| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoxia Ji, Qinghua Guo, Qidi Xue, Ruifang Kong, Shiben Wang, Kang Lei, Renmin Liu, Xuekun Wan. Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes. Molecules (Basel, Switzerland). vol 26. issue 22. 2021-11-30. PMID:34833999. |
glp-1, as an incretin, can enhance glucose-dependent secretion of insulin from pancreatic beta cells and reduce blood glucose. |
2021-11-30 |
2023-08-13 |
Not clear |
| Feng Zhang, Zhinan Chen, Dan Wu, Le Tian, Qing Chen, Yuqing Ye, Wei Chen, Xiaoxing Wu, Peng Wu, Weilan Yuan, Yan Qiu, Zhiguang Zhou, Zhiqiang Du, Fang H. Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice. iScience. vol 24. issue 12. 2021-11-30. PMID:34841227. |
the aim of this study was to determine the action of recombinant human glp-1 (rhglp-1) beinaglutide (bn) in the insulin sensitivity and lipid metabolism of adipose tissues. |
2021-11-30 |
2023-08-13 |
mouse |
| Hiroyuki Nakamori, Koji Iida, Hikaru Hashitan. Mechanisms underlying the prokinetic effects of endogenous glucagon-like peptide-1 in the rat proximal colon. American journal of physiology. Gastrointestinal and liver physiology. vol 321. issue 6. 2021-11-29. PMID:34643099. |
glucagon-like peptide-1 (glp-1), a well-known insulin secretagogue, is released from enteroendocrine l cells both luminally and basolaterally to exert different effects. |
2021-11-29 |
2023-08-13 |
rat |
| Safaa M Awad, Nora M El-Sheikh, Hanem Abdel-Sabour Ali, Huda M Ismail Abo El-Fad. Moringa, Rosemary and Purslane Leaves Extracts Alleviate Metabolic Syndrome in Rats Induced by High Fat-High Fructose Diet. Pakistan journal of biological sciences : PJBS. vol 24. issue 10. 2021-11-29. PMID:34842371. |
some anthropometric measurements (bmi, lee index and adiposity index), biochemical parameters such as glucose hemostasis parameters (glucose, insulin, homa-ir and glp-1), lipids profile (tags, tc, ldl-c, hdl-c, free fatty acids, apo-b and apo a1), adipokines (leptin and adiponectin), some inflammatory markers (tnf-α and il-6) and oxidative stress markers (pcc, no and mda), some anti-oxidant markers (gsh, cat and taoc) as well as, the gene expression level of endothelial nitric oxide synthase were determined. |
2021-11-29 |
2023-08-13 |
rat |
| Ying Zhao, Yan Shu, Ning Zhao, Zili Zhou, Xiong Jia, Chenxing Jian, Si Ji. Insulin resistance induced by long-term sleep deprivation in rhesus macaques can be attenuated by Bifidobacterium. American journal of physiology. Endocrinology and metabolism. 2021-11-29. PMID:34843659. |
the incretin hormone, glucagon-like peptide-1 (glp-1), is a critical insulin release determinant secreted by the intestinal l-cell upon food intake. |
2021-11-29 |
2023-08-13 |
monkey |
| Bo Ahré. Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice. Peptides. vol 146. 2021-11-26. PMID:34547355. |
we evaluated effects of glp-1 on the insulin response to a gradual increase in glucose in mice within physiological levels. |
2021-11-26 |
2023-08-13 |
mouse |
| Bo Ahré. Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice. Peptides. vol 146. 2021-11-26. PMID:34547355. |
glp-1 at 0.5 nmol/kg as bolus plus 0.3 nmol/kg/min over 40 min progressively increased this insulin response by 100-fold, to 9.5 ± 0.2 nmol/l (p < 0.001). |
2021-11-26 |
2023-08-13 |
mouse |
| Bo Ahré. Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice. Peptides. vol 146. 2021-11-26. PMID:34547355. |
higher doses of glp-1 enhanced the insulin response similarly (1.0 or 3.0 nmol/kg bolus followed by 0.4 or 1.2 nmol/kg/min), whereas a lower dose (0.3 nmol/kg bolus plus 0.15 nmol/kg/min) had no significant effect compared to controls. |
2021-11-26 |
2023-08-13 |
mouse |
| Bo Ahré. Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice. Peptides. vol 146. 2021-11-26. PMID:34547355. |
moreover, there was no significant difference in insulin responses between controls and glp-1 receptor knockout mice. |
2021-11-26 |
2023-08-13 |
mouse |
| Bo Ahré. Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice. Peptides. vol 146. 2021-11-26. PMID:34547355. |
we also conclude that glp-1 is extraordinarily potent in enhancing the insulin response to a slow increase in glucose levels. |
2021-11-26 |
2023-08-13 |
mouse |
| Ayse G Zengul, Sarah Et Hoover, Paula C Chandler-Lane. Secondary analysis of gut hormone data from children with and without in utero exposure to gestational diabetes: Differences in the associations among ghrelin, GLP-1, and insulin secretion. Pediatric obesity. vol 16. issue 6. 2021-11-25. PMID:33236516. |
secondary analysis of gut hormone data from children with and without in utero exposure to gestational diabetes: differences in the associations among ghrelin, glp-1, and insulin secretion. |
2021-11-25 |
2023-08-13 |
Not clear |
