| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Wang, L Li, M Yang, H Liu, G Boden, G Yan. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes, obesity & metabolism. vol 13. issue 11. 2012-01-05. PMID:21651690. |
the glp-1 group was associated with a greater reduction in ppg than the insulin group. |
2012-01-05 |
2023-08-12 |
Not clear |
| Y Wang, L Li, M Yang, H Liu, G Boden, G Yan. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes, obesity & metabolism. vol 13. issue 11. 2012-01-05. PMID:21651690. |
glp-1 ra are promising new agents compared with insulin. |
2012-01-05 |
2023-08-12 |
Not clear |
| Gian Paolo Fadini, Angelo Avogar. Cardiovascular effects of DPP-4 inhibition: beyond GLP-1. Vascular pharmacology. vol 55. issue 1-3. 2012-01-05. PMID:21664294. |
in turn, glp-1 improves meal-stimulated insulin secretion by pancreatic β-cells thus reducing hyperglycemia. |
2012-01-05 |
2023-08-12 |
Not clear |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
dynamics of plasma active glp-1 versus insulin and glucose concentrations during glp-1 infusion in rat model of postprandial hyperglycemia. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
in vitro studies in isolated pancreas and islets have shown that glucagon-like peptide-1 (glp-1) promotes insulin release in a typical concentration-dependent manner. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
in contrast, the relationship between plasma glp-1 and insulin concentrations in vivo is complicated, because glp-1-promoted insulin release lowers blood glucose, which influences glucose-dependent insulinotropic ability of glp-1. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
glp-1 also stimulates insulin release via hepatoportal neuronal mechanism. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
hence, the dynamic relationship between plasma active glp-1 vs. insulin and glucose concentrations is obscure. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
glp-1 infusion from jugular vein significantly and concentration-dependently enhanced area under the curve (auc) of the 1st phase insulin, in which the minimum effective active glp-1 concentration was 6.6 pmol/l. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
in contrast, bell-shaped dose responses were observed for both the 2nd phase and total insulin aucs, in which a significant increase was obtained only with 11 pmol/l of active glp-1 for total insulin auc. |
2012-01-03 |
2023-08-12 |
rat |
| Jun-ichi Eiki, Toshihiko Yad. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine journal. vol 58. issue 8. 2012-01-03. PMID:21673460. |
these results indicate that glp-1 markedly enhances the 1st phase insulin release while less potently the 2nd phase insulin release, possibly due to a negative feedback regulation of β-cells via reduced plasma glucose levels by the enhanced 1st phase insulin release. |
2012-01-03 |
2023-08-12 |
rat |
| Shu-Jen Chen, Weir-Torn Jiaan. Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein. Current topics in medicinal chemistry. vol 11. issue 12. 2011-12-29. PMID:21510839. |
glp-1 regulates glucose homeostasis by stimulating insulin secretion, inhibiting glucagon release, and delaying gastric emptying. |
2011-12-29 |
2023-08-12 |
Not clear |
| Shu-Jen Chen, Weir-Torn Jiaan. Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein. Current topics in medicinal chemistry. vol 11. issue 12. 2011-12-29. PMID:21510839. |
intravenous glp-1 has been shown to increase insulin secretion in response to elevated glucose levels and offers therapeutic benefit for patients with type 2 diabetes. |
2011-12-29 |
2023-08-12 |
Not clear |
| Edward A Carter, Ali A Bonab, Jeremy Goverman, Kasie Paul, John Yerxa, Ronald G Tompkins, Alan J Fischma. Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance. International journal of molecular medicine. vol 28. issue 4. 2011-12-28. PMID:21805045. |
in the acute care setting, several approaches have been used for treating insulin resistance, including insulin infusion, propranolol and glucagon-like-peptide-1 (glp-1). |
2011-12-28 |
2023-08-12 |
mouse |
| Sze Wa Chan, Ge Lin, David Tai Wai Yew, John Anthony Rud. A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew). European journal of pharmacology. vol 668. issue 1-2. 2011-12-27. PMID:21756894. |
glucagon-like peptide-1 (7-36) amide (glp-1) is released from the gut as an incretin hormone to stimulate glucose-stimulated insulin secretion. |
2011-12-27 |
2023-08-12 |
Not clear |
| Sze Wa Chan, Ge Lin, David Tai Wai Yew, John Anthony Rud. A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew). European journal of pharmacology. vol 668. issue 1-2. 2011-12-27. PMID:21756894. |
the data suggests that the central glp-1 system may regulate glucose homeostasis by increasing insulin secretion. |
2011-12-27 |
2023-08-12 |
Not clear |
| Manuel Dolz, Jamileh Movassat, Danielle Bailbé, Hervé Le Stunff, Marie-Hélène Giroix, Magali Fradet, Micheline Kergoat, Bernard Porth. cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1. American journal of physiology. Endocrinology and metabolism. vol 301. issue 5. 2011-12-20. PMID:21750265. |
camp-raising agents with glucagon-like peptide-1 (glp-1) as the first in class, exhibit multiple actions that are beneficial for the treatment of type 2 diabetic (t2d) patients, including improvement of glucose-induced insulin secretion (giis). |
2011-12-20 |
2023-08-12 |
rat |
| Manuel Dolz, Jamileh Movassat, Danielle Bailbé, Hervé Le Stunff, Marie-Hélène Giroix, Magali Fradet, Micheline Kergoat, Bernard Porth. cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1. American journal of physiology. Endocrinology and metabolism. vol 301. issue 5. 2011-12-20. PMID:21750265. |
even in the presence of ibmx or glp-1, their insulin release did not significantly change despite further enhanced camp accumulation in both cases. |
2011-12-20 |
2023-08-12 |
rat |
| Manuel Dolz, Jamileh Movassat, Danielle Bailbé, Hervé Le Stunff, Marie-Hélène Giroix, Magali Fradet, Micheline Kergoat, Bernard Porth. cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1. American journal of physiology. Endocrinology and metabolism. vol 301. issue 5. 2011-12-20. PMID:21750265. |
moreover, the gk/par insulin release apparatus appears less sensitive to camp, since gk/par islets released less insulin at submaximal camp levels and required five times more camp to reach a maximal secretion rate no longer different from w. glp-1 was able to reactivate gk/par insulin secretion so that giis became indistinguishable from that of w. the exaggerated camp production is instrumental, since glp-1-induced giis reactivation was lost in the presence the ac blocker 2',5'-dideoxyadenosine. |
2011-12-20 |
2023-08-12 |
rat |
| B Laferrèr. Diabetes remission after bariatric surgery: is it just the incretins? International journal of obesity (2005). vol 35 Suppl 3. 2011-12-20. PMID:21912382. |
the improved insulin release and glucose tolerance after gbp were shown by others to be blocked by the administration of a glp-1 antagonist, demonstrating that the favorable metabolic changes after gbp are, in part, glp-1 dependent. |
2011-12-20 |
2023-08-12 |
Not clear |