| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine Tomaro-Duchesneau, Stephanie L LeValley, Daniel Roeth, Liang Sun, Frank T Horrigan, Markus Kalkum, Joseph M Hyser, Robert A Britto. Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease. Scientific reports. vol 10. issue 1. 2020-11-23. PMID:32188864. |
glucagon-like peptide-1 (glp-1), an incretin secreted by l-cells lining the gastrointestinal epithelium, has important functions: promoting insulin secretion, insulin sensitivity, and β-cell mass, while inhibiting gastric emptying and appetite. |
2020-11-23 |
2023-08-13 |
mouse |
| Raphael Alhadeff, Arieh Warshe. A free-energy landscape for the glucagon-like peptide 1 receptor GLP1R. Proteins. vol 88. issue 1. 2020-11-20. PMID:31294890. |
the glucagon-like peptide 1 (glp-1) hormone receptor glp1r is closely involved in insulin secretion by pancreatic β-cells and constitutes a major druggable target for the development of anti-diabetes and obesity agents. |
2020-11-20 |
2023-08-13 |
human |
| Mariana Igoillo-Esteve, Ana F Oliveira, Cristina Cosentino, Federica Fantuzzi, Céline Demarez, Sanna Toivonen, Amélie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, Décio L Eizirik, Miriam Cno. Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia. JCI insight. vol 5. issue 2. 2020-11-20. PMID:31877117. |
the glp-1 analog exenatide improved glucose homeostasis of frataxin-deficient mice through enhanced insulin content and secretion in pancreatic β cells. |
2020-11-20 |
2023-08-13 |
mouse |
| Arnaldo Henrique de Souza, Jiayin Tang, Amanjot Kaur Yadev, Samuel T Saghafi, Carly R Kibbe, Amelia K Linnemann, Matthew J Merrins, Dawn Belt Davi. Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets. Scientific reports. vol 10. issue 1. 2020-11-19. PMID:32071395. |
interestingly, while glp-1 is well known to stimulate insulin secretion by the pancreatic β-cells, direct evidence of cck promoting insulin release in human islets remains to be determined. |
2020-11-19 |
2023-08-13 |
mouse |
| Arnaldo Henrique de Souza, Jiayin Tang, Amanjot Kaur Yadev, Samuel T Saghafi, Carly R Kibbe, Amelia K Linnemann, Matthew J Merrins, Dawn Belt Davi. Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets. Scientific reports. vol 10. issue 1. 2020-11-19. PMID:32071395. |
here, we tested whether islet-derived glp-1 or cck is necessary for the full stimulation of insulin secretion. |
2020-11-19 |
2023-08-13 |
mouse |
| Arnaldo Henrique de Souza, Jiayin Tang, Amanjot Kaur Yadev, Samuel T Saghafi, Carly R Kibbe, Amelia K Linnemann, Matthew J Merrins, Dawn Belt Davi. Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets. Scientific reports. vol 10. issue 1. 2020-11-19. PMID:32071395. |
we confirm that mouse pancreatic islets secrete glp-1 and cck, but only glp-1 acts locally within the islet to promote insulin release ex vivo. |
2020-11-19 |
2023-08-13 |
mouse |
| Arnaldo Henrique de Souza, Jiayin Tang, Amanjot Kaur Yadev, Samuel T Saghafi, Carly R Kibbe, Amelia K Linnemann, Matthew J Merrins, Dawn Belt Davi. Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets. Scientific reports. vol 10. issue 1. 2020-11-19. PMID:32071395. |
in summary, our data suggest no direct role for cck in stimulating insulin secretion and highlight the critical role of intra-islet glp-1 signaling in the regulation of human β-cell function. |
2020-11-19 |
2023-08-13 |
mouse |
| Eugene E Wright, Vanita R Arod. Clinical review of the efficacy and safety of oral semaglutide in patients with type 2 diabetes considered for injectable GLP-1 receptor agonist therapy or currently on insulin therapy. Postgraduate medicine. vol 132. issue sup2. 2020-11-09. PMID:32815423. |
clinical review of the efficacy and safety of oral semaglutide in patients with type 2 diabetes considered for injectable glp-1 receptor agonist therapy or currently on insulin therapy. |
2020-11-09 |
2023-08-13 |
Not clear |
| Stephen A Brunton, Carol H Wysha. GLP-1 receptor agonists in the treatment of type 2 diabetes: role and clinical experience to date. Postgraduate medicine. vol 132. issue sup2. 2020-11-09. PMID:32815454. |
glucagon-like peptide-1 (glp-1) is a hormone of the incretin system responsible for a variety of glucoregulatory effects, including glucose-dependent secretion of insulin and inhibition of glucagon release, the effects of which are impaired in people with type 2 diabetes (t2d). |
2020-11-09 |
2023-08-13 |
Not clear |
| Dawood Khan, Ryan Kelsey, Rashmi R Maheshwari, Virginia M Stone, Annie Hasib, Fiona N Manderson Koivula, Aoife Watson, Stephen Harkin, Nigel Irwin, James A Shaw, Neville H McClenaghan, Viktória Venglovecz, Attila Ébert, Malin Flodström-Tullberg, Michael G White, Catriona Kell. Short-term CFTR inhibition reduces islet area in C57BL/6 mice. Scientific reports. vol 9. issue 1. 2020-11-06. PMID:31375720. |
temporary cftr inhibition had little long-term impact on glucose-stimulated, or glp-1 potentiated insulin secretion. |
2020-11-06 |
2023-08-13 |
mouse |
