| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Chiara Pelle, Michele Provenzano, Isabella Zaffina, Roberta Pujia, Federica Giofrè, Stefania Lucà, Michele Andreucci, Angela Sciacqua, Franco Artur. Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054422. |
unlike glp-1, gip has little acute effect on insulin secretion and no effect on food intake; instead it seems that the gip may be an obesity-promoting hormone. |
2022-01-21 |
2023-08-13 |
Not clear |
| John R Ussher, Amanda A Greenwell, My-Anh Nguyen, Erin E Mulvihil. Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials. Diabetes. vol 71. issue 2. 2022-01-20. PMID:35050311. |
incretin hormones, including glp-1 (glucagon-like peptide 1) and gip (glucose-dependent insulinotropic polypeptide), are gut hormones secreted in response to nutrient intake that maintain glycemic control by regulating insulin and glucagon release. |
2022-01-20 |
2023-08-13 |
Not clear |
| Yuko Ohara Nemoto, Yu Shimoyama, Toshio Ono, Mohammad Tanvir Sarwar, Manami Nakasato, Minoru Sasaki, Takayuki K Nemot. Expanded substrate specificity supported by P1' and P2' residues enables bacterial dipeptidyl-peptidase 7 to degrade bioactive peptides. The Journal of biological chemistry. 2022-01-15. PMID:35032549. |
intravenous injection of dpp7 into mice orally administered glucose caused declines in plasma glp-1 and insulin, accompanied by increased blood glucose levels. |
2022-01-15 |
2023-08-13 |
mouse |
| Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisi. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008973. |
this study aimed to explore the roles of central glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic alzheimer's disease (sad). |
2022-01-11 |
2023-08-13 |
rat |
| Lucie Marousez, Léa Tran, Edwina Micours, Marie De Lamballerie, Frédéric Gottrand, Véronique Pierrat, Delphine Eberlé, Delphine Ley, Jean Lesag. Metabolic hormones in human breast milk are preserved by high hydrostatic pressure processing but reduced by Holder pasteurization. Food chemistry. vol 377. 2022-01-06. PMID:34990954. |
compared with raw dm, hop milk displayed reduced concentrations of insulin, nesfatin-1, cortisol, leptin, apelin and glp-1, though adiponectin levels were unchanged. |
2022-01-06 |
2023-08-13 |
human |
| Lucie Marousez, Léa Tran, Edwina Micours, Marie De Lamballerie, Frédéric Gottrand, Véronique Pierrat, Delphine Eberlé, Delphine Ley, Jean Lesag. Metabolic hormones in human breast milk are preserved by high hydrostatic pressure processing but reduced by Holder pasteurization. Food chemistry. vol 377. 2022-01-06. PMID:34990954. |
hhp processing maintained the levels of insulin, nesfatin-1, cortisol and leptin at their initial levels in raw dm, reduced apelin and adiponectin levels, but increased glp-1 level. |
2022-01-06 |
2023-08-13 |
human |
| Tomoyuki Hioki, Gen Kuroyanagi, Kazuhiko Fujita, Go Sakai, Tetsu Kawabata, Woo Kim, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa, Haruhiko Tokud. Incretins Enhance PGF2α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 54. issue 1. 2022-01-05. PMID:34986499. |
incretins including glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), which are secreted from the small intestine after oral food ingestion, are currently well-known to stimulate insulin secretion from pancreatic β-cells and used for the treatment of type 2 diabetes mellitus. |
2022-01-05 |
2023-08-13 |
Not clear |
| Laura N Deden, Jan Booij, Joanes Grandjean, Judith R Homberg, Eric J Hazebroek, Martin Gotthardt, Marti Bos. Brain Imaging of the GLP-1 Receptor in Obesity Using Brain sciences. vol 11. issue 12. 2021-12-24. PMID:34942949. |
brain imaging of the glp-1 receptor in obesity using stimulation of glucagon-like peptide-1 (glp-1) receptors increases the insulin release in the pancreas during high glucose levels, and also stimulates a feeling of satiety. |
2021-12-24 |
2023-08-13 |
Not clear |
| Amalia E Yanni, Panagiotis Konstantopoulos, Kleio Kartsioti, Panagiota Binou, Vaios Τ Karathanos, Artemis Chatzigeorgiou, Alexander Kokkino. Effects of 12-week, non-energy-restricted dietary intervention with conventional yogurt οn appetite hormone responses of type 2 diabetic patients. Food science & nutrition. vol 9. issue 12. 2021-12-20. PMID:34925790. |
at the beginning and the end of the intervention, a mixed meal tolerance test assessing the postprandial response of glucose, insulin, ghrelin, glucagon-like peptide-1 (glp-1), and peptide-yy (pyy) was performed. |
2021-12-20 |
2023-08-13 |
human |
| Amalia E Yanni, Panagiotis Konstantopoulos, Kleio Kartsioti, Panagiota Binou, Vaios Τ Karathanos, Artemis Chatzigeorgiou, Alexander Kokkino. Effects of 12-week, non-energy-restricted dietary intervention with conventional yogurt οn appetite hormone responses of type 2 diabetic patients. Food science & nutrition. vol 9. issue 12. 2021-12-20. PMID:34925790. |
area under the curve for glucose, insulin, ghrelin, glp-1, and pyy responses did not differ after the 12-week intervention with yogurt ( |
2021-12-20 |
2023-08-13 |
human |
