| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karina V Sørensen, Mads H Kaspersen, Jeppe H Ekberg, Annette Bauer-Brandl, Trond Ulven, Kurt Højlun. Effects of Delayed-Release Olive Oil and Hydrolyzed Pine Nut Oil on Glucose Tolerance, Incretin Secretion and Appetite in Humans. Nutrients. vol 13. issue 10. 2021-11-15. PMID:34684407. |
to investigate the potential synergistic effects of olive oil releasing 2-oleoylglycerol and hydrolyzed pine nut oil containing 20% pinolenic acid on glp-1 secretion, glucose tolerance, insulin secretion and appetite in healthy individuals, when delivered to the small intestine as potential agonists of gpr119, ffa1 and ffa4. |
2021-11-15 |
2023-08-13 |
Not clear |
| Sumin Kang, Nam Hyuk Kim, Yeon Gyu Y. Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G Biochemical and biophysical research communications. vol 583. 2021-11-15. PMID:34739856. |
identification of novel positive allosteric modulators of glp1r that stimulate its interaction with ligands and g glucagon-like peptide-1 (glp-1) is a major incretin hormone that enhances the release of insulin from pancreatic β-cells by activating the glucagon-like peptide-1 receptor (glp1r), which belongs to secretin-like class b of g protein-coupled receptors (gpcrs). |
2021-11-15 |
2023-08-13 |
Not clear |
| Marina V Geraldi, Cínthia B B Cazarin, Marcelo Cristianini, Ana C Vasques, Bruno Geloneze, Mário R Maróstica Júnio. Jabuticaba juice improves postprandial glucagon-like peptide-1 and antioxidant status in healthy adults: a randomized crossover trial. The British journal of nutrition. 2021-11-15. PMID:34776021. |
blood samples were collected at 0, 15, 30, 45, 60, 90, and 120 min after each test product to analyze the concentrations of glucose, insulin, c-peptide, antioxidant capacity, plasma glucagon-like peptide-1 (glp-1), and appetite sensations. |
2021-11-15 |
2023-08-13 |
human |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
the insulin response to oral glucose in gip and glp-1 receptor knockout mice: review of the literature and stepwise glucose dose response studies in female mice. |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
a key factor for the insulin response to oral glucose is the pro-glucagon derived incretin hormone glucagon-like peptide-1 (glp-1), together with the companion incretin hormone, glucose-dependent insulinotropic polypeptide (gip). |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
in a previous study in mice with genetic deletion of both glp-1 and gip receptors we showed that these mice have impaired insulin response to oral glucose after large but not small glucose loads, suggesting that the relevance of the incretin hormones may be dependent on the glucose load. |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
in contrast, glp-1 receptor ko mice have normal glucose tolerance after all glucose loads, in the presence of a compensatory increase in the insulin response. |
2021-11-10 |
2023-08-13 |
mouse |
| Andrea Kelly, Saba Sheikh, Darko Stefanovski, Amy J Peleckis, Sarah C Nyirjesy, Jack N Eiel, Aniket Sidhaye, Russell Localio, Robert Gallop, Diva D De Leon, Denis Hadjiliadis, Ronald C Rubenstein, Michael R Rickel. Effect of Sitagliptin on Islet Function in Pancreatic Insufficient Cystic Fibrosis With Abnormal Glucose Tolerance. The Journal of clinical endocrinology and metabolism. vol 106. issue 9. 2021-11-10. PMID:34406395. |
the study objective was to test the hypothesis that dipeptidyl peptidase-4 (dpp-4) inhibitor-induced increases in intact incretin hormone [glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip)] concentrations augment insulin secretion and glucagon suppression and lower postprandial glycemia in pi-cf with agt. |
2021-11-10 |
2023-08-13 |
Not clear |
| C M McLaughlin, P A Harnedy-Rothwell, R A Lafferty, S Sharkey, V Parthsarathy, P J Allsopp, E M McSorley, R J FitzGerald, F P M O'Hart. Macroalgal protein hydrolysates from Palmaria palmata influence the 'incretin effect' in vitro via DPP-4 inhibition and upregulation of insulin, GLP-1 and GIP secretion. European journal of nutrition. vol 60. issue 8. 2021-11-09. PMID:34081167. |
macroalgal protein hydrolysates from palmaria palmata influence the 'incretin effect' in vitro via dpp-4 inhibition and upregulation of insulin, glp-1 and gip secretion. |
2021-11-09 |
2023-08-13 |
Not clear |
| Heng Yang, Shuo Wang, Yingchun Ye, Min Xie, Yubin Li, Hong Jin, Jing Li, Ling Ga. GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice. Neuropeptides. vol 85. 2021-11-08. PMID:33307381. |
glp-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Heng Yang, Shuo Wang, Yingchun Ye, Min Xie, Yubin Li, Hong Jin, Jing Li, Ling Ga. GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice. Neuropeptides. vol 85. 2021-11-08. PMID:33307381. |
