| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuta Nakamura, Ichiro Horie, Kengo Kanetaka, Susumu Eguchi, Seiko Nakamichi, Ryoko Hongo, Miwa Takashima, Atsushi Kawakami, Norio Abir. Exenatide challenge in oral glucose tolerance test is insufficient for predictions of glucose metabolism and insulin secretion after sleeve gastrectomy (SG) in obese patients with type 2 diabetes: a pilot study to establish a preoperative model to estimate β-cell function following augmented glucagon-like peptide-1 secretion after SG. Endocrine journal. 2022-07-27. PMID:35896344. |
the significant decrease in glucose levels with enhanced secretions of insulin and glp-1 was observed in ogtt at 3 months after sg. |
2022-07-27 |
2023-08-14 |
Not clear |
| Andrew D Biancolin, Hyerin Jeong, Kimberly W Y Mak, Zixuan Yuan, Patricia L Brubake. Disrupted and elevated circadian secretion of glucagon-like peptide-1 in a murine model of type 2 diabetes. Endocrinology. 2022-07-25. PMID:35876276. |
metabolism and circadian rhythms are intimately linked, with circadian glucagon-like peptide-1 (glp-1) secretion by the intestinal l-cell entraining rhythmic insulin release. |
2022-07-25 |
2023-08-14 |
mouse |
| Hiroshi Miura, Naokazu Muramae, Kenta Mori, Kazunori Otsui, Kazuhiko Sakaguch. Successful Resolution of Glucose Toxicity With the Use of Fixed-Ratio Combination Injection of Basal Insulin and Short-Acting Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist. Cureus. vol 14. issue 6. 2022-07-18. PMID:35844351. |
successful resolution of glucose toxicity with the use of fixed-ratio combination injection of basal insulin and short-acting glucagon-like peptide 1 (glp-1) receptor agonist. |
2022-07-18 |
2023-08-14 |
Not clear |
| Hiroshi Miura, Naokazu Muramae, Kenta Mori, Kazunori Otsui, Kazuhiko Sakaguch. Successful Resolution of Glucose Toxicity With the Use of Fixed-Ratio Combination Injection of Basal Insulin and Short-Acting Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist. Cureus. vol 14. issue 6. 2022-07-18. PMID:35844351. |
we present a case involving the successful resolution of glucose toxicity easily, immediately, and safely by using a fixed-ratio combination (frc) injection of basal insulin and short-acting glucagon-like peptide 1 (glp-1) receptor agonists (glp-1 ra). |
2022-07-18 |
2023-08-14 |
Not clear |
| Areeba Javed, Ayman Muzammal, Muhammad Sajid Hamid Akash, Kanwal Rehma. Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion. Dose-response : a publication of International Hormesis Society. vol 20. issue 3. 2022-07-14. PMID:35832769. |
further, co-administration of lut and res with dpp-4i revealed beneficial effects on measures of insulin resistance, circulating lipids, glycemic index, oxidative stress, and inflammatory status along with restoration of histological morphology of pancreatic cells and enterocytes that seemed to improve the level of glp-1. |
2022-07-14 |
2023-08-14 |
rat |
| Yahiya Y Sye. Tirzepatide: First Approval. Drugs. 2022-07-13. PMID:35830001. |
native gip and glp-1 are incretin hormones that stimulate insulin secretion and decrease glucagon secretion. |
2022-07-13 |
2023-08-14 |
Not clear |
| Vivek P Chavda, Jinal Ajabiya, Divya Teli, Joanna Bojarska, Vasso Apostolopoulo. Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807558. |
tirzepatide, known as a 'twincretin', is a 'first-in-class' and the only dual glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) receptor agonist, that can significantly reduce glycemic levels and improve insulin sensitivity, as well as reducing body weight by more than 20% and improving lipid metabolism. |
2022-07-09 |
2023-08-14 |
human |
| Sarah C Nyirjesy, Amy J Peleckis, Jack N Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J Flatt, Diva D De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A D'Alessio, Ronald C Rubenstein, Andrea Kelly, Michael R Rickel. Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis. Diabetes. 2022-07-07. PMID:35796669. |
in pi-cf with agt, glp-1 substantially augmented second-phase insulin secretion, but without effect on the acute insulin response to gpa or the proinsulin secretory ratio (pisr), while gip infusion did not enhance second phase or gpa-induced insulin secretion but increased the pisr. |
2022-07-07 |
2023-08-14 |
Not clear |
| Sarah C Nyirjesy, Amy J Peleckis, Jack N Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J Flatt, Diva D De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A D'Alessio, Ronald C Rubenstein, Andrea Kelly, Michael R Rickel. Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis. Diabetes. 2022-07-07. PMID:35796669. |
these data indicate that glp-1, but not gip, augments glucose-dependent insulin secretion in pi-cf, supporting the likelihood that glp-1 agonists could have therapeutic benefit in this population. |
2022-07-07 |
2023-08-14 |
Not clear |
| Youngsook Kim, Ji Hye Huh, Minyoung Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Le. Tolerability and Effectiveness of Switching to Dulaglutide in Patients With Type 2 Diabetes Inadequately Controlled With Insulin Therapy. Frontiers in endocrinology. vol 13. 2022-07-05. PMID:35784534. |
however, few studies have investigated the effects of switching from insulin to glp-1 receptor agonists. |
2022-07-05 |
2023-08-14 |
Not clear |
