| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yalin Liu, Xianghang Lu. New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation. Frontiers of medicine. 2022-02-28. PMID:35226299. |
semaglutide is a kind of human glucagon-like peptide-1 (glp-1) analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism. |
2022-02-28 |
2023-08-13 |
human |
| Taichi Nagahisa, Shintaro Yamaguchi, Shotaro Kosugi, Koichiro Homma, Kazutoshi Miyashita, Junichiro Irie, Jun Yoshino, Hiroshi Ito. Intestinal epithelial NAD + biosynthesis regulates GLP-1 production and postprandial glucose metabolism in mice. Endocrinology. 2022-02-26. PMID:35218657. |
inko mice displayed diminished glucagon-like peptide-1 (glp-1) production, at least partly contributing to reduced early-phase insulin secretion and postprandial hyperglycemia. |
2022-02-26 |
2023-08-13 |
mouse |
| Sonya Vasto, Alessandra Amato, Patrizia Proia, Sara Baldassan. Is the Secret in the Gut? SuperJump Activity Improves Bone Remodeling and Glucose Homeostasis by GLP-1 and GIP Peptides in Eumenorrheic Women. Biology. vol 11. issue 2. 2022-02-25. PMID:35205162. |
the analysis was performed on blood samples and investigated glp-1, gip, glp-2, pyy, ghrelin, glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity. |
2022-02-25 |
2023-08-13 |
Not clear |
| Debra K M Tacad, Ashley P Tovar, Christine E Richardson, William F Horn, Giri P Krishnan, Nancy L Keim, Sridevi Krishna. Satiety Associated with Calorie Restriction and Time-restricted Feeding: Peripheral Hormones. Advances in nutrition (Bethesda, Md.). 2022-02-22. PMID:35191467. |
further, a reduction in fasting leptin, insulin, and glp-1 has been observed. |
2022-02-22 |
2023-08-13 |
Not clear |
| Debra K M Tacad, Ashley P Tovar, Christine E Richardson, William F Horn, Giri P Krishnan, Nancy L Keim, Sridevi Krishna. Satiety Associated with Calorie Restriction and Time-restricted Feeding: Peripheral Hormones. Advances in nutrition (Bethesda, Md.). 2022-02-22. PMID:35191467. |
in conclusion, when other determinants of food intake are held equal, the peripheral satiety systems appeared to be somewhat similarly affected by cr and trf with regard to leptin, insulin and glp-1. |
2022-02-22 |
2023-08-13 |
Not clear |
| Yolanda Diz-Chaves, Salvador Herrera-Pérez, Lucas C González-Matías, Federico Mall. Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus. Vitamins and hormones. vol 118. 2022-02-19. PMID:35180937. |
the glucagon-like peptide-1 (glp-1) is a pleiotropic hormone very well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. |
2022-02-19 |
2023-08-13 |
Not clear |
| Rumaisa Rashid, Suhail Ahmad Mir, Ozaifa Kareem, Tabassum Ali, Rifat Ara, Anjum Malik, Fiza Amin, G N Bade. Polycystic ovarian syndrome-current pharmacotherapy and clinical implications. Taiwanese journal of obstetrics & gynecology. vol 61. issue 1. 2022-02-19. PMID:35181044. |
our focus has been mainly on novel therapeutic modalities for treatment/management of pcos, like use of newer insulin sensitizers viz., inositols, glucagon-like peptide-1(glp-1) agonists, dipeptidyl pepdidase-4 (dpp-4) inhibitors, and sodium-glucose transport protein 2 (sglt2) inhibitors. |
2022-02-19 |
2023-08-13 |
Not clear |
| Liping Qiao, Sarah Saget, Cindy Lu, Tianyi Zang, Brianna Dzyuba, William W Hay, Jianhua Sha. The Essential Role of Pancreatic α-cells in Maternal Metabolic Adaptation to Pregnancy. Diabetes. 2022-02-11. PMID:35147704. |
however, glp-1 receptor agonist improved insulin production and glucose metabolism of α-null dams. |
2022-02-11 |
2023-08-13 |
mouse |
| Liping Qiao, Sarah Saget, Cindy Lu, Tianyi Zang, Brianna Dzyuba, William W Hay, Jianhua Sha. The Essential Role of Pancreatic α-cells in Maternal Metabolic Adaptation to Pregnancy. Diabetes. 2022-02-11. PMID:35147704. |
furthermore, glp-1 receptor antagonist exendin (9-39) attenuated pregnancy-enhanced insulin secretion and glp-1 restored glucose-induced insulin secretion of cultured islets from α-null dams. |
2022-02-11 |
2023-08-13 |
mouse |
| Richard M Bergenstal, Deborah M Mullen, Ellie Strock, Mary L Johnson, Min X X. Randomized comparison of self-monitored blood glucose (BGM) versus continuous glucose monitoring (CGM) data to optimize glucose control in type 2 diabetes. Journal of diabetes and its complications. 2022-02-08. PMID:35131155. |
methods-multi-arm parallel: trial of three type 2 diabetes (t2d) therapies ± metformin: (1) sulfonylurea (su), (2) incretin (dpp4 inhibitor or glp-1 agonist), or (3) insulin. |
2022-02-08 |
2023-08-13 |
human |
| Nathalie Esser, Stephen M Mongovin, Jacqueline Parilla, Breanne M Barrow, Thomas O Mundinger, Brendy S Fountaine, Megan J Larmore, Joseph J Castillo, Rehana Akter, Rebecca Hull, Sakeneh Zraik. Neprilysin Inhibition Improves Intravenous but not Oral Glucose-Mediated Insulin Secretion via GLP-1R Signaling in Mice with Beta-Cell Dysfunction. American journal of physiology. Endocrinology and metabolism. 2022-02-07. PMID:35128957. |