we hypothesized that glp-1 may protect β cell function via its action on insulin signaling pathway. |
2021-11-08 |
2023-08-13 |
mouse |
| Jelica Bjekić-Macut, Tamara Vukašin, Zelija Velija-Ašimi, Azra Bureković, Marija Zdravković, Zoran Andrić, Marija Branković, Slobodanka Crevar-Marinović, Tatjana Madić, Olivera Stanojlović, Danijela V Milutinović, Sarantis Livadas, George Mastorako. Polycystic Ovary Syndrome: A Contemporary Clinical Approach. Current pharmaceutical design. vol 27. issue 36. 2021-11-08. PMID:33463457. |
metabolic therapies involve a lifestyle intervention followed by the introduction of insulin sensitizers including metformin and inositols, glucagon-like peptide 1 receptor agonists (glp-1 ra), as recently sodium-glucose cotransporter-2 (sglt2) inhibitors. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ann Catherine Archer, Serva Peddha Muthukumar, Prakash Motiram Halam. Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats. Probiotics and antimicrobial proteins. vol 13. issue 4. 2021-11-08. PMID:33575913. |
additionally, the potential probiotic cultures also displayed normalization of markers related to intestinal barrier integrity (zo-1), tlr-4 receptor, and insulin sensitivity (glut-4, glp-1, adiponectin). |
2021-11-08 |
2023-08-13 |
rat |
| Devon L Graham, Heather H Durai, Taylor S Trammell, Brenda L Noble, Douglas P Mortlock, Aurelio Galli, Gregg D Stanwoo. A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain. The Journal of comparative neurology. vol 528. issue 14. 2021-11-05. PMID:32170734. |
these functions, which include insulin secretion, gastric emptying, satiety, and the hedonic aspects of food and drug intake, are primarily mediated through stimulation of the glp-1 receptor. |
2021-11-05 |
2023-08-13 |
mouse |
| Prabhsimran Kaur, Bidwan Sekhar Behera, Sandeep Singh, Anjana Munsh. "The pharmacological profile of SGLT2 inhibitors: Focus on mechanistic aspects and pharmacogenomics". European journal of pharmacology. vol 904. 2021-11-05. PMID:33984301. |
current treatment strategies for diabetes include biguanides, sulfonylureas, alpha-glucosidase inhibitors, thiazolidinediones, insulin and its analogs, dpp-4(dipeptidyl peptidase-4) and glp-1 (glucagon-like peptide) analogs. |
2021-11-05 |
2023-08-13 |
Not clear |
| Seon Mee Kang, Jeong Hyun Par. Pleiotropic Benefits of DPP-4 Inhibitors Beyond Glycemic Control. Clinical medicine insights. Endocrinology and diabetes. vol 14. 2021-11-05. PMID:34733107. |
glp-1 increases the glucose level, dependent on insulin secretion from pancreatic β-cells; it also decreases the abnormally increased level of glucagon, eventually decreasing the blood glucose level in patients with type 2 diabetes. |
2021-11-05 |
2023-08-13 |
Not clear |
| Sodai Kubota, Daisuke Yab. Elevation of Fasting GLP-1 Levels in Child and Adolescent Obesity: Friend or Foe? The Journal of clinical endocrinology and metabolism. vol 106. issue 9. 2021-11-03. PMID:33950185. |
il-6-induced glp-1 secretion could therefore play a role in expanding the β-cell reservoir in compensation for increased insulin needs due to exacerbation of insulin resistance. |
2021-11-03 |
2023-08-13 |
human |
| Sodai Kubota, Daisuke Yab. Elevation of Fasting GLP-1 Levels in Child and Adolescent Obesity: Friend or Foe? The Journal of clinical endocrinology and metabolism. vol 106. issue 9. 2021-11-03. PMID:33950185. |
on the other hand, augmented glp-1 secretion leads to increased insulin secretion, thereby enhancing hepatic lipogenesis and stimulating adipogenesis, which might underlie the associations of fasting glp-1 with % body fat, triglycerides, and alanine aminotransferase. |
2021-11-03 |
2023-08-13 |
human |
| Chihiro Nagase, Masaya Tanno, Hidemichi Kouzu, Takayuki Miki, Junichi Nishida, Naoto Murakami, Nobuaki Kokubu, Nobutaka Nagano, Ryo Nishikawa, Nobuhiro Yoshioka, Tohru Hasegawa, Hiroyuki Kita, Akihito Tsuchida, Hirofumi Ohnishi, Tetsuji Miur. Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34341424. |
the patients (mean age, 66.5 ± 8.8 years; 71% males, n = 173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active glp-1 levels. |
2021-11-03 |
2023-08-13 |
human |
| Wanfang Zheng, Linghuan Li, Hanbing L. Phytochemicals modulate pancreatic islet β cell function through glucagon-like peptide-1-related mechanisms. Biochemical pharmacology. 2021-10-31. PMID:34717897. |
glp-1 plays an important role in improving glycemic homeostasis by stimulating insulin biosynthesis and secretion, suppressing glucagon activity, delaying gastric emptying, and reducing appetite and food ingestion. |
2021-10-31 |
2023-08-13 |
Not clear |