| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice. Peptides. vol 135. 2021-11-19. PMID:33172827. |
the mediation by glp-1 receptors of glucagon-induced insulin secretion revisited in glp-1 receptor knockout mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice. Peptides. vol 135. 2021-11-19. PMID:33172827. |
it was found that the insulin response to intravenous glucagon was preserved in glp-1 receptor knockout mice but that glucagon-induced insulin secretion was markedly suppressed in islets from glp-1 receptor knockout mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice. Peptides. vol 135. 2021-11-19. PMID:33172827. |
similarly, the glp-1 receptor antagonist markedly suppressed glucagon-induced insulin secretion in wildtype mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice. Peptides. vol 135. 2021-11-19. PMID:33172827. |
however, neither of these seemed to explain why the insulin response to glucagon is not suppressed in glp-1 receptor knockout mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice. Peptides. vol 135. 2021-11-19. PMID:33172827. |
based on these data we confirm the hypothesis that glucagon-induced insulin secretion is partially mediated by glp-1 receptors on the beta cells and we propose that a compensatory mechanism, the nature of which remains to be established, is induced in glp-1 receptor knockout mice to counteract the expected impaired insulin response to glucagon in these mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Cong Liang, Xiao-Hong Zhou, Pi-Min Gong, Hai-Yue Niu, Lin-Zheng Lyu, Yi-Fan Wu, Xue Han, Lan-Wei Zhan. Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57BL/6J mice. Food & function. vol 12. issue 10. 2021-11-19. PMID:34031676. |
furthermore, the study identified that h-87 reduced tudca and gcdca levels in the ileum, which decreased the glp-1 secretion by l cells to alleviate insulin resistance in hfd-fed mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Yulin Zhang, Chengsheng Han, Wenzhen Zhu, Guoyi Yang, Xiaohong Peng, Sohum Mehta, Jin Zhang, Liangyi Chen, Yanmei Li. Glucagon Potentiates Insulin Secretion Via β-Cell GCGR at Physiological Concentrations of Glucose. Cells. vol 10. issue 9. 2021-11-19. PMID:34572144. |
incretin-potentiated glucose-stimulated insulin secretion (gsis) is critical to maintaining euglycemia, of which glp-1 receptor (glp-1r) on β-cells plays an indispensable role. |
2021-11-19 |
2023-08-13 |
mouse |
| Xuejun Victor Peng, Rajeev Ayyagari, Robert Lubwama, Lizheng Shi, Eboni G Price-Haywood, Priscilla Hollander, Vivian Fonsec. Impact of Simultaneous Versus Sequential Initiation of Basal Insulin and Glucagon-like Peptide-1 Receptor Agonists on HbA1c in Type 2 Diabetes: A Retrospective Observational Study. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 11. issue 4. 2021-11-18. PMID:32112204. |
this pilot study was conducted using the retrospective observational data from such patients to evaluate the impact on hba1c of three treatment sequences: simultaneous initiation of basal insulin (bi) and a glucagon-like peptide-1 receptor agonist (glp-1 ra; cohort 1); bi followed by glp-1 ra initiation within a 90-day timeframe (cohort 2); or bi followed by glp-1 ra initiation beyond 90 days (cohort 3). |
2021-11-18 |
2023-08-13 |
Not clear |
| Martin Haluzík, Milan Flekač, Csaba Lengyel, Zoltán Taybani, Cristian Guja, Bogdan-Mircea Mihai, Anca Cerghizan, Emil Martinka, Gabor Kovacs, Péter Kemple. Expert Opinion on the Therapeutic Use of the Fixed-Ratio Combination of Insulin Glargine 100 U/mL and Lixisenatide: a Central/Eastern European Perspective. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 11. issue 4. 2021-11-18. PMID:32144742. |
the fixed-ratio combination (frc) of a basal insulin and a glp-1 receptor agonist (glp-1 ra) has proven to be an effective therapeutic approach. |
2021-11-18 |
2023-08-13 |
Not clear |
| Lawrence Blonde, Lori Berard, Aramesh Saremi, Yao Huang, Vanita R Aroda, Denis Racca. Fixed-Ratio Combination of Insulin and GLP-1 RA in Patients with Longstanding Type 2 Diabetes: A Subanalysis of LixiLan-L. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 11. issue 4. 2021-11-18. PMID:32166620. |
fixed-ratio combination of insulin and glp-1 ra in patients with longstanding type 2 diabetes: a subanalysis of lixilan-l. with longer duration and progression of type 2 diabetes (t2d), β-cell function deteriorates and insulin therapy often becomes necessary. |
2021-11-18 |
2023-08-13 |
Not clear |
| Ming Wang, Gwangho Yoon, Juhyun Song, Jihoon J. Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:33859286. |