| Kalie L Tommerdahl, Kristen J Nadeau, Petter Bjornsta. Mechanisms of Cardiorenal Protection of Glucagon-Like Peptide-1 Receptor Agonists. Advances in chronic kidney disease. vol 28. issue 4. 2021-12-19. PMID:34922690. |
glucagon-like peptide-1 (glp-1) receptor agonists (ras), incretin hormones that stimulate postprandial insulin secretion, serve as a promising avenue for treatment of t2d as they result in a variety of antihyperglycemic effects including increased endogenous insulin secretion, decreased gluconeogenesis, inhibition of pancreatic α-cell glucagon production, decreased pancreatic β-cell apoptosis, and increased β-cell proliferation. |
2021-12-19 |
2023-08-13 |
Not clear |
| Teng-Teng Li, Cheng Peng, Ji-Qiu Wang, Zhi-Jian Xu, Ming-Bo Su, Jia Li, Wei-Liang Zhu, Jing-Ya L. Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain. Acta pharmacologica Sinica. 2021-12-15. PMID:34907358. |
dipeptidyl peptidase-4 (dpp4) plays a crucial role in regulating the bioactivity of glucagon-like peptide-1 (glp-1) that enhances insulin secretion and pancreatic β-cell proliferation, making it a therapeutic target for type 2 diabetes. |
2021-12-15 |
2023-08-13 |
human |
| Oleg Kornyushin, Dmitry Sonin, Alexander Polozov, Vitaly Masley, Nika Bulavinova, Maria Chervyak, Maria Istomina, Daria Mukhametdinova, Alexander Neimark, Yuri Cheburkin, Yana Toropova, Kira Derkach, Alexander Shpakov, Michael Galagudza, Evgenyi Shlyakht. Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia-reperfusion injury in non-obese non-diabetic rats. Scientific reports. vol 11. issue 1. 2021-12-14. PMID:34903800. |
fasting plasma levels of glucagon-like peptide-1 (glp-1), leptin, ghrelin, and insulin were measured using elisa. |
2021-12-14 |
2023-08-13 |
rat |
| Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K Pasupulati, Simon S Evers, Ian J Sipula, Michael Jurczak, Randy J Seeley, Yatrik M Shah, Sadeesh K Ramakrishna. Intestinal HIF-2α regulates GLP-1 secretion via lipid sensing in L-cells. Cellular and molecular gastroenterology and hepatology. 2021-12-13. PMID:34902628. |
compelling evidence shows that glucagon-like peptide-1 (glp-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. |
2021-12-13 |
2023-08-13 |
Not clear |
| Eleonora Cremonini, Elena Daveri, Angela Mastaloudis, Patricia I Oteiz. (-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells. The Journal of nutrition. vol 151. issue 6. 2021-12-11. PMID:33693759. |
glp-1 regulates insulin secretion and overall glucose homeostasis. |
2021-12-11 |
2023-08-13 |
Not clear |
| Eleonora Cremonini, Elena Daveri, Angela Mastaloudis, Patricia I Oteiz. (-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells. The Journal of nutrition. vol 151. issue 6. 2021-12-11. PMID:33693759. |
the capacity of dietary bioactives to increase glp-1 circulating levels, and therefore increase insulin secretion and glucose metabolism, has gained significant interest of late. |
2021-12-11 |
2023-08-13 |
Not clear |
| Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C Kalior. Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity. Pharmacological research. vol 175. 2021-12-11. PMID:34798266. |
no differences in insulin, pyy, glp-1 and glicentin were observed. |
2021-12-11 |
2023-08-13 |
human |
| Cristian Guja, Francesco Giorgino, Lawrence Blonde, Amar Ali, Martin Prázný, Juris J Meier, Elisabeth Souhami, Robert Lubwama, Chen Ji, Julio Rosenstoc. Concomitant iGlarLixi and Sodium-Glucose Co-transporter-2 Inhibitor Therapy in Adults with Type 2 Diabetes: LixiLan-G Trial and Real-World Evidence Results. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2021-12-11. PMID:34894329. |
iglarlixi, the once-daily fixed-ratio combination of insulin glargine 100 u/ml and lixisenatide, robustly improves glycaemic control in adults with type 2 diabetes irrespective of previous treatment [oral antihyperglycaemic drugs (oads), basal insulin or glucagon-like peptide-1 receptor agonists (glp-1 ras)]. |
2021-12-11 |
2023-08-13 |
Not clear |
| Luís Maurício T R Lima, Luis Peña Icar. Amyloidogenicity of peptides targeting diabetes and obesity. Colloids and surfaces. B, Biointerfaces. vol 209. issue Pt 1. 2021-12-10. PMID:34715595. |
the focus on quality has shifted from impure and unstable preparations of animal insulin to highly pure, homologous recombinant insulin, along with other peptide-based hormones and analogs such as amylin analogs (pramlintide, davalintide, cagrilintide), glucagon and glucagon-like peptide-1 receptor agonists (glp-1, liraglutide, exenatide, semaglutide). |
2021-12-10 |
2023-08-13 |
Not clear |
| Sarah E Martchenko, Alexandre Martchenko, Andrew D Biancolin, Alison Waller, Patricia L Brubake. L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis. Molecular metabolism. vol 54. 2021-12-09. PMID:34520858. |
although glp-1 plays an essential role in metabolism through enhancement of both glucose-stimulated insulin secretion and satiety, recent evidence has also demonstrated its importance in regulating intestinal and microbial homeostasis. |
2021-12-09 |
2023-08-13 |
Not clear |