| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doreen Häberer, Maria Tasker, Martin Foltz, Nori Geary, Margriet Westerterp, Wolfgang Langhan. Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein. Physiology & behavior. vol 104. issue 5. 2012-02-06. PMID:21763707. |
plasma lactate, alanine, insulin, glucagon, glp-1 and paracetemol (an index of gastric emptying) all increased similarly, and glucose decreased similarly, after pph or pp. |
2012-02-06 |
2023-08-12 |
rat |
| Sheila A Doggrel. Sitagliptin or exenatide once weekly for type 2 diabetes: comparison of the clinical trials. Expert opinion on pharmacotherapy. vol 12. issue 13. 2012-02-03. PMID:21534885. |
glucagon-like peptide 1 (glp-1) is a gut hormone that stimulates insulin secretion and the levels of glp-1 can be increased by inhibiting dpp-4. |
2012-02-03 |
2023-08-12 |
Not clear |
| Pierre-Olivier Bastien-Dionne, Luca Valenti, Ning Kon, Wei Gu, Jean Butea. Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion. Diabetes. vol 60. issue 12. 2012-02-01. PMID:22013015. |
the glucoincretin hormone glucagon-like peptide 1 (glp-1) enhances glucose-stimulated insulin secretion and stimulates pancreatic β-cell mass expansion. |
2012-02-01 |
2023-08-12 |
human |
| James T Patterson, Jonathan W Day, Vasily M Gelfanov, Richard D DiMarch. Functional association of the N-terminal residues with the central region in glucagon-related peptides. Journal of peptide science : an official publication of the European Peptide Society. vol 17. issue 10. 2012-01-31. PMID:21661079. |
glp-1 is an incretin peptide involved in the regulation of glucose metabolism and the glucose-dependent stimulation of insulin secretion. |
2012-01-31 |
2023-08-12 |
Not clear |
| Ho-Sang Moon, Mi-Kyung Kim, Moon-Ho So. The development of non-peptide glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes. Archives of pharmacal research. vol 34. issue 7. 2012-01-31. PMID:21811909. |
glucagon-like peptide-1 (glp-1) is the main member of the incretin family and stimulates insulin secretion by binding with its specific receptor on pancreatic β-cells. |
2012-01-31 |
2023-08-12 |
Not clear |
| Morten Gram Pedersen, Chiara Dalla Man, Claudio Cobell. Multiscale modeling of insulin secretion. IEEE transactions on bio-medical engineering. vol 58. issue 10. 2012-01-31. PMID:21846600. |
recently, we have proposed a minimal model for the incretin effect by which the gut hormone glucagon-like peptide 1 (glp-1) enhances insulin secretion. |
2012-01-31 |
2023-08-12 |
Not clear |
| Morten Gram Pedersen, Chiara Dalla Man, Claudio Cobell. Multiscale modeling of insulin secretion. IEEE transactions on bio-medical engineering. vol 58. issue 10. 2012-01-31. PMID:21846600. |
to understand how this model couples to cellular events, we use a previously published mechanistic model of insulin secretion, and show mathematically that induction of glucose competence in beta cells by glp-1 can underlie derivative control by glp-1. |
2012-01-31 |
2023-08-12 |
Not clear |
| Helga Ellingsgaard, Irina Hauselmann, Beat Schuler, Abdella M Habib, Laurie L Baggio, Daniel T Meier, Elisabeth Eppler, Karim Bouzakri, Stephan Wueest, Yannick D Muller, Ann Maria Kruse Hansen, Manfred Reinecke, Daniel Konrad, Max Gassmann, Frank Reimann, Philippe A Halban, Jesper Gromada, Daniel J Drucker, Fiona M Gribble, Jan A Ehses, Marc Y Donat. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature medicine. vol 17. issue 11. 2012-01-23. PMID:22037645. |
glucagon-like peptide-1 (glp-1) is a hormone that induces insulin secretion. |
2012-01-23 |
2023-08-12 |
Not clear |
| Helga Ellingsgaard, Irina Hauselmann, Beat Schuler, Abdella M Habib, Laurie L Baggio, Daniel T Meier, Elisabeth Eppler, Karim Bouzakri, Stephan Wueest, Yannick D Muller, Ann Maria Kruse Hansen, Manfred Reinecke, Daniel Konrad, Max Gassmann, Frank Reimann, Philippe A Halban, Jesper Gromada, Daniel J Drucker, Fiona M Gribble, Jan A Ehses, Marc Y Donat. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature medicine. vol 17. issue 11. 2012-01-23. PMID:22037645. |
here we show that administration of il-6 or elevated il-6 concentrations in response to exercise stimulate glp-1 secretion from intestinal l cells and pancreatic alpha cells, improving insulin secretion and glycemia. |
2012-01-23 |
2023-08-12 |
Not clear |
| Juan Patricio Valderas, Veronica Irribarra, Lorena Rubio, Camilo Boza, Manuel Escalona, Yessica Liberona, Andrea Matamala, Alberto Mai. Effects of sleeve gastrectomy and medical treatment for obesity on glucagon-like peptide 1 levels and glucose homeostasis in non-diabetic subjects. Obesity surgery. vol 21. issue 7. 2012-01-19. PMID:21347823. |
this study aims to assess plasma glucose levels, insulin sensitivity and secretion, and glp-1 levels before and after sleeve gastrectomy (sg) or medical treatment (med) for obesity. |
