clinical trials with a glp-1 mimetic show good effects in patients with parkinson's disease, improving motor control and insulin signaling in the brain. |
2021-10-11 |
2023-08-13 |
Not clear |
| Austin J Graybeal, Andreas Kreutzer, Petra Rack, Kamiah Moss, Garrett Augsburger, Jada L Willis, Robyn Braun-Trocchio, Meena Sha. Perceptions of appetite do not match hormonal measures of appetite in trained competitive cyclists and triathletes following a ketogenic diet compared to a high-carbohydrate or habitual diet: A randomized crossover trial. Nutrition research (New York, N.Y.). vol 93. 2021-10-08. PMID:34487977. |
mixed-effects model repeated measures analysis and effect sizes and 95% confidence intervals showed that postprandial ghr and insulin were lower and glp-1 was higher following the ketogenic versus the standard and high-carbohydrate meals. |
2021-10-08 |
2023-08-13 |
human |
| Austin J Graybeal, Andreas Kreutzer, Petra Rack, Kamiah Moss, Garrett Augsburger, Jada L Willis, Robyn Braun-Trocchio, Meena Sha. Perceptions of appetite do not match hormonal measures of appetite in trained competitive cyclists and triathletes following a ketogenic diet compared to a high-carbohydrate or habitual diet: A randomized crossover trial. Nutrition research (New York, N.Y.). vol 93. 2021-10-08. PMID:34487977. |
in conclusion, both fasting and postprandial concentrations of ghr were lower and glp-1 were higher following the kd than the hc and hd, and postprandial insulin was lower on the kd. |
2021-10-08 |
2023-08-13 |
human |
| Huinan Zhang, Yunhan Liu, Liusiyuan Cheng, Xue Ma, Xiaoxing Lu. Exendin-4 induces a novel extended effect of ischemic tolerance via crosstalk with IGF-1R. Brain research bulletin. vol 169. 2021-10-07. PMID:33197537. |
although glp-1 analogs were reported to induce sustained insulin secretion and glucose tolerance improved after cessation of treatment, no study has revealed whether ex-4 exerts sustained neuroprotection against stroke and the underlying mechanism after treatment cessation. |
2021-10-07 |
2023-08-13 |
mouse |
| Jens Juul Holst, Lærke Smidt Gasbjerg, Mette Marie Rosenkild. The Role of Incretins on Insulin Function and Glucose Homeostasis. Endocrinology. vol 162. issue 7. 2021-10-07. PMID:33782700. |
the incretin effect-the amplification of insulin secretion after oral vs intravenous administration of glucose as a mean to improve glucose tolerance-was suspected even before insulin was discovered, and today we know that the effect is due to the secretion of 2 insulinotropic peptides, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1). |
2021-10-07 |
2023-08-13 |
Not clear |
| Jens Juul Holst, Lærke Smidt Gasbjerg, Mette Marie Rosenkild. The Role of Incretins on Insulin Function and Glucose Homeostasis. Endocrinology. vol 162. issue 7. 2021-10-07. PMID:33782700. |
the availability of antagonists for glp-1 and most recently also for gip has made it possible to directly estimate the individual contributions to postprandial insulin secretion of a) glucose itself: 26%; b) gip: 45%; and c) glp-1: 29%. |
2021-10-07 |
2023-08-13 |
Not clear |
| Chen-Yi Yang, Ying-Ren Chen, Huang-Tz Ou, Shihchen Ku. Cost-effectiveness of GLP-1 receptor agonists versus insulin for the treatment of type 2 diabetes: a real-world study and systematic review. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33468131. |
cost-effectiveness of glp-1 receptor agonists versus insulin for the treatment of type 2 diabetes: a real-world study and systematic review. |
2021-10-05 |
2023-08-13 |
Not clear |
| Chen-Yi Yang, Ying-Ren Chen, Huang-Tz Ou, Shihchen Ku. Cost-effectiveness of GLP-1 receptor agonists versus insulin for the treatment of type 2 diabetes: a real-world study and systematic review. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33468131. |
to conduct a real-word-study-based cost-effectiveness analysis of a glp-1 receptor agonist (glp-1ra) versus insulin among type 2 diabetes patients requiring intensified injection therapy and a systematic review of cost-effectiveness studies of glp-1ras versus insulin. |
2021-10-05 |
2023-08-13 |
Not clear |
| Jo E Lewis, Emily L Miedzybrodzka, Rachel E Foreman, Orla R M Woodward, Richard G Kay, Deborah A Goldspink, Fiona M Gribble, Frank Reiman. Selective stimulation of colonic L cells improves metabolic outcomes in mice. Diabetologia. vol 63. issue 7. 2021-10-04. PMID:32342115. |
glp-1 is a well-known insulin secretagogue, and glp-1 and pyy are anorexigenic, whereas insl5 is considered orexigenic. |
2021-10-04 |
2023-08-13 |
mouse |
| Seyed Ebrahim Alavi, Hasan Ebrahimi Shahmabad. GLP-1 peptide analogs for targeting pancreatic beta cells. Drug discovery today. vol 26. issue 8. 2021-10-04. PMID:33839290. |
glucagon-like peptide-1 receptor (glp-1r) is the receptor of glp-1, an incretin hormone that causes insulin secretion in a glucose-dependent manner. |
2021-10-04 |
2023-08-13 |
Not clear |
| Miranda K Boggild, Angela M Cheun. Basal insulin plus GLP-1 RA or SGLT2 inhibitor was noninferior to basal-bolus insulin intensification for HbA Annals of internal medicine. vol 174. issue 9. 2021-10-04. PMID:34487441. |
basal insulin plus glp-1 ra or sglt2 inhibitor was noninferior to basal-bolus insulin intensification for hba giugliano d, longo m, caruso p, et al. |
2021-10-04 |
2023-08-13 |
Not clear |
| Ottavio D'Urso, Filippo Drag. Pharmacological significance of extra-oral taste receptors. European journal of pharmacology. vol 910. 2021-10-04. PMID:34496302. |
tas1r2/3 are responsible for sweet taste perception and may induce glp-1 release and insulin secretion. |
2021-10-04 |
2023-08-13 |
Not clear |
| Ottavio D'Urso, Filippo Drag. Pharmacological significance of extra-oral taste receptors. European journal of pharmacology. vol 910. 2021-10-04. PMID:34496302. |
finally, gene-protein coupled receptor 40 (gpr40) and gpr120 for fatty taste perception are also protein-coupled receptors and may induce glp-1 secretion and insulin release, similar to those of other receptors belonging to the same superfamily. |
2021-10-04 |
2023-08-13 |
Not clear |
| Alba C Arcones, Rocío Vila-Bedmar, Mercedes Mirasierra, Marta Cruces-Sande, Mario Vallejo, Ben Jones, Alejandra Tomas, Federico Mayor, Cristina Murg. GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo. BMC biology. vol 19. issue 1. 2021-10-01. PMID:33658023. |
incretin hormones such as glucagon-like peptide-1 (glp-1) act as key physiological potentiators of insulin release through binding to the g protein-coupled receptor glp-1r. |
2021-10-01 |
2023-08-13 |
Not clear |