we sought to determine whether pharmacological neprilysin inhibition on its own confers beneficial effects on glycemic status and beta-cell function in a mouse model of reduced insulin secretion, and whether any such effects are dependent on glp-1 receptor (glp-1r) signaling. |
2022-02-07 |
2023-08-13 |
mouse |
| Florian Kahles, Matthias Rau, Martin Reugels, Ann C Foldenauer, Robert W Mertens, Maria C Arrivas, Jörg Schröder, Paul Idel, Julia Moellmann, Emiel P C van der Vorst, Nikolaus Marx, Michael Lehrk. The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury. Cardiovascular diabetology. vol 21. issue 1. 2022-02-06. PMID:35123462. |
the gut incretin hormones glp-1 (glucagon-like peptide-1) and gip (glucose-dependent insulinotropic peptide) are secreted by enteroendocrine cells following food intake leading to insulin secretion and glucose lowering. |
2022-02-06 |
2023-08-13 |
mouse |
| Thomas P J Solomon, Steven Carter, Jacob M Haus, Kristian Karstoft, Stephanie von Holstein-Rathlou, Mette S Nielsen, Matthew P Gillu. Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans. PeerJ. vol 10. 2022-02-03. PMID:35111398. |
plasma fgf21 concentrations are regulated by glucose independently of insulin and glp-1 in lean, healthy humans. |
2022-02-03 |
2023-08-13 |
Not clear |
| Thomas P J Solomon, Steven Carter, Jacob M Haus, Kristian Karstoft, Stephanie von Holstein-Rathlou, Mette S Nielsen, Matthew P Gillu. Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans. PeerJ. vol 10. 2022-02-03. PMID:35111398. |
this study aimed to determine whether fgf21 secretion is stimulated by elevations in plasma glucose, insulin, or glucagon-like peptide-1 (glp-1) in humans. |
2022-02-03 |
2023-08-13 |
Not clear |
| Erica Yeo, Patricia L Brubaker, Deborah M Slobod. The intestine and the microbiota in maternal glucose homeostasis during pregnancy. The Journal of endocrinology. 2022-01-31. PMID:35099411. |
specifically, we discuss how bacterial components and metabolites could facilitate the effects of the microbiota on host physiology, including nutrient absorption and glp-1 secretion and action, and whether these mechanisms may change maternal insulin sensitivity and secretion during pregnancy. |
2022-01-31 |
2023-08-13 |
Not clear |
| Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede, Oleg G Chepurny, Colin A Leech, George G Hol. Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon. The Journal of biological chemistry. vol 298. issue 2. 2022-01-27. PMID:34896391. |
we report that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and glp-1 receptors (gcgr and glp-1r), thereby conferring to rat islets their competence to exhibit first-phase glucose-stimulated insulin secretion (gsis). |
2022-01-27 |
2023-08-15 |
rat |
| Marthe Isaksen Aukan, Siren Nymo, Karoline Haagensli Ollestad, Guro Akersveen Boyesen, Julia Nicole DeBenedictis, Jens Frederik Rehfeld, Silvia Coutinho, Catia Martin. Differences in gastrointestinal hormones and appetite ratings among obesity classes. Appetite. 2022-01-22. PMID:35063622. |
body weight/composition, and basal and postprandial (after a 600 kcal fixed breakfast) plasma concentrations of acylated ghrelin, active glucagon-like peptide 1 (glp-1), total peptide yy (pyy), cholecystokinin (cck) and insulin, as well as subjective ratings of hunger, fullness, desire to eat (dte) and prospective food consumption (pfc) were measured. |
2022-01-22 |
2023-08-13 |
Not clear |
| Jinhua Zhang, Yuanzhen Dong, Yufeng He, Jinzhu Han, Haifeng Hu, Jun Fen. Efficient synthesis of Aib Journal of peptide science : an official publication of the European Peptide Society. 2022-01-22. PMID:35064598. |
efficient synthesis of aib glucagon-like peptide-1 (glp-1) is a potential therapeutic agent for treating type 2 diabetes, owing to its glucose-dependent capability to stimulate insulin secretion. |
2022-01-22 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantoni. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel, Switzerland). vol 10. issue 1. 2022-01-21. PMID:35052168. |
nutraceuticals that quell an increase in beta cell ros production, that amplify or mimic autocrine insulin signaling, or that boost glp-1 production, should help to maintain gsis and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. |
2022-01-21 |
2023-08-13 |
Not clear |
| Maria Chiara Pelle, Michele Provenzano, Isabella Zaffina, Roberta Pujia, Federica Giofrè, Stefania Lucà, Michele Andreucci, Angela Sciacqua, Franco Artur. Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054422. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are two gut hormones, defined incretins, responsible for the amplification of insulin secretion after oral glucose intake. |
2022-01-21 |
2023-08-13 |
Not clear |