| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hélène Duez, Bertrand Cariou, Bart Stael. DPP-4 inhibitors in the treatment of type 2 diabetes. Biochemical pharmacology. vol 83. issue 7. 2012-04-10. PMID:22172989. |
these agents inhibit the degradation of the incretins glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) and hence potentiate glucose-dependent insulin secretion. |
2012-04-10 |
2023-08-12 |
Not clear |
| B Vergès, C Bonnard, E Renar. Beyond glucose lowering: glucagon-like peptide-1 receptor agonists, body weight and the cardiovascular system. Diabetes & metabolism. vol 37. issue 6. 2012-04-03. PMID:21871831. |
glucagon-like peptide-1 (glp-1) belongs to the incretin hormone family: in the presence of elevated blood glucose, it stimulates insulin secretion and inhibits glucagon production. |
2012-04-03 |
2023-08-12 |
Not clear |
| Jens Juul Holst, Maria A McGil. Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: focus on bile acid sequestrants. Clinical drug investigation. vol 32. issue 1. 2012-04-03. PMID:21958333. |
the incretin hormones glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) stimulate glucose-induced insulin secretion; however, in patients with type 2 diabetes, the incretin system is impaired by loss of the insulinotropic effects of gip as well as a possible reduction in secretion of glp-1. |
2012-04-03 |
2023-08-12 |
mouse |
| Jens Juul Holst, Maria A McGil. Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: focus on bile acid sequestrants. Clinical drug investigation. vol 32. issue 1. 2012-04-03. PMID:21958333. |
both the gpcr agonist ar231453 and the novel bile acid mimetic int-777 have been shown to stimulate glp-1 release, leading to increased insulin secretion and improved glucose tolerance in mice. |
2012-04-03 |
2023-08-12 |
mouse |
| Jens Juul Holst, Maria A McGil. Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: focus on bile acid sequestrants. Clinical drug investigation. vol 32. issue 1. 2012-04-03. PMID:21958333. |
similarly, a study in insulin-resistant rats demonstrated that the bile acid sequestrant colesevelam increased glp-1 secretion and improved glucose levels and insulin resistance. |
2012-04-03 |
2023-08-12 |
mouse |
| Jae-Hyung Park, Sun-Joo Kim, Sung-Hee Park, Dae-Gu Son, Jae-Hoon Bae, Hyoung Kyu Kim, Jin Han, Dae-Kyu Son. Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A. Endocrinology. vol 153. issue 2. 2012-03-27. PMID:22147008. |
these results suggested that glp-1 can further potentiate gsis by enhancing gk activity through the signaling of epac2 to rim2 and rab3a, which is the similar pathway for glp-1 to potentiate ca(2+)-dependent insulin granule exocytosis. |
2012-03-27 |
2023-08-12 |
rat |
| Mi Jin Moon, Hee Young Kim, Sumi Park, Dong-Kyu Kim, Eun Bee Cho, Cho Rong Park, Dong-Joo You, Jong-Ik Hwang, Kyungjin Kim, Han Choe, Jae Young Seon. Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22105074. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) play important roles in insulin secretion through their receptors, glp1r and gipr. |
2012-03-25 |
2023-08-12 |
Not clear |
| Jonas B Møller, William J Jusko, Wei Gao, Torben Hansen, Oluf Pedersen, Jens J Holst, Rune V Overgaard, Henrik Madsen, Steen H Ingwerse. Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test. Journal of pharmacokinetics and pharmacodynamics. vol 38. issue 6. 2012-03-20. PMID:21922329. |
glp-1 is an insulinotropic hormone that synergistically with glucose gives rise to an increased insulin response. |
2012-03-20 |
2023-08-12 |
human |
| Jonas B Møller, William J Jusko, Wei Gao, Torben Hansen, Oluf Pedersen, Jens J Holst, Rune V Overgaard, Henrik Madsen, Steen H Ingwerse. Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test. Journal of pharmacokinetics and pharmacodynamics. vol 38. issue 6. 2012-03-20. PMID:21922329. |
the goal was thus to model the secretion of glp-1, and not its effect on insulin production. |
2012-03-20 |
2023-08-12 |
human |
| Jonas B Møller, William J Jusko, Wei Gao, Torben Hansen, Oluf Pedersen, Jens J Holst, Rune V Overgaard, Henrik Madsen, Steen H Ingwerse. Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test. Journal of pharmacokinetics and pharmacodynamics. vol 38. issue 6. 2012-03-20. PMID:21922329. |