| Erina Albinsson-Stenholm, Johannes Bergsén, Simon Ingves, Nathalie Vilhelmsson, Hans Guldbrand, Fredrik H Nystro. Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin. Nutrition research (New York, N.Y.). vol 72. 2020-11-03. PMID:31759769. |
subjects with high fasting insulin also have higher postprandial glp-1 and glucagon levels than controls with lower insulin. |
2020-11-03 |
2023-08-13 |
human |
| Erina Albinsson-Stenholm, Johannes Bergsén, Simon Ingves, Nathalie Vilhelmsson, Hans Guldbrand, Fredrik H Nystro. Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin. Nutrition research (New York, N.Y.). vol 72. 2020-11-03. PMID:31759769. |
little is known about postprandial release of serum ghrelin, glucagon, and glucagon-like peptide-1 (glp-1) in relation with differing fasting insulin levels. |
2020-11-03 |
2023-08-13 |
human |
| Erina Albinsson-Stenholm, Johannes Bergsén, Simon Ingves, Nathalie Vilhelmsson, Hans Guldbrand, Fredrik H Nystro. Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin. Nutrition research (New York, N.Y.). vol 72. 2020-11-03. PMID:31759769. |
we hypothesized that these hormones are affected by insulin resistance, and hence, we compared different postprandial responses of glp-1, glucagon, and ghrelin in subjects with relatively high (rhi) or relatively low (rli) fasting insulin levels. |
2020-11-03 |
2023-08-13 |
human |
| Erina Albinsson-Stenholm, Johannes Bergsén, Simon Ingves, Nathalie Vilhelmsson, Hans Guldbrand, Fredrik H Nystro. Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin. Nutrition research (New York, N.Y.). vol 72. 2020-11-03. PMID:31759769. |
thus, subjects with rhi displayed both higher postprandial serum glp-1 and glucagon than the participants with rli, suggesting that glucagon could play a role in the advent of dysglycemia by insulin resistance. |
2020-11-03 |
2023-08-13 |
human |
| Ghulam Abbas, Quazi M I Haq, Ahmad Hamaed, Mohammed Al-Sibani, Hidayat Hussai. Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets for an Effective Management of Diabetes Mellitus. Current pharmaceutical design. vol 26. issue 4. 2020-11-03. PMID:32003684. |
along with insulin, glucagon and glp-1 are critical hormones for maintaining normal serum glucose within the human body. |
2020-11-03 |
2023-08-13 |
human |
| Ghulam Abbas, Quazi M I Haq, Ahmad Hamaed, Mohammed Al-Sibani, Hidayat Hussai. Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets for an Effective Management of Diabetes Mellitus. Current pharmaceutical design. vol 26. issue 4. 2020-11-03. PMID:32003684. |
glp-1 is secreted by the l-cells of the small intestine to stimulate insulin secretion and inhibit glucagon action. |
2020-11-03 |
2023-08-13 |
human |
| Alexandra Camara, Adronie Verbrugghe, Cara Cargo-Froom, Kylie Hogan, Trevor J DeVries, Andrea Sanchez, Lindsay E Robinson, Anna K Shovelle. The daytime feeding frequency affects appetite-regulating hormones, amino acids, physical activity, and respiratory quotient, but not energy expenditure, in adult cats fed regimens for 21 days. PloS one. vol 15. issue 9. 2020-10-29. PMID:32946478. |
on day 14, two fasted and 11 postprandial blood samples were collected over 24 hours to measure plasma concentrations of ghrelin, glp-1, gip, leptin, pyy, insulin and amino acids, and whole blood glucose. |
2020-10-29 |
2023-08-13 |
cat |
| Mattea Müller, Manuel A González Hernández, Gijs H Goossens, Dorien Reijnders, Jens J Holst, Johan W E Jocken, Hans van Eijk, Emanuel E Canfora, Ellen E Blaa. Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans. Scientific reports. vol 9. issue 1. 2020-10-28. PMID:31467327. |
circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and glp-1 concentrations in humans. |
2020-10-28 |
2023-08-13 |
human |
| Nils B Jørgensen, Kirstine N Bojsen-Møller, Carsten Dirksen, Christoffer Martinussen, Maria S Svane, Viggo B Kristiansen, Jens J Holst, Sten Madsba. Sustained Improvements in Glucose Metabolism Late After Roux-En-Y Gastric Bypass Surgery in Patients with and Without Preoperative Diabetes. Scientific reports. vol 9. issue 1. 2020-10-28. PMID:31641146. |
glycemic control, insulin resistance, beta-cell function and glp-1 remained improved late after surgery in both groups. |
2020-10-28 |
2023-08-13 |
human |
| Antonello E Rigamonti, Sofia Tamini, Sabrina Cicolini, Alessandra De Col, Diana Caroli, Stefania Mai, Eugenia Rondinelli, Antonella Saezza, Silvano G Cella, Alessandro Sartori. Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal. Journal of clinical medicine. vol 9. issue 9. 2020-10-28. PMID:32971830. |
the aim of the present study was to evaluate the effects of an amino acid mix (l-arginine + l-leucine + l-glutamine + l-tryptophan) on the secretion of some gastrointestinal peptides (i.e., ghrelin and glucagon-like peptide type 1, glp-1), glucometabolic homeostasis (i.e., glucose, insulin, and glucagon), and appetite (hunger/satiety scored by visual analogue scale, vas) in obese adolescents ( |
2020-10-28 |
2023-08-13 |
human |