| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuejun Victor Peng, Rory J McCrimmon, Leah Shepherd, Anders Boss, Robert Lubwama, Terry Dex, Neil Skolnik, Linong Ji, Angelo Avogaro, Lawrence Blond. Glycemic Control Following GLP-1 RA or Basal Insulin Initiation in Real-World Practice: A Retrospective, Observational, Longitudinal Cohort Study. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 11. issue 11. 2020-10-20. PMID:32902774. |
glycemic control following glp-1 ra or basal insulin initiation in real-world practice: a retrospective, observational, longitudinal cohort study. |
2020-10-20 |
2023-08-13 |
Not clear |
| Xuejun Victor Peng, Rory J McCrimmon, Leah Shepherd, Anders Boss, Robert Lubwama, Terry Dex, Neil Skolnik, Linong Ji, Angelo Avogaro, Lawrence Blond. Glycemic Control Following GLP-1 RA or Basal Insulin Initiation in Real-World Practice: A Retrospective, Observational, Longitudinal Cohort Study. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 11. issue 11. 2020-10-20. PMID:32902774. |
injectable therapies such as glucagon-like peptide-1 receptor agonists (glp-1 ras) and basal insulin (bi) are well-established agents for people with type 2 diabetes (t2d). |
2020-10-20 |
2023-08-13 |
Not clear |
| Valerie D Heuvelman, Daniël H Van Raalte, Mark M Smit. Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes. Cardiovascular research. vol 116. issue 5. 2020-10-19. PMID:31825468. |
glp-1 reduces blood glucose levels by stimulating insulin secretion, however, it is rapidly degraded, and thereby losing its glycaemic effect. |
2020-10-19 |
2023-08-13 |
human |
| Hirofumi Nohara, Ryunosuke Nakashima, Shunsuke Kamei, Haruka Fujikawa, Keiko Ueno-Shuto, Taisei Kawakami, Yuka Eto, Mary Ann Suico, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shut. Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases. Biochemical and biophysical research communications. vol 524. issue 2. 2020-10-16. PMID:31996306. |
glucagon-like peptide-1 (glp-1) is a gastrointestinal hormone that stimulates glucose-mediated insulin production by pancreatic beta cells. |
2020-10-16 |
2023-08-13 |
mouse |
| Fahima Mayer, Amanda L Gunawan, Patrick Tso, Gregory W Apont. Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves. American journal of physiology. Gastrointestinal and liver physiology. vol 319. issue 1. 2020-10-16. PMID:32421358. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are released from enteroendocrine cells (eecs) in response to nutrient ingestion and lower blood glucose levels by stimulation of insulin secretion and thus are defined as incretins. |
2020-10-16 |
2023-08-13 |
Not clear |
| Lu Zhu, Diptadip Dattaroy, Jonathan Pham, Lingdi Wang, Luiz F Barella, Yinghong Cui, Kenneth J Wilkins, Bryan L Roth, Ute Hochgeschwender, Franz M Matschinsky, Klaus H Kaestner, Nicolai M Doliba, Jürgen Wes. Intra-islet glucagon signaling is critical for maintaining glucose homeostasis. JCI insight. vol 5. 2020-10-15. PMID:31012868. |
additional studies with mouse and human islets indicated that intra-islet glucagon stimulates insulin release primarily by activating β-cell glp-1 receptors. |
2020-10-15 |
2023-08-13 |
mouse |
| Ki-Suk Kim, Chelsea R Hutch, Landon Wood, Irwin J Magrisso, Randy J Seeley, Darleen A Sandova. Glycemic effect of pancreatic preproglucagon in mouse sleeve gastrectomy. JCI insight. vol 4. issue 20. 2020-10-15. PMID:31619587. |
the objective of these experiments was to determine whether changes in nutrition or alteration of gut hormone secretion by bariatric surgery would result in a larger role for intestinal glp-1 in the regulation of insulin secretion and glucose homeostasis. |
2020-10-15 |
2023-08-13 |
mouse |
| Miriam Ejarque, Fernando Guerrero-Pérez, Nuria de la Morena, Anna Casajoana, Nuria Virgili, Rafael López-Urdiales, Elsa Maymó-Masip, Jordi Pujol Gebelli, Amador Garcia Ruiz de Gordejuela, Manuel Perez-Maraver, Silvia Pellitero, Sonia Fernández-Veledo, Joan Vendrell, Nuria Vilarras. Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes. Scientific reports. vol 9. issue 1. 2020-10-09. PMID:31000783. |
biochemical parameters, fasting plasma insulin, glucagon and area under the curve (auc) of glp-1 following a standard meal test were determined before and 1 year after bariatric surgery. |
2020-10-09 |
2023-08-13 |
Not clear |
| Manuela Bomba, Alberto Granzotto, Vanessa Castelli, Marco Onofrj, Rossano Lattanzio, Annamaria Cimini, Stefano L Sens. Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31256135. |
glp-1, the glucagon-like peptide 1, facilitates insulin signaling, regulates glucose homeostasis, and modulates synaptic plasticity. |
2020-10-09 |
2023-08-13 |
mouse |
| Daniel F Arruda-Junior, Flavia L Martins, Thiago Almeida Salles, Leonardo Jensen, Rafael Dariolli, Ednei L Antonio, Leonardo Dos Santos, Renato O Crajoinas, Paulo J F Tucci, Luís Henrique W Gowdak, José Eduardo Krieger, Alexandre C Pereira, Adriana C Girard. Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure. Clinical science (London, England : 1979). vol 134. issue 9. 2020-10-07. PMID:32352510. |
serum concentrations of total and intact glp-1 and insulin were measured after an overnight fast and 15 min after the ingestion of a mixed breakfast meal in 49 non-diabetic patients with severe hf and 40 healthy control subjects. |