glucagon-like peptide 1 (glp-1) secreted from gut l-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. |
2021-11-18 |
2023-08-13 |
mouse |
| Tina Ovlund, Giovanni Pacini, Bo Ahré. Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34168617. |
we have previously shown that the two incretin hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) increase this process and, therefore, seem to contribute to glucose disposal both through this effect and through the classical incretin effect resulting in enhanced insulin levels. |
2021-11-18 |
2023-08-13 |
mouse |
| Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Lara Tramontan, Angelo Avogaro, Gian Paolo Fadin. Cardiovascular outcomes after initiating GLP-1 receptor agonist or basal insulin for the routine treatment of type 2 diabetes: a region-wide retrospective study. Cardiovascular diabetology. vol 20. issue 1. 2021-11-18. PMID:34774054. |
cardiovascular outcomes after initiating glp-1 receptor agonist or basal insulin for the routine treatment of type 2 diabetes: a region-wide retrospective study. |
2021-11-18 |
2023-08-13 |
Not clear |
| Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Lara Tramontan, Angelo Avogaro, Gian Paolo Fadin. Cardiovascular outcomes after initiating GLP-1 receptor agonist or basal insulin for the routine treatment of type 2 diabetes: a region-wide retrospective study. Cardiovascular diabetology. vol 20. issue 1. 2021-11-18. PMID:34774054. |
we aimed to compare cardiovascular outcomes of patients with type 2 diabetes (t2d) who initiated glp-1 receptor agonists (glp-1ra) or basal insulin (bi) under routine care. |
2021-11-18 |
2023-08-13 |
Not clear |
| Yimei Shen, Xiaohua Yang, Xiaojun Han, Wei Xi, Lihua Jiang, Shuqin Wang, Haifeng Zhong, Yunjuan G. Influence of GLP-1 receptor agonist on insulin dosage and blood glucose control of patients with type 2 diabetes mellitus. American journal of translational research. vol 13. issue 10. 2021-11-18. PMID:34786110. |
influence of glp-1 receptor agonist on insulin dosage and blood glucose control of patients with type 2 diabetes mellitus. |
2021-11-18 |
2023-08-13 |
Not clear |
| Haopeng Lin, Nancy Smith, Aliya F Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A Alghamdi, Sophie L Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E Manning Fox, Matthew J Merrins, Jean Buteau, Patrick E MacDonal. β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice. Diabetes. vol 70. issue 11. 2021-11-17. PMID:34462260. |
islet mass was not different, but insulin secretion and β-cell exocytotic responses to the glp-1 receptor agonist exendin-4 (ex4) and gip were impaired in islets lacking senp1. |
2021-11-17 |
2023-08-13 |
mouse |
| Alexandre Martchenko, Patricia Lee Brubake. Effects of Obesogenic Feeding and Free Fatty Acids on Circadian Secretion of Metabolic Hormones: Implications for the Development of Type 2 Diabetes. Cells. vol 10. issue 9. 2021-11-17. PMID:34571945. |
following introduction of the core biological clock and the hierarchical organization of the mammalian circadian system, the circadian regulation of normal l and β cell function and the importance of glp-1 and insulin in establishing metabolic control are discussed. |
2021-11-17 |
2023-08-13 |
Not clear |
| Xijun Zhang, Jianjun Yuan, Nanqian Zhou, Kaikai Shen, Yisa Wang, Ke Wang, Haohui Zh. Omarigliptin Prevents TNF-α-Induced Cellular Senescence in Rat Aorta Vascular Smooth Muscle Cells. Chemical research in toxicology. vol 34. issue 9. 2021-11-16. PMID:34382399. |
glucagon-like peptide-1 (glp-1) is an important incretin hormone involved in insulin release and vascular tone. |
2021-11-16 |
2023-08-13 |
rat |
| Rofida A Saleh, Tarek F Eissa, Dalaal M Abdallah, Muhammed A Saad, Hanan S El-Abha. Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34103557. |
peganum harmala enhanced glp-1 and restored insulin signaling to alleviate alcl peganum harmala (p. harmala) is a folk medicinal herb used in the sinai peninsula (egypt) as a remedy for central disorders. |
2021-11-15 |
2023-08-13 |
rat |
| Stefano Del Prato, Steven E Kahn, Imre Pavo, Govinda J Weerakkody, Zhengyu Yang, John Doupis, Diego Aizenberg, Alan G Wynne, Jeffrey S Riesmeyer, Robert J Heine, Russell J Wies. Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Lancet (London, England). vol 398. issue 10313. 2021-11-15. PMID:34672967. |
we aimed to assess efficacy and safety, with a special focus on cardiovascular safety, of the novel dual gip and glp-1 receptor agonist tirzepatide versus insulin glargine in adults with type 2 diabetes and high cardiovascular risk inadequately controlled on oral glucose-lowering medications. |
2021-11-15 |
2023-08-13 |
Not clear |