2012-01-19 |
2023-08-12 |
human |
| Luciana Mela Umeda, Eliana A Silva, Glaucia Carneiro, Carlos H Arasaki, Bruno Geloneze, Maria Teresa Zanell. Early improvement in glycemic control after bariatric surgery and its relationships with insulin, GLP-1, and glucagon secretion in type 2 diabetic patients. Obesity surgery. vol 21. issue 7. 2012-01-19. PMID:21559794. |
early improvement in glycemic control after bariatric surgery and its relationships with insulin, glp-1, and glucagon secretion in type 2 diabetic patients. |
2012-01-19 |
2023-08-12 |
Not clear |
| Riccardo Perfett. Combining basal insulin analogs with glucagon-like peptide-1 mimetics. Diabetes technology & therapeutics. vol 13. issue 9. 2012-01-19. PMID:21711120. |
the combination of basal insulin with a glucagon-like peptide-1 (glp-1) mimetic is a potentially attractive solution to this problem for some patients with type 2 diabetes. |
2012-01-19 |
2023-08-12 |
Not clear |
| Meixia Dan, Janet K Chantle. A novel pancreatropic coxsackievirus vector expressing glucagon-like peptide 1 reduces hyperglycemia in streptozotocin-treated mice. Journal of virology. vol 85. issue 23. 2012-01-19. PMID:21937637. |
inoculation of streptozotocin (stz)-treated mice with vcvb(dm)glp-1 was found to suppress development of hyperglycemia and increase insulin production relative to mice treated with stz alone or with empty vector. |
2012-01-19 |
2023-08-12 |
mouse |
| Koichiro Tanaka, Yoshihisa Urita, Kazuhiko Nara, Oto Miura, Motonobu Sugimot. Effects of the traditional Japanese medicine Rikkunshito on postprandial glucose and lipid metabolism. Hepato-gastroenterology. vol 58. issue 109. 2012-01-17. PMID:21937360. |
the aim of the present study was to investigate associations between blood glucose and insulin levels and glp-1 response after administration of solid test meals. |
2012-01-17 |
2023-08-12 |
Not clear |
| Gordon Goodall, María Costi, Louise Timlin, Jesús Reviriego, José Antonio Sacristán, Jayne Smith-Palmer, Tatiana Dill. [Cost-effectiveness of exenatide versus insulin glargine in Spanish patients with obesity and type 2 diabetes mellitus]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. vol 58. issue 7. 2012-01-16. PMID:21719364. |
exenatide, a glp-1 receptor agonist for adjuvant treatment of type 2 diabetes mellitus (t2dm), has been shown to be as effective as insulin glargine (ig) for reducing glycated hemoglobin levels combined with metformin or/and sulphonylureas. |
2012-01-16 |
2023-08-12 |
Not clear |
| Jason G Barrera, Darleen A Sandoval, David A D'Alessio, Randy J Seele. GLP-1 and energy balance: an integrated model of short-term and long-term control. Nature reviews. Endocrinology. vol 7. issue 9. 2012-01-09. PMID:21647189. |
glucagon-like peptide 1 (glp-1), a peptide secreted from the intestine in response to nutrient ingestion, is perhaps best known for its effect on glucose-stimulated insulin secretion. |
2012-01-09 |
2023-08-12 |
Not clear |
| Vanita R Aroda, Robert Ratne. The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review. Diabetes/metabolism research and reviews. vol 27. issue 6. 2012-01-05. PMID:21484979. |
stimulation of pancreatic insulin secretion by glp-1 receptor agonists is glucose dependent, conferring a lesser risk of hypoglycaemia than that seen with sulfonylureas. |
2012-01-05 |
2023-08-12 |
human |
| C G Jolivalt, M Fineman, C F Deacon, R D Carr, N A Calcut. GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. Diabetes, obesity & metabolism. vol 13. issue 11. 2012-01-05. PMID:21635674. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that induces glucose-dependent insulin secretion and may have neurotrophic properties. |
2012-01-05 |
2023-08-12 |
mouse |
| Y Wang, L Li, M Yang, H Liu, G Boden, G Yan. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes, obesity & metabolism. vol 13. issue 11. 2012-01-05. PMID:21651690. |
to compare the effect and safety of glucagon-like peptide-1 receptor agonists (glp-1 ra) with insulin therapy on type 2 diabetes mellitus (t2dm) patients inadequately controlled with metformin and/or sulfonylurea. |
2012-01-05 |
2023-08-12 |
Not clear |
| Y Wang, L Li, M Yang, H Liu, G Boden, G Yan. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes, obesity & metabolism. vol 13. issue 11. 2012-01-05. PMID:21651690. |
the mean net change [95% confidence interval (cis)] for hba1c, weight loss and fpg for patients treated with glp-1 ra as compared with insulin was -0.14% (-2 mmol/mol) [95% ci; (-0.27, -0.02)%; p = 0.03]; -4.40 kg [95% ci; (-5.23, -3.56) kg; p < 0.01] and 1.18 mmol/l [95% ci; (0.43, 1.93) mmol/l; p < 0.01], respectively, with negative values favouring glp-1 and positive values favouring insulin. |
2012-01-05 |
2023-08-12 |
Not clear |