| Ayse G Zengul, Sarah Et Hoover, Paula C Chandler-Lane. Secondary analysis of gut hormone data from children with and without in utero exposure to gestational diabetes: Differences in the associations among ghrelin, GLP-1, and insulin secretion. Pediatric obesity. vol 16. issue 6. 2021-11-25. PMID:33236516. |
ghrelin and glp-1 have opposite functions in nutritional homeostasis and are associated with insulin secretion, but it is not known if individuals exposed to gdm exhibit dysregulation in these associations. |
2021-11-25 |
2023-08-13 |
Not clear |
| Fajar Husen, Hernayanti Hernayanti, Nuraeni Ekowati, Dalia Sukmawati, Nuniek Ina Ratnaningtya. Antidiabetic Effects and Antioxidant Properties of the Saggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), in Streptozotocin-Induced Hyperglycemic Rats. International journal of medicinal mushrooms. vol 23. issue 10. 2021-11-25. PMID:34595888. |
antidiabetic effects of alkaloids and saponin were seen in blood glucose and glycated hemoglobin (hba1c) degradation, increased insulin, and increased inhibition of glp-1 through dipeptidyl peptidase-4 activity. |
2021-11-25 |
2023-08-13 |
rat |
| Fajar Husen, Hernayanti Hernayanti, Nuraeni Ekowati, Dalia Sukmawati, Nuniek Ina Ratnaningtya. Antidiabetic Effects and Antioxidant Properties of the Saggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), in Streptozotocin-Induced Hyperglycemic Rats. International journal of medicinal mushrooms. vol 23. issue 10. 2021-11-25. PMID:34595888. |
the 250-mg dose was effective in increasing insulin (8.11 mlu/ml) and reducing blood glucose (23.92%) and hba1c (3.775%), whereas the 500-mg dose was effective in increasing levels of glp-1 (1056.923 ng/l) and gsh (4.62 μmol/l). |
2021-11-25 |
2023-08-13 |
rat |
| Cristian Sandoval, Sybella Santibañez, Francisca Villagrá. Effectiveness of intermittent fasting to potentiate weight loss or muscle gains in humans younger than 60 years old: a systematic review. International journal of food sciences and nutrition. vol 72. issue 6. 2021-11-24. PMID:33397167. |
intermittent fasting could be beneficial in resistance trained subjects or in overweight individuals to improve body composition by decreasing fat mass and at least maintain muscle mass; decrease in glp-1 levels and; improving health-related biomarkers such glucose and insulin levels. |
2021-11-24 |
2023-08-13 |
human |
| Brie Sorrenson, Waruni C Dissanayake, Fengyun Hu, Kate L Lee, Peter R Shepher. A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. The Biochemical journal. vol 478. issue 8. 2021-11-22. PMID:33605402. |
we find that reduction in pak1 levels using sirna attenuates both glucose and glp-1 stimulated phosphorylation of β-catenin ser552 and the effects of these on insulin secretion in β-cell models. |
2021-11-22 |
2023-08-13 |
mouse |
| - Ruqaya, Mohammad Saleh Soomro, Nazish Waris, Iftikhar Ahmed Siddiqui, Asher Fawwad, Abdul Basi. Glucagon-like peptide 1 and its association with dipeptidyl peptidase IV in subjects with various degrees of glucose tolerance. Pakistan journal of pharmaceutical sciences. vol 33. issue 6(Supplementary). 2021-11-22. PMID:33879436. |
dipeptidyl peptidase iv (dpp-4) and glucagon like peptide 1 (glp-1) has profound effect on insulin and glucagon secretion; ultimately decreasing glucose levels. |
2021-11-22 |
2023-08-13 |
human |
| . Expanding access to newer medicines for people with type 2 diabetes in low-income and middle-income countries: a cost-effectiveness and price target analysis. The lancet. Diabetes & endocrinology. vol 9. issue 12. 2021-11-22. PMID:34656210. |
for patients with type 2 diabetes in low-income and middle-income countries (lmics), access to newer antidiabetic drugs (eg, sodium-glucose co-transporter-2 [sglt2] inhibitors, glucagon-like peptide-1 [glp-1] receptor agonists, and insulin analogues) could reduce the incidence of diabetes-related complications. |
2021-11-22 |
2023-08-13 |
Not clear |
| Ji Yeon Park, Oh Kyoung Kwon, Jae-Han Jeon, Yeon-Kyung Choi, Ki Bum Par. Impact of the different biliopancreatic limb length on diabetes and incretin hormone secretion following distal gastrectomy in gastric cancer patients. Scientific reports. vol 11. issue 1. 2021-11-21. PMID:34789863. |
serum glucose, insulin, glucagon, glucagon-like peptide-1 (glp-1), and glucose-dependent insulinotropic polypeptide (gip) were serially measured. |
2021-11-21 |
2023-08-13 |
Not clear |
| Priska Stahel, Changting Xiao, Avital Nahmias, Lili Tian, Gary Franklin Lewi. Multi-organ Coordination of Lipoprotein Secretion by Hormones, Nutrients and Neural Networks. Endocrine reviews. vol 42. issue 6. 2021-11-20. PMID:33743013. |
hormones and peptides originating from the pancreas (insulin, glucagon), gut [glucagon-like peptide 1 (glp-1) and 2 (glp-2), ghrelin, cholecystokinin (cck), peptide yy], adipose tissue (leptin, adiponectin) and brain (glp-1) modulate trl secretion by receptor-mediated responses and indirectly via neural networks. |
2021-11-20 |
2023-08-13 |
Not clear |