2020-10-07 |
2023-08-13 |
human |
| Elisa P Jensen, Sophie Møller, Aleksander Vauvert Hviid, Simon Veedfald, Jens J Holst, Jens Pedersen, Cathrine Ørskov, Charlotte M Sorense. GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in prehypertensive rats. American journal of physiology. Renal physiology. vol 318. issue 6. 2020-10-07. PMID:32390511. |
glucagon-like peptide-1 (glp-1) is an incretin hormone known to stimulate postprandial insulin release. |
2020-10-07 |
2023-08-13 |
mouse |
| Linda E Watson, Liza K Phillips, Tongzhi Wu, Michelle J Bound, Helen Checklin, Jacqueline Grivell, Karen L Jones, Michael Horowitz, Christopher K Rayne. Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clinical nutrition (Edinburgh, Scotland). vol 38. issue 6. 2020-10-05. PMID:30583967. |
our aim was to evaluate, in type 2 diabetes, the acute effects of low dose "preloads" of whey and guar, given alone or in combination before a meal, on postprandial glycemia, insulin, glp-1, and gastric emptying. |
2020-10-05 |
2023-08-13 |
Not clear |
| Jay Lin, Melissa Lingohr-Smith, Tao Fa. Real-world medication persistence and outcomes associated with basal insulin and glucagon-like peptide 1 receptor agonist free-dose combination therapy in patients with type 2 diabetes in the US. ClinicoEconomics and outcomes research : CEOR. vol 9. 2020-10-01. PMID:28053550. |
free-dose combination treatment with basal insulin and short-acting glucagon-like peptide-1 receptor agonists (glp-1 ras) reduces hyperglycemia via complementary targeting of fasting and postprandial blood glucose levels, however, in the real world, due to injection burden and clinical inertia, the full efficacy may not be able to translate into clinical and economic benefits. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hitoshi Ishii, Tetsuji Niiya, Yasuhiro Ono, Naoyuki Inaba, Hideaki Jinnouchi, Hirotaka Watad. Improvement of quality of life through glycemic control by liraglutide, a GLP-1 analog, in insulin-naive patients with type 2 diabetes mellitus: the PAGE1 study. Diabetology & metabolic syndrome. vol 9. 2020-10-01. PMID:28074109. |
liraglutide, a glp-1 receptor agonist, is a novel injection drug that promotes insulin secretion. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shingo Kainuma, Haruhiko Tokuda, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Atsushi Harada, Osamu Kozawa, Takanobu Otsuk. Attenuation by incretins of thyroid hormone-stimulated osteocalcin synthesis in osteoblasts. Biomedical reports. vol 5. issue 6. 2020-10-01. PMID:28105345. |
incretins, the polypeptide hormone glucose- dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) secreted from the small intestine after nutrient ingestion, are generally known to stimulate insulin secretion from pancreatic β-cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dorte Glintborg, Hanne Mumm, Jens Juul Holst, Marianne Anderse. Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome. Endocrine connections. vol 6. issue 4. 2020-10-01. PMID:28432082. |
insulin resistance in polycystic ovary syndrome (pcos) may increase the risk of reactive hypoglycaemia (rh) and decrease glucagon-like peptide-1 (glp-1) secretion. |
2020-10-01 |
2023-08-13 |
Not clear |
| Seungah Lee, Dong Yun Le. Glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes. Annals of pediatric endocrinology & metabolism. vol 22. issue 1. 2020-10-01. PMID:28443255. |
glp-1 has been shown to ameliorate diabetes-related conditions by augmenting pancreatic β-cell insulin secretion and having the low risk of causing hypoglycemia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Virginia Valentine, Jennifer Goldman, Jay H Shubroo. Rationale for, Initiation and Titration of the Basal Insulin/GLP-1RA Fixed-Ratio Combination Products, IDegLira and IGlarLixi, for the Management of Type 2 Diabetes. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 8. issue 4. 2020-10-01. PMID:28721686. |
native glucagon-like peptide-1 (glp-1) is a peptide hormone secreted by the gut in response to nutrient ingestion; it increases insulin secretion, inhibits glucagon secretion, and prolongs gastric emptying, thereby lowering overall food intake. |
2020-10-01 |
2023-08-13 |
Not clear |
| Soojin Kim, Jaewon Jeong, Hye-Seon Jung, Bokyung Kim, Ye-Eun Kim, Da-Sol Lim, So-Dam Kim, Yun Seon Son. Anti-inflammatory Effect of Glucagon Like Peptide-1 Receptor Agonist, Exendin-4, through Modulation of IB1/JIP1 Expression and JNK Signaling in Stroke. Experimental neurobiology. vol 26. issue 4. 2020-10-01. PMID:28912645. |
glucagon like peptide-1 (glp-1) stimulates glucose-dependent insulin secretion. |
2020-10-01 |
2023-08-13 |
mouse |
| Mari Amagai, Hirohisa Tsuchiya, Yukari Chiba, Jun Suzuki, Jo Nagakura, Erina Shigematsu, Tadashi Yamakawa, Yasuo Terauch. Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome. Journal of clinical medicine research. vol 9. issue 10. 2020-10-01. PMID:28912925. |
in patients with late dumping syndrome following gastrectomy, it has been reported that hypoglycemia occurs due to inhibition of glucagon secretion as a result of excessive insulin production facilitated by an increase in glucagon-like peptide-1 (glp-1). |
2020-10-01 |
2023-08-13 |
Not clear |