glucose, insulin, and total glp-1 concentrations were measured. |
2012-03-20 |
2023-08-12 |
human |
| Xiaofang Xu, Victoria L Browning, Jon S Odoric. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mechanisms of development. vol 128. issue 7-10. 2012-03-19. PMID:21855631. |
further differentiation occurs after ebs are embedded in matrigel and cultured in serum-free media containing insulin, transferrin, selenium, fgf7, nicotinamide, islet neogenesis associated peptide (ingap) and exendin-4, a long acting glp-1 agonist. |
2012-03-19 |
2023-08-12 |
human |
| Mi Jin Moon, Hee Young Kim, Sumi Park, Dong-Kyu Kim, Eun Bee Cho, Jong-Ik Hwang, Jae Young Seon. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Molecules and cells. vol 32. issue 4. 2012-03-16. PMID:21904878. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion from pancreatic β-cells in a glucose-dependent manner. |
2012-03-16 |
2023-08-12 |
Not clear |
| Mi Jin Moon, Hee Young Kim, Sumi Park, Dong-Kyu Kim, Eun Bee Cho, Jong-Ik Hwang, Jae Young Seon. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Molecules and cells. vol 32. issue 4. 2012-03-16. PMID:21904878. |
in this study, we examined the possible involvement of insulin and receptor tyrosine kinase signaling in regulation of the glp-1 responsiveness of β-cells. |
2012-03-16 |
2023-08-12 |
Not clear |
| Mi Jin Moon, Hee Young Kim, Sumi Park, Dong-Kyu Kim, Eun Bee Cho, Jong-Ik Hwang, Jae Young Seon. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Molecules and cells. vol 32. issue 4. 2012-03-16. PMID:21904878. |
these results suggest that insulin contributes to fine-tuning of the β-cell response to glp-1. |
2012-03-16 |
2023-08-12 |
Not clear |
| B Ahrén, B Burk. Using albumin to improve the therapeutic properties of diabetes treatments. Diabetes, obesity & metabolism. vol 14. issue 2. 2012-03-12. PMID:21812895. |
recent advances include insulin analogues that more closely mimic physiologic insulin levels, and incretin-based therapies, which capitalize on the glucoregulatory properties of native glucagon-like peptide-1 (glp-1). |
2012-03-12 |
2023-08-12 |
Not clear |
| B Ahrén, B Burk. Using albumin to improve the therapeutic properties of diabetes treatments. Diabetes, obesity & metabolism. vol 14. issue 2. 2012-03-12. PMID:21812895. |
although promising, these agents are associated with limitations, including hypoglycaemia with insulin, gastrointestinal adverse events with glp-1 receptor agonists and frequent dosing with both classes. |
2012-03-12 |
2023-08-12 |
Not clear |
| Melissa A Burmeister, Tura Ferre, Jennifer E Ayala, Emily M King, Rochelle M Holt, Julio E Ayal. Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice. American journal of physiology. Endocrinology and metabolism. vol 302. issue 3. 2012-03-09. PMID:22094469. |
acute activation of central glp-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice. |
2012-03-09 |
2023-08-12 |
mouse |
| Melissa A Burmeister, Tura Ferre, Jennifer E Ayala, Emily M King, Rochelle M Holt, Julio E Ayal. Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice. American journal of physiology. Endocrinology and metabolism. vol 302. issue 3. 2012-03-09. PMID:22094469. |
glucagon-like peptide-1 (glp-1) receptor knockout (glp1r(-/-)) mice exhibit impaired hepatic insulin action. |
2012-03-09 |
2023-08-12 |
mouse |
| Melissa A Burmeister, Tura Ferre, Jennifer E Ayala, Emily M King, Rochelle M Holt, Julio E Ayal. Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice. American journal of physiology. Endocrinology and metabolism. vol 302. issue 3. 2012-03-09. PMID:22094469. |
intracerebroventricular ex-9 impaired the suppression of hepatic glucose production by insulin, whereas icv glp-1 improved it. |
2012-03-09 |
2023-08-12 |
mouse |
| Akira Hirasawa, Takafumi Hara, Atsuhiko Ichimura, Gozoh Tsujimot. [Free fatty acid receptors and their physiological role in metabolic regulation]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 131. issue 12. 2012-03-06. PMID:22129861. |
gpr40 is expressed mainly in pancreatic β-cell and mediates insulin secretion, whereas gpr120 is expressed abundantly in the intestine and regulates the secretion of cholecystokinin (cck) and glucagons-like peptide-1 (glp-1), it promotes insulin secretion. |
2012-03-06 |
2023-08-12 |
Not clear |