| Sebastian Ciężki, Emilia Kurpiewska, Artur Bossowski, Barbara Głowińska-Olszewsk. Multi-Faceted Influence of Obesity on Type 1 Diabetes in Children - From Disease Pathogenesis to Complications. Frontiers in endocrinology. vol 13. 2022-07-05. PMID:35784568. |
recently treatment of insulin resistance with biguanids, and treatment with typical for type 2 new diabetes drugs like glp-1 analogues, sglt-2 receptor inhibitors, or even cases of bariatric surgery also has been reported. |
2022-07-05 |
2023-08-14 |
Not clear |
| Amela Dizdarevic Bostandzic, Vanja Karlovic Beslic, Ismana Surkovic, Sefkija Balic, Tanja Dujic, Zelija Velija Asimi, Azra Burekovi. IDegLira Improves Metabolic Control in Patients with Type 2 Diabetes Previously Treated with Premix Insulin. Medical archives (Sarajevo, Bosnia and Herzegovina). vol 76. issue 2. 2022-07-01. PMID:35774039. |
ideglira( fixed combination of glp 1 receptor agonist and insulin) has been shown to be effective in improving the glucoregulation in patients previously treated with oral therapy as well as individual components, glp-1 receptor agonist or basal insulin. |
2022-07-01 |
2023-08-14 |
Not clear |
| Sarah M Gray, Andrew L Hoselton, Radha Krishna, Cris A Slentz, David A D'Alessi. GLP-1 receptor blockade reduces stimulated insulin secretion in fasted subjects with low circulating GLP-1. The Journal of clinical endocrinology and metabolism. 2022-07-01. PMID:35775723. |
glp-1 receptor blockade reduces stimulated insulin secretion in fasted subjects with low circulating glp-1. |
2022-07-01 |
2023-08-14 |
human |
| Sarah M Gray, Andrew L Hoselton, Radha Krishna, Cris A Slentz, David A D'Alessi. GLP-1 receptor blockade reduces stimulated insulin secretion in fasted subjects with low circulating GLP-1. The Journal of clinical endocrinology and metabolism. 2022-07-01. PMID:35775723. |
glucagon-like peptide 1 (glp-1), an insulinotropic peptide released into the circulation from intestinal enteroendocrine cells, is considered a hormonal mediator of insulin secretion. |
2022-07-01 |
2023-08-14 |
human |
| Mengyang Wang, Fan Yang, Xiang Yan, Xinyu Chao, Wencheng Zhang, Chuanxun Yuan, Qingmei Zen. Anti-diabetic effect of banana peel dietary fibers on type 2 diabetic mellitus mice induced by streptozotocin and high-sugar and high-fat diet. Journal of food biochemistry. 2022-06-29. PMID:35765856. |
after 5 weeks of intervention with banana peel dietary fibers (bp-dfs), food intake was reduced, body weight was increased, blood lipids and glucose were reduced, fasting insulin and glp-1 levels were increased, and liver and pancreatic tissue damage was reduced. |
2022-06-29 |
2023-08-14 |
mouse |
| Zonghao Yue, Yanjuan Chen, Qian Dong, Dan Li, Meng Guo, Li Zhang, Yini Shi, Huiting Wu, Lili Li, Zhongke Su. Acrylamide induced glucose metabolism disorder in rats involves gut microbiota dysbiosis and changed bile acids metabolism. Food research international (Ottawa, Ont.). vol 157. 2022-06-28. PMID:35761659. |
further analysis indicated that bas sensing nuclear receptor farnesoid x receptor (fxr) gene was activated and glucagon-like peptide-1 (glp-1) which stimulates insulin secretion was downregulated. |
2022-06-28 |
2023-08-14 |
rat |
| Viktor V Smirnov, Narasimha M Beeraka, Dmitry Yu Butko, Vladimir N Nikolenko, Sergey A Bondarev, Evgeniy E Achkasov, Mikhail Y Sinelnikov, P R Hemanth Sinelniko. Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS. Reproductive sciences (Thousand Oaks, Calif.). 2022-06-28. PMID:35764857. |
glp-1 agonists, insulin sensitizers (metformin), and diet and exercise regimens efficacy were explained in enhancing the fertility outcomes among the overweight or obese females with pcos. |
2022-06-28 |
2023-08-14 |
Not clear |
| Hui-Jun Liao, Jason T C Tze. Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Metabolites. vol 12. issue 6. 2022-06-23. PMID:35736482. |
investigating potential glp-1 receptor agonists in cyclopeptides from glp-1 receptor agonists stimulate glp-1r to promote insulin secretion, whereas dpp4 inhibitors slow glp-1 degradation. |
2022-06-23 |
2023-08-14 |
Not clear |
| Manuel Blandino-Rosano, Joshua O Scheys, Joao Pedro Werneck-de-Castro, Ruy A Louzada, Joana Almaca, Gil Leibowitz, Markus A Ruegg, Michael N Hall, Ernesto Bernal-Mizrach. Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. American journal of physiology. Endocrinology and metabolism. 2022-06-20. PMID:35723227. |
mechanistically, glucagon-like peptide-1 (glp-1), but not gastric inhibitory polypeptide (gip), rescued insulin secretion in vivo and in vitro by improving actin polymerization in βricko islets. |
2022-06-20 |
2023-08-14 |
mouse |
| Man Zhang, Yining Zhang, Xiaohong Peng, Anshun He, Yue Wang, Ying Deng, Cheng Cui, Fangkai Xue, Bing Wei, Wancai Xing, Yuzhen Qian, Michelle Mazuranic, Wei Che. GZR18, a novel long-acting GLP-1 analog, demonstrated positive in vitro and in vivo pharmacokinetic and pharmacodynamic characteristics in animal models. European journal of pharmacology. 2022-06-19. PMID:35718129. |
in vitro pharmacology and activity of gzr18 were characterized by a binding assay of gzr18 using human serum albumin (hsa), an activation assay in human glp-1 receptor-expressing cell lines, and its effect on glucose-stimulated insulin secretion (gsis) in primary mice islets. |
2022-06-19 |
2023-08-14 |
mouse |